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| 1 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 2 | Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis显示文摘The liver is an important site for iron and lipid metabolism and the main site for the interactions between these two metabolic pathways. Although conflicting results have been obtained, most studies support the hypothesis that iron plays a role in hepatic lipogenesis. Iron is an integral part of some enzymes and transporters involved in lipid metabolism and, as such, may exert a direct effect on hepatic lipid load, intrahepatic metabolic pathways and hepatic lipid secretion. On the other hand, iron in its ferrous form may indirectly affect lipid metabolism through its ability to induce oxidative stress and inflammation, a hypothesis which is currently the focus of much research in the field of nonalcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH). The present review will first discuss how iron might directly interact with the metabolism of hepatic lipids and then consider a new perspective on the way in which iron may have a role in the two hit hypothesis for the progression of NAFLD via ferroportinand the iron regulatory molecule hepcidin. The review concludes that iron has important interactions with lipid metabolism in the liver that can impact on the development of NAFLD/NASH. More defined studies are required to improve our understanding of these effects. | Umbreen Ahmed Patricia S Latham Phillip S Oates | 2012 | World Journal of Gastroenterology2012，18，34： | 20 |
| 3 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 4 | Heme in intestinal epithelial cell turnover, differentiation, detoxification, inflammation, carcinogenesis, absorption and motility显示文摘胃肠道被经历包含两极分裂,区别和细胞死亡的经常的更新的一张单层上皮衬里。另外,上皮的衬里分开由保护上皮免受被突破的伤害的防御机制从内部周围的无菌的环境发生在肠的腔的消化和吸收的敌对过程。对这些防御过程中央是合成他我和它的分解代谢由他我氧合酶(惊讶) 。饮食他我也是为被收起的身体的铁的重要来源由 enterocyte 未经触动。这评论在肠道在 heme/HO 的多样的性质上描述最近的文学。在房间 cycle/apoptosis, xenobiotics 的 detoxification,氧化压力,发炎,结肠癌的发展, heme 铁吸收和肠的活动性的规定的 heme/HO 的角色明确地被检验。 | Phillip S Oates Adrian R West | 2006 | World Journal of Gastroenterology2006，12，27： | 8 |
| 5 | Circular smooth muscle contributes to esophageal shortening during peristalsis显示文摘AIM:To study the angle between the circular smooth muscle(CSM) and longitudinal smooth muscle(LSM) fibers in the distal esophagus.METHODS:In order to identify possible mechanisms for greater shortening in the distal compared to proximal esophagus during peristalsis,the angles between the LSM and CSM layers were measured in 9 cadavers.The outer longitudinal layer of the muscularis propria was exposed after stripping the outer serosa.The inner circular layer of the muscularis propria was then revealed after dissection of the esophageal mucosa and the underlying muscularis mucosa.Photographs of each specimen were taken with half of the open esophagus folded back showing both the outer longitudinal and inner circular muscle layers.Angles were measured every one cm for 10 cm proximal to the squamocolumnar junction(SCJ) by two independent investigators.Two human esophagi were obtained from organ transplant donors and the angles between the circular and longitudinal smooth muscle layers were measured using micro-computed tomography(micro CT) and Image J software.RESULTS:All data are presented as mean ± SE.The CSM to LSM angle at the SCJ and 1 cm proximal to SCJ on the autopsy specimens was 69.3 ± 4.62 degrees vs 74.9 ± 3.09 degrees,P = 0.32.The CSM to LSM angle at SCJ were statistically significantly lower than at 2,3,4 and 5 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 82.58 ± 1.34 degrees,84.04 ± 1.64 degrees,84.87 ± 1.04 degrees and 83.72 ± 1.42 degrees,P = 0.013,P = 0.008,P = 0.004,P = 0.009 respectively.The CSM to LSM angle at SCJ was also statistically significantly lower than the angles at 6,7 and 8 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 80.18 ± 2.09 degrees,81.81 ± 1.75 degrees and 80.96 ± 2.04 degrees,P = 0.05,P = 0.02,P = 0.03 respectively.The CSM to LSM angle at 1 cm proximal to SCJ was statistically significantly lower than at 3,4 and 5 cm proximal to the SCJ,74.94 ± 3.09 degrees vs 84.04 ± 1.64 degrees,84.87 ± 1.04 degrees and 83.72 ± 1.42 degrees,P = 0.019,P = 0.008,P = 0.02 respectively.At 10 cm above SCJ the angle was 80.06 ± 2.13 degrees which is close to being perpendicular but less than 90 degrees.The CSM to LSM angles measured on virtual dissection of the esophagus and the stomach on micro CT at the SCJ and 1 cm proximal to the SCJ were 48.39 ± 0.72 degrees and 50.81 ± 1.59 degrees.Rather than the angle of the CSM and LSM being perpendicular in the esophagus we found an acute angulation between these two muscle groups throughout the lower 10 cm of the esophagus.CONCLUSION:The oblique angulation of the CSM may contribute to the significantly greater shortening of distal esophagus when compared to the mid and proximal esophagus during peristalsis. | Anil K Vegesna Keng-Yu Chuang Ramashesai Besetty Steven J Phillips Alan S Braverman Mary F Barbe Michael R Ruggieri Larry S Miller | 2012 | World Journal of Gastroenterology2012，18，32： | 7 |
| 6 | 新型他汀类药物——ZD4522对ApoE基因敲除小鼠血管内皮粘附功能的影响显示文摘目的 :观察他汀类新药ZD45 2 2对ApoE基因敲除小鼠主动脉内皮粘附单核细胞的抑制效应。 方法 :40只高胆固醇血症动物模型 ApoE基因敲除小鼠随机均分为A ,B ,C ,D ,E 5组 ,各组ZD45 2 2的皮下注射剂量分别为 0 ,1,5 ,2 0和 2 0mg·kg-1,qd ,E组给药 6周 ,其余 4组均给药 2周。 2或 6周后测定小鼠血浆胆固醇水平和主动脉内皮对单核细胞的粘附率。结果 :5组ApoE基因敲除小鼠血浆胆固醇水平均比正常小鼠显著升高 (P <0 .0 1) ,与A组比较 ,E组血浆胆固醇水平明显降低 (P <0 .0 1)。 5组ApoE基因敲除小鼠的主动脉内皮单核细胞粘附率均高于正常组 ,与A组比较 ,C ,D ,E组的单核细胞粘附率均显著降低 (P <0 .0 5 ,P <0 .0 1,P <0 .0 1)。结论 :他汀类新药ZD45 2 2对ApoE基因敲除小鼠血管内皮粘附单核细胞有明显的抑制作用 。 | 黄海英 周广耀 Phillip S Tsao | 2001 | 中国新药杂志2001，10，12： | 5 |
| 7 | Mechanisms of heme iron absorption:Current questions and controversies显示文摘Iron is a critical micronutrient, and iron derived from heme contributes a large proportion of the total iron absorbed in a typical Western diet. Heme iron is absorbed by different mechanisms than non-heme iron, but despite considerable study over many years these mechanisms remain poorly understood. This review provides an overview of the importance of heme iron in the diet and discusses the two prevailing hypotheses of heme absorption; namely receptor mediated endocytosis of heme, and direct transport into the intestinal enterocyte by recently discovered heme transporters. A specific emphasis is placed on the questions surrounding the site of heme catabolism and the identity of the enzyme that performs this task. Additionally, we present the hypothesis that a non-heme iron transport protein may be required for heme iron absorption and discuss the experiences of our laboratory in examining this hypothesis. | Adrian R West Phillip S Oates | 2008 | World Journal of Gastroenterology2008，14，26： | 5 |
| 8 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 9 | Green tea extract:A potential cause of acute liver failure显示文摘The use of herbal products has increased significantly in recent years.Because these products are not subject to regulation by the Food and Drug Administration and are often used without supervision by a healthcare provider,the indication for and consumption of these supplements is quite variable.Moreover,their use is generally regarded as safe and natural by the lay-public.Unfortunately,there has been an increase in the number of reported adverse events occurring with the use of herbal products.We present a case of acute impending liver failure in an adolescent male using a weightloss product containing green tea extract.Our case adds to the growing concern surrounding the ingestion of green tea extract and serves to heighten healthcare provider awareness of a potential green tea extract hepatotoxicity.Despite the generally touted benefits of green tea as a whole,clinical concern regarding its use is emerging and has been linked to its concentration in multiple herbal supplements.Interestingly,the suspected harmful compounds are those previously proposed to be advantageous for weight-loss,cancer remedy,and anti-inflammatory purposes.Yet,we emphasize the need to be aware of not just green tea extract,but the importance of monitoring patient use of all dietary supplements and herbal products. | Shreena S Patel Stacey Beer Debra L Kearney Garrett Phillips Beth A Carter | 2013 | World Journal of Gastroenterology2013，19，31： | 3 |
| 10 | Dairy food consumption and body weight and fatness studied longitudinally over the adolescent period显示文摘 | PHILLIPS S M BANDINI L G CYR H | 2003 | International Journal of Obesity2003，27，： | 2 |
| 11 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 12 | Intralesioanl fluorouracil/epinephrine injectable gel for treatment of condylomata acuminata:a phase 3 clinical study显示文摘 | Swinehart JM Sperling M Phillips S | 1997 | Arch Dermatol1997，133，1： | 2 |
| 13 | Monsoonal precipitation responses of shrubs in a cold desert community of the Colorado Plateau显示文摘 | Lin J Phillips S Ehleringer J R | 1996 | Oecologia1996，106，： | 1 |
| 14 | Temperature modulation of the stereochemistry of enzymatic catalysis:prospects for exploitation 显示文摘 | Phillips R S | 1995 | Trends in Biochemistry1995，14，1： | 1 |
| 15 | Modeling of Species Distributions With MaxEnt: New Extensions anti a Comprehensive Evaluation 显示文摘 | PHILLIPS S J DUDIK M | 2008 | Ecography2008，31，2： | 1 |
| 16 | Mathematical programming solution of a hoist scheduling program显示文摘 | Unger P S | 1976 | AIIE Transactions1976，28，2： | 1 |
| 17 | IST Collaborative Group:Blood pressure and clinical outcomes in the International Stroke Trial显示文摘 | Bath PM Phillips S J | 2002 | Stroke2002，33，： | 1 |
| 18 | Refinement of diagnostic assays for a probable causal mutation for porcine and human malignant hyperthermia显示文摘 | Otsu K Phillips M S Khanna V K | 1992 | Genomics1992，13，： | 1 |
| 19 | Laparoscopic transcystic duct common bile duct exploration显示文摘 | Lyass S Phillips EH | 2006 | Surg Endosc2006，20，2： | 1 |
| 20 | Selective excitation of corticofugal neurons by surface-anodal stimulation of the baboon's motor cortex显示文摘 | Hem JEC Landgren S Phillips CG | 1962 | J Physiol1962，161，6： | 1 |
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