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| 1 | Escitalopram-induced liver injury: A case report and review of literature显示文摘BACKGROUND Depression is a growing public health problem that affects over 350 million people globally and accounts for approximately 7.5%of healthy years lost due to disability.Escitalopram,one of the first-line medications for the treatment of depression,is a selective serotonin reuptake inhibitor and one of the most commonly prescribed antidepressant medications worldwide.Although thought to be generally safe and with minimal drug-drug interactions,we herein present an unusual case of cholestatic liver injury,likely secondary to escitalopram initiation.CASE SUMMARY A 56-year-old Chinese lady presented with fever and cholestatic liver injury two weeks after initiation of escitalopram for the treatment of psychotic depression.Physical examination was unremarkable.Further investigations,including a computed tomography scan of the abdomen and pelvis and tests for hepatitis A,B and C and for autoimmune liver disease were unyielding.Hence,a diagnosis of escitalopram-induced liver injury was made.Upon stopping escitalopram,repeat liver function tests showed downtrending liver enzymes with eventual normalization of serum aspartate aminotransferase and alanine aminotransferase one-week post-discharge.CONCLUSION Clinicians should be aware of the possibility of escitalopram-induced liver injury when initiating depressed patients on antidepressant treatment.This requires extra vigilance as most patients may remain asymptomatic.Measurement of liver function tests could be considered after initiation of antidepressant treatment,especially in patients with pre-existing liver disease. | Qin Xiang Ng Christl Suet Kwan Yong Wayren Loke Wee Song Yeo Alex Yu Sen Soh | 2019 | World Journal of Hepatology2019，11，10： | 3 |
| 2 | Mesoplasticity Approach to Studies of the Cutting Mechanism in Ultra-precision Machining显示文摘There have been various theoretical attempts by researchers worldwide to link up different scales of plasticity studies from the nano-, micro- and macro-scale of observation, based on molecular dynamics, crystal plasticity and continuum mechanics. Very few attempts, however, have been reported in ultra-precision machining studies. A mesoplasticity approach advocated by Lee and Yang is adopted by the authors and is successfully applied to studies of the micro-cutting mechanisms in ultra-precision machining. Traditionally, the shear angle in metal cutting, as well as the cutting force variation, can only be determined from cutting tests. In the pioneering work of the authors, the use of mesoplasticity theory enables prediction of the fluctuation of the shear angle and micro-cutting force, shear band formation, chip morphology in diamond turning and size effect in nano-indentation. These findings are verified by experiments. The mesoplasticity formulation opens up a new direction of studies to enable how the plastic behaviour of materials and their constitutive representations in deformation processing, such as machining can be predicted, assessed and deduced from the basic properties of the materials measurable at the microscale. | LEE WB Rongbin WANG Hao TO Suet CHEUNG Chi Fai CHAN Chang Yuen | 2014 | Chinese Journal of Mechanical Engineering2014，27，2： | 2 |
| 3 | A Common PCSK9 Haplotype, Encompassing the E670G Coding Single Nucleotide Polymorphism, Is a Novel Genetic Marker for Plasma Low-Density Lipoprotein Cholesterol Levels and Severity of Coronary Atherosclerosis显示文摘 | Suet N. Chen Christie M. Ballantyne Antonio M. Gotto Yanli Tan James T. Willerson Ali J. Marian | 2005 | Journal of the American College of Cardiology2005，，10： | 2 |
| 4 | Antralization at the edge of proximal gastric ulcers:Does Helicobacter pylori infection play a role?显示文摘AIM: To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect ofH. pylori eradication on the mucosal appearances.
METHODS: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type.H. pylori positive patients receivedeither triple therapy, or omeprazole.
RESULTS: Patients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge inH. pylori-positive patients thanH.pylori-negative patients (93% vs 60%, OR=8.95,95%CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61%, P=0.004) at the ulcer edge in patients with H. pyloribeing eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection.
CONCLUSION: H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection. | Harry Hua-Xinag Xia Shiu Kum Lam Wai Man Wong Wayne Hsing Cheng Hu Kam Chuen Lai Sau Hing Wong Suet Yi Leung Siu Tsan Yuen Nicholas A.Wright Benjamin Chun-Yu Wong | 2003 | World Journal of Gastroenterology2003，9，6： | 2 |
| 5 | Resolution of Established Cardiac Hypertrophy and Fibrosis and Prevention of Systolic Dysfunction in a Transgenic Rabbit Model of Human Cardiomyopathy Through Thiol-Sensitive Mechanisms显示文摘 | Raffaella Lombardi Gabriela Rodriguez Suet Nee Chen Crystal M. Ripplinger Wenwen Li Junjie Chen James T. Willerson Sandro Betocchi Samuel A. Wickline Igor R. Efimov Ali J. Marian | 2009 | Circulation2009，，10： | 1 |
| 6 | Retinol bindingprotein 4 levels and clinical features of type 2 diabetes patients显示文摘 | Takebayashi K Suet sugu M Wakabayashi S | 2007 | J Clin Endocrinol Metab2007，92，27： | 1 |
| 7 | A theoretical and experimental investigation of the tool tip vibration and its influence upon surface generation in single point diamond turning显示文摘 | WANG Hao TO Suet CHAN C Y | 2010 | International Journal of Machine Tools andManufacture2010，50，3： | 1 |
| 8 | Toward silicon-based lasers for Terahertz sources显示文摘 | Lynch S A Paul D J Townsend P Matmon G M Suet Z Kelsall R W Ikonic Z Harrison P Zhang J Noriss D J Cullis A G Pidgeon C R Murzyn P Murdin B Bain M Gamble H S Zhao M Ni W X | | 0，，06： | 1 |
| 9 | Evaluation of mammalian cell adhesion on surface-modified porous silicon 显示文摘 | SUET P L KERYN A WILLIAMS B | 2006 | Biomaterials2006，27，26： | 1 |
| 10 | Antifibrotic Effects of Antioxidant N-Acetylcysteine in a Mouse Model of Human Hypertrophic Cardiomyopathy Mutation显示文摘 | Ali J. Marian Vinitha Senthil Suet N. Chen Raffaella Lombardi | 2006 | Journal of the American College of Cardiology2006，，4： | 1 |
| 11 | Prevention of Cardiac Hypertrophy by Atorvastatin in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy显示文摘 | Vinitha Senthil Suet N. Chen Natalie Tsybouleva Tripti Halder Sherif F. Nagueh James T. Willerson Robert Roberts A J. Marian | 2005 | Circulation Research2005，，3： | 1 |
| 12 | BRAFand KRAS Mutations in Colorectal Hyperplastic Polpys and Serrated Adanomas显示文摘 | Tsun LC Wei Z Suet YL | 2003 | Cancer Res2003，63，15： | 1 |
| 13 | Generating Test Cases for XML-based Web Component Interactions Using Mutation Analysis 显示文摘 | SUET CHUN LEE JEFF OFFUTT | 2001 | ISSRE 012001，，12： | 1 |
| 14 | Associat ion between plasma visfa-t in and vascularendothelial function in patients with type 2 diabetesmellitus显示文摘 | Takebayashi K Suet sugu M Wakabayashi S | 2007 | Metabolism2007，56，4： | 1 |
| 15 | Modelling and characterization of generation of 3Dmicro-structured surfaces with self-cleaning and optical functions显示文摘 | KONG Lingbao CHEUNG Chifai TO Suet | 2013 | OPTIK-International Journal for Light and Electron Optics2013，124，17： | 1 |
| 16 | Effect of assembling errors on the diffraction efficiency for multilyaer diffractive optical elements 显示文摘 | Gao Long Suet Yang Hongfang | 2014 | Applied Optics2014，53，37： | 1 |
| 17 | Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis 显示文摘 | Suet Nee Chen Mehmet Cilingiroglu Josh Todd | 2009 | BMC Med Genet2009，10，： | 1 |
| 18 | Resol- ution of Established Cardiac Hypertrophy and Fibrosis and Prevention of Systolic Dysfunction in a Transgenic Rabbit Model of Human Car- diomyopathy Through Thiol-Sensitive Mechanisms显示文摘 | Raffaella Lombardi Gabriela Rodriguez Suet Nee Chen | | Circulation0，119，10： | 1 |
| 19 | Myozenin 2 is a novel fene for human hypertrophic cardiomyopathy 显示文摘 | Osio A Tan L Suet N | 2007 | Circ Res2007，100，6： | 1 |
| 20 | Evaluation of mammalian cell adhesion on surfacemodified porous silicon显示文摘 | Suet Peng Low | 2006 | Biomaterials2006，17，： | 1 |
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