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| 1 | An important role of the hepcidin-ferroportin signaling in affecting tumor growth and metastasis显示文摘 | Wenli Guo Shuping Zhang Yue Chen Daoqiang Zhang Lin Yuan Haibo Cong Sijin Liu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 14 |
| 2 | Atomic force microscopic observation on substructure of pollen exine in Cedrus deodara and Metasequoia glyptostroboides显示文摘The substructure of pollen exine in Cedrus deodara (Roxb.) Loud, and Metasequoia glyptostroboides Hu et Cheng has been examined with an atomic force microscope (AFM). The results indicate that the exine substructure units containing sporopollenin in two species are similar in shape, which are granular, but slightly different in size. In Cedrus the substructure unit of pollen exine appears to be 56-99 nm long and 42-74 nm wide, while in Metasequoia it appears to be 81-118 nm long and 43-98 nm wide. It has been observed that the subunits of pollen exine in Cedrus arranged tightly to form short-rod-like or spheroidal pollen exine units, several or more than ten of which formed an island-like structure. There are various spaces among these island-like structures which are interconnected to occupy the entire pollen exine. In Metasequoia, the subunits of pollen exine also arranged tightly with a distribution tendency of cluster of 3-10, however, no obvious boundary exists among these clusters. From our | XING Shuping LI Bingshi WANG Chen HU Yuxi LIN Jinxing | 2000 | Chinese Science Bulletin2000，45，16： | 5 |
| 3 | Multiple fields manipulation on nitride material structures in ultraviolet light-emitting diodes显示文摘As demonstrated during the COVID-19 pandemic,advanced deep ultraviolet(DUV)light sources(200–280 nm),such as AlGaN-based light-emitting diodes(LEDs)show excellence in preventing virus transmission,which further reveals their wide applications from biological,environmental,industrial to medical.However,the relatively low external quantum efficiencies(mostly lower than 10%)strongly restrict their wider or even potential applications,which have been known related to the intrinsic properties of high Al-content AlGaN semiconductor materials and especially their quantum structures.Here,we review recent progress in the development of novel concepts and techniques in AlGaNbased LEDs and summarize the multiple physical fields as a toolkit for effectively controlling and tailoring the crucial properties of nitride quantum structures.In addition,we describe the key challenges for further increasing the efficiency of DUV LEDs and provide an outlook for future developments. | Jinchai Li Na Gao Duanjun Cai Wei Lin Kai Huang Shuping Li Junyong Kang | 2021 | Light(Science & Applications)2021，10，7： | 4 |
| 4 | Mild metal-organic-gel route for synthesis of stable sub-5-nm metal-organic framework nanocrystals显示文摘 | Yue Qi Chun-Ting He Juntao Lin Shuping Lin Jin Liu Jinghong Huang Wei Xue Guicheng Yu Hsiu-Yi Chao Yexiang Tong Zhengping Qiao | 2017 | Nano Research2017，10，11： | 3 |
| 5 | Resorcinol-formaldehyde resin-based porous carbon spheres with high CO_2 capture capacities显示文摘Porous carbon spheres are prepared by direct carbonization of potassium salt of resorcinol-formaldehyde resin spheres, and are investigated as CO_2 adsorbents. It is found that the prepared carbon materials still maintain the typical spherical shapes after the activation, and have highly developed ultra-microporosity with uniform pore size, indicating that almost the activation takes place in the interior of the polymer spheres. The narrow-distributed ultra-micropores are attributed to the 'in-situ homogeneous activation'effect produced by the mono-dispersed potassium ions as a form of -OK groups in the bulk of polymer spheres. The CS-1 sample prepared under a KOH/resins weight ratio of 1 shows a very high CO_2 capture capacity of 4.83 mmol/g and good CO_2/N_2 selectivity of ~17-45. We believe that the presence of a welldeveloped ultra-microporosity is responsible for excellent CO_2 sorption performance at room temperature and ambient pressure. | Xuan Wang Jin Zhou Wei Xing Boyu Liu Jianlin Zhang Hongtao Lin Hongyou Cui Shuping Zhuo | 2017 | Journal of Energy Chemistry2017，26，5： | 3 |
| 6 | Clear mortality gap caused by graft macrosteatosis in Chinese patients after cadaveric liver transplantation显示文摘Background:Liver transplantation(LT)is one of the most effective surgical treatment for patients with end-stage liver disease.Steatosis is a contributor for inferior graft quality.But its impact and safety on transplantation was less assessed in Chinese patients.Methods:Graft steatosis and related information involved in recipients,donors and surgical procedures were retrospectively collected from 239 patients.Results:Donor macrosteatosis(MaS)caused about 2.14 and 2.80 folds of increment on patient and graft mortality.Dose-response analysis revealed prominent risk of grafts on overall patient/organ mortality when MaS content exceeded 10%(P<0.05).Noteworthy,deaths were only observed in MaS group when concurrent with extremely higher post-transplant alanine aminotransferase(ALT,64%).However,microsteatosis(MiS)grafts didn’t affect outcomes after LT.In a cohort of Chinese patients,MaS had comprehensive effects on post-transplant outcomes with relatively lower safety threshold at 10%.Mortality gap caused by MaS grafts was observed in patients with severer ischemia reperfusion injury.Conclusions:Our study revealled the graft MaS affected the post-transplant outcomes in lower risk cutoff in Chinese patients.Further study is worthy to validate these results and investigate inner mechanism under the phenomenon. | Zhengtao Liu Wenchao Wang Li Zhuang Jingfeng Liu Shuping Que Dan Zhu Linfang Dong Jian Yu Lin Zhou Shusen Zheng | 2020 | Hepatobiliary Surgery and Nutrition2020，9，6： | 2 |
| 7 | Identification and Functional Characterization of a NovelΔ12 Fatty Acid Desaturase Gene from Haematococcus pluvialis显示文摘The freshwater microalga Haematococcus pluvialis accumulates large amounts of fatty acids in response to adverse conditions.However,the key fatty acid desaturase genes in H.pluvialis remain unknown.In this study,we cloned and functionally characterized aΔ12 fatty acid desaturase gene,and designated it as HpFAD2.The open reading frame of HpFAD2 consisted of 1137 base pairs and encoded 378 amino acids.The deduced polypeptide showed 70%identity to other endoplasmic reticulumΔ12 fatty acid desaturases,whereas it had only 44%identity to plastidΔ12 fatty acid desaturases.The PSORT algorithm and phylogenetic analysis further confirmed its affiliation to the endoplasmic reticulumΔ12 fatty acid desaturases.Heterologous expression was performed in Saccharomyces cerevisiae cells transformed with the recombinant plasmid pYES2-HpFAD2.Two additional fatty acids(C16:2 and C18:2)were detected in the yeast transformants.The results indicatedΔ12 desaturation activity and substrate preference for C18:1 over C16:1.The transcriptional levels of H.pluvialis HpFAD2 at different growth stages were measured by quantitative polymerase chain reaction(PCR),indicating that the HpFAD2 transcriptional levels were significantly higher in red cells than those in green cells.Our study brings more insight into the fatty acid biosynthetic pathway of H.pluvialis. | ZHANG Lin CHEN Wenbi YANG Shuping ZHANG Yuanbo XU Jilin YANG Dongjie WU Zuyao LIU Tong CAO Jiayi | 2020 | Journal of Ocean University of China2020，19，6： | 2 |
| 8 | Review on Alkali Element Doping in Cu(In,Ga)Se2 Thin Films and Solar Cells显示文摘 | Yun Sun Shuping Lin Wei Li Shiqing Cheng Yunxiang Zhang Yiming Liu Wei Liu | 2017 | Engineering2017，3，4： | 2 |
| 9 | Functional and pathological improvements of the hearts in diabetes model by the combined therapy of bFGF-loaded nanoparticles with ultrasound-targeted microbubble destruction显示文摘 | Ying-Zheng Zhao Xin-Qiao Tian Ming Zhang Lu Cai Ao Ru Xiao-Tong Shen Xi Jiang Rong-Rong Jin Lei Zheng Kyle Hawkins Subrata Charkrabarti Xiao-Kun Li Qian Lin Wen-Ze Yu Shuping Ge Cui-Tao Lu Ho Lun Wong | 2014 | Journal of Controlled Release2014，，： | 1 |
| 10 | Stochastic Linear Quadratic Regulatiors with Indefinite Control weight Costs显示文摘 | Shuping Chen XunJing Lin Xun Yu Zhou | 1998 | SIAM J control Optim1998，36，5： | 1 |
| 11 | Density-controlled growth of well-aligned ZnO nanowires using chemical vapor deposition显示文摘Well-aligned ZnO nanowires were grown on Si substrate by chemical vapor deposition.The experimental results showed that the density of nanowires was related to the heating process and growth temperature.High-density ZnO nanowires were obtained under optimal conditions.The growth mechanism of the ZnO nanowires was presented as well. | WU ZhiMing,LIN XianGan,HUANG Kai,LI ShuPing&KANG JunYong Key Laboratory of Semiconductors and Applications,Department of Physics,Xiamen University,Xiamen 361005,China | 2010 | Science China(Technological Sciences)2010，53，3： | 1 |
| 12 | Boosting Cu(In,Ga)Se_(2)Thin Film Growth in Low-Temperature Rapid-Deposition Processes:An Improved Design for the Single-Heating Knudsen Effusion Cell显示文摘The Knudsen effusion cell is often used to grow high-quality Cu(In,Ga)Se_(2)(CIGS)thin film in coevaporation processes.However,the traditional single-heating Knudsen effusion cell cannot deliver complete metal selenides during the whole deposition process,particularly for a low-temperature deposition process,which is probably due to the condensation and droplet ejection at the nozzle of the crucible.In this study,thermodynamics analysis is conducted to decipher the reason for this phenomenon.Furthermore,a new single-heating Knudsen effusion is proposed to solve this difficult problem,which leads to an improvement in the quality of CIGS film and a relative increase in conversion efficiency of 29%at a growth rate of about 230 nmmin1,compared with the traditional efficiency in a lowtemperature rapid-deposition process. | Yunxiang Zhang Shuping Lin Shiqing Cheng Zhichao He Zhaojing Hu Zhiqiang Zhou Wei Liu Yun Sun | 2021 | Engineering2021，7，4： | 0 |
| 13 | A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer显示文摘Modulating Tankyrases(TNKS),interactions with USP25 to promote TNKS degradation,rather than inhibiting their enzymatic activities,is emerging as an alternative/specific approach to inhibit the Wnt/β-catenin pathway.Here,we identified UAT-B,a novel neoantimycin analog isolated from Streptomyces conglobatus,as a small-molecule inhibitor of TNKS-USP25 protein-protein interaction(PPI)to overcome multi-drug resistance in colorectal cancer(CRC).The disruption of TNKS-USP25 complex formation by UAT-B led to a significant decrease in TNKS levels,triggering cell apoptosis through modulation of the Wnt/β-catenin pathway.Importantly,UAT-B successfully inhibited the CRC cells growth that harbored high TNKS levels,as demonstrated in various in vitro and in vivo studies utilizing cell line-based and patient-derived xenografts,as well as APC^(min/+)spontaneous CRC models.Collectively,these findings suggest that targeting the TNKS-USP25 PPI using a small-molecule inhibitor represents a compelling therapeutic strategy for CRC treatment,and UAT-B emerges as a promising candidate for further preclinical and clinical investigations. | Hongrui Zhu Yamin Gao Liyun Liu Mengyu Tao Xiao Lin Yijia Cheng Yaoyao Shen Haitao Xue Li Guan Huimin Zhao Li Liu Shuping Wang Fan Yang Yongjun Zhou Hongze Liao Fan Sun Houwen Lin | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 14 | Synthetic and immunological studies on the OCT4 immunodominant motif antigen-based anti-cancer vaccine显示文摘Objective:Cancer stem cell is one of the important causes of tumorigenesis as well as a drug target in the treatment of malignant tumor.However,at present,there is no immune vaccine targeting these cells.Octamer-binding transcription factor 4(OCT4),a marker of embryonic stem cells and germ cells,often highly expresses in the early stages of tumorigenesis and is therefore a good candidate for cancer vaccine development.Methods:To identify the optimal carrier and adjuvant combination,we chemically synthesized and linked three different OCT4 epitope antigens to a carrier protein,keyhole limpet hemocyanin(KLH),combined with Toll-like receptor 9 agonist(TLR9).Results:Immunization with OCT4-3+TLR9 produced the strongest immune response in mice.In prevention assays,significant tumor growth inhibition was achieved in BABL/c mice treated with OCT4-3+TLR9(P<0.01).Importantly,the results showed that cytotoxic T lymphocyte activity and the inhibition of tumor growth were enhanced in mice immunized with OCT4-3 combined with TLR9.Meanwhile,multiple cytokines[such as interferon(IFN)-γ(P<0.05),interleukin(IL)-12(P<0.05),IL-2(P<0.01),and IL-6(P<0.05)]promoting cellular immune responses were shown to be greatly enhanced in mice immunized with OCT4-3+TLR9.Moreover,we considered safety considerations in terms of the composition of the vaccines to help facilitate the development of effective next-generation vaccines.Conclusions:Collectively,these experiments demonstrated that combination therapy with TLR9 agonist induced a tumor-specific adaptive immune response,leading to the suppression of primary tumor growth in testis embryonic carcinoma. | Tingting Chen Kan Liu Jiangyao Xu Tianying Zhan Maixian Liu Li Li Zhiwen Yang Shuping Yuan Wenyi Zou Guimiao Lin Dennis ACarson Christina CNWu Xiaomei Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 0 |
| 15 | Analysis on the Layout of Villages and Towns and the Characteristics of Residential Buildings from the Perspective of Rural Revitalization in Liaoning Province显示文摘Rural houses in Liaoning Province have a long history and distinctive regional characteristics.Rural houses are designed in combination with family agricultural production habits to meet their production and living functions,and the building materials are mostly local materials.With the full implementation of the rural revitalization strategy,the countryside of Liaoning Province has become the main battlefield for rural revitalization.Based on a large number of field investigations,the layout of villages and towns and residential buildings in Liaoning Province were analyzed from three levels of villages,courtyard forms to residential functions,aiming to provide a basic theoretical reference for the renovation and renewal of rural residential buildings in Liaoning Province. | ZHU Lin GE Shuping LUO Jian | 2022 | Journal of Landscape Research2022，14，2： | 0 |
| 16 | Progress on the use of satellite technology for gravity exploration显示文摘In this paper,the technological progress on Chinese gravity exploration satellites is presented.Novel features such as ultra-stable structure,high accurate thermal control,drag-free and attitude control,micro-thrusters,aerodynamic configuration,the ability to perform micro-vibration analyses,microwave ranging system and mass center trimmer are described. | Ding Yanwei Ma Li Xu Zhiming Li Ming Huo Hongqing Tan Shuping Gou Xingyu Wang Xudong Yang Fuquan Mao Wei Liu Yingna Zhong Xingwang Xi Dongxue Hu Lingyun Huang Lin Li Songming Zhang Xiaomin | 2015 | Geodesy and Geodynamics2015，6，4： | 0 |
| 17 | Recent Progress and Future Direction for the Application of Multiomics Data in Clinical Liver Transplantation显示文摘Omics data address key issues in liver transplantation(LT)as the most effective therapeutic means for end-stage liver disease.The purpose of this study was to review the current application and future direction for omics in LT.We reviewed the use of multiomics to elucidate the pathogenesis leading to LT and prognostication.Future directions with respect to the use of omics in LT are also described based on perspectives of surgeons with experience in omics.Significant molecules were identified and summarized based on omics,with a focus on post-transplant liver fibrosis,early allograft dysfunction,tumor recurrence,and graft failure.We emphasized the importance omics for clinicians who perform LTs and prioritized the directions that should be established.We also outlined the ideal workflow for omics in LT.In step with advances in technology,the quality of omics data can be guaranteed using an improved algorithm at a lower price.Concerns should be addressed on the translational value of omics for better therapeutic effects in patients undergoing LT. | Zhengtao Liu Jun Xu Shuping Que Lei Geng Lin Zhou Adil Mardinoglu Shusen Zheng | 2022 | Journal of Clinical and Translational Hepatology2022，10，2： | 0 |
| 18 | Precise Synthesis of Organic Heterostructures via the Synergy Approach of Polymorphism and Cocrystal Engineering for Optical Applications显示文摘Organic heterostructures that can integrate the physiochemical properties of two or more substances have atracted widespread attention in the field of optoelectronics.However,the epitaxial growth process between different organic material molecules is unpredictable,and the precise synthesis of organic heterostructures is stll particularly challenging.Herein,through the synergy approach of polymorphism and cocrystal engineering,a series of organic branched heterostructures have been successfully prepared.Interestingly,by simply adjusting the solvent ratio,different crystalline phases of perylene microplates can be epitaxilly grown on the perylene-OFN cocrystal microwires,which provides a feasible approach for the preparation of organic heterostructures.Meanwhile,these as-prepared organic branched heterostructures can realize multi-channel and multi-color emission,and act as optical logic gates,which promotes the multifunctional integrated optoelectronics. | Huiling Yin Yingxin Ma Hongtao Lin Shuhai Chen Ziyan Zhou Shuping Zhuo Xuedong Wang | 2022 | Chinese Journal of Chemistry2022，40，10： | 0 |
| 19 | FGF8 signaling sustains progenitor status and multipotency of cranial neural crest-derived mesenchymal cells in vivo and in vitro显示文摘The cranial neural crest(CNC)cells play a vital role in craniofacial development and regeneration.They are multi-potent progenitors,being able to differentiate into various types of tissues.Both pre-migratory and post-migratory CNC cells are plastic,taking on diverse fates by responding to different inductive signals.However,what sustains the multipotency ofCNCcells andderivatives remains largely unknown.In this study,we present evidence that FGF8 signaling is able to sustain progenitor status and multipotency of CNC-derived mesenchymal cells both in vivo and in vitro.We show that augmented FGF8 signaling in pre-migratory CNC cells prevents cell differentiation and organogenesis in the craniofacial region by maintaining their progenitor status.CNC-derived mesenchymal cells with Fgf8 overexpression or control cells in the presence of exogenous FGF8 exhibit prolonged survival,proliferation,and multi-potent differentiation capability in cell cultures.Remarkably,exogenous FGF8 also sustains the capability of CNC-derived mesenchymal cells to participate in organogenesis such as odontogenesis.Furthermore,FGF8-mediated signaling strongly promotes adipogenesis but inhibits osteogenesis of CNC-derived mesenchymal cells in vitro.Our results reveal a specific role for FGF8 in the maintenance of progenitor status and in fate determination of CNC cells,implicating a potential application in expansion and fate manipulation of CNC-derived cells in stem cell-based craniofacial regeneration. | Meiying Shao Chao Liu Yingnan Song Wenduo Ye Wei He Guohua Yuan Shuping Gu Congxin Lin Liang Ma Yanding Zhang Weidong Tian Tao Hu YiPing Chen | 2015 | Journal of Molecular Cell Biology2015，7，5： | 0 |
| 20 | Alternation in F-wave parameters of median nerve from unaffected extremity in stroke patients with hemiplegia under dynamic state显示文摘BACKGROUND: For many years, the extremities of stroke patients are divided into affected side and unaffected side according to clinical symptoms and body signs. Moreover, previous rehabilitation function training is developed simply aiming to the dysfunction manifested by unaffected extremity. Problems of unaffected extremity are always ignored, such as left- and right- side connection dysfunction, abnormal muscular tension of unaffected side and so on. OBJECTIVE: To observe neurophysiological change characteristics of unaffected extremity of stroke patients with hemiplegia by electromyographical method. DESIGN: Case-control observation. SETTING: First Hospital, Jilin University. PARTICIPANTS: Eighty stroke patients with hemiplegia confirmed by skull CT or MRI, who firstly hospitalized in the Department of Neurology, First Hospital, Jilin University between July 2004 and March 2005, were retrieved. They were scored > 8 points in Glasgow Coma Scale and had stable vital sign. Nineteen normal persons who received healthy examination in the clinic were involved in normal control group. Following the classification criteria of Brunnstrom's Recovery Stages of Stroke (BRSS), 80 stroke patients with hemiplegia were assigned into 3 groups: BRSS Ⅰ-Ⅱ group (n =36), BRSS Ⅲ-Ⅳ group (n =23) and BRSSⅤ-Ⅵ (n =21). METHODS: F-wave parameters of median nerve of unaffected extremity were detected by electromyographical technique. The recording electrode (muscular belly of abductor pollicis brevis) and reference electrode (first finger bone) were connected with grounding electrode. Stimulating electrode was placed in the median part of wrist joint with stimulation intensity of 130% that of threshold stimulation, stimulation frequency of 2 Hz, current pulse width of 0.2 ms, time course of 5 ms and sensitivity of 2 mV. The F-wave of median nerve of affected extremity under the resting stage (static status) and that of unaffected extremity under the maximum resistant contracted state were detected in order. The amplitude and appearance percentage of F wave were recorded. MAIN OUTCOME MEASURES: Comparison of F-wave parameters of median nerve between the unaffected extremity of stroke patients with hemiplegia and the extremity of control subjects under different status. RESULTS: All the patients accomplished the detection, and all of them participated in the final analysis. ①Under dynamic status, the amplitude and appearance percentage of F wave of unaffected extremity of patients in BRSS Ⅲ-Ⅳ group were significantly higher than those in the normal control group, respectively[(0.803 9±0.157 3) mV vs. (0.406 7±0.170 3) mV; (0.856 1±0.266 8)% vs. (0.650 0±0.197 6)%, P < 0.05]. Under static status, there were no significant differences in F-wave parameters of median nerve in the unaffected extremity of patients between BRSS Ⅰ-Ⅱ group and BRSS Ⅴ-Ⅵ group (P > 0.05). ②F-wave parameters of median nerve of unaffected extremity of patients in BRSS Ⅰ-Ⅱ group and BRSS Ⅴ-Ⅵ group under dynamic statewere higher than those under static status, without significant difference (P > 0.05), while the amplitude and appearance percentage of F wave of median nerve of unaffected extremity of patients in BRSS Ⅲ-Ⅳ group under dynamic statewere significantly higher than those under static state[(0.803 9±0.157 3) mV vs. (0.391 7±0.131 6) mV; (0.856 1±0.266 8 )% vs.(0.639 1 ±0.259 4)%,P < 0.05]. ③ There was no significant difference in F wave parameters among groups under static state(P > 0.05). However, under dynamic status, the amplitude and appearance percentage of F wave parameters of median nerve of unaffected extremity of patients in BRSS Ⅲ-Ⅳ group [(0.803 9±0.157 3) mV,(0.856 1±0.266 8)%] were significantly lower than those in the other two groups [(0.395 1±0.148 8),(0.437 1±0.157 6) mV;(0.612 5±0.232 8)%,(0.657 1±0.232 5)%,P < 0.05]. CONCLUSION: With the development of disease condition and the increase of muscular tension at anesthetic side, combination motor of affected extremity is caused following movement and muscular tension enhances to non-anesthetic-side. Therefore, F-wave parameters increase under dynamic status. | Hang Zhao Yong Lin Wenhua Qi Shuping Yin Jiachun Feng | 2006 | Neural Regeneration Research2006，1，9： | 0 |
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