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| 1 | Zircon SHRIMP Dating for the Weiya Pluton, Eastern Tianshan: Its Geological Implications显示文摘The timing of the emplacement of the Weiya pluton remains controversial due to the absence of systematic and precise dating. This paper reports zircon SHRIMP U-Pb dating of different lithologic phases in the Weiya pluton, and discusses the genesis and tectonic environment. The ages of gabbro, quartz syenite, diorite porphyrite and fine-grained granite are 236?6 Ma, 246?6 Ma, 233?8 Ma and 237?8 Ma, respectively. All these phases were formed in early-middle Indosinian (Triassic) in a post-orogenic environment. In addition to underplating, intraplating of mantle-derived magmas is also a substantial mechanism for magma generation and vertical accretion of the continental crust. Granitoid rocks are important products of vertical continental accretion as underplating evolves gradually to intraplating. The existence of post-orogenic Indosinian granites shows that the middle Tianshan orogenic belt underwent an important tectonic conversion from the Paleo-Asian ocean subduction-collision system to the Paleo-Tethys ocean regime. | ZHANG Zunzhong GU Lianxing WU Changzhi LI Weiqiang XI Aihua WANG Shuo | 2005 | Acta Geologica Sinica(English Edition)2005，79，4： | 53 |
| 2 | Addition of prokinetics to PPI therapy in gastroesophageal reflux disease:A meta-analysis显示文摘AIM:To investigate the efficacy of adding prokinetics to proton pump inhibitors(PPIs)for the treatment of gastroesophageal reflux disease(GERD).METHODS:PubMed,Cochrane Library,and Web of Knowledge databases(prior to October 2013)were systematically searched for randomized controlled trials(RCTs)that compared therapeutic efficacy of PPI alone(single therapy)or PPI plus prokinetics(combined therapy)for GERD.The primary outcome of those selected trials was complete or partial relief of non-erosive reflux disease symptoms or mucosal healing in erosive reflux esophagitis.Using the test of heterogeneity,we established a fixed or random effects model where the risk ratio was the primary readout for measuring efficacy.RESULTS:Twelve RCTs including 2403 patients in total were enrolled in this study.Combined therapy was not associated with significant relief of symptoms or alterations in endoscopic response relative to single therapy(95%CI:1.0-1.2,P=0.05;95%CI:0.66-2.61,P=0.44).However,combined therapy was associated with a greater symptom score change(95%CI:2.14-3.02,P<0.00001).Although there was a reduction in the number of reflux episodes in GERD[95%CI:-5.96-(-1.78),P=0.0003]with the combined therapy,there was no significant effect on acid exposure time(95%CI:-0.37-0.60,P=0.65).The proportion of patients with adverse effects undergoing combined therapy was significantly higher than for PPI therapy alone(95%CI:1.06-1.36,P=0.005)when the difference between 5-HT receptor agonist and PPI combined therapy and single therapy(95%CI:0.84-1.39,P=0.53)was excluded.CONCLUSION:Combined therapy may partially improve patient quality of life,but has no significant effect on symptom or endoscopic response of GERD. | Li-Hua Ren Wei-Xu Chen Li-Juan Qian Shuo Li Min Gu Rui-Hua Shi | 2014 | World Journal of Gastroenterology2014，20，9： | 14 |
| 3 | Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019显示文摘Since late 2011,outbreaks of pseudorabies virus(PRV)have occurred in southern China causing major economic losses to the pig industry.We previously reported that variant PRV forms and recombination in China could be the source of continued epidemics.Here,we analyzed samples from intensive pig farms in eastern China between 2017 and 2019,and sequenced the main glycoproteins(gB,gC,gD,and gE)to study the evolution characteristics of PRV.Based on the gC gene,we found that PRV variants belong to clade 2 and detected a founder effect during by the PRV epidemic.In addition,we detected inter-and intra-clade recombination;in particular,inter-clade recombination in the gB genes of strains FJ-ZXF and FJ-W2,which were recombinant with clade 1 strains.We also found specific amino-acid changes and positively selected sites,possibly associated with functional changes.This analysis of the emergence of PRV in China illustrates the need for continuous monitoring and the development of vaccines against specific variants of PRV. | Xiaofeng Zhai Wen Zhao Kemang Li Cheng Zhang Congcong Wang Shuo Su Jiyong Zhou Jing Lei Gang Xing Haifeng Sun Zhiyu Shi Jinyan Gu | 2019 | Virologica Sinica2019，34，6： | 12 |
| 4 | Imaging through unknown scattering media based on physics-informed learning显示文摘Imaging through scattering media is one of the hotspots in the optical field, and impressive results have been demonstrated via deep learning(DL). However, most of the DL approaches are solely data-driven methods and lack the related physics prior, which results in a limited generalization capability. In this paper, through the effective combination of the speckle-correlation theory and the DL method, we demonstrate a physics-informed learning method in scalable imaging through an unknown thin scattering media, which can achieve high reconstruction fidelity for the sparse objects by training with only one diffuser. The method can solve the inverse problem with more general applicability, which promotes that the objects with different complexity and sparsity can be reconstructed accurately through unknown scattering media, even if the diffusers have different statistical properties. This approach can also extend the field of view(FOV) of traditional speckle-correlation methods. This method gives impetus to the development of scattering imaging in practical scenes and provides an enlightening reference for using DL methods to solve optical problems. | SHUO ZHU ENLAI GUO JIE GU LIANFA BAI JING HAN | 2021 | Photonics Research2021，9，5： | 10 |
| 5 | Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles显示文摘Liver fibrosis is the common consequence of almost all liver diseases and has become an urgent clinical problem without efficient therapies.Recent evidence has shown that hepatocytes-derived extracellular vesicles(EVs)play important roles in liver pathophysiology,but little is known about the role of damaged hepatocytes-derived EVs in hepatic stellate cell(HSC)activation and following fibrosis.Tetramethylpyrazine(TMP)from Ligusticum wallichii Franchat exhibits a broad spectrum of biological activities including liver protection.In this study,we investigated whether TMP exerted liver-protective action through regulating EV-dependent intercellular communication between hepatocytes and HSCs.Chronic liver injury was induced in mice by CCl_(4)(1.6 mg/kg,i.g.)twice a week for 8 weeks.In the last 4 weeks of CCl_(4) administration,mice were given TMP(40,80,160 mg·kg^(-1)·d^(-1),i.g.).Acute liver injury was induced in mice by injection of a single dose of CCl_(4)(0.8 mg/kg,i.p.).After injection,mice were treated with TMP(80 mg/kg)every 24 h.We showed that TMP treatment dramatically ameliorated CCl_(4)-induced oxidative stress and hepatic inflammation as well as acute or chronic liver fibrosis.In cultured mouse primary hepatocytes(MPHs),treatment with CCl_(4) or acetaminophen resulted in mitochondrial dysfunction,release of mitochondrial DNA(mtDNA)from injured hepatocytes to adjacent hepatocytes and HSCs through EVs,mediating hepatocyte damage and fibrogenic responses in activated HSCs;pretreatment of MPHs with TMP(25μM)prevented all these pathological effects.Transplanted serum EVs from TMP-treated mice prevented both initiation and progression of liver fibrosis caused by CCl_(4).Taken together,this study unravels the complex mechanisms underlying the protective effects of TMP against mtDNA-containing EV-mediated hepatocyte injury and HSC activation during liver injury,and provides critical evidence inspiring the development of TMP-based innovative therapeutic agents for the treatment of liver fibrosis. | Ya-jing Li Run-ping Liu Ming-ning Ding Qi Zheng Jian-zhi Wu Xiao-yong Xue Yi-qing Gu Bo-ning Ma Ya-jie Cai Shuo Li Sheng Lin Lu-yong Zhang Xiaojiaoyang Li | 2022 | Acta Pharmacologica Sinica2022，43，8： | 5 |
| 6 | Questions about NgAgo显示文摘 | Shawn Burgess Linzhao Cheng Feng Gu Zhiwei Huang Shuo Lin Jinsong Li Wei Li Wei Qin Yujie Sun Zhou Songyang Wensheng Wei Qiang Wu Haoyi Wang Xiaoqun Wang Jing-Wei Xiong Jianzhong Xi Hui Yang Bin Zhou Bo Zhang Junjiu Huang | 2016 | Protein & Cell2016，7，12： | 5 |
| 7 | Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach显示文摘Chinese herbal medicine(CHM)addresses complex diseases through polypharmacological interactions.However,systematic studies of herbal medicine pharmacology remain challenging due to the complexity of CHM ingredients and their interactions with various targets.In this study,we aim to address this challenge with computational approaches.We investigated the herb-target-disease associations of 197 commonly prescribed CHMs using the similarity ensemble approach and DisGeNET database.We demonstrated that this method can be applied to associate herbs with their putative targets.In the case study of three well-known herbs,Radix Glycyrrhizae,Flos Lonicerae,and Rhizoma Coptidis,approximately 70%of the predicted targets were supported by scientific literature.By linking 406 targets to 2439 annotated diseases,we further analyzed the pharmacological functions of 197 herbs.Finally,we proposed a strategy of target-oriented herbal formula design and illustrated the target profiles for four common chronic diseases,namely,Alzheimer’s disease,depressive disorder,hypertensive disease,and non-insulin-dependent diabetes mellitus.This computational approach holds great potential in the target identification of herbs,understanding the molecular mechanisms of CHM,and designing novel herbal formulas. | Shuo Gu Lu-hua Lai | 2020 | Acta Pharmacologica Sinica2020，41，3： | 4 |
| 8 | Redevelopment of urban brownfield sites in China:Motivation,history,policies and improved management显示文摘Rapid urbanisation in China has resulted in an increased demand for land in towns and cities.To upgrade and modernise,China has also moved many major industries from urban centres to less populated areas.With the high economic value of urban land,the transformation and utilisation of brownfield areas have become important economically and socially.The Chinese government has recognised the need for strong frameworks to safeguard soil and groundwater quality,with brownfield sites a key category for management.Strong scientific,regulatory and decision-making frameworks are needed and being adopted to ensure practical,careful and wise use of central and localised government resources,to manage the reuse and regeneration of these brownfield sites.This paper reviews the context,policies and management procedures of developing brownfield sites in countries with a history of brownfield management and discusses China’s current situation and priorities for brownfield governance and redevelopment.These include(1)clarification of brownfield site soil contamination risk control standards and risk assessment procedures,(2)the responsibilities of different national and local agencies,(3)the establishment of a national expert committee to advise on best practices,policy and process,(4)the use of registered brownfield databases at national,provincial,municipal and county levels,and(5)the set up of soil pollution prevention fund at the provincial level. | Yiming Sun Hong Li Shuo Lei Kirk TSemple Frederic Coulon Qing Hu Jingyang Gao Guanlin Guo Qingbao Gu Kevin C.Jones | 2022 | Eco-Environment & Health2022，1，2： | 2 |
| 9 | An Energy-Efficient UAV Deployment Scheme for Emergency Communications in Air-Ground Networks with Joint Trajectory and Power Optimization显示文摘The space-air-ground integrated network(SAGIN)has gained widespread attention from academia and industry in recent years.It is widely applied in many practical fields such as global observation and mapping,intelligent transportation systems,and military missions.As an information carrier of air platforms,the deployment strategy of unmanned aerial vehicles(UAVs)is essential for communication systems’performance.In this paper,we discuss a UAV broadcast coverage strategy that can maximize energy efficiency(EE)under terrestrial users’requirements.Due to the non-convexity of this issue,conventional approaches often solve with heuristics algorithms or alternate optimization.To this end,we propose an iterative algorithm by optimizing trajectory and power allocation jointly.Firstly,we discrete the UAV trajectory into several stop points and propose a user grouping strategy based on the traveling salesman problem(TSP)to acquire the number of stop points and the optimization range.Then,we use the Dinkelbach method to dispose of the fractional form and transform the original problem into an iteratively solvable convex optimization problem by variable substitution and Taylor approximation.Numerical results validate our proposed solution and outperform the benchmark schemes in EE and mission completion time. | Shuo Zhang Shuo Shi Weizhi Wang Zhenyu Xu Xuemai Gu | 2022 | China Communications2022，19，7： | 2 |
| 10 | The stimulation of osteogenic differentiation of human adipose-derived stem cells by ionic products from akermanite dissolution via activation of the ERK pathway显示文摘 | Huijie Gu Fangfang Guo Xiao Zhou Lunli Gong Yun Zhang Wanyin Zhai Lei Chen Lian Cen Shuo Yin Jiang Chang Lei Cui | 2011 | Biomaterials2011，，29： | 1 |
| 11 | Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assay显示文摘 | Yulan Sun Mifang Liang Jing Qu Cong Jin QuanFu Zhang Jiandong Li Xiaolin Jiang Qin Wang Jing Lu Wen Gu Shuo Zhang Chuan Li XianJun Wang Faxian Zhan Wenqing Yao Zhenqiang Bi Shiwen Wang Dexin Li | 2011 | Journal of Clinical Virology2011，，1： | 1 |
| 12 | Molecular Detection of Anaerobic Ammonium-Oxidizing (Anammox) Bacteria in High-Temperature Petroleum Reservoirs显示文摘 | Hui Li Shuo Chen Bo-Zhong Mu Ji-Dong Gu | 2010 | Microbial Ecology2010，，4： | 1 |
| 13 | Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation显示文摘Interleukin-33(IL-33)is a crucial nuclear cytokine that induces the type 2 immune response and maintains immune homeostasis.The fine-tuned regulation of IL-33 in tissue cells is critical to control of the type 2 immune response in airway inflammation,but the mechanism is still unclear.Here,we found that healthy individuals had higher phosphate-pyridoxal(PLP,an active form of vitamin B6)concentrations in the serum than asthma patients.Lower serum PLP concentrations in asthma patients were strongly associated with worse lung function and inflammation.In a mouse model of lung inflammation,we revealed that PLP alleviated the type 2 immune response and that this inhibitory effect relied on the activity of IL-33.A mechanistic study showed that in vivo,pyridoxal(PL)needed to be converted into PLP,which inhibited the type 2 response by regulating IL-33 stability.In mice heterozygous for pyridoxal kinase(PDXK),the conversion of PL to PLP was limited,and IL-33 levels were increased in the lungs,aggravating type 2 inflammation.Furthermore,we found that the mouse double minute 2 homolog(MDM2)protein,an E3 ubiquitin-protein ligase,could ubiquitinate the N-terminus of IL-33 and sustain IL-33 stability in epithelial cells.PLP reduced MDM2-mediated IL-33 polyubiquitination and decreased the level of IL-33 through the proteasome pathway.In addition,inhalation of PLP alleviated asthma-related effects in mouse models.In summary,our data indicate that vitamin B6 regulates MDM2-mediated IL-33 stability to constrain the type 2 response,which might help develop a potential preventive and therapeutic agent for allergy-related diseases. | Songling Zhu Shufen Zhong Kebin Cheng Li-Sha Zhang Jiu-wu Bai Zu Cao Su Wang Wen Chen Shipeng Cheng Liyan Ma Zhiyang Ling Yuying Huang Wangpeng Gu Xiaoyu Sun Chunyan Yi Meng Zhao Shuo Liang Jin-Fu Xu Bing Sun Yaguang Zhang | 2023 | Cellular & Molecular Immunology2023，20，7： | 1 |
| 14 | The Solar Upper Transition Region Imager(SUTRI)Onboard the SATech-01 Satellite显示文摘The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections. | Xianyong Bai Hui Tian Yuanyong Deng Zhanshan Wang Jianfeng Yang Xiaofeng Zhang Yonghe Zhang Runze Qi Nange Wang Yang Gao Jun Yu Chunling He Zhengxiang Shen Lun Shen Song Guo Zhenyong Hou Kaifan Ji Xingzi Bi Wei Duan Xiao Yang Jiaben Lin Ziyao Hu Qian Song Zihao Yang Yajie Chen Weidong Qiao Wei Ge Fu Li Lei Jin Jiawei He Xiaobo Chen Xiaocheng Zhu Junwang He Qi Shi Liu Liu Jinsong Li Dongxiao Xu Rui Liu Taijie Li Zhenggong Feng Yamin Wang Chengcheng Fan Shuo Liu Sifan Guo Zheng Sun Yuchuan Wu Haiyu Li Qi Yang Yuyang Ye Weichen Gu Jiali Wu Zhe Zhang Yue Yu Zeyi Ye Pengfeng Sheng Yifan Wang Wenbin Li Qiushi Huang Zhong Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，6： | 1 |
| 15 | Pilot study on the interaction between B16 melanoma cell-line and bone-marrow derived mesenchymal stem cells显示文摘 | SUN Tao SUN Baocun NI Chunsheng ZHAO Xiulan WANG Xinghui QIE Shuo ZHANG Danfang GU Qiang QI Hong ZHAO Nan | 2008 | Cancer Lett2008，263，1： | 1 |
| 16 | Direct bandgap engineering with local biaxial strain in few-layer MoS2 bubbles显示文摘Nano Research volume 13,pages2072–2078(2020)Cite this article 211 Accesses Metrics details Abstract Strain engineering provides an important strategy to modulate the optical and electrical properties of semiconductors for improving devices performance with mechanical force or thermal expansion difference.Here,we present the investigation of the local strain distribution over few-layer MoS2 bubbles,by using scanning photoluminescence and Raman spectroscopies.We observe the obvious direct bandgap emissions with strain in the few-layer MoS2 bubble and the strain-induced continuous energy shifts of both resonant excitons and vibrational modes from the edge of the MoS2 bubble to the center(10μm scale),associated with the oscillations resulted from the optical interference-induced temperature distribution.To understand these results,we perform ab initio simulations to calculate the electronic and vibrational properties of few-layer MoS2 with biaxial tensile strain,based on density functional theory,finding good agreement with the experimental results.Our study suggests that local strain offers a convenient way to continuously tune the physical properties of a few-layer transition metal dichalcogenides(TMDs)semiconductor,and opens up new possibilities for band engineering within the 2D plane. | Yang Guo Bin Li Yuan Huang Shuo Du Chi Sun Hailan Luo Baoli Liu Xingjiang Zhou Jinlong Yang Junjie Li Changzhi Gu | 2020 | Nano Research2020，13，8： | 1 |
| 17 | Classification of weed seeds based on visual images and deep learning显示文摘Weeds are mainly spread by weed seeds being mixed with agricultural and forestry crop seeds,grain,animal hair,and other plant products,and disturb the growing environment of target plants such as crops and wild native plants.The accurate and efficient classification of weed seeds is important for the effective management and control of weeds.However,classification remains mainly dependent on destructive sampling-based manual inspection,which has a high cost and rather low flux.We considered that this problem could be solved using a nondestructive intelligent image recognition method.First,on the basis of the establishment of the image acquisition system for weed seeds,images of single weed seeds were rapidly and completely segmented,and a total of 47696 samples of 140 species of weed seeds and foreign materials remained.Then,six popular and novel deep Convolutional Neural Network(CNN)models are compared to identify the best method for intelligently identifying 140 species of weed seeds.Of these samples,33600 samples are randomly selected as the training dataset for model training,and the remaining 14096 samples are used as the testing dataset for model testing.AlexNet and GoogLeNet emerged from the quantitative evaluation as the best methods.AlexNet has strong classification accuracy and efficiency(low time consumption),and GoogLeNet has the best classification accuracy.A suitable CNN model for weed seed classification could be selected according to specific identification accuracy requirements and time costs of applications.This research is beneficial for developing a detection system for weed seeds in various applications.The resolution of taxonomic issues and problems associated with the identi-fication of these weed seeds may allow for more effective management and control. | Tongyun Luo Jianye Zhao Yujuan Gu Shuo Zhang Xi Qiao Wen Tian Yangchun Han | 2023 | Information Processing in Agriculture2023，10，1： | 1 |
| 18 | The role of physical and chemical parameters on forward osmosis membrane fouling during algae separation 显示文摘 | Shan Zou Yang shuo Gu De zhong Xiao | 2011 | Journal of Membrane Science2011，393，5： | 1 |
| 19 | Service-Driven Coded Forward Scheme Based on Streaming Transmission Model for Lunar Space Communication Networks显示文摘With the rapid development of lunar exploration,a large amount of scientific data and media stream service needs to be transmitted through Lunar Space Communication Networks(LSCNs).Due to limited transmitter power and intermittent,long delay and packet loss connections,the reliable and efficient multi-priority services’transmission in LSCNs becomes an urgent problem.Firstly,we propose a Streaming Transmission Model(STM)based on temporal and spatial topology graph to describe the delay and energy consumption for data transmission in LSCNs.Then,we further devise a Coded Forward Scheme based on STM,termed CFS-STM,to achieve multi-priority service in two steps:i).Link Stability Function(LSF)is established by solving an optimization problem to choose the appropriate single-hop path.ii).Raptor code is employed to further save delay and energy with adjustable code-rate according to the different channel conditions.Experiment results show that,CFS-STM can significantly improve the transmission efficiency of multi-service priority streaming delivery in LSCNs. | Shushi Gu Ye Wang Guoqing Chen Shuo Shi | 2020 | China Communications2020，17，7： | 1 |
| 20 | Topological flat band models with arbitrary Chern numbers显示文摘 | Yang Shuo Gu Zhengcheng Sun Kai | 2012 | Phys Rev B2012，86，24： | 1 |
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