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| 1 | Optimization and Simulation of Plastic Injection Process using Genetic Algorithm and Moldflow显示文摘The use of plastic-based products is continuously increasing. The increasing demands for thinner products, lower production costs, yet higher product quality has triggered an increase in the number of research projects on plastic molding processes. An important branch of such research is focused on mold cooling system. Conventional cooling systems are most widely used because they are easy to make by using conventional machining processes.However, the non-uniform cooling processes are considered as one of their weaknesses. Apart from the conventional systems, there are also conformal cooling systems that are designed for faster and more uniform plastic mold cooling. In this study, the conformal cooling system is applied for the production of bowl-shaped product made of PP AZ564. Optimization is conducted to initiate machine setup parameters, namely, the melting temperature, injection pressure, holding pressure and holding time. The genetic algorithm method and Moldflow were used to optimize the injection process parameters at a minimum cycle time. It is found that, an optimum injection molding processes could be obtained by setting the parameters to the following values: T_M= 180 °C; P_(inj)= 20 MPa;P_(hold)= 16 MPa and t_(hold)= 8 s, with a cycle time of 14.11 s. Experiments using the conformal cooling system yielded an average cycle time of 14.19 s. The studied conformal cooling system yielded a volumetric shrinkage of 5.61% and the wall shear stress was found at 0.17 MPa.The difference between the cycle time obtained through simulations and experiments using the conformal cooling system was insignificant(below 1%). Thus, combining process parameters optimization and simulations by using genetic algorithm method with Moldflow can be considered as valid. | Sigit Yoewono Martowibowo Agung Kaswadi | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 13 |
| 2 | How far is Lignin from being a biomedical material?显示文摘Lignin is a versatile biomass that possesses many different desirable properties such as antioxidant,antibacterial,anti-UV,and good biocompatibility.Natural lignin can be processed through several chemical processes.The processed lignin can be modified into functionalized lignin through chemical modifications to develop and enhance biomaterials.Thus,lignin is one of the prime candidate for various biomaterial applications such as drug and gene delivery,biosensors,bioimaging,3D printing,tissue engineering,and dietary supplement additive.This review presents the potential of developing and utilizing lignin in the outlook of new and sustainable biomaterials.Thereafter,we also discuss on the challenges and outlook of utilizing lignin as a biomaterial. | Sigit Sugiarto Yihao Leow Chong Li Tan Guan Wang Dan Kai | 2022 | Bioactive Materials2022，7，2： | 9 |
| 3 | Hepatitis B virus subgenotypes and basal core promoter mutations in Indonesia显示文摘AIM:To identify the distribution of hepatitis B virus (HBV) subgenotype and basal core promoter (BCP) mutations among patients with HBV-associated liver disease in Indonesia.METHODS: Patients with chronic hepatitis (CH, n=61), liver cirrhosis (LC, n=62), and hepatocellular carcinoma (HCC,n=48) were included in this study. HBV subgenotype was identified based on S or preS gene sequence, and mutations in the HBx gene including the overlapping BCP region were examined by direct sequencing.RESULTS: HBV genotype B (subgenotypes B2, B3, B4, B5 and B7) the major genotype in the samples, accounted for 75.4%, 71.0% and 75.0% of CH, LC and HCC patients, respectively, while the genotype C (subgenotypes C1, C2 and C3) was detected in 24.6%, 29.0%, and 25.0% of CH, LC, and HCC patients, respectively. Subgenotypes B3 (84.9%) and C1 (82.2%) were the main subgenotype in HBV genotype B and C, respectively. Serotype adw2 (84.9%) and adrq+ (89.4%) were the most prevalent in HBV genotype B and C, respectively. Double mutation (A1762T/G1764A) in the BCP was significantly higher in LC (59.7%) and HCC (54.2%) than in CH (19.7%), suggesting that this mutation was associated with severity of liver disease. The T1753V was also higher in LC (46.8%), but lower in HCC (22.9%) and CH (18.0%), suggesting that this mutation may be an indicator of cirrhosis.CONCLUSION: HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia. Mutations in BCP, such as A1762T/G1764A and T1753V, might have an association with manifestations of liver disease. | Andi Utama Sigit Purwantomo Marlinang Diarta Siburian Rama Dhenni Rino Alvani Gani Irsan Hasan Andri Sanityoso Upik Anderiani Miskad Fardah Akil Irawan Yusuf Wenny Astuti Achwan Soewignjo Soemohardjo Syafruddin AR Lelosutan Ruswhandi Martamala Benyamin Lukito Unggul Budihusodo Laurentius Adrianus Lesmana Ali Sulaiman Susan Tai | 2009 | World Journal of Gastroenterology2009，15，32： | 4 |
| 4 | Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients显示文摘AIM:To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients.METHODS:Sixty-four patients with chronic hepatitis,65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this study.HBeAg and hepatitis B e antibody (HBeAb) tests were performed using enzyme-linked immunosorbent assay and the mutations were analyzed by sequencing.Viral load was measured by real-time polymerase chain reaction.RESULTS:Of 179 patients,108 (60.3%) were HBeAg(-) and 86 (79.6%) of these HBeAg(-) patients had been seroconverted.The A1896 mutation was not found in HBeAg(+) patients,however,this mutation was detected in 70.7% of HBeAg(-) patients.This mutation was frequently found when HBeAg was not expressed (87.7%),compared to that found in HBeAg seroconverted patients (65.1%).The A1899 mutation was also more prevalent in HBeAg(-) than in HBeAg(+) patients (P=0.004).The T1762/A1764 mutation was frequently found in both HBeAg(+) and HBeAg(-) patients,however,the prevalence of this mutation did not significantly differ among the two groups (P=0.054).In HBeAg(+) patients,the T1762/A1764 mutation was correlated with lower HBV DNA (P < 0.001).The A1899 mutation did not correlate with HBV DNA (P=0.609).In HBeAg(-) patients,the T1762/A1764 mutation alone was not correlated with HBV DNA (P=0.095),however,the presence of either the T1762/A1764 or A1896 mutations was associated with increased HBV DNA (P < 0.001).CONCLUSION:The percentage of HBeAg(-) patients is high in Indonesia,and most of the HBeAg(-) patients had been seroconverted.The A1896 mutation was most likely the major cause of HBeAg loss.The T1762/A1764 mutation alone was associated with lower viral loads in HBeAg(+) patients,but not in HBeAg(-) patients. | Andi Utama Marlinang Diarta Siburian Sigit Purwantomo Mariana Destila Bayu Intan Tri Shinta Kurniasih Susan Tai Rino Alvani Gani Laurentius Adrianus Lesmana All Sulaiman Wenny Astuti Achwan Soewignjo Soemohardjo Arnelis Nasrul Zubir Julius Syafruddin AR Lelosutan Benyamin Lukito Tantoro Harmono | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 5 | Comparison of Microbubble and Air Layer Injection with Porous Media for Drag Reduction on a Self-propelled Barge Ship Model显示文摘Ship resistance issues are related to fuel economy,speed,and cost efficiency.Air lubrication is a promising technique for lowering hull frictional resistance as it is supposed to modify the energy in the turbulent boundary layer and thereby reduce hull friction.In this paper,the objective is to identify the optimum type of air lubrication using microbubble drag reduction(MBDR)and air layer drag reduction(ALDR)techniques to reduce the resistance of a 56-m Indonesian self-propelled barge(SPB).A model with the following dimensions was constructed:length L=2000 mm,breadth B=521.60 mm,and draft T=52.50 mm.The ship model was towed using standard towing tank experimental parameters.The speed was varied over the Froude number range 0.11–0.31.The air layer flow rate was varied at 80,85,and 90 standard liters per minute(SLPM)and the microbubble injection coefficient over the range 0.20–0.60.The results show that the ship model using the air layer had the highest drag reduction up to a maximum of 90%.Based on the characteristics of the SPB,which operates at low speed,the optimum air lubrication type to reduce resistance in this instance is ALDR. | Yanuar Kurniawan T.Waskito Sigit Y.Pratama Bagus D.Candra Bilmantasya A.Rahmat | 2018 | Journal of Marine Science and Application2018，17，2： | 3 |
| 6 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 7 | Spatial time-dependent reliability analysis of corroding pretensioned prestressed concrete bridge girders显示文摘 | M. Sigit Darmawan Mark G. Stewart | 2006 | Structural Safety2006，，1： | 2 |
| 8 | Fractal geometry of the Sumatra active fault system and its geodynamical implications显示文摘 | Sigit Sukmono Zen M T Kadir W G A | 1996 | Geodynamics1996，22，： | 1 |
| 9 | Fractal pattern of the Sumatra fault seismicity and its possible application to earthquake prediction显示文摘 | SIGIT SUKMONO ZEN M T HENDRAJAYA L | 1997 | Bull Seism Soc Am1997，87，6： | 1 |
| 10 | High-dose Simvastatin(80 mg/day) decreases plasma concentrations of total homoysteine in patients with ypercholesterolemia显示文摘 | Luftjohann D Sigit IJ Locatelli S | 2001 | Atherosclerosis2001，155，： | 1 |
| 11 | The influence of Buton asphalt additive on skid resistance based on penetration index and tem- perature 显示文摘 | Sigit Pranowo Hadiwardoyo Eky Supriadi Sinaga Husnul Fikri | 2013 | Construction and Building Materials2013，，42： | 1 |
| 12 | Effect of an ultralight metal filler on the bending collapse behavior of thin-walled prismatic columns 显示文摘 | Sigit Santosa Tomasz Wierzbicki | 1999 | International Journal of Mechanical Sciences1999，，41： | 1 |
| 13 | The influence of buton asphalt additive on skid resistance based on penetration index and temperature显示文摘 | Sigit Pranowo Hadiwardoyo | 2013 | Construction and Building Materials2013，42，： | 1 |
| 14 | Bending crushing resistance of partially foam-filled sections显示文摘 | Sigit Santosa John Banhart Tomasz Wierzbicki | 2000 | Advanced Engineering Materials2000，2，： | 1 |
| 15 | 4-D seismic that works: A successful large scale application, Duri Steamflood, Sumatra, Indonesia显示文摘 | Sigit R Morse P J Kimbe K D | 1999 | Expanded Abstracts of 69^th Annual Internat SEG Mtg1999，，： | 1 |
| 16 | Experimental and numerical studies offoam-filled sections显示文摘 | Sigit P Santosa Tomasz Wierzbicki Arve GHanssen | 2000 | International Journal ofImpact Engineering2000，24，5： | 1 |
| 17 | High-dose simvastatin (80 mg/day) decreases plasma concentrations oftotal homocysteine in patients with hypercholesterolemia 显示文摘 | LUFTJOHANN D SIGIT I J LOCATELLI S | 2001 | Atherosclerosis2001，155，1： | 1 |
| 18 | Process Parameters Optimization for Area-forming Rapid Prototyping System 显示文摘 | Shih-Hsuan Chiu Kun-Ting Chen Sigit Tri Wicaksono | 2015 | Rapid Prototyping Journal2015，21，1： | 1 |
| 19 | Fractal Geometry of the Sumatra Active fault System and Its Geodynamical Implications显示文摘 | Sigit Sukmono Zen M T Kadir W G A | 1996 | Geodynamics1996，22，1： | 1 |
| 20 | High-dose simvastatin (80 mg/day) decreases plasma concentrations of total homocyst(e)ine in patients with hypercholesterolemia显示文摘 | Dieter Lüftjohann Joseph I Sigit Sandra Locatelli Klaus von Bergmann | 2001 | Atherosclerosis2001，，1： | 1 |
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