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| 1 | Initial identification of heavy metals contamination in Taihu Lake, a eutrophic lake in China显示文摘A detailed investigation of seven heavy metals (Cu, Cd, Cr, As, Pb, Zn, Ni) in the water column, interstitial water and surface sediment was conducted to quantify the extent of their contamination in Taihu Lake. Results showed the average total concentrations ranged from 0.93 μg/L for Cd to 47.03 μg/L for Zn. The dissolved concentrations in the overlying water ranged from 0.06 μg/L for Cd to 15.86 μg/L for Zn. The metals in the Taihu Lake surface water were primarily in the particulate phase, especially for Cd, whose particulate concentration represented 94.3% of the total. In the surface sediment, the mean concentrations for Cr, Ni, Cu, Zn, As, Cd and Pb were 41.50, 28.72, 27.82, 65.46, 5.94, 0.82 and 41.17 mg/kg, respectively. The metals in the water column and sediments of Taihu Lake displayed significant spatial variations, and the higher metal concentrations mainly occurred in the north and west of Taihu Lake, especially in Zhushan Bay and West Taihu Lake. A quality assessment indicated that most of the metals in the surface water of Taihu Lake had no or low adverse health effects on organisms, except for Pb and Cu, which may cause chronic toxicity. Compared with the 'Consensus-Based Sediment Quality Guidelines', the polluting metals were Cr, Ni and Cd, and the polluted regions were confined to Zhushan Bay, Meiliang Bay and the west of Taihu Lake, especially for north of Zhushan Bay. The polluted areas for Cr, Ni and Cd were 14.36, 34.70 and 13.24 km 2 , respectively. We suggest that Cr, Ni, and Cd in the polluted areas should be addressed and that tissue chemistry and sediment toxicity assessments be performed as soon as possible. | Xia Jiang Wenwen Wang Shuhang Wang Bo Zhang Jiachen Hu | 2012 | Journal of Environmental Sciences2012，24，9： | 26 |
| 2 | Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors显示文摘 | Shuhang Wang Yongping Song Feifei Yan Delong Liu | 2016 | Frontiers of Medicine2016，10，4： | 21 |
| 3 | Distr ibution, risk and bioavailability of metals in sediments of Lake Yamdrok Basin on the Tibetan Plateau, China显示文摘Total contents of metals in soil and sediments on the Tibetan Plateau of China have been widely analyzed,but existing information is insufficient to effectively evaluate metal ecological risk because of a lack of metal bioavailability data.In this study,distribution,potential risk,mobility and bioavailability of metals in sediments of Lake Yamdrok Basin in Tibet of China were explored by combined use of total digestion,sequential extraction and the diffusive gradient in thin-films(DGT).Average concentrations of Cr,Ni,Cu,Zn,As,Cd and Pb in surface sediments were 31.25,30.31,22.00,45.04,31.32,0.13 and 13.39 mg/kg,respectively.Higher levels of metals were found near the inflowing rivers.Residual form was dominant in Cr,Ni,Zn,Cd and Pb,and reducible form was dominant in As and Cd.Metals in surface sediments showed a low enrichment degree overall,but Cd and As had higher ecological risk levels than the other metals.Furthermore,there was a larger average proportion of exchangeable form of As(20.4%)and Cd(9.0%)than the other metals(1.7%-3.3%),implying their higher mobility and release risk.Average DGT-labile concentrations of Cr,Ni,Cu,Zn,As,Cd and Pb were 0.5,4.5,0.7,25.1,60.0,0.22 and 1.0μg/L,respectively.The DGT-labile As was significantly correlated with extractable As forms(p<0.01),suggesting that extractable As in sediments acts as a'mobile pool'for bioavailable As.These results suggest potential risks of As and Cd,especially As,deserve further attention in Lake Yamdrok Basin. | Feifei Che Junyi Chen Bo Zhang Xia Jiang Shuhang Wang | 2020 | Journal of Environmental Sciences2020，32，11： | 4 |
| 4 | Survival difference between EGFR Del19 and L858R mutant advanced non-small cell lung cancer patients receiving gefitinib:a propensity score matching analysis显示文摘Objective: Although superior clinical benefits of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in the treatment of advanced non-small-cell lung cancer(NSCLC) had been reported,the survival difference between exon 19 deletion(Del19) and exon 21 Leu858 Arg substitution(L858 R) remains controversial.The purpose of this study is to investigate the differences in progression-free survival(PFS) and overall survival(OS) between different EGFR mutant subtypes among advanced NSCLC patients receiving gefitinib.Methods: There were 204 advanced NSCLC patients with EGFR mutations treated with gefitinib were enrolled in this retrospective cohort study.Patients were divided into the EGFR Del19 group and the L858 R mutated group according to their mutant subtype.Propensity score matching(PSM) was conducted by using a nearest-neighbor algorithm(1:1) to adjust for demographical and clinical covariates.Survival curves were constructed with the Kaplan-Meier method and compared by using the log-rank test.Results: The PFS in Del19 group was similar to that in the L858 R group [before PSM 8.6 vs.7.2 months,P=0.072; after PSM 7.3 vs.7.2 months,P=0.155].No differences were detected in OS between the L858 R and the Del19 group(before PSM 17.8 vs.13.1 months,P=0.253; after PSM 16.9 vs.13.1 months,P=0.339).The Del19 group was significantly younger compared with the L858 R mutation group in age(P=0.015).Conclusions: No significant difference was found in the PFS or OS between the Del19 and L858 R mutant NSCLC patients receiving gefitinib.The age gap might contribute to the survival differences between Del19 and L858 R groups.PSM is of important value to the elimination of potential bias. | Minglei Zhuo Qiwen Zheng Jun Zhao Meina Wu Tongtong An Yuyan Wang Jianjie Li Shuhang Wang Jia Zhong Xue Yang Hanxiao Chen Bo Jia Zhi Dong Emei Gao JingjingWang Ziping Wang | 2017 | Chinese Journal of Cancer Research2017，29，6： | 4 |
| 5 | A phase I study of nimotuzumab plus docetaxel in chemotherapy- refractory/resistant patients with advanced non-small-cell lung cancer显示文摘Background: To determine the safety and therapeutic efficacy of nimotuzumab(h-R3) combined with docetaxel in advanced non-small-cell lung cancer(NSCLC) patients who have failed to respond to prior first-line chemotherapy.Methods: In this single-center, open-label, dose-escalating phase I trial, patients with epidermal growth factor receptor(EGFR)-expressing stage IV NSCLC were treated with nimotuzumab plus docetaxel according to a dose escalation schedule. The safety and efficacy of the combination treatment were observed and analyzed.Results: There were 12 patients with EGFR-expressing stage IV NSCLC enrolled. The dose of nimotuzumab was escalated from 200 to 600 mg/week. The longest administration of study drug was 40 weeks at the 600 mg/week dose level. Grade III–IV toxicities included neutropenia and fatigue, and other toxicities included rash. Dose-limiting toxicity occurred with Grade 3 fatigue at the 200 mg dose level of nimotuzumab and Grade 4 neutropenia with pneumonia at the 600 mg dose level of nimotuzumab. No objective responses were observed, and stable disease was observed in eight patients(66.7%). The median progression-free survival(PFS) was 4.4 months in all patients, 1.3 months in patients with the EGFR mutation, and 4.4 months in those with wild type EGFR(EGFR WT). The median survival time(MST) was 21.1 months in all patients, 21.1 months in patients with EGFR mutation, and 26.4 months in patients with EGFR WT.Conclusions: Nimotuzumab and docetaxel combination therapy was found to be well tolerated and efficacious. Further study of nimotuzumab is warranted in advanced NSCLC patients. | Jun Zhao Minglei Zhuo Zhijie Wang Jianchun Duan Yuyan Wang Shuhang Wang Tongtong An Meina Wu Jie Wang | 2016 | Chinese Journal of Cancer Research2016，28，1： | 3 |
| 6 | The role of distinct co-mutation patterns with TP53 mutation in immunotherapy for NSCLC显示文摘TP53 mutations was reported to be correlated to the efficacy of program death-1(PD-1)and program death ligand-1(PD-L1).The role of co-mutations of TP53 with other recurrently mutated genes in outcome of anti-PD-(L)1 treatment for non-small cell lung cancer(NSCLC)is unknown.Here we mined a previously generated dataset to address the effect of co-mutations on the progression free survival(PFS)of NSCLC patients.Non-synonymous mutations and clinical data of 240 NSCLC patients with anti-PD-(L)1 based therapy was downloaded from cBioPortal.Totally 206 patients received monotherapy and 34 patients received combination therapy.In 240 NSCLC patients,TP53 mutation rate was 59.2%.For the monotherapy cohort,TP53 mutated NSCLC patients have a significantly longer PFS(4.3 vs.2.5 months,P=0.0019)compared with TP53 wild type NSCLC patients.The same tendency was also observed in the combination therapy cohort,but the difference in PFS(6.3 vs.5.4 months,P=0.12)was not significant.Ever-smoker had a longer PFS compared to never-smokers(4.0 vs.2.7 months).For further co-mutation analysis with TP53 including KEAP1 mutation(53/240,22.1%),KMT3C mutation(26/240,10.8%),STK11 mutation(56/240,23.3%),EGFR mutation(28/240,11.7%)and KRAS mutation(86/240,35.8%).Patients with both TP53 plus KEAP1 mutations in all 240 patients had a longer PFS compared with co-wild population(PFS 9.2 vs.4.2 months,P=0.012)when treated with PD-1/PD-L1 inhibitors.TP53 might be the dominating mutation correlating with longer PFS in PD-1/PD-L1 monotherapy.Different genes displayed distinct effect when co-mutated with TP53 in NSCLC patients. | Shuhang Wang Miaomiao Jiang Zuozhen Yang Xiaoyun Huang Ning Li | 2022 | Genes & Diseases2022，9，1： | 2 |
| 7 | Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice显示文摘Introduction:We previously demonstrated that magnesium ions(Mg^(2+))was a novel therapeutic alternative for osteoarthritis(OA)through promoting the hypoxia inducible factor-1α(HIF-1α)-mediated cartilage matrix synthesis.However,oxidative stress can inhibit the expression of HIF-1α,amplify the inflammation that potentially impairs the therapeutic efficacy of Mg^(2+) in OA.Vitamin(VC),a potent antioxidant,may enhance the efficacy of Mg^(2+) in OA treatment.This study aims to investigate the efficacy of combination of Mg^(2+)and VC on alleviating joint destruction and pain in OA.Material and methods:Anterior cruciate ligament transection with partial medial meniscectomy induced mice OA model were randomly received intra-articular injection of either saline,MgCl2(0.5 mol/L),VC(3 mg/ml)or MgCl2(0.5 mol/L)plus VC(3 mg/ml)at week 2 post-operation,twice weekly,for 2 weeks.Joint pain and pathological changes were assessed by gait analysis,histology,western blotting and micro-CT.Results:Mg^(2+) and VC showed additive effects to significantly alleviate the joint destruction and pain.The efficacy of this combined therapy could sustain for 3 months after the last injection.We demonstrated that VC enhanced the promotive effect of Mg^(2+) on HIF-1αexpression in cartilage.Additionally,combination of Mg^(2+) and VC markedly promoted the M2 polarization of macrophages in synovium.Furthermore,combination of Mg^(2+) and VC inhibited osteophyte formation and expressions of pain-related neuropeptides.Conclusions:Intra-articular administration of Mg^(2+)and VC additively alleviates joint destruction and pain in OA.Our current formulation may be a cost-effective alternative treatment for OA. | Hao Yao Jiankun Xu Jiali Wang Yifeng Zhang Nianye Zheng Jiang Yue Jie Mi Lizhen Zheng Bingyang Dai Wenhan Huang Shuhang Yung Peijie Hu Yechun Ruan Qingyun Xue Kiwai Ho Ling Qin | 2021 | Bioactive Materials2021，6，5： | 1 |
| 8 | Single image haze removal using content-adaptive dark channel and post enhancement显示文摘 | Bo Li Shuhang Wang Jin Zheng Liping Zheng | 2014 | IET Computer Vision2014，8，2： | 1 |
| 9 | Influence of Chemotherapy on EGFR Mutation Status Among Patients With Non–Small-Cell Lung Cancer显示文摘 | Hua Bai Zhijie Wang Keneng Chen Jun Zhao J. Jack Lee Shuhang Wang Qinghua Zhou Minglei Zhuo Li Mao Tongtong An Jianchun Duan Lu Yang Meina Wu Zhen Liang Yuyan Wang Xiaozheng Kang Jie Wang | 2012 | Journal of Clinical Oncology2012，，25： | 1 |
| 10 | Naturalness preserved enhancement algorithm for non-uniform illumination images显示文摘 | Wang Shuhang Zheng Jin Hu Haimiao | 2013 | IEEE Transactions on Image Processing2013，22，9： | 1 |
| 11 | A fast image dehazing algorithm based on negative correction显示文摘 | Gao Yuanyuan Hu Haimiao Wang Shuhang | 2014 | Signal Processing2014，103，10： | 1 |
| 12 | Community-based study of the association of subclinical thyroid dysfunction with blood pressure显示文摘 | Yu Duan Wen Peng Xiaodong Wang Wei Tang Xiaoyun Liu Shuhang Xu Xiaodong Mao Shangyong Feng Yu Feng Youwen Qin Kuanfeng Xu Cuiping Liu Chao Liu | 2009 | Endocrine2009，，2： | 1 |
| 13 | Spatial-temporal variability of snow cover over the Amur River Basin inferred from MODIS daily snow products in recent decades显示文摘MODIS snow products MOD10A1\MYD10A1 provided us a unique chance to investigate snow cover as well as its spatial-temporal variability in response to global changes from regional and global perspectives.By means of MODIS snow products MOD10A1\MYD10A1 derived from an extensive area of the Amur River Basin,mainly located in the Northeast part of China,some part in far east area of the former USSR and a minor part in Republic of Mongolia,the reproduced snow datasets after removal of cloud effects covering the whole watershed of the Amur River Basin were generated by using 6 different cloud-effect-removing algorithms.The accuracy of the reproduced snow products was evaluated with the time series of snow depth data observed from 2002 to 2010 within the Chinese part of the basin,and the results suggested that the accuracies for the reproduced monthly mean snow depth datasets derived from 6 different cloud-effect-removing algorithms varied from 82%to 96%,the snow classification accuracies(the harmonic mean of Recall and Precision)was higher than 80%,close to the accuracy of the original snow product under clear sky conditions when snow cover was stably accumulated.By using the reproduced snow product dataset with the best validated cloud-effect-removing algorithm newly proposed,spatial-temporal variability of snow coverage fraction(SCF),the date when snow cover started to accumulate(SCS)as well as the date when being melted off(SCM)in the Amur River Basin from 2002 to 2016 were investigated.The results indicated that the SCF characterized the significant spatial heterogeneity tended to be higher towards East and North but lower toward West and South over the Amur River Basin.The inter-annual variations of SCF showed an insignificant increase in general with slight fluctuations in majority part of the basin.Both SCS and SCM tended to be slightly linear varied and the inter-annual differences were obvious.In addition,a clear decreasing trend in snow cover is observed in the region.Trend analysis(at 10%significance level)showed that 71%of areas between 2,000 and 2,380 m a.s.l.experienced a reduction in duration and coverage of annual snow cover.Moreover,a severe snow cover reduction during recent years with sharp fluctuations was investigated.Overall spatial-temporal variability of Both SCS and SCM tended to coincide with that of SCF over the basin in general. | XiaoLin Lu WanChang Zhang ShuHang Wang Bo Zhang QuanFu Niu JinPing Liu Hao Chen HuiRan Gao | 2020 | Research in Cold and Arid Regions2020，12，6： | 1 |
| 14 | Single Image Haze Removal Using Content-adaptive Dark Channel and Post Enhancement显示文摘 | Li Bo Wang Shuhang Zheng Jin | 2014 | IET Computer Vision2014，8，2： | 1 |
| 15 | A'messenger zone hypothesis'based on the visual three-dimensional spatial distribution of motoneurons innervating deep limb muscles显示文摘Coordinated contraction of skeletal muscles relies on selective connections between the muscles and multiple classes of the spinal motoneuro ns.Howeve r,current research on the spatial location of the spinal motoneurons innervating differe nt muscles is limited.In this study,we investigated the spatial distribution and relative position of different motoneurons that control the deep muscles of the mouse hindlimbs,which were innervated by the obturator nerve,femoral nerve,inferior gluteal nerve,deep pe roneal nerve,and tibial nerve.Locations were visualized by combining a multiplex retrograde tracking technique compatible with three-dimensional imaging of solvent-cleared o rgans(3DISCO)and 3-D imaging technology based on lightsheet fluorescence microscopy(LSFM).Additionally,we propose the hypothesis that'messenger zones'exist as interlaced areas between the motoneuron pools that dominate the synergistic or antagonist muscle groups.We hypothesize that these interlaced neurons may participate in muscle coordination as messenger neurons.Analysis revealed the precise mutual positional relationships among the many motoneurons that innervate different deep muscles of the mouse.Not only do these findings update and supplement our knowledge regarding the overall spatial layout of spinal motoneurons that control mouse limb muscles,but they also provide insights into the mechanisms through which muscle activity is coordinated and the architecture of motor circuits. | Chen Huang Shen Wang Jin Deng Xinyi Gu Shuhang Guo Xiaofeng Yin | 2024 | Neural Regeneration Research2024，19，7： | 0 |
| 16 | Whole-exome sequencing reveals genetic underpinnings of salivary adenoid cystic carcinoma in the Chinese population显示文摘Salivary gland carcinomas(SGCs)are rare malignancies that remain poorly understood owing to their low incidence(Matsuba et al.,1986b;Liu et al.,2012).As per GLOBOCAN 2018.52.800 new cancers arising from salivary glands were estimated to be diag-nosed across the world that year.Because of their high propensity to invade local and perineural structures. | Shuhang Wang Yue Yu Yuan Fang Huiyao Huang Dawei Wu Hong Fang Ying Bai Chao Sun Anqi Yu Qi Fan Zicheng Yu Chao Zhang Changxi Wang Zaixian Tai Yi Huang Ning Li | 2020 | Journal of Genetics and Genomics2020，47，7： | 0 |
| 17 | A deep insight into the structural characteristics of Yilan oil shale kerogen through selective oxidation显示文摘The structural characteristics of oil shale are important to its application.In this work,a deep insight into the structural characteristics of Yilan oil shale kerogen(YLK)was studied using alkali-oxygen oxidation at different times and ruthenium ion catalyzed oxidation(RICO).The results indicate that YLK is gradually converted to humic acids(HAs),water-soluble acids(WSAs),carboxylic acids(CAs),CO_(2)and H_(2)O.^(13)C NMR analyses of YLK,residues and HAs indicate that C-O bonds,especially C_(ar)-O bonds of YLK,are easily cleaved.The condensed aromatic rings and long alkyl chains are difficult to be oxidized during the oxidation process.With increasing oxidation time,the molar fraction of aromatic bridgehead carbon(Xb)of YLK and the residues increases from 0.174 to 0.201,and that of HAs increases from 0.225 to 0.267.The result indicates that the aromatic structures of YLK are composed of 1-ring aromatic clusters(26.5%),2-ring aromatic clusters(67.1%)and 3 or more-ring aromatic clusters(6.4%).Also,the average methylene chain(Cn)of YLK and the residues increases from 2.0 to 5.1,and that of HAs increases from 1.3 to 2.7,indicating that the alkyl chain length is not average but has a distribution.2.5%methylene carbons exist as long n-alkyl chains in the alkyl side chains groups(SCGs)on the aromatic rings in YLK.The carbon number of SCGs ranges from 5 to 22,and C_(15)and C_(17)are predominant.3.8%methylene carbons exist as alkyl bridges linkages(BLs)connecting aromatic rings in YLK.The carbon number of BLs connecting aromatic rings ranges from 6 to 19,and C_(8)is predominant.Because of the existence of above long n-alkyl chains,93.7%methylene carbons in YLK exist as alkyl chains with an average length of 1.84. | Qian Wang Yucui Hou Weize Wu Yupeng Wang Qing Liu Shuhang Ren | 2019 | Carbon Resources Conversion2019，2，3： | 0 |
| 18 | Rare tumors: a blue ocean of investigation显示文摘Advances in novel drugs,therapies,and genetic techniques have revolutionized the diagnosis and treatment of cancers,substantially improving cancer patients’prognosis.Although rare tumors account for a non-negligible number,the practice of precision medicine and development of novel therapies are largely hampered by many obstacles.Their low incidence and drastic regional disparities result in the difficulty of informative evidence-based diagnosis and subtyping.Sample exhaustion due to difficulty in diagnosis also leads to a lack of recommended therapeutic strategies in clinical guidelines,insufficient biomarkers for prognosis/efficacy,and inability to identify potential novel therapies in clinical trials.Herein,by reviewing the epidemiological data of Chinese solid tumors and publications defining rare tumors in other areas,we proposed a definition of rare tumor in China,including 515 tumor types with incidences of less than 2.5/100000 per year.We also summarized the current diagnosis process,treatment recommendations,and global developmental progress of targeted drugs and immunotherapy agents on the status quo.Lastly,we pinpointed the current recommendation chance for patients with rare tumors to be involved in a clinical trial by NCCN.With this informative report,we aimed to raise awareness on the importance of rare tumor investigations and guarantee a bright future for rare tumor patients. | Shuhang Wang Peiwen Ma Ning Jiang Yale Jiang Yue Yu Yuan Fang Huilei Miao Huiyao Huang Qiyu Tang Dandan Cui Hong Fang Huishan Zhang Qi Fan Yuning Wang Gang Liu Zicheng Yu Qi Lei Ning Li | 2023 | Frontiers of Medicine2023，17，2： | 0 |
| 19 | Present Situation of Enhanced Recovery after Surgery in Shiyan Taihe Hospital and Plan of Establishing Strategic Alliance with General Surgery Department显示文摘The accelerated rehabilitation specialist surgery and general established strategic alliance plan of Taihe hospital is introduced in the paper.The background of strategic alliances established,and the political,environmental and technological factors are introduced,and stakeholder analysis and management plan,risk analysis and management plan are made.Furthermore,a junior coalition problem that may occur in the process and the resulting deep thinking is analyzed,to provide the reference and enlightenment for the management of hospital and establishment of strategic alliance. | Yang YAO Shuwen WANG Chunming MA Chao YU Pengtao ZHOU Qing ZHAO Shuhang ZHANG Jingping MU | 2021 | Medicinal Plant2021，12，6： | 0 |
| 20 | Radar Signal Intra-Pulse Modulation Recognition Based on Deep Residual Network显示文摘In view of low recognition rate of complex radar intra-pulse modulation signal type by traditional methods under low signal-to-noise ratio(SNR),the paper proposes an automatic recog-nition method of complex radar intra-pulse modulation signal type based on deep residual network.The basic principle of the recognition method is to obtain the transformation relationship between the time and frequency of complex radar intra-pulse modulation signal through short-time Fourier transform(STFT),and then design an appropriate deep residual network to extract the features of the time-frequency map and complete a variety of complex intra-pulse modulation signal type recognition.In addition,in order to improve the generalization ability of the proposed method,label smoothing and L2 regularization are introduced.The simulation results show that the proposed method has a recognition accuracy of more than 95%for complex radar intra-pulse modulation sig-nal types under low SNR(2 dB). | Fuyuan Xu Guangqing Shao Jiazhan Lu Zhiyin Wang Zhipeng Wu Shuhang Xia | 2024 | Journal of Beijing Institute of Technology2024，33，2： | 0 |
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