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| 1 | Enteric glial cells and their role in gastrointestinal motor abnormalities: Introducing the neuro-gliopathies显示文摘The role of enteric glial cells has somewhat changed from that of mere mechanical support elements, gluing together the various components of the enteric nervous system, to that of active participants in the complex interrelationships of the gut motor and inflammatory events. Due to their multiple functions, spanning from supporting elements in the myenteric plexuses to neurotransmitters, to neuronal homeostasis, to antigen presenting cells, this cell population has probably more intriguing abilities than previously thought. Recently, some evidence has been accumulating that shows how these cells may be involved in the pathophysiological aspects of some diseases. This review will deal with the properties of the enteric glial cells more strictly related to gastrointestinal motor function and the human pathological conditions in which these cells may play a role, suggesting the possibility of enteric neuro- gliopathies. | Gabrio Bassotti Vincenzo Villanacci Simona Fisogni Elisa Rossi Paola Baronio Carlo Clerici Christoph A Maurer Gieri Cathomas Elisabetta Antonelli | 2007 | World Journal of Gastroenterology2007，13，30： | 16 |
| 2 | Mycophenolate mofetil for drug-induced vanishing bile duct syndrome显示文摘Amoxicillin/clavulanate is associated with liver injury, mostly of a cholestatic pattern. While outcomes are usually benign, progression to cirrhosis and death has been reported. The role of immunosuppressive therapy for patients with a protracted course is unclear. We report the case of an elderly patient who developed prolonged cholestasis secondary to amoxicillin/clavulanate. Vanishing bile duct syndrome was confirmed by sequential liver biopsies. The patient responded to prednisone treatment, but could not be weaned off corticosteroids, even when azathioprine was added. Complete withdrawal of both prednisone and azathioprine was possible by using mycophenolate mofetil, an inosine monophosphate dehydrogenase inhibitor. Sustained remission has been maintained for more than 3 years with low-dose mycophenolate mofetil. | S Simona Jakab A Brian West Dennis M Meighan Robert S Brown Jr William B Hale | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 3 | Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis显示文摘 | Tetsuya Ueda Stefano Volinia Hiroshi Okumura Masayoshi Shimizu Cristian Taccioli Simona Rossi Hansjuerg Alder Chang-gong Liu Naohide Oue Wataru Yasui Kazuhiro Yoshida Hiroki Sasaki Sachiyo Nomura Yasuyuki Seto Michio Kaminishi George A Calin Carlo M Croce | 2010 | Lancet Oncology2010，，2： | 4 |
| 4 | Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease显示文摘BACKGROUND In non-alcoholic fatty liver disease(NAFLD), a high-fat or high-fructose diet increases intestinal permeability and promotes derangement of the gut-liver axis.We hypothesize that, diet could be able to modulate intestinal permeability in patients with NAFLD.AIM To detect diet-induced modification of intestinal permeability in patients with NAFLD undergoing a Mediterranean diet or a low-fat diet.METHODS The current study was a dietary intervention for non-diabetic, patients with biopsy-verified NAFLD and increased transaminases. A crossover design was employed: participants underwent 16 weeks of Mediterranean diet, 16 wk of free wash-out, and 16 weeks of low-fat diet. Both diets were hypocaloric and no consumption of supplements was allowed. All patients were followed bimonthly by a dietitian. Evaluations of clinical and metabolic parameters were completed at baseline and at the end of each dietary period. Intestinal permeability was assessed by chromium-51 ethylene diamine tetraacetate excretion testing(51 CrEDTA).RESULTS Twenty Caucasian patients, 90% male, median age 43 years, body mass index(BMI) 30.9, with biopsy-verified NAFLD were enrolled. At the end of 16 weeks of a Mediterranean diet, a significant reduction in mean body weight(-5.3 ± 4.1 kg,P = 0.003), mean waist circumference(-7.9 ± 4.9 cm, P = 0.001), and mean transaminase levels [alanine aminotransferase(ALT)-28.3 ± 11.9 IU/L, P =0.0001; aspartate aminotransferase(AST)-6.4 ± 56.3 IU/L, P = 0.01] were observed. These benefits were maintained after 16 wk of wash-out and also after16 wk of low-fat diet, without further improvements. Fourteen of the 20 patients had intestinal permeability alteration at baseline(mean percentage retention of51 Cr-EDTA = 5.4%), but no significant changes in intestinal permeability were observed at the end of the 16 wk of the Mediterranean diet or 16 wk of the low-fat diet.CONCLUSION Mediterranean diet is an effective strategy for treating overweight, visceral obesity and serum transaminase in patients with NAFLD. If the Mediterranean diet can improve intestinal permeability in patients with NAFLD, it deserves further investigation. | Marco Biolato Fiorella Manca Giuseppe Marrone Consuelo Cefalo Simona Racco Giacinto A Miggiano Venanzio Valenza Antonio Gasbarrini Luca Miele Antonio Grieco | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 5 | Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis显示文摘 | Tetsuya Ueda Stefano Volinia Hiroshi Okumura Masayoshi Shimizu Cristian Taccioli Simona Rossi Hansjuerg Alder Chang-gong Liu Naohide Oue Wataru Yasui Kazuhiro Yoshida Hiroki Sasaki Sachiyo Nomura Yasuyuki Seto Michio Kaminishi George A Calin Carlo M Croce | 2010 | Lancet Oncology2010，，2： | 2 |
| 6 | Exogenous cytokinin application to Actinidia chinensis var. deliciosa ‘Hayward’ fruit promotes fruit expansion through water uptake显示文摘Exogenous application of a cytokinin-like compound forchlorfenuron(CPPU)can promote fruit growth,although often at the expense of dry matter(DM),an important indicator of fruit quality.Actinidia chinensis var.deliciosa‘Hayward’fruit are very responsive to CPPU treatments,but the mechanism underlying the significant fruit weight increase and associated decrease in DM is unclear.In this study,we hypothesised that CPPU-enhanced growth increases fruit carbohydrate demand,but limited carbohydrate supply resulted in decreased fruit DM.During fruit development,CPPU effects on physical parameters,metabolites,osmotic pressure and transcriptional changes were assessed under conditions of both standard and a high carbohydrate supply.We showed that CPPU increased fruit fresh weight but the dramatic DM decrease was not carbohydrate limited.Enhanced glucose and fructose concentrations contributed to an increase in soluble carbohydrate osmotic pressure,which was correlated with increased water accumulation in CPPU-treated fruit and up-regulation of water channel aquaporin gene PIP2.4 at 49 days after anthesis.Transcipt analysis suggested that the molecular mechanism contributing to increased glucose and fructose concentrations was altered by carbohydrate supply.At standard carbohydrate supply,the early glucose increase in CPPU fruit was associated with reduced starch synthesis and increased starch degradation.When carbohydrate supply was high,the early glucose increase in CPPU fruit was associated with a general decrease in starch synthesis but up-regulation of vacuolar invertase and fructokinase genes.We conclude that CPPU affected fruit expansion by increasing the osmotically-driven water uptake and its effect was not carbohydrate supply-limited. | Simona Nardozza Helen L Boldingh Mark W Wohlers Andrew P Gleave Zhiwei Luo Guglielmo Costa Elspeth A MacRae Michael J Clearwater Annette C Richardson | 2017 | Horticulture Research2017，4，1： | 2 |
| 7 | Proteomic analysis of tomato fruits from two ecotypes during ripening 显示文摘 | Mariapina R Chiara D Simona A | 2006 | Proteomies2006，，6： | 1 |
| 8 | The epidemology of schizophrenia replacing dog- ma with knowledge 显示文摘 | Simona A Robin M | 2010 | Dialogues Clin Neurosci2010，12，： | 1 |
| 9 | Carbon and nitrogen isotope variations in sedimenting organic matter in Lake Lugano显示文摘 | Bernasconi SM Barbieri A Simona M | | 0，，08： | 1 |
| 10 | Role of CDIA and HSP60 in the antitumoral response of oesophageal cancer 显示文摘 | Simona C Giampiero LR Rita A et ol | 2008 | Oncol Rev2008，1，4： | 1 |
| 11 | Phenotypic and functional characteristics of tumor-derived microvascular endothelial cells显示文摘 | Giulio A Renato GS Simona F | 1999 | Clin Expe Metast1999，17，： | 1 |
| 12 | Both Intedeukin-4 (IL-4) and IL-4 Receptor (Signaling Contribute to the Development of Hepatic Gnmulomas with Optimal AntileishmaniM Activity显示文摘 | Simona Stager James A Christine KC | 2003 | Infection and Immunity2003，71，8： | 1 |
| 13 | Human Hspl0 and early pregnancy factor (EPF) and their relationship andinvolvement in cancer and immunity: Current knowl- edge and perspectives显示文摘 | Simona C Claudia C Rita A | 2010 | Life Sciences2010，86，： | 1 |
| 14 | Immunohistochemical evalu- ation of COX- 2 expression in HPV -positive cervical squa- mous intraepithelial lesions显示文摘 | Raluca B Cornelia A Simona E | 2011 | Rom J Morphol Embryol2011，52，1： | 1 |
| 15 | Fermentative production of superoxide dismutase with Kluyveromyces marxianus显示文摘 | Clementina D Alberto A Simona Z | 2007 | J Ind Microbiol Biotechnol2007，34，1： | 1 |
| 16 | The effect of different N substrates on biological N2O production from forest and agricultural light textured soils显示文摘 | Simona C Keith A S | 1998 | Plant and Soil1998，199，： | 1 |
| 17 | Scherffelia dubia centrin exhibits a specific mechanism for Ca2 -controlled target binding 显示文摘 | Laura R Isabelle D Liliane A Yves B Simona M Jos A C Constantin T C | 2010 | Biochemistry2010，49，： | 1 |
| 18 | In-transit shipboard fumigation for pine wood chips to control Bursaphelenthus xylophilus显示文摘 | Leesch J G Davis R Simonaitis R A | 1989 | Bulletin OEPP/EPPO Bulletin1989，19，： | 1 |
| 19 | Tocopherols and tocotrienols as free radical - scavengers in refined vege- table oils and their stability during deep - fat frying 显示文摘 | ] Margherita R Cristina A Simona R | 2007 | Food Chemistry2007，102，3： | 1 |
| 20 | Surgical Stress after Open and Transumbilieal Laparoseopic-Assisted Appendectomy in Children显示文摘 | Impellizzeri P Simona A Grasso M | 2013 | Eur J Pediatr Surg2013，1，1： | 1 |
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