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		题名	作者	年代	出处	被引量
	1	Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘	Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm	2005	The Lancet . 2005 (9454)2005，，：	2
	2	Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘	Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm	2005	2005 (9454)2005，，9454：	1
	3	Sustained HBeAg and HBsAg Loss After Long-term Follow-up of HBeAg-Positive Patients Treated With Peginterferon α-2b显示文摘	Erik H.C.J. Buster Hajo J. Flink Yilmaz Cakaloglu Krzysztof Simon J?rg Trojan Fehmi Tabak Thomas M.K. So S. Victor Feinman Tomasz Mach Ulus S. Akarca Martin Schutten Wanda Tielemans Anneke J. van Vuuren Bettina E. Hansen Harry L.A. Janssen	2008	Gastroenterology2008，，2：	1
	4	Role of rpsA gene se- quencing in diagnosis of pyrazinamide resistance显示文摘	Simons SO Mulder A van Ingen J	2013	J Clin Micro- biol2013，51，1：	1
	5	Sustained HBeAg and HBsAg Loss After Long-term Follow-up of HBeAg-Positive Patients Treated With Peginterferon α-2b显示文摘	Erik H.C.J. Buster Hajo J. Flink Yilmaz Cakaloglu Krzysztof Simon J?rg Trojan Fehmi Tabak Thomas M.K. So S. Victor Feinman Tomasz Mach Ulus S. Akarca Martin Schutten Wanda Tielemans Anneke J. van Vuuren Bettina E. Hansen Harry L.A. Janssen	2008	Gastroenterology2008，，2：	1
	6	Efficacy of sirolimus therapy for chylous effusions in lymphangioleiomyomatosis显示文摘	Barrera P Simons SO Luijk B	2013	Ann Am Thorac Soc2013，10，4：	1
	7	Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘	Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm	2005	The Lancet2005，，9454：	1
	8	Tissue plasminogen activa- tor and DNase in empyema 显示文摘	Simons SO Smits D Van Der Heijden E	2011	N Engl J Ivied2011，365，20：	1
	9	Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer显示文摘	Suet Yi Leung Siu Tsan Yuen Kent-Man Chu Jonathan A. Mathy Rui Li Annie S.Y. Chan Simon Law John Wong Xin Chen Samuel So	2004	Gastroenterology2004，，2：	1
	10	Phytoestrogens and their humanmetabolites show distinct agonistic and antagonistic properties on es-trogen receptor alpha ( ERalpha ) and ERbeta in human cells 显示文摘	Mneller SO Simon S Chae K	2004	Toxicological sciences2004，8，1：	1
	11	Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial 显示文摘	Janssen HL van Zonneveld M Senturk H Zeuzem S Akarca US Cakaloglu Y Simon C So TM Gerken G de Man RA Niesters HG Zondervan P Hansen B Schalm SW HBV 99-01 Study Group Rotterdam Foundation for Liver Research	2005	Lancet2005，365，9454：	1
	12	DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway显示文摘	KANG M A SO E Y SIMONS A L	2012	Cell Death and Disease2012，3，：	1
	13	DNA damage induces reac- tive oxygen species generation through the H2AX-Noxl/Racl pathway 显示文摘	Kang MA So EY Simons AL	2012	Cell Death Dis2012，3，：	1
	14	Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and Erbeta in human ceils 显示文摘	Mueller SO Simon S Chae K	2004	Toxicol Sci2004，80，1：	1
	15	HM30181A,a potent P-glycoprotein inhibitor,potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model显示文摘Objective:Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma,owing to the presence of the blood-brain barrier and the activity of P-gp,which pumps its substrate back into the systemic circulation.The aim of the present study was to develop an intravenous formulation of HM30181 A(HM)to inhibit P-gp in the brain to effectively deliver paclitaxel(PTX)for the treatment of malignant glioma.Methods:Two formulations of solubilized HM were designed on the basis of different solid dispersion strategies:i)spray-drying[polyvinlypyrrolidone(PVP)-HM]and ii)solvent evaporation[HP-β-cyclodextrin(cyclodextrin)-HM].The P-gp inhibition of these 2 formulations was assessed on the basis of rhodamine 123 uptake in cancer cells.Blood and brain pharmacokinetic parameters were also determined,and the antitumor effect of cyclodextrin-HM with PTX was evaluated in an orthotopic glioma xenograft mouse model.Results:Although both PVP-HM and cyclodextrin-HM formulations showed promising P-gp inhibition activity in vitro,cyclodextrin-HM had a higher maximum tolerated dose in mice than did PVP-HM.Pharmacokinetic study of cyclodextrin-HM revealed a plasma concentration plateau at 20 mg/kg,and the mice began to lose weight at doses above this level.Cyclodextrin-HM(10 mg/kg)administered with PTX at 10 mg/kg showed optimal antitumor activity in a mouse model,according to both tumor volume measurement and survival time(P<0.05).Conclusions:In a mouse orthotopic brain tumor model,the intravenous co-administration of cyclodextrin-HM with PTX showed potent antitumor effects and therefore may have potential for glioma therapy in humans.	Wu Zeng Betty Yuen Kwan Law Vincent Kam Wai Wong Denise So Bik Chan Simon Wing Fai Mok Joyce Jia Ying Gao Rebecca Ka Yan Ho Xu Liang Jia Hao Li Ming Tsung Lee Weng Li Yoon Michael P Smolinski Johnson Yiu Nam Lau Christopher Wai Kei Lam Manson Fok	2020	Cancer Biology & Medicine2020，17，4：	0

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