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| 1 | Role of microRNAs in translation regulation and cancer显示文摘MicroRNAs(miRNAs) are pervasively expressed and regulate most biological functions. They function by modulating transcriptional and translational programs and therefore they orchestrate both physiological and pathological processes, such as development, cell differentiation, proliferation, apoptosis and tumor growth. miRNAs work as small guide molecules in RNA silencing, by negatively regulating the expression of several genes both at mRNA and protein level, by degrading their mRNA target and/or by silencing translation. One of the most recent advances in the field is the comprehension of their role in oncogenesis. The number of miRNA genes is increasing and an alteration in the level of miRNAs is involved in the initiation, progression and metastases formation of several tumors. Some tumor types show a distinct miRNA signature that distinguishes them from normal tissues and from other cancer types. Genetic and biochemical evidence supports the essential role of miRNAs in tumor development. Although the abnormal expression of miRNAs in cancer cells is a widely accepted phenomenon, the cause of this dysregulation is still unknown. Here, we discuss the biogenesis of miRNAs, focusing on the mechanisms by which they regulate protein synthesis. In addition we debate on their role in cancer, highlighting their potential to become therapeutic targets. | Stefania Oliveto Marilena Mancino Nicola Manfrini Stefano Biffo | 2017 | World Journal of Biological Chemistry2017，8，1： | 60 |
| 2 | 光学相干层析成像检测斑块形态的误差来源及解释 | Manfrini O. Mont E. Leone O. R. Bugiardini 刘相飞 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，0，1： | 3 |
| 3 | Antibodies to bovine beta- casein in diabetes and other autoimmune diseases 显示文摘 | Monetini L Cavallo MG Manfrini S | 2002 | Horm Metab Res2002，34，： | 1 |
| 4 | Osteosarcoma magnetic resonance imaging of the effects of preoperative chemotherapy 显示文摘 | Spina V Torricelli P Manfrini M | 1993 | Radiol Med1993，85，6： | 1 |
| 5 | The effects of calcitriol andnicotinamide on residual pancreatic beta-cell function in patients with recent-onset Type 1 diabetes(IMDIAB XI)显示文摘 | Pitocco D Di Stasio E Manfrini S | | 0，，08： | 1 |
| 6 | Intraepiphyseal resection of the proximal tibia and its impact on lewer limb growth显示文摘 | Manfrini M Gasbarrini A Malaguti C | 1999 | Clin Orthop1999，358，： | 1 |
| 7 | Unanswered ques- tions for management of acute eoronary syndrome: risk stratifi- cation of patients with minimal disease or normal findings on coronary angiography 显示文摘 | Bugiardini R Manfrini O De Ferrari GM | 2006 | Arch Intern Med2006，166，13： | 1 |
| 8 | Staging of intraosseous extent of osteosarcoma: correlation of preoperative CT and MR imaging with pathologic macroslides 显示文摘 | Gillespy T Manfrini M Ruggieri P | 1988 | Radiology1988，167，3： | 1 |
| 9 | Staging of intraosseous extent of osteosarcoma: correlation of preoperative ct and mr imaging with pathologic macroslides显示文摘 | GILLESPY T 3rd MANFRINI M RUGG1ERI P | 1988 | Radiology1988，167，3： | 1 |
| 10 | Unanswered questions for management of acute coronary syndrome risk stratification of patients with minimal disease or normal findings on coronary angiography显示文摘 | Bugiardini R Manfrini O Gaetano M | 2006 | Arch Intern Med2006，166，： | 1 |
| 11 | Angiotensin-converting enzyme inhibitors and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cardiac syndrome X显示文摘 | Pizzi C Manfrini O Fontana F | 2004 | Circulation2004，109，1： | 1 |
| 12 | Vascularized proximal fibular epiphyseal transfer for distal radial reconstruction显示文摘 | Innocenti M Delcroix L Manfrini M | 2004 | J Bone Joint Surg Am2004，86，： | 1 |
| 13 | Antibodies to bovine beta - casein in diabetes and other autoimmune diseases 显示文摘 | Monetini L Cavallo MG Manfrini S | 2002 | Horm Metab Res2002，34，： | 1 |
| 14 | Intraepiphyseal resection of the proximal tibia and its impact on lower limb growth显示文摘 | Manfrini M Gasbarrini A Malaguti C | 1999 | Clin Orthop1999，358，： | 1 |
| 15 | Heart rate variability today显示文摘 | XHYHERI B MANFRINI O MAZZOLINI M | 2012 | Prog Cardiovasc Dis2012，55，3： | 1 |
| 16 | Endovenous management of saphenous vein reflux 显示文摘 | Manfrini S Gasbarro V Danielsson G | 2000 | J Vasc Surg2000，32，2： | 1 |
| 17 | Heart rate variability today显示文摘 | Xhyheri B Manfrini O Mazzolini M | 2012 | Prog Cardiovase Dis2012，55，3： | 1 |
| 18 | DiaPep277 peptide ther- apy in the context of other immune intervention trials in type 1 diabetes显示文摘 | Tuccinardi D Fioriti E Manfrini S | 2011 | Expert Opin Biol Ther2011，11，9： | 1 |
| 19 | Parasympathetic failure and risk of subsequent coronary events in unstable angina and non- ST-segment elevation myocardial infarction 显示文摘 | Manfrini O Pizzi C Trere D | 2003 | European heart journal2003，24，17： | 1 |
| 20 | Free vascularized growth-plate transfer after bone tumor resection in children 显示文摘 | Innocenti M Ceruso M Manfrini M | 1998 | J Reconstr Microsurg1998，14，2： | 1 |
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