|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 2 | Mutants, Overexpressors, and Interactors of Arabidopsis Plastocyanin Isoforms: Revised Roles of Plastocyanin in Photosynthetic Electron Flow and Thylakoid Redox State显示文摘二相应 plastocyanin isoforms 被基因 PETE1 和 PETE2 编码为 Arabidopsis thaliana 的原子染色体。PETE2 抄本被表示在更加高水平和 PETE2 蛋白质是更丰富的 isoform。在 PETE 基因的空变化导致了植物,指明的 pete1 和 pete2,与减少的 plastocyanin 内容。尽管有在超过 90% 减少 plastocyanin 层次,而 pete1 大美人种,然而,它的自己上的一个 pete2 0 变化仅仅稍微影响光合作用和生长的率,与大约 6080% 野类型的 plastocyanin 水平,没显示出任何改变。因此, plastocyanin 集中不在最佳的生长条件下面为光合的电子流动正在限制,也许为蛋白质暗示另外的可能的生理的角色。确实, plastocyanin 以前被建议了在 thylakoid 氧化还原作用反应与细胞色素 c6A (Cyt c6A ) 合作,但是我们不为在二蛋白质之间的一个物理相互作用发现证据,用在酵母的相互作用试金。我们在酵母相互作用试金观察了 Cyt c6A 的 homodimerization,而且 Cyt c6A homodimers 没能与 plastocyanin 交往。而且, atc6-1 pete1 的 phenotypic 分析和 atc6-1 pete2 加倍异种,每缺乏的 Cyt c6A 并且二编码 plastocyanin 基因之一,没能揭示任何基因相互作用。在 pete1 pete2 的 PETE1 或 PETE2 的 Overexpression 在实质上野类型的光合的性能的两倍猛烈变异的背景结果,排除二 plastocyanin isoforms 能在 thylakoid 有不同函数的可能性电子流动。 | Paolo Pesaresi Michael Scharfenberg Martin Weigel Irene Granlund Wolfgang R Schroder Giovanni Finazzi Fabrice Rappaport Simona Masiero Antonella Furini Peter Jahns Dario Leister | 2009 | Molecular Plant2009，2，2： | 7 |
| 3 | Proteomic analysis of tomato fruits from two ecotypes during ripening 显示文摘 | Mariapina R Chiara D Simona A | 2006 | Proteomies2006，，6： | 1 |
| 4 | Association between 5,10-Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Conotruncal Heart Defects显示文摘 | Storti Simona Vittorini Simona Iascone Maria R | 2003 | Clin Chem Lab Med2003，41，3： | 1 |
| 5 | Decreased expression of DNA-dependent protein kinase,a DNA repair protein,during human colon carcinogenesis显示文摘 | BASIL R SIMONA B ABDELMONEM E | 2001 | Cancer Res2001，61，1： | 1 |
| 6 | Determination of nineteen 4- alkylphenol endocrine disrupters in Geneva municipal sewage wastewater显示文摘 | Espejo R Valter K Simona M | 2002 | Journal of Chromatography A2002，976，： | 1 |
| 7 | The perception of risks associated with food- related hazards and the perceived reliability of sources of information 显示文摘 | Simona R Anna S | 2004 | International Journal of Food Science & Technology2004，39，5： | 1 |
| 8 | EphB signaling directs peripheral nerve regeneration through sox 2 -dependent Schwann cell sorting显示文摘 | Simona P Ilaria N Sara R | 2010 | Cell2010，143，1： | 1 |
| 9 | Integrated uhrasound and biochemical screening for trisomy 21 using fetal nuchal translucency, absent fetal nasal bone, free β-hCG and PAPP-A at 11 to 14 weeks显示文摘 | Simona C Renu B Georgios R | 2003 | Prenat Diagn2003，，23： | 1 |
| 10 | Oral preoperative antioxidants in pancreatic surgery: A double-blind, randomized, clinical trial显示文摘 | Marco B Massimiliano B Simona R | 2012 | Nutrition2012，28，2： | 1 |
| 11 | Fluorousmaterials in microbubble engineering science and techno-logy-Design and development of new bubble preparation andsizing technologies显示文摘 | Simona R Csongor S Frédéric G | 2011 | J Fluorine Chem2011，15，2： | 1 |
| 12 | Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis显示文摘 | BASIL R SIMONA B ABDELMONEM E | 2001 | Cancer Res2001，61，23： | 1 |
| 13 | Determination of nineteen 4-alkylphenol endocrine disrupters in Geneva municipal sewage wastewater 显示文摘 | Espejo R Valter K Simona M | 2002 | Journal of Chromatography A2002，976，12： | 1 |
| 14 | Effects of Gene Deletion of the Tissue Inhibitor of the Matrix Metalloproteinase-type 1 (TIMP-1) on Left Ventricular Geometry and Function in Mice显示文摘 | Lisa Roten Shintaro Nemoto Janet Simsic Mytsi L Coker Vijay Rao Simona Baicu Gilberto Defreyte Paul J Soloway Michael R Zile Francis G Spinale | 2000 | Journal of Molecular and Cellular Cardiology2000，，1： | 1 |
| 15 | Comparsion of different methods for the detoxification of lignocellulose hydrolyzates of spruce显示文摘 | Simona L Anders R Nils-Olof N | 1999 | Appl Biochem Biotechnol1999，7779，： | 1 |
| 16 | Determination of nineteen 4-alkylphenol endocrine disrupters in Geneva municipal sewage wastewater显示文摘 | Espejo R Valter K Simona M | 2002 | Journal of Chromatography A2002，976，12： | 1 |
| 17 | Decreased expression of DNA-dependent protein kinase,a DNA repair protein,during human colon carcinogenesis显示文摘 | Basil R Simona B Abdelmonem E | 2001 | Cancer Res2001，61，23： | 1 |
| 18 | N - methyl - p - aminophenol (metol) ozonation in aqueous solution: kinetics, mechanism and toxicological characterization of ozonized samples 显示文摘 | Andreozzi R Simona M Marotta R | 2000 | Water Re-search2000，34，18： | 1 |
| 19 | Prevalence and bio - di- versity of Brettanomyces bruxellensis in wine from Northwestern Italy 显示文摘 | Simona C Kalliopi R Manuela G | 2010 | AmJEnolViticuh2010，61，4： | 1 |
| 20 | Comparison of different methods for the detoxification of lignocellulose hydrolyzates of spruce显示文摘 | ANDERS R NILS-OLOF N | 1999 | Applied Biochemistry and Biotechnology1999，7779，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员