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| 1 | Nationwide trends and predictors of inpatient mortality in 83884 transjugular intrahepatic portosystemic shunt显示文摘AIM: To evaluate and validate the national trends and predictors of in-patient mortality of transjugular intrahepatic portosystemic shunt(TIPS) in 15 years.METHODS: Using the National Inpatient Sample which is a part of Health Cost and Utilization Project, we identified a discharge-weighted national estimate of 83884 TIPS procedures performed in the United States from 1998 to 2012 using international classification of diseases-9 procedural code 39.1. The demographic, hospital and co-morbility data were analyzed using a multivariant analysis. Using multi-nominal logistic regression analysis, we determined predictive factors related to increases in-hospital mortality. Comorbidity measures are in accordance to the Comorbidity Software designed by the Agency for Healthcare Research and Quality.RESULTS: Overall, 12.3% of patients died during hospitalization with downward trend in-hospitalmortality with the mean length of stay of 10.8 ± 13.1 d. Notable, African American patients(OR = 1.809 vs Caucasian patients, P < 0.001), transferred patients(OR = 1.347 vs non-transferred, P < 0.001), emergency admissions(OR = 3.032 vs elective cases, P < 0.001), patients in the Northeast region(OR = 1.449 vs West, P < 0.001) had significantly higher odds of inhospital mortality. Number of diagnoses and number of procedures showed positive correlations with in-hospital death(OR = 1.249 per one increase in number of procedures). Patients diagnosed with acute respiratory failure(OR = 8.246), acute kidney failure(OR = 4.359), hepatic encephalopathy(OR = 2.217) and esophageal variceal bleeding(OR = 2.187) were at considerably higher odds of in-hospital death compared with ascites(OR = 0.136, P < 0.001). Comorbidity measures with the highest odds of in-hospital death were fluid and electrolyte disorders(OR = 2.823), coagulopathy(OR = 2.016), and lymphoma(OR = 1.842).CONCLUSION: The overall mortality of the TIPS procedure is steadily decreasing, though the length of stay has remained relatively constant. Specific patient ethnicity, location, transfer status, primary diagnosis and comorbidities correlate with increased odds of TIPS in-hospital death. | Edward Wolfgang Lee Andrew Kuei Sammy Saab Ronald W Busuttil Francisco Durazo Steven-Huy Han Mohamed M El-Kabany Justin P Mc Williams Stephen T Kee | 2016 | World Journal of Gastroenterology2016，22，25： | 7 |
| 2 | Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation显示文摘Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation. | Darin S Krygier Urs P Steinbrecher Martin Petric Siegfried R Erb Stephen W Chung Charles H Scudamore Andrzej K Buczkowski Eric M Yoshida | 2009 | World Journal of Gastroenterology2009，15，32： | 3 |
| 3 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 4 | Consequences of the Allee effect for behaviour, ecology and censer?vation显示文摘 | Stephens P A Sutherland W J | 1999 | Trends in Ecology and Evolution1999，14，10： | 1 |
| 5 | Steepest algorithm for neural network controllers and filters显示文摘 | STEPHEN W P | 1994 | IEEE Trans Neural Networks1994，5，2： | 1 |
| 6 | Anti-inflammatory activity of Chinese medicinal vine plants显示文摘 | Rachel W Li G David Lin Stephen P Myers David N Leach | 2002 | Journal of Ethnopharmacology2002，，1： | 1 |
| 7 | Stability of networked control systems显示文摘 | Zhang W Michael S B Stephen M P | 2001 | IEEE Control Systems Magazine2001，21，1： | 1 |
| 8 | Enforced stacking in crowded arenes显示文摘 | Bushey M L Hwang A Stephens P W | 2001 | J Am Chem Soc2001，123，： | 1 |
| 9 | Consequences of the Allee effect for behaviour, ecology and conservation显示文摘 | Stephens P A Sutherland W J | 1999 | Trends in Ecology and Evolution1999，14，： | 1 |
| 10 | The consequences of chirality in crowded arenes-macromolectdar helieity,hierarchical ordering,and directed assembly显示文摘 | Bushey M L Hwang A Stephens P W | 2002 | Angew Chem Int Ed2002，41，： | 1 |
| 11 | Coping style as a psychological resource of grateful people显示文摘 | Alex M W Stephen J Linley A P | 2007 | Journal of Social and Clinical Psychology2007，26，9： | 1 |
| 12 | Tidal energy dissipation at the sill of Sechelt Inlet, British Columbia 显示文摘 | SCOTT W T STEPHEN P | 2001 | Journal of Physical Oceanog- raphy2001，31，12： | 1 |
| 13 | Effect of soil layering on NAPL removal behavior in soil-heated vapor extraction显示文摘 | Stephen W W James M P | 1997 | Journal of Contaminant Hydrology1997，27，34： | 1 |
| 14 | Optical fibre long-period grating sensors: characteristics and application显示文摘 | Stephen W J Ralph P T | 2003 | Measurement Science and Technology2003，15，5： | 1 |
| 15 | Global lithium resources : relative importanceof pegmatite,brine and other deposits 显示文摘 | Stephen E Kealer Paul W Gruber Pablo A Medina Gregory A Keoleian Mark P Everson Timothy J Wall-ington | 2012 | Ore GeologyReviews2012，48，： | 1 |
| 16 | The role of neuropeptide Y in the antiobesity action of the obese gene product显示文摘 | Stephens T W Basinski M Bristow P K | 1995 | Nature1995，377，6549： | 1 |
| 17 | Nanoscale Atoms in Solid- State Chemistry 显示文摘 | Roy X Lee C H Crowther A C Schenck C L Besara T Lalancette R A Siegrist T Stephens P W Brus L E Kim P Steigerwald M L Nuckolls C | 2013 | Science2013，，341： | 1 |
| 18 | The development and application of genetic markers for the Kuruma prawn Penaeus japonicus 显示文摘 | Stephen S M Vicki W Gerard P D | 1999 | Aquaculture1999，173，： | 1 |
| 19 | Application of the HilbertHuang Transform to the Analysis of Molecular Dynamics Simulations显示文摘 | Stephen C P Robert J G Jonathan W E | | 0，，： | 1 |
| 20 | The role of neu ropeptide Y in the antiobesity action of the obese gene product显示文摘 | Stephens T W Basinski Bristow P K | 1995 | Nature (Lond)1995，377，： | 1 |
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