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您的检索式：作者名="Robert Fitridge"
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| 1 | 国际糖尿病足工作组:糖尿病足溃疡周围动脉病变诊断、预后与管理指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘1999年以来,国际糖尿病足工作组(IWGDF)已经多次发表循证医学基础上的糖尿病足预防与管理指南。该指南是有关糖尿病足溃疡合并周围动脉病变(PAD)患者的诊断、预后和管理指南,更新了以前IWGDF指南的内容。高达50%的糖尿病足溃疡患者同时患有PAD,这种病变使得患者截肢和心血管病变的风险明显增加。这类患者的诊断、预后和治疗明显地不同于那些没有PAD的糖尿病患者,但仅有很少的关于这类患者的高质量的研究强调了这点。我们遵循GRADE方法来提出临床问题并以至少包括患者-干预-比较-结局(PICO)形式说明重要结局,进行了系统的医学科学文献评价,写出推荐意见及其合理性。这类推荐是建立在系统文献评价的循证医学基础上的,没有证据时则在权衡利弊和患者选择、便宜性和干预的费用等因素后,采用专家的观点。这里我们发布更新的2019年糖尿病足溃疡合并PAD患者的有关PAD诊断、预后和管理的指南,以及一些需要未来特别关注的研究课题。 | Robert J.Hinchliffe Rachael O.Forsythe Jan Apelqvist Ed J.Boyko Robert Fitridge Joon Pio Hong Konstantinos Katsanos Joseph L.Mills Sigrid Nikol Jim Reekers Maarit Venermo R.Eugene Zierler Nicolaas C.Schaper 无 许樟荣(译) 冉兴无(审校) | 2019 | 感染.炎症.修复2019，20，4： | 10 |
| 2 | Plasma-polymerized pericyte patches improve healing of murine wounds through increased angiogenesis and reduced inflammation显示文摘Pericytes have the potential to be developed as a cell therapy for the treatment of wounds;however,the efficacy of any cell therapy relies on the successful delivery of intact and functioning cells.Here,the effect of delivering pericytes on wound repair was assessed alongside the development of a surface-functionalized pericyte patch.Plasma polymerization(PP)was used to functionalize the surface of silicone patches with heptylamine(HA)or acrylic acid(AA)monomers.Human pericytes were subsequently delivered to murine excisional wounds by intradermal injection or using the pericyte-laden patches and the comparative effects on wound healing,inflammation and revascularization determined.The AA surface provided the superior transfer of the cells to de-epidermized dermis.Excisional murine wounds treated either with pericytes injected directly into the wound or with the pericyte-laden AA patches showed improved healing with decreased neutrophil infiltration and reduced numbers of macrophages in the wounds.Pericyte delivery also enhanced angiogenesis through a mechanism independent of VEGF signalling.Pericytes,when delivered to wounds,improved healing responses by dampening inflammation and promoting angiogenesis.Delivery of pericytes using PP-AA-functionalized patches was equally as effective as direct injection of pericytes into wounds.Pericyte-functionalized dressings may therefore be a clinically relevant approach for the treatment of wounds. | Hannah M.Thomas Parinaz Ahangar Robert Fitridge Giles T.S.Kirby Stuart J.Mills Allison J.Cowin | 2021 | Regenerative Biomaterials2021，8，4： | 1 |
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