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| 1 | Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes显示文摘Being infected by SARS-CoV-2 may cause damage to multiple organs in patients, such as the lung, liver and heart. Angiotensin-converting enzyme 2(ACE2), reported as a SARS-CoV-2 receptor, is also expressed in human male testes. This suggests a potential risk in human male reproductive system. However, the characteristics of ACE2-positive cells and the expression of other SARS-CoV-2 process-related genes are still worthy of further investigation. Here, we performed singlecell RNA seq(scRNA-seq) analysis on 853 male embryo primordial germ cells(PGCs) and 2,854 normal testis cells to assess the effects of the SARS-CoV-2 virus on the male reproductive system from embryonic stage to adulthood. We also collected and constructed the scRNA-seq library on 228 Sertoli cells from three non-obstructive azoospermia(NOA) patients to assess the effects at disease state. We found that ACE2 expressing cells existed in almost all testis cell types and Sertoli cells had highest expression level and positive cells ratio. Moreover, ACE2 was also expressed in human male PGCs. In adulthood, the level of ACE2 expression decreased with the increase of age. We also found that ACE2 positive cells had high expressions of stress response and immune activation-related genes. Interestingly, some potential SARS-CoV-2 process-related genes such as TMPRSS2, BSG, CTSL and CTSB had different expression patterns in the same cell type. Furthermore, ACE2 expression level in NOA donors’ Sertoli cells was significantly decreased. Our work would help to assess the risk of SARS-CoV-2 infection in the male reproductive system. | Xixi Liu Yidong Chen Wenhao Tang Li Zhang Wei Chen Zhiqiang Yan Peng Yuan Ming Yang Siming Kong Liying Yan Jie Qiao | 2020 | Science China(Life Sciences)2020，63，7： | 14 |
| 2 | Metaverse:Perspectives from graphics,interactions and visualization显示文摘The metaverse is a visual world that blends the physical world and digital world.At present,the development of the metaverse is still in the early stage,and there lacks a framework for the visual construction and exploration of the metaverse.In this paper,we propose a framework that summarizes how graphics,interaction,and visualization techniques support the visual construction of the metaverse and user-centric exploration.We introduce three kinds of visual elements that compose the metaverse and the two graphical construction methods in a pipeline.We propose a taxonomy of interaction technologies based on interaction tasks,user actions,feedback and various sensory channels,and a taxonomy of visualization techniques that assist user awareness.Current potential applications and future opportunities are discussed in the context of visual construction and exploration of the metaverse.We hope this paper can provide a stepping stone for further research in the area of graphics,interaction and visualization in the metaverse. | Yuheng Zhao Jinjing Jiang Yi Chen Richen Liu Yalong Yang Xiangyang Xue Siming Chen | 2022 | Visual Informatics2022，6，1： | 10 |
| 3 | Low-noise 1.3 μm InAs/GaAs quantum dot laser monolithically grown on silicon显示文摘We report low-noise, high-performance single transverse mode 1.3 μm InAs/GaAs quantum dot lasers monolithically grown on silicon(Si) using molecular beam epitaxy. The fabricated narrow-ridge-waveguide Fabry–Perot(FP) lasers have achieved a room-temperature continuous-wave(CW) threshold current of 12.5 mA and high CW temperature tolerance up to 90°C. An ultra-low relative intensity noise of less than-150 dB∕Hz is measured in the 4–16 GHz range. Using this low-noise Si-based laser, we then demonstrate 25.6 Gb/s data transmission over13.5 km SMF-28. These low-cost FP laser devices are promising candidates to provide cost-effective solutions for use in uncooled Si photonics transmitters in inter/hyper data centers and metropolitan data links. | MENGYA LIAO SIMING CHEN ZHIXIN LIU YI WANG LALITHA PONNAMPALAM ZICHUAN ZHOU JIANG WU MINGCHU TANG SAMUEL SHUTTS ZIZHUO LIU PETER M.SMOWTON SIYUAN YU ALWYN SEEDS HUIYUN LIU | 2018 | Photonics Research2018，，11： | 7 |
| 4 | Xeno-repopulation of Fah^(-/-)Nod/Scid mice livers by human hepatocytes显示文摘Functional human hepatocytes xenografted into the liver of mice can be used as a model system to study pharmacokinetics,infection of hepatitis viruses,and the efficacy of hepatitis vaccines.Significant levels of liver xeno-repopulation have been reported in Fah-/-Rag2-/-Il2rg-/-mice.However,the high mortality and low breeding rate of this model may hinder its application.A new model,termed Fah-/-Nod/Scid mice,which combines the advantages of liver repopulation in Fah-/-mice with the ease of xenotransplantation in Nod/Scid mice was obtained by gradual cross-breeding.Fah-/-Nod/Scid mice were easily maintained in breeding colonies and in adult animal care facilities.FK506 treatment combined with gradual withdrawal of NTBC before cell transplantation ensured that Fah-/-Nod/Scid mice were susceptible to liver xeno-repopulation by human hepatocytes;the proportion of engrafted human hepatocytes reached 33.6%.The function of the expanded human hepatocytes within the chimeric liver was confirmed by weight curve analysis,the expression of characteristic proteins,and the biochemical analysis of liver function.These results show that Fah-/-Nod/Scid mice are an ideal humanized liver mouse model with many useful applications. | SU BaoLiang LIU ChangCheng XIANG Dao ZHANG HaiBin YUAN SiMing WANG MinJun CHEN Fei ZHU HaiYing HE ZhiYing WANG Xin HU YiPing | 2011 | Science China(Life Sciences)2011，54，3： | 5 |
| 5 | Northern Hemisphere Sudden Stratospheric Warming and Its Downward Impact in Four Chinese CMIP6 Models显示文摘Using the World Meteorological Organization definition and a threshold-based classification technique,simulations of vortex displacement and split sudden stratospheric warmings(SSWs)are evaluated for four Chinese models(BCC-CSM2-MR,FGOALS-f3-L,FGOALS-g3,and NESM3)from phase 6 of the Coupled Model Intercomparison Project(CMIP6)with the Japanese 55-year reanalysis(JRA-55)as a baseline.Compared with six or seven SSWs in a decade in JRA-55,three models underestimate the SSW frequency by~50%,while NESM3 doubles the SSW frequency.SSWs mainly appear in midwinter in JRA-55,but one-month climate drift is simulated in the models.The composite of splits is stronger than displacements in both the reanalysis and most models due to the longer pulse of positive eddy heat flux before onset of split SSWs.A wavenumber-1-like temperature anomaly pattern(cold Eurasia,warm North America)before onset of displacement SSWs is simulated,but cold anomalies are mainly confined to North America after displacement SSWs.Although the lower tropospheric temperature also displays a wavenumber-1-like pattern before split SSWs,most parts of Eurasia and North America are covered by cold anomalies after split SSWs in JRA-55.The models have different degrees of fidelity for the temperature anomaly pattern before split SSWs,but the wavenumber-2-like temperature anomaly pattern is well simulated after split SSWs.The center of the negative height anomalies in the Pacific sector before SSWs is sensitive to the SSW type in both JRA-55 and the models.A negative North Atlantic Oscillation is simulated after both types of SSWs in the models,although it is only observed for split SSWs. | Jian RAO Siming LIU Yuanhao CHEN | 2021 | Advances in Atmospheric Sciences2021，38，2： | 4 |
| 6 | Chemical characteristics,oxidative potential,and sources of PM_(2.5)in wintertime in Lahore and Peshawar,Pakistan显示文摘The chemical characteristics,oxidative potential,and sources of PM_(2.5)were analyzed at the urban sites of Lahore and Peshawar,Pakistan in February 2019.Carbonaceous species,water soluble ions,and metal elements were measured to investigate the chemical composition and sources of PM_(2.5).The dithiothreitol(DTT)consumption rate was measured to evaluate the oxidative potential of PM_(2.5).Both cities showed a high exposure risk of PM_(2.5)regarding its oxidative potential(DTT v).Carbonaceous and some of the elemental species of PM_(2.5)correlated well with DTT v in both Lahore and Peshawar.Besides,the DTT v of PM_(2.5)in Lahore showed significant positive correlation with most of the measured water soluble ions,however,ions were DTT-inactive in Peshawar.Due to the higher proportions of carbonaceous species and metal elements,Peshawar showed higher mass-normalized DTT activity of PM_(2.5)compared to Lahore although the average PM_(2.5)concentration in Peshawar was lower.The high concentrations of toxic metals also posed serious non-carcinogenic and carcinogenic risks to the residents of both cities.Principle component analysis coupled with multiple linear regression was applied to investigate different source contributions to PM_(2.5)and its oxidative potential.Mixed sources of traffic and road dust resuspension and coal combustion,direct vehicle emission,and biomass burning and formation of secondary aerosol were identified as the major sources of PM_(2.5)in both cities.The findings of this study provide important data for evaluation of the potential health risks of PM_(2.5)and for formulation of efficient control strategies in major cities of Pakistan. | Mushtaq Ahmad Qing Yu Jing Chen Siming Cheng Weihua Qin Yuepeng Zhang | 2021 | Journal of Environmental Sciences2021，33，4： | 4 |
| 7 | Understanding the improved performance of sulfur-doped interconnected carbon microspheres for Na-ion storage显示文摘As one of the low-cost energy storage systems,Na-ion batteries(NIBs)have received tremendous attention.However,the performance of current anode materials still cannot meet the requirements of NIBs.In our work,we obtain sulfur-doped interconnected carbon microspheres(S-CSs)via a simple hydrothermal method and subsequent sulfurizing treatment.Our S-CSs exhibit an ultrahigh reversible capacity of 520 mAh g^(-1) at 100 mA g^(-1) after 50 cycles and an excellent rate capability of 257 mAh g^(-1),even at a high current density of 2 A g^(-1).The density functional theory calculations demonstrate that sulfur doping in carbon favors the adsorption of Na atom during the sodiation process,which is accountable for the performance enhancement.Furthermore,we also utilize operando Raman spectroscopy to analyze the electrochemical reaction of our S-CSs,which further highlights the sulfur doping in improving Na-ion storage performance. | Xinran Yuan Siming Chen Jinliang Li Junpeng Xie Genghua Yan Botian Liu Xibo Li Rui Li Likun Pan Wenjie Mai | 2021 | Carbon Energy2021，3，4： | 3 |
| 8 | Study on Commercial Application of FP-DSN Sulfur Transfer Additive in FCC Unit显示文摘The FCC unit with addition of various inventories of the FP-DSN type sulfur transfer additive was tested in a commercial scale. The effect of the sulfur transfer additive was analyzed by investigating the indicators related with the regenerator flue gas composition,the dry gas composition before desulfurization,the LPG composition before desulfurization,the acid gas,and the yield of gasoline and diesel. The test results indicated that the sulfur was trans ferred from the feed stream into the dry gas,LPG and acid gas,and the sulfur transfer effect was obvious only when the inventory of sulfur transfer additive exceeded over 2.0% of total FCC catalyst inventory. | Gao Siming Han Rongxian Chen Desheng(SINOPEC Qingdao Petrochemical Company,Qingdao 266043) | 2009 | China Petroleum Processing & Petrochemical Technology2009，11，2： | 2 |
| 9 | AN UTILITIES BASED APPROACH FOR MULTI-PERIOD DYNAMIC PORTFOLIO SELECTION显示文摘这篇论文建议了一个多时期动态最佳的公事包选择模型。假设被做保证推理的严格。这条途径描绘了开发;真实证券市场变化;是一次尝试补救一些最近的研究的缺乏。模型是二次的编程的一种标准形式。而且,这篇论文在真实证券市场论述了一个数字例子。 | Guoliang YANG Siming HUANG Wei CHEN | 2007 | Journal of Systems Science and Systems Engineering2007，16，3： | 2 |
| 10 | Expression of PTEN and Dephosphorylated FAK in Oral Squamous Cell Carcinoma and Precancerous Lesions显示文摘 | Siming Xie Xi Chen Lijia Shen Cao Yin Tingling Zhu Fufang Zhang Junyu Ke Jianliang Chen | 2011 | Journal of US-China Medical Science2011，8，4： | 1 |
| 11 | Cancer‐associated molecular signature in the tissue samples of patients with cirrhosis显示文摘 | Jin Woo Kim Qinghai Ye Marshonna Forgues Yidong Chen Anuradha Budhu Jessica Sime Lorne J. Hofseth Rashmi Kaul Xin Wei Wang | 2004 | Hepatology2004，，2： | 1 |
| 12 | Precipitation study of CO2-loaded glycinate solution with the introduction of ethanol as an antisolvent显示文摘Focused beam reflectance measurement(FBRM)and 13C nuclear magnetic resonance(13C NMR)analysis were used to study the precipitation process of CO2-loaded potassium glycinate(KGLY)solutions at different CO2 loadings,during the addition of ethanol as an antisolvent at a rate of 10 mL·min−1.The volume ratio of ethanol added to the KGLY solution(3.0 mol·L−1,340 mL)ranged from 0 to 3.0.Three solid-liquid-liquid phases were formed during the precipitation process.The FBRM results showed that the number of particles formed increased with CO2 loading and ethanol addition for CO2-unsaturated KGLY solutions,whilst for CO2-saturated KGLY solution it first increased then decreased to a stable value with ethanol addition.13C NMR spectroscopic analysis showed that the crystals precipitated from the CO2-unsaturated KGLY solutions consisted of glycine only,and the quantity crystallised increased with CO2 loading and ethanol addition.However,a complex mixture containing glycine,carbamate and potassium bicarbonate was precipitated from CO2-saturated KGLY solution with the maximum precipitation percentages of 94.3%,31.4%and 89.6%,respectively,at the ethanol volume fractions of 1.6,2.5 and 2.3. | Siming Chen Yue Wu Geoffrey WStevens Guoping Hu Wenshou Sun Kathryn AMumford | 2020 | Frontiers of Chemical Science and Engineering2020，14，3： | 1 |
| 13 | A benchmark for visual analysis of insider threat detection显示文摘Dear editor,Malicious insiders are trusted entities that are given the power to violate rules in a given security policy,and insider threats occur when trusted entities abuse such a power.In modern networked work environments,malicious insiders and their malicious activities pose serious threats to organizations and businesses.Trusted employees travel the intranet of an organization with a high degree of freedom. | Ying ZHAO Kui YANG Siming CHEN Zhuo ZHANG Xin HUANG Qiusheng LI Qi MA Xinyue LUAN Xiaoping FAN | 2022 | Science China(Information Sciences)2022，65，9： | 1 |
| 14 | Work, home, and mar-ket: the social transformation of housing space in Guangzhou, China显示文摘 | Li Siming Hou Quan Chen Susu | 2010 | Urban Geography2010，31，4： | 1 |
| 15 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 16 | A loss-of-function mutant allele of a glycosyl hydrolase gene has been co-opted for seed weight control during soybean domestication显示文摘The resultant DNA from loss-of-function mutation can be recruited in biological evolution and development.Here,we present such a rare and potential case of“to gain by loss”as a neomorphic mutation during soybean domestication for increasing seed weight.Using a population derived from a chromosome segment substitution line of Glycine max(SN14)and Glycine soja(ZYD06),a quantitative trait locus(QTL)of 100-seed weight(q HSW)was mapped on chromosome 11,corresponding to a truncatedβ-1,3-glucosidase(βGlu)gene.The novel gene hsw results from a 14-bp deletion,causing a frameshift mutation and a premature stop codon in theβGlu.In contrast to HSW,the hsw completely lostβGlu activity and function but acquired a novel function to promote cell expansion,thus increasing seed weight.Overexpressing hsw instead of HSW produced large soybean seeds,and surprisingly,truncating hsw via gene editing further increased the seed size.We further found that the core 21-aa peptide of hsw and its variants acted as a promoter of seed size.Transcriptomic variation in these transgenic soybean lines substantiated the integration hsw into cell and seed size control.Moreover,the hsw allele underwent selection and expansion during soybean domestication and improvement.Our work cloned a likely domesticated QTL controlling soybean seed weight,revealed a novel genetic variation and mechanism in soybean domestication,and provided new insight into crop domestication and breeding,and plant evolution. | Siming Wei Bin Yong Hongwei Jiang Zhenghong An Yan Wang Bingbing Li Ce Yang Weiwei Zhu Qingshan Chen Chaoying He | 2023 | Journal of Integrative Plant Biology2023，65，11： | 1 |
| 17 | Recent progress in epitaxial growth of Ⅲ–Ⅴ quantum-dot lasers on silicon substrate显示文摘In the past few decades,numerous high-performance silicon(Si)photonic devices have been demonstrated.Si,as a photonic platform,has received renewed interest in recent years.Efficient Si-basedⅢ–Ⅴquantum-dot(QDs)lasers have long been a goal for semiconductor scientists because of the incomparable optical properties of Ⅲ–Ⅴcompounds.Although the material dissimilarity betweenⅢ–Ⅴmaterial and Si hindered the development of monolithic integrations for over 30 years,considerable breakthroughs happened in the 2000s.In this paper,we review recent progress in the epitaxial growth of various Ⅲ–ⅤQD lasers on both offcut Si substrate and on-axis Si(001)substrate.In addition,the fundamental challenges in monolithic growth will be explained together with the superior characteristics of QDs. | Shujie Pan Victoria Cao Mengya Liao Ying Lu Zizhuo Liu Mingchu Tang Siming Chen Alwyn Seeds Huiyun Liu | 2019 | Journal of Semiconductors2019，40，10： | 1 |
| 18 | Incorporation ofκ-carrageenan improves the practical features of agar/konjac glucomannan/κ-carrageenan ternary system显示文摘Three materials(agar,konjac glucomannan(KGM)andκ-carrageenan)were used to prepare ternary systems,i.e.,sol-gels and their dried composites conditioned at varied relative humidity(RH)(33%,54%and 75%).Combined methods,e.g.,scanning electron microscopy,small-angle X-ray scattering,infrared spectroscopy(IR)and X-ray diffraction(XRD),were used to disclose howκ-carrageenan addition tailors the features of agar/KGM/κ-carrageenan ternary system.As affirmed by IR and XRD,the ternary systems withκ-carrageenan below 25%(agar/KGM/carrageenan,50:25:25,m/m)displayed proper component interactions,which increased the sol-gel transition temperature and the hardness of obtained gels.For instance,the ternary composites could show hardness about 3 to 4 times higher than that for binary counterpart.These gels were dehydrated to acquire ternary composites.Compared to agar/KGM composite,the ternary composites showed fewer crystallites and nanoscale orders,and newly-formed nanoscale structures from chain assembly.Such multi-scale structures,for composites withκ-carrageenan below 25%,showed weaker changes with RH,as revealed by especially morphologic and crystalline features.Consequently,the ternary composites with lessκ-carrageenan(below 25%)exhibited stabilized elongation at break and hydrophilicity at different RHs.This hints to us that agar/KGM/κ-carrageenan composite systems can display series applications with improved features,e.g.,increased sol-gel transition point. | Dongling Qiao Hao Li Fatang Jiang Siming Zhao Sheng Chen Binjia Zhang | 2023 | Food Science and Human Wellness2023，12，2： | 1 |
| 19 | Evaluating the Rate of Aggregative Risk in Software Development Using Fuzzy Set Theory显示文摘 | | 1999 | Cybernetics and Systems1999，30，1： | 1 |
| 20 | Mechanism of removing ferrum impurity in lanthanum refined byelectron beam melting显示文摘Removal feasibility of Fe impurity form La metal by electron beam melting(EBM) was analyzed,the removal mechanism was discussed,and the verification experiments were carried out in this study.The research results indicate that,the evaporation coefficient of Fe in La metal is 35-175 at 1800-3000 K,and Fe impurity can be removed by EBM;the removal efficiency of Fe impurity is improved with the increasing EBM power,the Fe concentration is significantly decreased from 1482 to 0.1 μg/g under 50 kW and 2400 s;the reaction of Fe removal by EBM follows the first-order rate law,and Fe impurity is removed by evaporation as a single atom;transport from the La melt to the liquid boundary layer of the Fe atom is rate-controlling step in the EBM when the EBM power is 30-50 kW. | Siming Pang Wenli Lu Zhenfei Yang Xiaowei Zhang Dehong Chen Daogao Wu Lin Zhou Ruiying Miao | 2021 | Journal of Rare Earths2021，39，7： | 1 |
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