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| 1 | 预期寿命估计对脊柱转移瘤手术选择与预后预测的临床意义显示文摘背景与目的:目前,临床上对脊柱转移瘤患者是否采取手术治疗以及如何选择手术仍然存在较大的争议。预期寿命的估计是手术选择的决定因素之一。本研究旨在评价Tokuhashi和Tomita评分系统这两种常用的预期寿命估计方法对硬膜外脊柱转移瘤患者手术选择与预后预测的临床价值。方法:对2001年1月至2004年4月丹麦奥胡斯大学医院脊柱外科中心收治的169例硬膜外脊柱转移瘤入组患者,术前用Tokuhashi与Tomita评分系统进行评分以及估计预期寿命,并结合Tomita脊柱肿瘤分型,选择实施手术分级治疗。术后6个月、12个月以及24个月分别进行前瞻性随访观察。对在预期寿命为“3个月内死亡”、“6个月内死亡”以及“12个月内死亡”的患者通过Tokuhashi与Tomita评分系统绘制受试者作业特征曲线(receiveroperatingcharacteristiccurves,ROC曲线),比较两个评分系统对预期寿命估计的准确性。同时采用Kaplan-Meier生存曲线分析法,计算Tokuhashi和Tomita评分系统各分数段患者术后的实际平均生存时间。结果:预期寿命分别为“3个月内死亡”、“6个月内死亡”以及“12个月内死亡”的病例ROC曲线分析显示,Tomita评分系统与Tokuhashi评分系统之间的差异均无显著性(各组P值分别为0.16、0.47与0.38)。Kaplan-Meier生存曲线分析显示,Tomita评分系统在4~7分之间对预后估计过高,Tokuhashi评分系统在0~8分之间对预后估计过低。结论:Tokuhashi和Tomita评分系统均可成功地预测脊柱转移瘤患者术后预后的情况。Tokuhashi评分系统可较为准确地预测生存期较短的患者,从而避免对这类患者做不必要的大手术。 | 邹学农 Anders Grejs 李海声 Kristian Hφy Ebbe S Hansen Cody Bünger | 2006 | 癌症2006，25，11： | 18 |
| 2 | Trustworthiness as a Source of Competitive Advantage显示文摘 | Joy B Barney Mark H Hansen | 1994 | Strategic Management Journal1994，，： | 3 |
| 3 | Model selection and the principle of minimum description length显示文摘 | Hansen M H Yu B | 1998 | Journal of the American Statistical Association1998，96，454： | 2 |
| 4 | Sperm chromatin structure integrity in liquid stored boar semen and its relationships with field fertility 显示文摘 | BOE HANSEN G B CHRISTENSEN P VIVJERG D | 2008 | Theriogenology2008，69，6： | 1 |
| 5 | Epilepsy and pregnancy : lamotrigine as main drug used 显示文摘 | Sabers A Dam M A - Rogvi - Hansen B | 2004 | Acta Neurol Stand2004，109，： | 1 |
| 6 | Yeast beta-glucan amplifies phagocyte killing of iC3b-opsonized tumor cells via complement receptor 3-Syk-phosphatidylinositol 3-kinase pathway显示文摘 | Li B Allendorf D J Hansen R | 2006 | J Immunol2006，177，3： | 1 |
| 7 | Methane oxidation potentials and fluxes in agricultural soil:Effect of fertilization and soil compaction显示文摘 | Sitaula B K Hansen S | 2000 | Biogeochemistry2000，48，： | 1 |
| 8 | Priority setting for existing chemicals : The European Union risk ranking method 显示文摘 | HANSEN B J VAN HAELST A G VAN LEEUWEN K | 1999 | Environ Toxicol Chem1999，18，： | 1 |
| 9 | Modulation of iron homeostasis in macrophages by bacterial intracellular pathogens显示文摘 | Pan X Tamilselvam B Hansen EJ | 2010 | BMC Microbiol2010，1064，： | 1 |
| 10 | Cluster analysis and mathematical programming 显示文摘 | Hansen P Jaumard B | 1997 | Mathematical Programming1997，79，13： | 1 |
| 11 | Circadian rhythms in serum and CSF cortisol of rhesus monkeys, and their modulation by timed injections of L-5- hydroxytryptophan 显示文摘 | UMBERKOMAN-WIITA B HANSEN S HERBERT J | 1981 | Brain Research1981，222，： | 1 |
| 12 | Clinical management of metabolic syndrome: report of the Ameri- can Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management显示文摘 | Grundy S M Hansen B Smith S C Jr | 2004 | Circulation2004，109，4： | 1 |
| 13 | Do g-teen areas affect health? Results froma Danish survey on the use of green areas and health indicators显示文摘 | Nielsen T S Hansen K B | 2007 | Health Place2007，13，： | 1 |
| 14 | Bilirubin has wide spread inhib- itory effects on protein phosphorylation 显示文摘 | HANSEN T W MATHIESEN S B WALAAS S T | 1996 | Pediatr Res1996，39，6： | 1 |
| 15 | Enforced mobilization,early oral feeding, and balanced analgesia improve convalescence after colorectal surgery 显示文摘 | Henriksen M G Jensen M B Hansen H V | 2002 | Nutrition2002，18，2： | 1 |
| 16 | De Novo Biosynthesis of Vanillin in Fission Yeast (Schizosaccharomyces i?ombe) and Bakers Yeast (Saccharomyces cerevisiae)显示文摘 | Hansen E H Moiler B L Koek G R | 2009 | Applied md Environmentalmicrobiology2009，75，9： | 1 |
| 17 | Isolation and purifica- tion of immunoglobulins from chicken egs using thiophilic interaction chromatography 显示文摘 | HANSEN P SCOBLE J A HANSON B | 1998 | J Immunol Met1998，215，12： | 1 |
| 18 | E, The Grid Bootstrap and The Au- toregressive Model 显示文摘 | Hansen B | 1999 | The Review of Economics and Statistics1999，81，04： | 1 |
| 19 | Acute interstitial pneumonia in mink kits inoculated with defined isolates of Aleutian mink disease parvovirus显示文摘 | Alexandersen S Larsen S Aasted B Uttenthal A Bloom M E Hansen M | 1994 | Vet Patho1994，31，2： | 1 |
| 20 | Sodic soil reclamation using cottage cheese(acid)whey显示文摘 | Jones S B Robbins C W Hansen C L | 1993 | Arid Soil Research and Rehabilitation1993，7，1： | 1 |
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