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| 1 | ABCD^(2) risk score does not predict the presence of cerebral microemboli in patients with hyper-acute symptomatic critical carotid artery stenosis显示文摘Introduction:ABCD^(2) risk score and cerebral microemboli detected by transcranial Doppler(TCD)have been separately shown to the predict risk of recurrent acute stroke.We studied whether ABCD2 risk score predicts cerebral microemboli in patients with hyper-acute symptomatic carotid artery stenosis.Participants and methods:We studied 206 patients presenting within 2 weeks of transient ischaemic attack or minor stroke and found to have critical carotid artery stenosis(≥50% ).86 patients(age 70±1(SEM:years),58 men,83 Caucasian)had evidence of microemboli;72(84% )of these underwent carotid endarterectomy(CEA).120 patients(age 72±1 years,91 men,113 Caucasian)did not have microemboli detected;102(85% )of these underwent CEA.Data were analysed using X2 and Mann–Whitney U tests and receiver operating characteristic(ROC)curves.Results:140/206(68% :95% CI 61.63 to 74.37)patients with hyper-acute symptomatic critical carotid stenosis had an ABCD2 risk score≥4.There was no significant difference in the NICE red flag criterion for early assessment(ABCD^(2) risk score≥4)for patients with cerebral microemboli versus those without microemboli(59/86 vs 81/120 patients:OR 1.05 ABCD2 risk score≥4(95% CI 0.58 to 1.90,p=0.867)).The ABCD2 risk score was<4 in 27 of 86(31% :95% CI 21 to 41)embolising patients and in 39 of 120(31% :95% CI 23 to 39)without cerebral microemboli.After adjusting for pre-neurological event antiplatelet treatment(APT),area under the curve(AUC)of ROC for ABCD2 risk score showed no prediction of cerebral microemboli(no pre-event APT,n=57:AUC 0.45(95% CI 0.29 to 0.60,p=0.531);preevent APT,n=147:AUC 0.51(95% CI 0.42 to 0.60,p=0.804)).Conclusions:The ABCD2 score did not predict the presence of cerebral microemboli or carotid disease in over one-quarter of patients with symptomatic critical carotid artery stenosis.On the basis of NICE guidelines(refer early if ABCD2≥4),assessment of high stroke risk based on ABCD2 scoring may lead to inappropriate delay in urgent treatment in many patients. | Mahmud Saedon Charles E Hutchinson Christopher H E Imray Donald R J Singer | 2017 | Stroke & Vascular Neurology2017，2，2： | 6 |
| 2 | The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary corti- cal neurons 显示文摘 | SINGER C A FIGUEROA-MASOT X A BATCHELOR R H | 1999 | J Neurosci1999，19，7： | 1 |
| 3 | The influence of hot working on the subsequent recrystallization oI a dispersion strengthened superalloy-MA 6000 显示文摘 | SINGER R F GESSINGER G H | 1982 | Metall Trans A1982，13，8： | 1 |
| 4 | Fluorescence in situ hybridization: past, present and future 显示文摘 | Levsky J M Singer R H | 2003 | Journal of Cell Science2003，116，14： | 1 |
| 5 | Indoor pollutants emitted by office equipment: A review of re- ported data and information needs 显示文摘 | Destaillats H Maddalena R L Singer B C | 2008 | Atmospheric Environment2008，42，7： | 1 |
| 6 | First successful im plantation of a biodegradable metal stent into the left pulmonary artery of a preterm baby显示文摘 | Zartner P Cesnjevar R Singer H | | 0，，04： | 1 |
| 7 | Retrieval of Apparent Surface Reflectance from Aviris Data- A Comparison of Empirical Line, Radiative Transfer, and Spectral Mixture Methods显示文摘 | Farrand W H Singer R B Merenyi E | 1994 | Remote Sensing of Environment1994，47，3： | 1 |
| 8 | Fluorescence in situ hybridization:past, present and Future显示文摘 | Levsky J M Singer R H | 2003 | Journal of Cell Science2003，116，： | 1 |
| 9 | Diverse tumorigenic pathways in ovarian serous carcinoma显示文摘 | Singer G Kurman R Chang H | 2002 | Am J Pathol2002，160，4： | 1 |
| 10 | Blocking β-catenin binding to the ZBP1 promoter represses ZBP1 expression,leading to increased proliferation and migration of metastatic breast-cancer cells显示文摘 | Gu Wei Pan F Singer R H | 2009 | J Cell Sci2009，122，11： | 1 |
| 11 | First successful implantation of a biodegradable metal stent into the left pulmonary artery of a preterm baby显示文摘 | Zartner P Cesnjevar R Singer H | | 0，，04： | 1 |
| 12 | First successfulimplantation of a biode gradable metal stent into the left pul-monary artery of a preterm baby 显示文摘 | Zartner P Cesnjevar R Singer H | 2005 | Catheter CardiovascInterv2005，66，4： | 1 |
| 13 | Fluorescence in situ hybridization: past, present and future显示文摘 | LEVSKY J M SINGER R H | 2003 | Journal of Cell Science2003，116，14： | 1 |
| 14 | First successful implantation of a biodegradable metal stent into the left pulmonary artery of a preterm baby显示文摘 | Zartner P Cesnjevar R Singer H | 2005 | Catheter Card- iovasc Interv2005，66，4： | 1 |
| 15 | Volume Viscosity in Liquid Argon at High Pressure显示文摘 | Naugle D G Junsford J H Singer J R | 1966 | The Journal of Chemical Physics1966，45，： | 1 |
| 16 | Fluorescence in situ hybrid- ization: past, present and future显示文摘 | Levsky J M Singer R H | 2003 | J Cell Sci2003，116，14： | 1 |
| 17 | First successful implantation of a biodegradable metal stent into the left pulmonary artery of a preterm baby显示文摘 | Zartner P Cesnjevar R Singer H | 2005 | Catheter Cardiovasc Interv2005，66，： | 1 |
| 18 | Hereditary Deficiency of C3 in Animals and Humans 显示文摘 | Singer L Cohen H R Wetsel R A | 1994 | Pathobiology1994，62，1： | 1 |
| 19 | First successful implantation of a biodegradable metal stent into the left pulmonary artery of a preterm baby 显示文摘 | ZARTNER P CESNJEVAR R SINGER H | 2005 | Catheterization and Cardiovascular Interventions2005，66，7： | 1 |
| 20 | Fluorescence in situ hybridization:past, present and future 显示文摘 | Levsky J M Singer R H | 2003 | J Cell Sci2003，116，4： | 1 |
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