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| 1 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 2 | Optical property and spectroscopy studies on the selected lubricating oil in the terahertz range显示文摘The optical property and spectroscopy of selected kinds of lubricating oil are studied based on the terahertz time-domain spectroscopy (THz-TDS) in the spectral range of 0.3-1.6 THz. The samples are classified by their characteristics via the near-infrared spectrum. The experimental results reveal that lubricating oil is more sensitive in the range of terahertz than in the near-infrared,and the specific kinds of lubricating oil can be identified according to their different spectral features in the terahertz range. The THz-TDS technology applied to lubricating oil analysis has potentially significant impact on the petroleum field. | TIAN Lu ZHOU QingLi JIN Bin ZHAO Kun ZHAO SongQing SHI YuLei ZHANG CunLin | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 25 |
| 3 | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis显示文摘Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate a protection effect in wild-type mice by treatment with CR2-Crry, a specific inhibitor of C3 activation. The expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice and inhibition of Gly-tRFs in vivo decreases chronic ethanol feeding-induced hepatosteatosis without affecting inflammation. The expression of Gly-tRF was downregulated in C3-deficient or CR2-Crry-treated mice, but not in C5-deficient mice;Gly-tRF expression was restored by the C3 activation products C3a or Asp (C3a-des-Arg) via the regulation of CYP2E1. Transcriptome profiling of hepatic tissues showed that Gly-tRF inhibitors upregulate the expression of sirtuin1 (Sirt1) and subsequently affect downstream lipogenesis and β-oxidation pathways. Mechanistically, Gly-tRF interacts with AGO3 to downregulate Sirt1 expression via sequence complementarity in the 3′ UTR. Notably, the expression levels of C3d, CYP2E1 and Gly-tRF are upregulated, whereas Sirt1 is decreased in AFLD patients compared to healthy controls. Collectively, our findings suggest that C3 activation products contribute to hepatosteatosis by regulating the expression of Gly-tRF. Complement inhibition at the C3 activation step and treatment with Gly-tRF inhibitors may be potential and precise therapeutic approaches for AFLD. | Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He | 2019 | Cell Research2019，29，7： | 14 |
| 4 | Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis显示文摘 | Wenling Zhang Zhaoyang Zeng Yanhong Zhou Wei Xiong Songqing Fan Lan Xiao Donghai Huang Zheng Li Dan Li Minghua Wu Xiaoling Li Shourong Shen Rong Wang Li Cao Ke Tang Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 11 |
| 5 | The Arabidopsis P450 protein CYP82C2 modulates jasmonateinduced root growth inhibition, defense gene expression and indole glucosinolate biosynthesis显示文摘Jasmonic 酸(JA ) 是对草食动物和一些微生物引起的病原体调整大量植物防卫回答的一个丰满的导出酸的发信号分子。分子的基因研究证实了 JA 也在植物开发的几个方面执行一个关键角色。这里,我们描述 Arabidopsis 变异的 jasmonic acid-hypersensitive1-1 (jah1-1 ) 的描述,它在 JA 回答的几个方面是有缺点的。尽管异种在根生长抑制展出增加的敏感到 JA,它显示出 JA 可诱导的防卫基因和减少的抵抗的减少的表示到 necrotrophic 真菌 Botrytis cinerea。基因克隆研究显示这些缺点被一个变化在细胞色素 P450 蛋白质 CYP82C2 引起。我们提供证明的证据到 B 的 jah1-1 异种的损害抵抗。cinerea 被导致 JA 的防卫基因的减少的表示伴随并且减少了导致 JA 的吲哚 glucosinolates (IG ) 的累积。相反地,提高的抵抗到 B。在 CYP82C2-overexpressing 植物的 cinerea 被导致 JA 的防卫基因的增加的表示伴随并且提高了导致 JA 的 IG 的层次。我们证明 CYP82C2 影响 IG biosynthetic 先锋的导致 JA 的累积色氨酸(Trp ) ,然而并非导致 JA 的 IAA 或导致病原体的 camalexin。一起,我们 CYP82C2 可以在导出 Trp 的第二等的代谢物的新陈代谢扮演在下面的一个假设在 JA 在哪个铺平调节的结果支持被提高。jah1-1 异种应该因此在向理解位于调停 JA 的微分回答的复杂性下面的机制的未来研究是重要的,它是重要的让植物使他们的生长适应千变万化环境。 | Fang Liu Hongling Jiang Songqing Ye Wen-Ping Chen Wenxing Liang Yingxiu Xu Bo Sun Jiaqiang Sun Qiaomei Wang Jerry D Cohen Chuanyou Li | 2010 | Cell Research2010，20，5： | 10 |
| 6 | Adsorption behavior of carbon dioxide and methane in bituminous coal:A molecular simulation study显示文摘The adsorption behavior of CO_2, CH_4 and their mixtures in bituminous coal was investigated in this study. First, a bituminous coal model was built through molecular dynamic(MD) simulations, and it was confirmed to be reasonable by comparing the simulated results with the experimental data. Grand Canonical Monte Carlo(GCMC)simulations were then carried out to investigate the single and binary component adsorption of CO_2 and CH_4with the built bituminous coal model. For the single component adsorption, the isosteric heat of CO_2 adsorption is greater than that of CH_4 adsorption. CO_2 also exhibits stronger electrostatic interactions with the heteroatom groups in the bituminous coal model compared with CH_4, which can account for the larger adsorption capacity of CO_2 in the bituminous coal model. In the case of binary adsorption of CO_2 and CH_4mixtures, CO_2 exhibits the preferential adsorption compared with CH_4 under the studied conditions. The adsorption selectivity of CO_2 exhibited obvious change with increasing pressure. At lower pressure, the adsorption selectivity of CO_2 shows a rapid decrease with increasing the temperature, whereas it becomes insensitive to temperature at higher pressure. Additionally, the adsorption selectivity of CO_2 decreases gradually with the increase of the bulk CO_2 mole fraction and the depth of CO_2 injection site. | Jing You Li Tian Chao Zhang Hongxing Yao Wu Dou Bin Fan Songqing Hu | 2016 | Chinese Journal of Chemical Engineering2016，24，9： | 10 |
| 7 | Spectrum features of commercial derv fuel oils in the terahertz region显示文摘Characteristic spectra in the 0.5-2.5 terahertz (THz) range of three commercial derv fuel oils have been obtained using THz time-domain spectroscopy and calculated using density functional theory.The simulated results and experimental absorption curves suggest that the skeleton vibration is predominant in the THz region,and the absorption bumps of diesels are a superposition of various components.The investigation demonstrates that different diesels can be distinguished using THz time-domain spectroscopy and THz technology is a promising method to detect the composition and properties of diesels via chemical analysis. | ZHAO Hui ZHAO Kun TIAN Lu ZHAO SongQing ZHOU QingLi SHI YuLei ZHAO DongMei ZHANG CunLin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，2： | 8 |
| 8 | NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human coloreetal cancer显示文摘Colorectal 癌症(CRC ) 是与病态和死亡的增加的发生被联系的一个普通恶意的肿瘤。鼻咽的联系癌的基因(NGX6 ) 6 是肿瘤转移的新奇候选人 suppressor 基因,它在 CRC 是下面调整的。在现在的学习,我们构造了 colorectal 织物 microarray 在 CRC 纸巾检验 NGX6, phospho-c-Jun N 终端 kinase (p-JNK ) ,和 phospho 细胞外的调整信号的 kinase (津贴) 的表示侧面。而 p-JNK 和津贴的表情在 CRC 纸巾是更高的,我们发现 NGX6 表示在 CRC 纸巾和变形淋巴节点是更低的,比在正常肠的 mucosa。NGX6, p-JNK,和津贴的表情与 colorectal 纸巾的临床的病理学的特征被联系。NGX6 overexpression 禁止了激活和 JNK1 的原子 translocation,它在细胞质导致了 p-JNK 的累积,但是没禁止激活和 ERK1/2 的原子 translocation。NGX6 也禁止了抄写因素 AP-1 (c-jun 和 c-fos ) 和 Ets-1 的表示。另外, NGX6 overexpression 减少了 cyclin D1 并且戏剧性地的表示压制了 cyclin D1 倡导者的 transcriptional 效率。我们建议那 NGX6 表情沉醉于人的 colorectal carcinogenesis 的多步过程。它的 overexpression 能禁止抄写因素的表示 AP-1 和 Ets-1,和下面调整在人的 CRC 的 cyclin D1 倡导者的 transcriptional 活动。 | Ya Peng Hongtao Li Minghua Wu Xiaoyan Wang Songqing Fan Fen Liu Bo Xiang Qin Guo Xueyuan Tang Shourong Shen | 2009 | Acta Biochimica et Biophysica Sinica2009，41，6： | 8 |
| 9 | Effect of ambient oxygen pressure on structural, optical and electrical properties of SnO_2 thin films显示文摘Polycrystalline SnO2 thin films were deposited on sapphire substrates at 450°C under different ambient oxygen pressures by pulsed laser deposition technique. The effect of ambient oxygen pressure on the structural, optical and electri- cal properties of SnO2 thin films was studied. X-ray diffraction and Hall measurements show that increasing the ambient oxygen pressure can improve crystallization of the films and decrease resistivity of the films. A violet emission peak cen- tered at 409 nm was observed from photoluminescence measurements for SnO2 films under deposition ambient oxygen pressure above 5 Pa, which is related to the improvement of crystalline of the films. | ZHAO Songqing ZHOU Yueliang WANG Shufang ZHAO Kun HAN Peng | 2006 | Rare Metals2006，25，6： | 4 |
| 10 | Extracellular calcium elicits feedforward regulation of the roll-like receptor-triggered innate immune response显示文摘 | Songqing Tang Taoyong Chen Mingjin Yang Lei Wang Zhou Yu Bin Xie Cheng Qian Sheng Xu Nan Li Xuetao Cao Jianli Wang | 2017 | Cellular & Molecular Immunology2017，14，2： | 3 |
| 11 | Noncalcemic Actions of Vitamin D Receptor Ligands显示文摘 | Sunil Nagpal Songqing Na Radhakrishnan Rathnachalam | 2005 | Endocrine Reviews2005，，5： | 3 |
| 12 | Land rental markets in the process of rural structural transformation: Productivity and equity impacts from China显示文摘 | Songqing Jin Klaus Deininger | 2009 | Journal of Comparative Economics2009，，4： | 3 |
| 13 | A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice显示文摘 | He Songqing Atkinson Carl Qiao Fei Cianflone Katherine Chen Xiaoping Tomlinson Stephen | 2009 | Journal of Clinical Investigation2009，，8： | 2 |
| 14 | Securing property rights in transition: Lessons from implementation of China’s rural land contracting law显示文摘 | Klaus Deininger Songqing Jin | 2009 | Journal of Economic Behavior and Organization2009，，1： | 2 |
| 15 | Reliable Space Pursuing for Reliability-based Design Optimization with Black-box Performance Functions显示文摘Reliability-based design optimization(RBDO) is intrinsically a double-loop procedure since it involves an overall optimization and an iterative reliability assessment at each search point.Due to the double-loop procedure, the computational expense of RBDO is normally very high.Current RBDO research focuses on problems with explicitly expressed performance functions and readily available gradients.This paper addresses a more challenging type of RBDO problem in which the performance functions are computation intensive.These computation intensive functions are often considered as a'black-box'and their gradients are not available or not reliable.On the basis of the reliable design space(RDS) concept proposed earlier by the authors, this paper proposes a Reliable Space Pursuing(RSP) approach, in which RDS is first identified and then gradually refined while optimization is performed.It fundamentally avoids the nested optimization and probabilistic assessment loop.Three well known RBDO problems from the literature are used for testing and demonstrating the effectiveness of the proposed RSP method. | SHAN Songqing WANG G Gary | 2009 | Chinese Journal of Mechanical Engineering2009，22，1： | 2 |
| 16 | Oil Shale Resources and Its Distribution in China显示文摘油页岩是有高灰内容,油收益比 3.5% 高的一种稳固的易燃的器官的矿物质,热产量比 4187J/g 等于或高。它也在有机物的高内容展示,主要象 sapropel 腐殖一样 sapropel 和腐殖的物质创作了。页岩油能在低温度通过干燥蒸馏被获得。作为一种重要精力和非常规的油和煤气的资源,油页岩尽最大努力起一个重要作用燃料和热电。 | Liu Zhaojun Dong Qingshui Zhu Jianwei Guo Wei Ye Songqing Liu Rong Zhang Hailong | 2007 | China Oil & Gas2007，14，3： | 2 |
| 17 | Multiple weighted estimates for commutators of multilinear fractional integral operators显示文摘Multilinear commutators and iterated commutators of multilinear fractional integral operators with BMO functions are studied. Both strong type and weak type endpoint weighted estimates involving the multiple weights for such operators are established and the weak type endpoint results are sharp in some senses. In particular, we extend the results given by Cruz-Uribe and Fiorenza in 2003 and 2007 to the multilinear setting. Moreover, we modify the weak type of endpoint weighted estimates and improve the strong type of weighted norm inequalities on the multilinear commutators given by Chen and Xue in 2010 and 2011. | CHEN SongQing WU HuoXiong | 2013 | Science China Mathematics2013，56，9： | 2 |
| 18 | A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5显示文摘Studies of herpes simplex virus type 1(HSV-1)infection have shown that many known and unknown cellular molecules involved in viral proliferation are up-regulated following HSV-1 infection.In this study,using two-dimensional polyacrylamide gel electrophoresis,we found that the expression of the HSV-1 infection response repressive protein(HIRRP,GI 16552881)was up-regulated in human L02 cells infected with HSV-1.HIRRP,an unknown protein,was initially localized in the cytoplasm and then translocated into the nucleus of HSV-1-infected cells.Further analysis showed that HIRRP represses HSV-1proliferation by inhibiting transcription of the viral genome by interacting with the cellular transcription factor,ATF5,via its N-terminal domain.ATF5 represses the transcription of many host genes but can also act as an activator of genes containing a specific motif.We found that ATF5 promotes the proliferation of HSV-1 via a potential mechanism by which ATF5 enhances the transcription of viral genes during the course of an HSV-1 infection;HIRRP then induces feedback repression of this transcription by interacting with ATF5. | WU LianQiu ZHANG XueMei CHE YanChun ZHANG Ying TANG SongQing LIAO Yun NA RuiXiong XIONG XiangLin LIU LongDing LI QiHan | 2013 | Science China(Life Sciences)2013，56，12： | 2 |
| 19 | Utilize cloud computing to support dust storm forecasting显示文摘The simulations and potential forecasting of dust storms are of significant interest to public health and environment sciences.Dust storms have interannual variabilities and are typical disruptive events.The computing platform for a dust storm forecasting operational system should support a disruptive fashion by scaling up to enable high-resolution forecasting and massive public access when dust storms come and scaling down when no dust storm events occur to save energy and costs.With the capability of providing a large,elastic,and virtualized pool of computational resources,cloud computing becomes a new and advantageous computing paradigm to resolve scientific problems traditionally requiring a large-scale and high-performance cluster.This paper examines the viability for cloud computing to support dust storm forecasting.Through a holistic study by systematically comparing cloud computing using Amazon EC2 to traditional high performance computing(HPC)cluster,we find that cloud computing is emerging as a credible solution for(1)supporting dust storm forecasting in spinning off a large group of computing resources in a few minutes to satisfy the disruptive computing requirements of dust storm forecasting,(2)performing high-resolution dust storm forecasting when required,(3)supporting concurrent computing requirements,(4)supporting real dust storm event forecasting for a large geographic domain by using recent dust storm event in Phoniex,05 July 2011 as example,and(5)reducing cost by maintaining low computing support when there is no dust storm events while invoking a large amount of computing resource to perform high-resolution forecasting and responding to large amount of concurrent public accesses. | Qunying Huang Chaowei Yang Karl Benedict Songqing Chen Abdelmounaam Rezgui Jibo Xie | 2013 | International Journal of Digital Earth2013，6，4： | 2 |
| 20 | The potential of land rental markets in the process of economic development: Evidence from China显示文摘 | Klaus Deininger Songqing Jin | 2005 | Journal of Development Economics2005，，1： | 2 |
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