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| 1 | Transjugular intrahepatic portosystemic shunts and portal hypertension-related complications显示文摘Portal hypertension(PH)plays an important role in the natural history of cirrhosis,and is associated with several clinical consequences.The introduction of transjugular intrahepatic portosystemic shunts(TIPS)in the 1980s has been regarded as a major technical advance in the management of the PH-related complications.At present,polytetrafluoroethylene-covered stents are the preferred option over traditional bare metal stents.TIPS is currently indicated as a salvage therapy in patients with bleeding esophageal varices who fail standard treatment.Recently,applying TIPS early(within 72 h after admission)has been shown to be an effective and life-saving treatment in those with high-risk variceal bleeding.In addition,TIPS is recommended as the second-line treatment for secondary prophylaxis.For bleeding gastric varices,applying TIPS was able to achieve hemostasis in more than 90%of patients.More trials are needed to clarify the efficacy of TIPS compared with other treatment modalities,including cyanoacrylate injection and balloon retrograde transvenous obliteration of gastric varices.TIPS should also be considered in bleeding ectopic varices and refractory portal hypertensive gastropathy.In patients with refractory ascites,there is growing evidence that TIPS not only results in better control of ascites,but also improves long-term survivalin appropriately selected candidates.In addition,TIPS is a promising treatment for refractory hepatic hydrothorax.However,the role of TIPS in the treatment of hepatorenal and hepatopulmonary syndrome is not well defined.The advantage of TIPS is offset by a risk of developing hepatic encephalopathy,the most relevant postprocedural complication.Emerging data are addressing the determination the optimal time and patient selection for TIPS placement aiming at improving long-term treatment outcome.This review is aimed at summarizing the published data regarding the application of TIPS in the management of complications related to PH. | Sith Siramolpiwat | 2014 | World Journal of Gastroenterology2014，20，45： | 41 |
| 2 | Lymphomatous involvement of gastrointestinal tract: Evaluation by positron emission tomography with ^(18)F-fluorodeoxyglucose显示文摘AIM: To demonstrate the 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) findings in patients with non-Hodgkin's lymphoma (NHL) involving the gastrointestinal (GI) tract and the clinical utility of modality despite of the known normal uptake of FDG in the GI tract.METHODS: Thirty-three patients with biopsy-proven gastrointestinal NHL who had undergone FDG-PET scan were included. All the patients were injected with 10-15 mCi FDG and scanned approximately 60 min later with a CTI/Siemens HR (+) PET scanner. PET scans were reviewed and the maximum standard uptake value (SUVmax) of the lesions was measured before and after the treatment,if data were available and compared with histologic diagnoses.RESULTS: Twenty-five patients had a high-grade lymphoma and eight had a low-grade lymphoma. The stomach was the most common site of the involvement (20 patients). In high-grade lymphoma, PET showed focal nodular or diffuse hypermetabolic activity. The average SUVmax±SD was 11.58±5.83. After the therapy,the patients whose biopsies showed no evidence of lymphoma had a lower uptake without focal lesions.The SUVmax±SD decreased from 11.58±5.83 to 2.21±0.78. In patients whose post-treatment biopsies showed lymphoma, the SUVmax±SD was 9.42±6.27. Low-grade follicular lymphomas of the colon and stomach showed diffuse hypermetabolic activity in the bowel wall (SUVmax 8.2 and 10.3, respectively). The SUVmax was 2.02-3.8 (mean 3.02) in the stomach lesions of patients with MALT lymphoma.CONCLUSION: 18F-FDG PET contributes to the diagnosis of high-grade gastrointestinal non-Hodgkin's lymphoma,even when there is the normal background FDG activity. Furthermore, the SUV plays a role in evaluating treatment response. Low-grade NHL demonstrates FDG uptake but at a lesser intensity than seen in high-grade NHL. | Sith Phongkitkarun Vithya Varavithya Toshiki Kazama Silvana C Faria Martha V Mar Donald A Podoloff Homer A Macapinlac | 2005 | World Journal of Gastroenterology2005，11，46： | 6 |
| 3 | Added value of hepatobiliary phase gadoxetic acid-enhanced MRI for diagnosing hepatocellular carcinoma in high-risk patients显示文摘AIM:To determine the added value of hepatobiliary phase(HBP)gadoxetic acid-enhanced magnetic resonance imaging(MRI)in evaluating hepatic nodules in high-risk patients.METHODS:The institutional review board approved this retrospective study and waived the requirement for informed consent.This study included 100 patients at high risk for hepatocellular carcinoma(HCC)and 105hepatic nodules that were larger than 1 cm.A blind review of two MR image sets was performed in a random order:set 1,unenhanced(T1-and T2-weighted)and dynamic images;and set 2,unenhanced,dynamic20-min and HBP images.The diagnostic accuracy,sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were compared for the two image sets.Univariate and multivariate analyses were performed on the MR characteristics utilized to diagnose HCC.RESULTS:A total of 105 hepatic nodules were identified in 100 patients.Fifty-nine nodules were confirmed to be HCC.The diameter of the 59 HCCs ranged from1 to 12 cm(mean:1.9 cm).The remaining 46 nodules were benign(28 were of hepatocyte origin,nine were hepatic cysts,seven were hemangiomas,one was chronic inflammation,and one was focal fat infiltration).The diagnostic accuracy significantly increased with the addition of HBP images,from 88.7%in set 1to 95.5%in set 2(P=0.002).In set 1 vs set 2,the sensitivity and NPV increased from 79.7%to 93.2%and from 78.9%to 91.8%,respectively,whereas the specificity and PPV were not significantly different.The hypointensity on the HBP images was the most sensitive(93.2%),and typical arterial enhancement followed by washout was the most specific(97.8%).The multivariate analysis revealed that typical arterial enhancement followed by washout,hyperintensity on T2-weighted images,and hypointensity on HBP images were statistically significant MRI findings that could diagnose HCC(P<0.05).CONCLUSION:The addition of HBP gadoxetic acidenhanced MRI statistically improved the diagnostic accuracy in HCCs larger than 1 cm.Typical arterial enhancement followed by washout and hypointensity on HBP images are useful for diagnosing HCC. | Sith Phongkitkarun Kuruwin Limsamutpetch Penampai Tannaphai Janjira Jatchavala | 2013 | World Journal of Gastroenterology2013，19，45： | 3 |
| 4 | Assessment of gastrointestinal stromal tumors with computed tomography following treatment with imatinib mesylate显示文摘AIM: To evaluate and characterize the patterns of disease progression of metastatic or unresectable gastrointestinal stromal tumor (GIST) treated with imatinib mesylate, and to determine the prognostic significance associated with disease progression. METHODS: Clinical data and computed tomography (CT) images were retrospectively reviewed in 17 GIST patients who were treated with imatinib mesylate from October 2002 to October 2006. Apart from using size measurement for evaluation of tumor response [Response Evaluation Criteria in Solid Tumors (RECIST) criteria], patterns of CT changes during treatment were evaluated and correlated with clinical data. RESULTS: There were eight non-responders and nine responders. Five patterns of CT change during treatment were found: focal progression (FP), generalized progression (GP), generalized cystic change (GC), new cystic lesion (NC) and new solid lesion (NS). At the end of study, all non-responders showed GP, whereas responders showed cystic change (GC and NC) and response according to RECIST criteria. Overall survival was significantly better in patients with cystic change or response within the RECIST criteria compared with GP patients (P = 0.0271). CONCLUSION: Various patterns of CT change in patients with GIST who responded to imatinib mesylate were demonstrated, and might determine the prognosis of the disease. A combination of RECIST criteria and pattern of CT change are proposed for response evaluation in GIST. | Sith Phongkitkarun Cholada Phaisanphrukkun Janjira Jatchavala Ekaphop Sirachainan | 2008 | World Journal of Gastroenterology2008，14，6： | 2 |
| 5 | An Update for the Calculation of Reference Evapotranspiration显示文摘 | Allen R G M Sith L S Pereira and A Perrier | 1994 | ICID Bulletin1994，43，2： | 1 |
| 6 | Organochlorine chemicals in seafood, occurrence and health concern 显示文摘 | Sith A G Gangolli S d | 2002 | J Food Chem Toxiccol2002，40，6： | 1 |
| 7 | Endoetrial autoantigens eliciting immunoglobulin IgG, IgA and IgM responses in endometriosis 显示文摘 | Mathur S Garza DE Sith CF | 1990 | Fertil Steril1990，54，1： | 1 |
| 8 | Functional CT for Quantifying Tumor Perfusion in Antisngiogenic Therapy in a Rat Modell显示文摘 | Zuxing Kan MD PhD Sith Phongkitkarun MD Satoshi Kobayashi MD | 2005 | Radiology2005，237，： | 1 |
| 9 | Arterial occulusion revealed byCT angiography predicts NIH stroke score and acute outcomes af-ter IV tPA treatment显示文摘 | Sims JR Rordof G Sith EE | 2005 | AJNR2005，26，2： | 1 |
| 10 | Effect of epidermal growth factor and insulin-like growth factor Ⅰ on porcine preantral follicular growth,antrum fimnatinn,and stimulation of granuosa cell proliferation and suppression of apoptosis in vitro显示文摘 | Mao J Sith M F Rcker E B | | 0，，07： | 1 |
| 11 | Diagnosis and Treatment of High-Grade Astrocytoma显示文摘 | Sith Sathornsumetee Jeremy N. Rich David A. Reardon | 2007 | Neurologic Clinics2007，，4： | 1 |
| 12 | Compression treatment of hemangiomas显示文摘 | Miller SH Sith RL Shochat SJ | 1976 | Plast Reconstr Surg1976，58，5： | 1 |
| 13 | E valuation of candidate traps as toels for conduc- ting surveillance for nopheles mosquitoes in a malaria - endemic area in western Thailand显示文摘 | Sith iprasasna R | 2004 | JM ed Entomo12004，41，2： | 1 |
| 14 | Emergency department in jury surveillance systems: the best use of limited resources? 显示文摘 | Stone DH Morrison A Sith GS | 1999 | Inj Prey1999，5，： | 1 |
| 15 | Emergency department in jurysurveillance systems : the best use of limited resources?显示文摘 | STONE D H MORRISON A SITH G S | 1999 | InjPrev1999，5，： | 1 |
| 16 | Bioassay-guided isolation of aldose reductase inhibitors from Artemisia dracunculus显示文摘 | Sithes Logendra David M. Ribnicky Hui Yang Alexander Poulev Jun Ma Edward J. Kennelly Ilya Raskin | 2006 | Phytochemistry2006，，14： | 1 |
| 17 | High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C显示文摘 | Ciifford BD Donahue D Sith L | 1995 | Hepatology1995，21，3： | 1 |
| 18 | Pilocarpine induced status epilepticus result in mossy fiber sprouting and spontaneous seizures in C57BC/6 and CD- 1 mice显示文摘 | Shibley H Sith BN | 2002 | Epilepsy Res2002，49，： | 1 |
| 19 | Arterial occulusion revealed by CT angiography predicts NIH stroke score and acute outcomes after IV rtPA treatment显示文摘 | Sims JR Rordof G Sith EE | 2005 | Am J Neuroradiol2005，26，2： | 1 |
| 20 | Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors 显示文摘 | OZA V B SITH C RAMAN P | 2002 | J Med Chem2002，45，2： | 1 |
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