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| 1 | Nature:死亡的肿瘤细胞释放出胞内钾离子来阻断免疫系统显示文摘在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。相关研究结果在线发表在Nature期刊上。 | Robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, Jenny H. Pan, Douglas C. Palmer, Alena Gros, Tori N. Yamamoto, Shashank J. Patel, Geoffrey C. Guittard, Zhiya Yu, David S. Schrump, W. Marston Linehan, Nicholas P. Restifo Christopher A. Klebanoff Valentina Carbonaro, Klaus Okkenhaug, Rahul Roychoudhuri | 2016 | 现代生物医学进展2016，16，31： | 12 |
| 2 | Colitis-associated colon cancer:Is it in your genes?显示文摘Colitis-associated colorectal cancer(CA-CRC) is the cause of death in 10%-15% of inflammatory bowel disease(IBD) patients. CA-CRC results from the accumulation of mutations in intestinal epithelial cells and progresses through a well-characterized inflammation to dysplasia to carcinoma sequence. Quantitative estimates of overall CA-CRC risks are highly variable ranging from 2% to 40% depending on IBD severity, duration and location, with IBD duration being the most significant risk factor associated with CA-CRC development. Recently, studies have identified IBD patients with similar patterns of colonic inflammation, but that differ with respect to CA-CRC development, suggesting a role for additional non-inflammatory risk factors in CA-CRC development. One suggestion is that select IBD patients carry polymorphisms in various low penetrance disease susceptibility genes, which predispose them to CA-CRC development, although these loci have proven difficult to identify in human genomewide association studies. Mouse models of CA-CRC have provided a viable alternative for the discovery, validation and study of individual genes in CA-CRC pathology. In this review, we summarize the current CA-CRC literature with a strong focus on genetic predisposition and highlight an emerging role for mouse models in the search for CA-CRC risk alleles. | Lauren Van Der Kraak Philippe Gros Nicole Beauchemin | 2015 | World Journal of Gastroenterology2015，21，41： | 5 |
| 3 | CALCULATION OF 3-D TRANSIENT TEMPERATURE FIELD DURING LASER TRANSFORMATION HARDENING PROCESS显示文摘A three-dimensional transient heat transfer model for laser transformation hardening process has been developed in this paper. The finite size of the laser treated sample, the surface heat loss of the sample, the latent heat of phase transformation and the temperature dependence of thermal properties of materials were considered. The heat source was considered as a moving Gaussian heat flux with a constant velocity. Three-dimension unequally spatial grid explicit finite difference equations, alternating direction implicit finite difference equations and implicit finite difference equations were deduced respectively. Three programs to calculate the temperature field were developed using Fortran language. The transient temperature fields of C22, 42CrMo, C60 steel samples during laser transformation hardening process were calculated using these programs, and the widths and depths of laser transformation hardening zones were also predicted. C22, 42CrMo, C60 steel samples were treated by CO2 laser,the widths and depths of laser transformation hardening zones of these samples were also measured experimentally. The calculated widths and depths of laser transformation hardening zones are in good agreement with the experimental results. | L. W Zhang, R.S. Wang, J. Th.M.De Hosson, Y.L. Xia and F. G. Wang 1) The State Key Lab. for Materials Modification by Laser, Ion and Electron Beams, Dalian University of Technology, Dalian 116023, China 2) Department of Applied Physics, University of Gro | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 4 |
| 4 | Post-cholecystectomy symptoms were caused by persistence of a functional gastrointestinal disorder显示文摘AIM:To classify gallstone disease as a basis for assessment of post-cholecystectomy symptoms.METHODS:One hundred and fifty three patients with a clinical and ultrasonographic diagnosis of gallstones filled out a structured questionnaire on abdominal pain symptoms and functional gastrointestinal disorder (FGID) before and at six months after cholecystectomy.Symptom frequency groups (SFG) were categorized according to frequency of pain attacks.According to certain pain characteristics in gallstone patients,a gallstone symptom score was accorded on a scale from one to ten.A visual analogue scale was used to quantify pain.Operative specimens were examined for size and magnitude of stone contents as well as presence of bacteria.Follow-up took place after six months with either a consultation or via a mailed questionnaire.Results were compared with those obtained pre-operatively to describe and analyze symptomatic outcome.RESULTS:SFG groups were categorized as severe (24.2%),moderate (38.6%) and mild (22.2%) attack frequency,and a chronic pain condition (15%).Pain was cured or improved in about 90% of patients and two-thirds of patients obtained complete symptom relief.Patients with the most frequent pain episodes were less likely to obtain symptom relief.FGID was present in 88% of patients pre-operatively and in 57% postoperatively (P=0.244).Those that became asymptomatic or improved with regard to pain also had most relief from FGID (P=0.001).No pre-operative FGID meant almost complete cure.CONCLUSION:Only one third of patients with FGID experienced postoperative relief,indicating that FGID was a dominant cause of post-cholecystectomy symptoms. | Malte Schmidt Karl Sφndenaa John A Dumot Steven Rosenblatt Trygve Hausken Maria Ramnefjell Gro Njφlstad Geir Egil Eide | 2012 | World Journal of Gastroenterology2012，18，12： | 4 |
| 5 | Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases显示文摘 | Jeremy Dupaul-Chicoine Garabet Yeretssian Karine Doiron Kirk S.B. Bergstrom Christian R. McIntire Philippe M. LeBlanc Charles Meunier Claire Turbide Philippe Gros Nicole Beauchemin Bruce A. Vallance Maya Saleh | 2010 | Immunity2010，，3： | 2 |
| 6 | A note on equality of MINQUE and simple estimator in the general Gauss-Markov model显示文摘 | Groβ J | 1997 | Statistics Probability letters1997，35，： | 2 |
| 7 | Development of an asthma vaccine:research into BCG显示文摘 | Scanga CB Le Gros G | | 0，，： | 2 |
| 8 | 新型HK750PT推管机用于阿姆河的穿越工程显示文摘本文详细介绍了采用水平定向钻进和直推铺管联合施工法穿越阿姆河铺设56”天然气管道的工程情况,包括工程的地质情况、施工过程和造斜施工等。 | J. Himmerich A. Groβmann M. Lubberger J. Eising 程国亮(译) | 2011 | 非开挖技术2011，，1： | 2 |
| 9 | In Vivo Function of Tic22, a Protein Import Component of the Intermembrane Space of Chloroplasts显示文摘进叶绿体的 Preprotein 进口在外部、内部的叶绿体信封膜(TOC 和 TIC ) 取决于 macromolecular 机械。两机械被 intermembrane 空间(IMS ) 的部件互连,这被建议。也就是说在其它之中, Tic22,二仔细联系了 isoforms 在 Arabidopsis thaliana 存在,也就是 atTic22-III 和 atTic22-IV。我们由分析相应基因的 T-DNA 插入线在 vivo 调查了 Tic22 的功能。当在单个基因的 T-DNA 插入引起了仅仅细微的缺点时,两 isoforms 的双异种在植物的光合的表演显示出延迟的生长,在热点条件下面的苍白的显型,减少的进口率,和减小。后者被变化在变异的植物的代谢物内容支持什么时候与相比野类型。因此,我们的结果支持 Tic22 直接涉及叶绿体 preprotein 进口并且可能在叶绿体生物的续生说指向到 Tic22 的特别重要性高进口率的时间的观点。 | Mareike Rudolf Anu B. Machettira Lucia E. Groβ Katrin L. Weber Kathrin Bolte Tihana Bionda Maik S. Sommer Uwe G. Maier Andreas RM. Weber Enrico Schleiff Joanna Tripp | 2013 | Molecular Plant2013，6，3： | 2 |
| 10 | The oral commensal Streptococcus mitis activates the aryl hydrocarbon receptor in human oral epithelial cells显示文摘Streptococcus mitis(S. mitis) is a pioneer commensal bacterial species colonizing many of the surfaces of the oral cavity in healthy individuals. Yet, not much information is available regarding its interaction with the host. We used examination of its transcriptional regulation in oral keratinocytes to elucidate some of its potential roles in the oral cavity. Transcription factor analysis of oral keratinocytes predicted S. mitis-mediated activation of aryl hydrocarbon receptor(Ah R). Activation and functionality of Ah R was confirmed through nuclear translocation determined by immunofluorescence microscopy and real-time polymerase chain reaction with reverse transcription analysis of CYP1A1, the hallmark gene for Ah R activation. Addition of Streptococcus mutans or Streptococcus gordonii did not induce CYP1A1 transcription in the keratinocyte cultures. Introduction of an Ah R-specific inhibitor revealed that S. mitis-mediated transcription of CXCL2 and CXCL8 was regulated by Ah R. Elevated levels of prostaglandin E2(enzyme-linked immunosorbent assay) in supernatants from S. mitis-treated oral epithelial cells were also attenuated by inhibition of Ah R activity. The observed Ah R-regulated activities point to a contribution of S. mitis in the regulation of inflammatory responses and thereby to wound healing in the oral cavity. The concept that the oral commensal microbiota can induce Ah R activation is important, also in view of the role that Ah R has in modulation of T-cell differentiation and as an anti-inflammatory factor in macrophages. | stian a engen gro h rørvik olav schreurs inger js blix karl schenck | 2017 | International Journal of Oral Science2017，9，3： | 2 |
| 11 | Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase显示文摘 | Thomas Gro?e-Steffen Thomas Giese Nathalia Giese Thomas Longerich Peter Schirmacher G. Maria H?nsch Matthias M. Gaida G. Opdenakker | 2012 | Clinical and Developmental Immunology2012，，： | 2 |
| 12 | Phosphatidylcholine translocase: a physiological role for the mdr2 gene 显示文摘 | Ruetz S Gros P | 1994 | Cell1994，77，7： | 1 |
| 13 | NDT Data Fusion at Pixel Level 显示文摘 | Gros X E Bousigue J | 1999 | NDT and E International1999，32，5： | 1 |
| 14 | Interleukin-15 enhances innate and adaptive immune reponses to bloodstage malaria infection in mice显示文摘 | Ing R Gros P Stevenson M M | 2005 | Infect Immun2005，73，5： | 1 |
| 15 | Foaming Process Analysis for a Stirred Column with a Narrow Annular Region显示文摘 | G Djelveh J B Gros J F Cornet | 1998 | Chemical Engineering Science1998，53，17： | 1 |
| 16 | Regulation production of mature insulin by non-β-cells显示文摘 | Gros L Montoliu L Riu E Lebrigand L Bosch F | | 0，，： | 1 |
| 17 | Specifying the role of BAK1-interacting receptor-like kinase 3 in brassinosteroid signaling显示文摘Brassinosteroids(BR) are involved in the control of several developmental processes ranging from root elongation to senescence and adaptation to environmental cues. Thus, BR perception and signaling have to be precisely regulated. One regulator is BRI1-associated kinase 1(BAK1)-interacting receptor-like kinase 3(BIR3). In the absence of BR, BIR3 forms complexes with BR insensitive 1(BRI1) and BAK1.However, the biophysical and energetic requirements for complex formation in the absence of the ligand have yet to be determined. Using computational modeling, we simulated the potential complexes between the cytoplasmic domains of BAK1, BRI1 and BIR3. Our calculations and experimental data confirm the interaction of BIR3 Rewith BAK1 and BRI1, with the BAK1 BIR3 interaction clearly favored. Furthermore, we demonstrate that BIR3 and BRI1 share the same interaction site with BAK1. This suggests a competition between BIR3 and BRI1 for binding to BAK1, which results in preferential binding of BIR3 to BAK1 in the absence of the ligand thereby preventing the active participation of BAK1 in BR signaling. Our model also suggests that BAK1 and BRI1 can interact even while BAK1 is in complex with BIR3 at an additional binding site of BAK1 that does not allow active BR signaling. | Ruth Groβeholz Anna Feldman-Salit Friederike Wanke Sarina Schulze Nina Glockner Birgit Kemmerling Klaus Harter Ursula Kummer | 2020 | Journal of Integrative Plant Biology2020，62，4： | 1 |
| 18 | Plasma membrane calcium ATPase overexpression in arterial smooth muscle increases vasomotor responsiveness and blood pressure显示文摘 | Gros R Afroze T You X M | 2003 | Circ Res2003，93，7： | 1 |
| 19 | Endotoxin tolerant mice have mutation in Toll-like receptor 4(Tlr4) 显示文摘 | Qureshi ST Leveque G Clermont S Clermont S Moore KJ Gros P | 1999 | J Exp Med1999，189，4： | 1 |
| 20 | Analysis of platinum group elements and gold in geological materials using NiS fire assay and Te coprecipitation,the NiS dissolution step revisited显示文摘 | GROS M LORAND J P LUGUET A | 2002 | Chem Geol2002，185，34： | 1 |
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