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| 1 | ABCD^(2) risk score does not predict the presence of cerebral microemboli in patients with hyper-acute symptomatic critical carotid artery stenosis显示文摘Introduction:ABCD^(2) risk score and cerebral microemboli detected by transcranial Doppler(TCD)have been separately shown to the predict risk of recurrent acute stroke.We studied whether ABCD2 risk score predicts cerebral microemboli in patients with hyper-acute symptomatic carotid artery stenosis.Participants and methods:We studied 206 patients presenting within 2 weeks of transient ischaemic attack or minor stroke and found to have critical carotid artery stenosis(≥50% ).86 patients(age 70±1(SEM:years),58 men,83 Caucasian)had evidence of microemboli;72(84% )of these underwent carotid endarterectomy(CEA).120 patients(age 72±1 years,91 men,113 Caucasian)did not have microemboli detected;102(85% )of these underwent CEA.Data were analysed using X2 and Mann–Whitney U tests and receiver operating characteristic(ROC)curves.Results:140/206(68% :95% CI 61.63 to 74.37)patients with hyper-acute symptomatic critical carotid stenosis had an ABCD2 risk score≥4.There was no significant difference in the NICE red flag criterion for early assessment(ABCD^(2) risk score≥4)for patients with cerebral microemboli versus those without microemboli(59/86 vs 81/120 patients:OR 1.05 ABCD2 risk score≥4(95% CI 0.58 to 1.90,p=0.867)).The ABCD2 risk score was<4 in 27 of 86(31% :95% CI 21 to 41)embolising patients and in 39 of 120(31% :95% CI 23 to 39)without cerebral microemboli.After adjusting for pre-neurological event antiplatelet treatment(APT),area under the curve(AUC)of ROC for ABCD2 risk score showed no prediction of cerebral microemboli(no pre-event APT,n=57:AUC 0.45(95% CI 0.29 to 0.60,p=0.531);preevent APT,n=147:AUC 0.51(95% CI 0.42 to 0.60,p=0.804)).Conclusions:The ABCD2 score did not predict the presence of cerebral microemboli or carotid disease in over one-quarter of patients with symptomatic critical carotid artery stenosis.On the basis of NICE guidelines(refer early if ABCD2≥4),assessment of high stroke risk based on ABCD2 scoring may lead to inappropriate delay in urgent treatment in many patients. | Mahmud Saedon Charles E Hutchinson Christopher H E Imray Donald R J Singer | 2017 | Stroke & Vascular Neurology2017，2，2： | 6 |
| 2 | Vasopressin versus norepinephrine infusion in patients with septic shock显示文摘 | Russell JA Walley KR Singer J | | 0，，09： | 2 |
| 3 | Analyzing mobile offshore bases using accelerated boundary-element methods显示文摘 | KRING D KORSMEYER F T SINGER J and WHITE J K | 2000 | Marine Structures2000，13，： | 2 |
| 4 | Interaction between duct fires and ventilation flow-An experimental study显示文摘 | Lee C K Chaiken R F Singer J M | 1979 | Combust Sci Technol1979，20，： | 2 |
| 5 | Coexistence of occult vascular malformations and developmental venous anomalies in the central nervous system: MR evaluation 显示文摘 | Abe T Singer R J Marks MP | 1998 | Am J Nenroradiol1998，19，： | 1 |
| 6 | In vitro antimicrobial activity against 10 North American and European Lawsonia intracellularis isolates显示文摘 | WATTANAPHANSAK S SINGER R S GEBHART C J | 2009 | Vet Microbiol2009，134，34： | 1 |
| 7 | The effects of early visual experience on the cat' s visual cortex and their possible explanation by Hebb synapses 显示文摘 | Rauschecker J P Singer W | 1981 | Journal of Physiology1981，310，： | 1 |
| 8 | Perspectives and vision for strain selection in bioaugmentation 显示文摘 | Singer AC van der Gast C J Thompson IP | 2005 | Trends in Biotechnology2005，23，2： | 1 |
| 9 | Vasopressin versus norepinephrine infusion in patients with septic shock显示文摘 | Russell JA Walley KR Singer J | | 0，，09： | 1 |
| 10 | Risk factor for invasive cervix cancer in young women显示文摘 | Cuzick J Sasicni P Singer A | 1996 | Eur J Cancer1996，32，5： | 1 |
| 11 | Recombinant granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for lymphoid cancer显示文摘 | Nemunaitis J Rabinowe SN Singer JW | 1991 | N Engl J Med1991，324，25： | 1 |
| 12 | Baclofen treatment in Tourette syndrome: a double-blind, placebo-controlled, crossover trial显示文摘 | Singer HS Wendlandt J Krieger M | 2001 | Neurology2001，56，5： | 1 |
| 13 | Fluorescence in situ hybridization: past, present and future 显示文摘 | Levsky J M Singer R H | 2003 | Journal of Cell Science2003，116，14： | 1 |
| 14 | Signal processing for underwater acoustic communications 显示文摘 | Singer A C Nelson J K Kozat S S | 2009 | 1EEE Com- munication Magazine2009，47，1： | 1 |
| 15 | Intramedullary nailing for the treatment of dislocated pedi- atric radial neck fractures 显示文摘 | Eberl R Singer G Fruhmann J Saxena A Hoellwarth ME | 2010 | Eur J Pediatr Surg2010，20，4： | 1 |
| 16 | Polypeptides p40, pOM2, and pAngR are required for iron uptake and for virulence of the marine fish pathogen Vibrio anguillarum 显示文摘 | Singer J T Schmidt K A Reno P W | 1991 | Bacteriology1991，173，3： | 1 |
| 17 | Nutrient distribution and cycling in a sub alpine coniferous forest ecosystem显示文摘 | TURNER J SINGER M J | 1976 | Journal of Ap plied Ecology1976，13，1： | 1 |
| 18 | The Impact of Corporate Social Responsiveness on Shareholder Wealth 显示文摘 | Holman W R New J R Singer D | 1985 | Research in Corporate Social Performance and Policy1985，，7： | 1 |
| 19 | Nitropropionic acid of succinate dehydrogenase by 3-nitropropionate 显示文摘 | Coles C J Edmondson D E Singer T P | 1979 | J Biol Chem1979，54，： | 1 |
| 20 | Megavoltage ex- ternal beam irradiation of eraniopharyngiomas: analysis of tumor control and morbidity显示文摘 | Flickinger JC Lunsford LD Singer J | 1990 | Int J Radiat Oncol Biol Phys1990，19，： | 1 |
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