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| 1 | Intraductal papillary neoplasm of the bile ducts: A case report and literature review显示文摘Intraductal papillary neoplasm of the bile duct(IPNB) is a rare bile duct neoplasm mostly found in far eastern nations where hepatolithiasis and clonorchiasis infections are endemic. In western countries,it is very rare and the etiology is unknown. In this article,we report the first IPNB patient we encountered in our clinic and a literature review. The patient is a 38-yearold female with a history of choledocholithiasis who presented with obstructive jaundice. She was found to have a papillary mass at the junction of the right hepatic duct and common hepatic duct with six masses in the liver parenchyma. The immunophenotypic and histologic features of the tumor are consistent with IPNB,gastric subtype. The patient had a partial hepatectomy and has been receiving palliative chemotherapy. In a search of Pub Med database,we collected 354 IPNB patients reported in 22 articles. In these patients,52.8% were from Japan and 27.7% were from western countries including the United States(11.0%). The age of the patients ranged from 35 to 80 years old with an average of 64.6. Male/female ratio was 1.5. Macroscopically,57.5% of the tumors were in the left lobe and 29.5% were in the right lobe. The average size of the tumor were 4.2 cm at the time of diagnosis. Histologically,pancreato-biliary subtype accounted for 41.8%,intestinal 28.0%,gastric 13.5% and oncocytic 16%. An invasive component is most often present in the pancreato-biliary and gastric subtypes. Despite recent advanced technologies,diagnosis of IPNB is still challenging,especially in western countries due to its rarity. Defined clinicopathologic features are in demand for the accurate diagnosis and proper treatment. | Yaohong Tan Clara Milikowski Yanelba Toribio Adam Singer Claudia P Rojas Monica T Garcia-Buitrago | 2015 | World Journal of Gastroenterology2015，21，43： | 19 |
| 2 | Understanding consumption-related sucralose emissions - A conceptual approach combining substance-flow analysis with sampling analysis 显示文摘 | Neset T S Singer H Longree P | 2010 | Sci Total Environ2010，408，16： | 1 |
| 3 | Bench-scale testing of a magnetic ion exchange resin for removal of disinfection by-product precursors 显示文摘 | Boyer T H Singer P C | 2005 | Water Res2005，39，7： | 1 |
| 4 | Polypeptides p40, pOM2, and pAngR are required for iron uptake and for virulence of the marine fish pathogen Vibrio anguillarum 显示文摘 | Singer J T Schmidt K A Reno P W | 1991 | Bacteriology1991，173，3： | 1 |
| 5 | Nitropropionic acid of succinate dehydrogenase by 3-nitropropionate 显示文摘 | Coles C J Edmondson D E Singer T P | 1979 | J Biol Chem1979，54，： | 1 |
| 6 | Mechanism of the neurotoxicity of 1-methyl-4-phenylpyridinium (MPP^+), the toxic bioactivation product of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)显示文摘 | Singer T P Ramsay R R McKeown K | 1988 | Toxicology1988，49，： | 1 |
| 7 | On-field measurement meth- od of vapor injection heat pump system 显示文摘 | Singer E Tran C T RiviSre P | 2014 | International Journal of Refrigeration2014，41，： | 1 |
| 8 | Inactivation of succinate dehydrogenase by 3-nitropropionate显示文摘 | COLES C J EEMONDSON D E SINGER T P | 1979 | J Biol Chem1979，254，： | 1 |
| 9 | A pilot-scale evaluation of magnetic ion exchange treatment for removal of natural organic material and inorganic anions 显示文摘 | Bayer T H Singer P C | 2006 | Water Res2006，40，15： | 1 |
| 10 | Studies on the respiratory chain-linked dihydrodiphosphopyridine nucleotide dehydrogenase 显示文摘 | MINAKAMI S RINGLER R L SINGER T P | 1962 | Biol Chem1962，237，2： | 1 |
| 11 | Empathic Neural Responses are Modulated by the PerceivedFairness of Others 显示文摘 | Singer T Seymour B 0 ’ Doherty J P Stephan K E Dolan R J FrithC D | 2006 | Nature2006，，439： | 1 |
| 12 | Empathic Neural Responses Are Modulated by the Perceived Fairness of Others显示文摘 | Singer T Seymour B O'Doherty J P | 2006 | Nature2006，439，7075： | 1 |
| 13 | Modeling the removal of dissolved organic carbon by ion exchange in a completely mixed flow reactor 显示文摘 | Boyer T H Miller C T Singer P C | 2008 | Water Res2008，42，89： | 1 |
| 14 | Bench scale testing of a magnetic ion exchange resin for removal of disinfection by-product precursors 显示文摘 | Boyer T H Singer P C | 2005 | Water Research2005，39，7： | 1 |
| 15 | Energy-dependent uptake of 1-methyl4-phenylpyridimium,the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,by mitochondria显示文摘 | Ramsay R R Singer T P | 1986 | J Biol Chem1986，261，17： | 1 |
| 16 | Bench-scale testing of a magnetic ion exchange resin for removal of disinfection by-product precursors 显示文摘 | Boyer T H Singer P C | 2005 | Water Research2005，39，7： | 1 |
| 17 | Empathic Neural Responses are Modulated by the Perceived Fairness of Others显示文摘 | Singer T Seymour B Doherty J P | | 0，，： | 1 |
| 18 | A pilot-scale evaluation of magnetic ion exchange treatment for removal of natural organic material and inorganic anions 显示文摘 | Boyer T H Singer P C | 2006 | Water Research2006，40，15： | 1 |
| 19 | Studies on wheat germ lipase methods of estimation, purification, and general properties of the enzyme 显示文摘 | Singer T P Hofstee B H J | 1948 | Archives of biochemistry1948，18，2： | 1 |
| 20 | A pilot-scale evaluation of magnetic ion exchange treatment for removal of natural organic material and inorganic anians显示文摘 | Boyer T H Singer P C | 2006 | Water Research2006，40，15： | 1 |
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