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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Proprmlolol Ibr severe infantile he- nmngiomas : Follow - up retport 显示文摘 | Sims V de la Roque ED Berge J | 2009 | Pediturics2009，124，3： | 1 |
| 3 | Effect of sample pretreatment on extractable soil potassium显示文摘 | Haby V A Sims J R Skogley E O | 1988 | Communications in Soil Science and Plant Analysis1988，19，： | 1 |
| 4 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 5 | A pre-clinical assessment of an atlas-based automatic segmentation tool for the head and neck 显示文摘 | Sims R Isambert A Gregoire V | 2009 | Radiother Oueol2009，93，3： | 1 |
| 6 | The role of direct high-resolution mass spectrometry in foodomics显示文摘 | IBá?EZ C SIMó C GARCíA-CA?AS V | 2015 | Analytical and Bioanalytical Chemistry2015，407，21： | 1 |
| 7 | Traumatic distal pancreatic transection: beware of the horses 显示文摘 | Jacko S Sim V Cernero A | 2012 | J Trauma Nurs2012，19，2： | 1 |
| 8 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 9 | Carboxypeptidase U(TAFIa) prevents lysis from proceeding into the propagation phase through a threshold-dependent mechanism显示文摘 | Leurs J Nerme V Sim Y | 2004 | J Thromb Haemost2004，2，3： | 1 |
| 10 | Carboxypeptidase U (TAFIa) prevents lysis from proceeding into the propaga-tion phase through a threshold-dependent mechanism显示文摘 | Leurs J Nerme V Sim Y | 2004 | J Thromb Haemost2004，2，： | 1 |
| 11 | Piezoelec sensors and actuators for milling tool stability lobes 显示文摘 | Sims N D Bayly P V Young K A | 2005 | Journal of Sound and Vibration2005，281，9： | 1 |
| 12 | Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees显示文摘 | Gro V Amdam Zilá L.P Sim?es Arne Hagen Kari Norberg Knut Schr?der ?yvind Mikkelsen Thomas B.L Kirkwood Stig W Omholt | 2004 | Experimental Gerontology2004，，5： | 1 |
| 13 | Long-lasting inhibition of presynaptic metabolism and neurotransmitter release by protein S-nitrosylation显示文摘 | Rudkouskaya A Sim V Shah AA | 2010 | Free Radic Biol Med2010，49，： | 1 |
| 14 | A combined genetic algorithms-shooting method approach to solving optimal control problems 显示文摘 | SIM Y C LENG S B SUBRAMANIAN V | 2000 | Int J of Systems Science2000，31，1： | 1 |
| 15 | In vitro prefabrication of human cartilage shapes using fibrin glue and human chondrocytes显示文摘 | Ting V Sims CD Brecht LE | 1998 | Ann Plast Surg1998，40，41： | 1 |
| 16 | Psychosocial predictors of quality of life in a sample of community-dwelling stroke survivors:a longitudinal study显示文摘 | Teoh V Sims J Milgrom J | 2009 | Top Stroke Rehabil2009，16，2： | 1 |
| 17 | Prospective survey of ( 1, 3 )-β-D-gluean and its relationship to invasive eandidiasis in the surgical intensive care unit setting 显示文摘 | Mohr J F Sims C Paetzniek V | 2011 | J C lin Mierobiol2011，40，1： | 1 |
| 18 | Psychosocial predictors of quality of life in a simple of community-dwelling stroke survivors:a longitudinal study显示文摘 | Teoh V Sims J Milgrom J | | 0，，： | 1 |
| 19 | Automated organization design for multi-agent显示文摘 | Sims M Corkill D Lesser V | 2008 | Autonomous Agents and Muhi-Agent System2008，16，2： | 1 |
| 20 | Prospective survey of(1,3)-beta-D-glucan and its relationship to invasive candidiasis in the surgical intensive care unit setting显示文摘 | Mohr JF Sims C Paetznick V | | 0，，01： | 1 |
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