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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Intralesioanl fluorouracil/epinephrine injectable gel for treatment of condylomata acuminata:a phase 3 clinical study显示文摘 | Swinehart JM Sperling M Phillips S | 1997 | Arch Dermatol1997，133，1： | 2 |
| 3 | Degradation of ethinyl estradiol by nitrifying activated sludge 显示文摘 | Vader J S Ginkel C G Sperling G M | 2000 | Chemosphere2000，41，8： | 1 |
| 4 | Group contribution analysis of damping behavior of homopolymers, statistical eopolymers, and interpenetrating polymer networks based on acrylic, vinyl and styrenic mers显示文摘 | CHANG M (' THOMAS D A SPERLING L H | 1988 | J Appl Sei Part B: Polym Phys1988，26，： | 1 |
| 5 | In vitro hemocompatibility of albumin-heparin multilayer coatings on polyethersulfone prepared by the layer-by-layer technique显示文摘 | Sperling C Houska M Brynda E | | 0，，04： | 1 |
| 6 | Organic cation transporter 2 mediates cisplatin-induced oto-and nephrotoxicity and is a target for protective interventions显示文摘 | Ciarimboli G Deuster D Knief A Sperling M Holtkamp M Edemir B | 2010 | Am J Pathol2010，176，3： | 1 |
| 7 | The inverse association of elevated serum bilirubin levels with subclinical carotid athersclerosis显示文摘 | Vitek L Novotny L SperL M | 2006 | Cerebrovasc Dis2006，21，56： | 1 |
| 8 | Complieations of total shoulder arthroplasty:are they fewer or different 显示文摘 | Chin PY Sperling JW Cofield RH et M | 2006 | J Shoulder Elbow Surg2006，15，1： | 1 |
| 9 | Degradation of ethinyl estradiol by nitrifying activated sludge显示文摘 | Vader J S Finkel C G Sperling F M G M | 2000 | Chemosphere2000，41，8： | 1 |
| 10 | A comparative study of semi and full interpenetrating polymer networks based on poly(γ-buty acrylate)/polystyrene显示文摘 | WIDMAIER Y M SPERLING L H | | 0，，9： | 1 |
| 11 | Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications显示文摘 | MEERMANN B SPERLING M | 2012 | Analytical and Bioanalytical Chemistry2012，403，6： | 1 |
| 12 | The current state of insect molecular systematics显示文摘 | Caterino M S Cho S Sperling F A H | 2000 | Ann Rev Entomol2000，45，： | 1 |
| 13 | Intracranial EEG in predicting surgical outcome in frontal lobe epilepsy显示文摘 | Holtkamp M Sharan A Sperling MR | | 0，，10： | 1 |
| 14 | Reliability analysis of wastewater treatment plants 显示文摘 | Oliveira S C Sperling M V | 2008 | Water Research2008，42，45： | 1 |
| 15 | Early versus late antiepileptie drug withdrawal for people with epilepsy in re- mission显示文摘 | Sirven J Sperling M R Wingerchuk D M | 2001 | Cochrane Database Syst Rev2001，，3： | 1 |
| 16 | Morphology, design and charcharacterization of IPN-containing structured latex particles for damping applications显示文摘 | El-Aasser M S Hu U R Dimonie V L Sperling L H | 1999 | Colloids and Surfaces A: Physiochemical and Engineering ASpects1999，153，： | 1 |
| 17 | Comparison and evaluation of empirical zone settling velocity parame- ters based on sludge volume index using a unified settling characteristics database 显示文摘 | Giokas D L Daigger G T Sperling M | 2003 | Water Res2003，37，16： | 1 |
| 18 | Viral host-range factor C7 or K1 is essential for modified vaccinia virus Anka- ra late gene expression in human and murine cells, irrespec- tive of their capacity to inhibit protein kinase R-mediated phosphorylation of eukaryotic translation initiation factor 2alpha 显示文摘 | Backes S Sperling K M Zwilling J | 2010 | J Gen Virol2010，91，2： | 1 |
| 19 | Interlisional flu- orouraeil/epinephrine injectable gel for treatment of condylomata acnrninata: a phase 3 clinical study 显示文摘 | Swinehart JM Sperling M Phillips S | 1997 | Arch Dermatol1997，133，1： | 1 |
| 20 | Structure and function of the pre-mRNA splicing machine 显示文摘 | Sperling J Azubel M Sperling R | 2008 | Structure2008，16，11： | 1 |
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