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| 1 | Cancer-related inflammation and treatment effectiveness显示文摘 | Connie I Diakos Kellie A Charles Donald C McMillan Stephen J Clarke | 2014 | Lancet Oncology2014，，： | 3 |
| 2 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 3 | Nanoscopy reveals surface-metallic black phosphorus显示文摘Black phosphorus(BP)is an emerging two-dimensional material with intriguing physical properties.It is highly anisotropic and highly tunable by means of both the number of monolayers and surface doping.Here,we experimentally investigate and theoretically interpret the near-field properties of a-few-atomic-monolayer nanoflakes of BP.We discover near-field patterns of bright outside fringes and a high surface polarizability of nanofilm BP consistent with its surface-metallic,plasmonic behavior at mid-infrared frequencies o1176 cm−1.We conclude that these fringes are caused by the formation of a highly polarizable layer at the BP surface.This layer has a thickness of~1 nm and exhibits plasmonic behavior.We estimate that it contains free carriers in a concentration of n≈1.1×10^(20) cm^(−3).Surface plasmonic behavior is observed for 10–40 nm BP thicknesses but absent for a 4-nm BP thickness.This discovery opens up a new field of research and potential applications in nanoelectronics,plasmonics and optoelectronics. | Yohannes Abate Sampath Gamage Zhen Li Viktoriia Babicheva Mohammad H Javani Han Wang Stephen B Cronin Mark I Stockman | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 4 | Studies on the anti-asthmatic and antitussive properties of aqueous leaf extract of Bryophyllum pinnatum in rodent species显示文摘Objective:To evaluate the antiasthmatic and antitussive properties of the aqueous leaf extract of Bryophyilum pinnatum {B.pinnatum)(BP) Lam.Methods:Ovalbiunin-sensilized guinea pigs which were treated with BP for 21 consecutive days were exposed to 0.2%histamine aerosol in a glass chamber.Mucus viscosity,white blood cell and lymphocyte counts and tracheal wall morphometry were measured.Bouts of cough were counted pre and post acute exposure of extract-treated(X7 d) guinea pigs to 7.5%citric acid aerosol in a chamber.Phenol red expectoration was estimated in mice after 7 d of daily administration of BP.Results:Doses of 200 and 400 mg/kg/day(×21 d) BP significantly increased the time for guinea pigs to experience preconvulsive dyspnoea.BP and salbutamol(0.5 mg/kg/day×21 d) reduced mucus viscosity in the sensitized group to values comparable with controls.White blood cell,lymphocyte counts and tracheal morphometry were not significantly altered.Both doses of BP also significantly reduced the bouts of cough but only 400 mg/kg/day significantly inhibited the amount of phenol red secreted.Conclusions:BP has demonstrated antiasthmatic and antitussive properties in these rodent models.These properties may underscore its use in Nigerian ethnomedicine. | Edward O Salami Raymond I Ozolua Stephen O Okpo Gerald I Eze Dickson O Uwaya | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，6： | 2 |
| 5 | Community-level physiological profiles of bacteria and fungi: plate type and incubation temperature influences on contrasting soils显示文摘 | Aimée T Classen Sarah I Boyle Kristin E Haskins Steven T Overby Stephen C Hart | | FEMS Microbiology Ecology0，，： | 2 |
| 6 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 7 | Identification of telmisartan as a unique angiotensin Ⅱ receptor antagonist with selective ppargamma- modulating activity 显示文摘 | Stephen C Benson Harrihar A Pershadsingh Christopher I Ho | 2004 | Hypertension2004，43，： | 1 |
| 8 | Relations algebras in qualitative spatial reasoning显示文摘 | DNTSCH I WANG H STEPHEN M | 1999 | Fundamenta Informaticae1999，39，3： | 1 |
| 9 | Finite element model for predic?ting time-dependent deformations and damage accumulation in laminated composite boltedJoints显示文摘 | Kallmeyer A R Stephens R I | 1999 | Journal of Composite Materials1999，33，9： | 1 |
| 10 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 11 | Minimizing the use of Platinum in hydrogen-evolving electrodes显示文摘 | Stephens I E L Chorkendorff I | 2011 | Angewandte Chemie International Edition2011，50，7： | 1 |
| 12 | Array feed synthesis for correction of reflector distortion vernier beamsteering 显示文摘 | STEPHEN J B WILLIAM A I | 1998 | IEEE Transaction on Antennas and Propagation1998，36，10： | 1 |
| 13 | Influence of Climate on Tea Yields in Mount Kenya Region显示文摘 | Stephen K Rwigi Silvery B B Oteng' i | 2009 | Journal of Meteorology and Re- lated Sciences2009，3，： | 1 |
| 14 | Treatment of COPD with cilomilast 显示文摘 | Stephen I Fccp R Schaehter N | 2006 | Chest2006，129，： | 1 |
| 15 | New understanding of pathogenesis and mechanisms can guide future therapy 显示文摘 | Stephen I Rennard D | 2002 | Postgraduate Medicine Minneapolis2002，6，111： | 1 |
| 16 | Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARY modulating activity 显示文摘 | Stephen C Harrihar A Christopher I | 2004 | Hypertention2004，43，： | 1 |
| 17 | Alloysof platinum and early transition metals as oxygen reduc- tion electrocatalysts显示文摘 | Greeley J Stephens I E L Bondarenko A S | 2009 | Nature Chemistry2009，1，7： | 1 |
| 18 | Network computing: a tutorial review显示文摘 | I Boyd C Stephens | 2001 | Electronics & Communication Engineering Journal2001，13，1： | 1 |
| 19 | The Gelation and Crystallization of Amylopeetin 显示文摘 | Stephen G Ring Paul Colonna Kenneth J I' Anson | 1987 | Carbohydr Res1987，162，： | 1 |
| 20 | A numerical study of flow and heat transfer in a smooth and ribbed U-duct with and without rotation显示文摘 | LIN Y L SHIH T I P STEPHENS M A | 2001 | Journal of Heat Transfer2001，123，： | 1 |
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