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| 1 | A Review on Swarm Intelligence and Evolutionary Algorithms for Solving Flexible Job Shop Scheduling Problems显示文摘Flexible job shop scheduling problems(FJSP)have received much attention from academia and industry for many years.Due to their exponential complexity,swarm intelligence(SI)and evolutionary algorithms(EA)are developed,employed and improved for solving them.More than 60%of the publications are related to SI and EA.This paper intents to give a comprehensive literature review of SI and EA for solving FJSP.First,the mathematical model of FJSP is presented and the constraints in applications are summarized.Then,the encoding and decoding strategies for connecting the problem and algorithms are reviewed.The strategies for initializing algorithms?population and local search operators for improving convergence performance are summarized.Next,one classical hybrid genetic algorithm(GA)and one newest imperialist competitive algorithm(ICA)with variables neighborhood search(VNS)for solving FJSP are presented.Finally,we summarize,discus and analyze the status of SI and EA for solving FJSP and give insight into future research directions. | Kaizhou Gao Zhiguang Cao Le Zhang Zhenghua Chen Yuyan Han Quanke Pan | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，4： | 32 |
| 2 | Hemiballism-hemichorea induced by ketotic hyperglycemia: case report with PET study and review of the literature显示文摘Hemiballism-hemichorea(HB-HC)is commonly used to describe the basal ganglion dysfunction in non-ketotic hyperglycemic elderly patients.Here we report two elderly female patients with acute onset of involuntary movements induced by hyperglycemia with positive urine ketones.We described the computed tomography and magnetic resonance imaging findings in these two patients,which is similar to that of non-ketotic hyperglycemic HB-HC patients.FDG-PET was performed and the glucose metabolism in the corresponding lesion in these two patients was contradictory with each other.We tried to clarify the underlying mechanisms of HB-HC and explain the contradictory neuroradiological findings in FDG-PET as being performed at different clinical stages. | Yuyan Tan Xiaoyu Xin Qin Xiao Shengdi Chen Li Cao Huidong Tang | 2014 | Translational Neurodegeneration2014，3，1： | 21 |
| 3 | Performance of dithiocarbamate-type flocculant in treating simulated polymer flooding produced water显示文摘Produced water from polymer flooding is difficult to treat due to its high polymer concentration,high viscosity,and emulsified characteristics.The dithiocarbamate flocculant,DTC (T403),was prepared by the amine-terminated polyoxypropane-ether compound known as Jeffamine-T403.The product was characterized by IR spectra and elemental analysis.The DTC agent chelating with Fe 2+ produced a network polymer matrix,which captured and removed oil droplets efficiently.Oil removal by the flocculent on simulated produced water with 0,200,500,900 mg/L of partially hydrolyzed polyacrylamide (HPAM) was investigated for aspects of effectiveness of DTC (T403) dosage and concentrations of HPAM and Fe 2+ ions in the wastewater.Results showed that HPAM had a negative influence on oil removal efficiency when DTC (T403) dosage was lower than 20 mg/L.However,residual oil concentrations in tested samples with different concentrations of HPAM all decreased below 10 mg/L when DTC (T403) dosage reached 30 mg/L.The concentration of Fe 2+ in the initial wastewater had a slight effect on oil removal at the range of 2-12 mg/L.Results showed that Fe 3+ could not be used in place of Fe 2+ as Fe 3+ could not react with DTC under flocculated conditions.The effects of mineral salts ions were also investigated. | Baoyu Gao | 2011 | Journal of Environmental Sciences2011，23，1： | 18 |
| 4 | Characteristics of Settings and Etiologic Agents of Foodborne Disease Outbreaks—China,2020显示文摘Introduction:Foodborne diseases are a growing public health problem and have caused a large burden of disease in China.This study analyzed epidemiological characteristics of foodborne diseases in China in 2020 to provide a scientific basis for prevention and control measures.Methods:Data were collected from 30 of 31 provincial-level administrative divisions(PLADs)in the mainland of China,excluding Xizang(Tibet)Autonomous Region,via the National Foodborne Disease Outbreaks Surveillance System・The number and proportion of outbreaks,illnesses,hospitalizations,deaths by setting,pathogen-food category pairs and etiology were calculated.Results:In 2020,7,073 foodborne disease outbreaks were reported,resulting in 37,454 illnesses and 143 deaths.Among the identified pathogens,microbial pathogens were the most common confirmed etiology,accounting for 41.7%of illnesses.Poisonous mushrooms caused the largest proportion of outbreaks(58.0%)and deaths(57.6%).For venues where foodborne disease outbreaks occur,household had the highest number of outbreaks(4,140)and deaths(128),and catering service locations caused the largest proportion of illnesses(59.9%).Outbreaks occurring between June and September accounted for 62.8%of total outbreaks.Conclusions:Foodborne disease outbreaks mainly occurred in households・Microbial pathogens remained the top cause of outbreak-associated illnesses.Poisonous mushrooms were ranked the top cause of deaths in private homes in China.The supervision and management of food safety and health education should be strengthened to reduce the burden of foodborne diseases・Publicity should be increased to reduce the incidence of mushroom poisonings in families,and supervision and management of food should be strengthened to reduce microbial contamination. | Hongqiu Li Weiwei Li Yue Dai Yuyan Jiang Junhua Liang Santao Wang Maoqiang Zhuang Zheng Huang Lizi Xu Bo Xue Jikai Liu Haihong Han Sara M.Pires Ping Fu Yunchang Guo | 2021 | China CDC weekly2021，3，42： | 14 |
| 5 | A de novo Genome of a Chinese Radish Cultivar显示文摘Here, we report a high-quality draft genome of a Chinese radish(Raphanus sativus) cultivar. This draft contains 387.73 Mb of assembled scaffolds, 83.93% of the scaffolds were anchored onto nine pseudochromosomes and 95.09% of 43 240 protein-coding genes were functionally annotated. 184.75 Mb(47.65%) of repeat sequences was identified in the assembled genome. By comparative analyses of the radish genome against 10 other plant genomes, 2 275 genes in 780 gene families were found unique to R. sativus. This genome is a good reference for genomic study and of great value for genetic improvement of radish. | ZHANG Xiaohui YUE Zhen MEI Shiyong QIU Yang YANG Xinhua CHEN Xiaohua CHENG Feng WU Zhangyan SUN Yuyan JING Yi LIU Bo SHEN Di WANG Haiping CUI Na DUAN Yundan WU Jian WANG Jinglei GAN Caixia WANG Jun WANG Xiaowu LI Xixiang | 2015 | Horticultural Plant Journal2015，1，3： | 10 |
| 6 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 7 | effective treatment of post-intubation subglottic stenosis in children with holmium laser therapy and cryotherapy via flexible bronchoscopy显示文摘Importance:Post-intubation subglottic stenosis(SGS)in children can be life threatening.Definitive treatment varies and lacks a universally accepted approach.Objective:We performed a prospective study to assess the safety and feasibility of holmium laser combined with cryotherapy delivered via flexible bronchoscopy for the treatment of post-intubation SGS in children.Methods:This study involved all patients with post-intubation SGS seen at the Interventional Pulmonology Department of Beijing Children's Hospital between July 2014 and December 2016.Holmium laser treatment and cryotherapy was then performed under flexible bronchoscopy,whose parents refused to accept the alternative standard treatment of tracheotomy and balloon dilation under direct laryngoscopy.results:Sixteen patients with post-intubation SGS were included in this study.Ages ranged from 2 months to 12.25 years old.According to the Cotton-Myer grading system,three cases were Grade II,12 cases were Grade III,and one case was Grade IV.According to the McCaffrey system,eight cases were Stage 1,two cases were Stage 2,and six cases were Stage 3.The average number of procedures was 4.88.Fifteen of the 16 patients achieved clinical cure.One patient achieved clinical improvement.The average treatment course duration was 55.31 days.No severe complications were seen.Post-treatment clinical symptoms,endoscopic findings and quality of life showed marked improvement.Interpretation:Our study supports the conclusion that holmium laser treatment combined with cryotherapy via flexible bronchoscopy appears to be a safe and feasible treatment for post-intubation SGS in children. | Anxia Jiao Fang Liu Andrew D.Lerner Xiaochun Rao Yan Guo Chenfang Meng Yuena Pan Gan Li Zheng Li Fang Wang Jing Zhao Yuyan Ma Xicheng Liu Xin Ni Kunling Shen | 2019 | Pediatric Investigation2019，3，1： | 10 |
| 8 | Freezing of gait in Parkinson’s disease: pathophysiology, risk factors and treatments显示文摘Background Freezing of gait(FOG)is a common,disabling symptom of Parkinson’s disease(PD),but the mechanisms and treatments of FOG remain great challenges for clinicians and researchers.The main focus of this review is to summarize the possible mechanisms underlying FOG,the risk factors for screening and predicting the onset of FOG,and the clinical trials involving various therapeutic strategies.In addition,the limitations and recommendations for future research design are also discussed.Main body In the mechanism section,we briefly introduced the physiological process of gait control and hypotheses about the mechanism of FOG.In the risk factor section,gait disorders,PIGD phenotype,lower striatal DAT uptake were found to be independent risk factors of FOG with consistent evidence.In the treatment section,we summarized the clinical trials of pharmacological and non-pharmacological treatments.Despite the limited effectiveness of current medications for FOG,especially levodopa resistant FOG,there were some drugs that showed promise such as istradefylline and rasagiline.Non-pharmacological treatments encompass invasive brain and spinal cord stimulation,noninvasive repetitive transcranial magnetic stimulation(rTMS)or transcranial direct current stimulation(tDCS)and vagus nerve stimulation(VNS),and physiotherapeutic approaches including cues and other training strategies.Several novel therapeutic strategies seem to be effective,such as rTMS over supplementary motor area(SMA),dual-site DBS,spinal cord stimulation(SCS)and VNS.Of physiotherapy,wearable cueing devices seem to be generally effective and promising.Conclusion FOG model hypotheses are helpful for better understanding and characterizing FOG and they provide clues for further research exploration.Several risk factors of FOG have been identified,but need combinatorial optimization for predicting FOG more precisely.Although firm conclusions cannot be drawn on therapeutic efficacy,the literature suggested that some therapeutic strategies showed promise. | Chao Gao Jun Liu Yuyan Tan Shengdi Chen | 2020 | Translational Neurodegeneration2020，9，2： | 9 |
| 9 | SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells显示文摘Intercellular adhesion molecule-1 (ICAM-1) plays an important role in the recruitment of leukocytes to the endothelium, which causes inflammation and initiation of atherosclerosis. We have previously shown that endothelium-specific over-expression of class III deacetylase SIRT1 decreases atherosclerosis. We therefore addressed the hypothesis that SIRT1 suppresses ICAM-1 expression in the endothelial cells. Here, we found that expression of SIRT1 and ICAM-1 was significantly induced by PMA and ionomycin (PMA/Io) in human umbilical vein endothelial cells (HUVECs). Adenovirus-mediated over-expression of SIRT1 significantly inhibited PMA/Io-induced ICAM-1 expression in HUVECs. Knockdown of SIRT1 by RNA interference (RNAi) resulted in increased expression of ICAM-1 in HUVECs. Luciferase report assay showed that over-expression of SIRT1 suppressed ICAM-1 promoter activity both in basic and in PMA/Io-induced conditions. We further found that SIRT1 was involved in transcription complex binding on the ICAM-1 promoter by chromatin immunoprecipitation (ChIP) assays. Furthermore, SIRT1 RNAi increased NF-κB p65 binding ability to the ICAM-1 promoter by ChIP assays. Overall, these data suggests that SIRT1 inhibits ICAM-1 expression in endothelial cells, which may contribute to its anti-atherosclerosis effect. | JIA YuYan GAO Peng CHEN HouZao WAN YanZhen ZHANG Ran ZHANG ZhuQin YANG RuiFeng WANG Xu XU Jing LIU DePei | 2013 | Science China(Life Sciences)2013，56，1： | 9 |
| 10 | Boost-Phase ballistic missile trajectory estimation with ground based radar显示文摘A conditional boost-phase trajectory estimation method based on ballistic missile (BM) information database and classification is developed to estimate and predict boos-phase BM trajectory. The main uncertain factors to describe BM dynamics equation are reduced to the control law of trajectory pitch angle in boost-phase. After the BM mass at the beginning of estimation, the BM attack angle and the modification of engine thrust denoting BM acceleration are modeled reasonably, the boost-phase BM trajectory estimation with ground based radar is well realized. The validity of this estimation method is testified by computer simulation with a typical example. | Tang Yuyan Huang Peikang | 2006 | Journal of Systems Engineering and Electronics2006，17，4： | 9 |
| 11 | Research of optical rainfall sensor based on CCD linear array显示文摘Rainfall monitoring is one of the most important meteorological observation elements for the disaster weather. The maintenance of current tipping bucket rain gauge and weighing type rain gauge is a critical issue. The optical rainfall sensor based on CCD linear array is mainly studied in this paper. Because of the maintenance-free time and good adaptability,it can be widely used in the automatic rainfall monitoring in severe environment and have a good perspective in using. | YANG Bifeng LIU Yuyan LU Ying WU Shangqian | 2015 | Instrumentation2015，2，3： | 9 |
| 12 | Mortality outcomes of low-dose computed tomography screening for lung cancer in urban China:a decision analysis and implications for practice显示文摘Background: Mortality outcomes in trials of low-dose computed tomography(CT) screening for lung cancer are inconsistent. This study aimed to evaluate whether CT screening in urban areas of China could reduce lung cancer mortality and to investigate the factors that associate with the screening effect.Methods: A decision tree model with three scenarios(low-dose CT screening, chest X-ray screening, and no screening) was developed to compare screening results in a simulated Chinese urban cohort(100,000 smokers aged45-80 years). Data of participant characteristics were obtained from national registries and epidemiological surveys for estimating lung cancer prevalence. The selection of other tree variables such as sensitivities and specificities of low-dose CT and chest X-ray screening were based on literature research. Differences in lung cancer mortality(primary outcome), false diagnoses, and deaths due to false diagnosis were calculated. Sensitivity analyses were performed to identify the factors that associate with the screening results and to ascertain worst and optimal screening effects considering possible ranges of the variables.Results: Among the 100,000 subjects, there were 448,541, and 591 lung cancer deaths in the low-dose CT, chest X-ray, and no screening scenarios, respectively(17.2% reduction in low-dose CT screening over chest X-ray screening and 24.2% over no screening). The costs of the two screening scenarios were 9387 and 2497 false diagnoses and 7and 2 deaths due to false diagnosis among the 100,000 persons, respectively. The factors that most influenced death reduction with low-dose CT screening over no screening were lung cancer prevalence in the screened cohort, lowdose CT sensitivity, and proportion of early-stage cancers among low-dose CT detected lung cancers. Considering all possibilities, reduction in deaths(relative numbers) with low-dose CT screening in the worst and optimal cases were16(5.4%) and 288(40.2%) over no screening, respectively.Conclusions: In terms of mortality outcomes, our findings favor conducting low-dose CT screening in urban China.However, approaches to reducing false diagnoses and optimizing important screening conditions such as enrollment criteria for screening are highly needed. | Zixing Wang Wei Han Weiwei Zhang Fang Xue Yuyan Wang Yaoda Hu Lei Wang Chunwu Zhou Yao Huang Shijun Zhao Wei Song Xin Sui Ruihong Shi Jingmei Jiang | 2017 | Chinese Journal of Cancer2017，36，8： | 9 |
| 13 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 14 | Differences of Hydrocarbon Enrichment between the Upper and the Lower Structural Layers in the Tazhong Paleouplift显示文摘Tazhong paleouplift 被划分成上面并且更低的结构的层,在奥陶纪碳酸盐岩石的顶由不顺从表面跳了。在从不同部分的二层的水库在数字变化,类型和储备,而是机制以前很少被研究。因此,机制的解释将在 Tazhong paleouplift 支持石油探索。在学习进化和 Tazhong paleouplift 的水库分发以后,在晚古苏格兰的、迟了的 Hercynian 和喜玛拉雅的时期的进化导致了,这被结束上面并且更低的结构的层。这也被定义在上面的结构的层,结构并且, stratigraphic 重叠水库为更低的结构的层在顶和 paleouplift 的上面的部分被开发,它被油水库统治, lithological 水库在 paleouplift 的更低的部分被开发,它被煤气的水库,和更多统治储备在更低的结构的层被发现比上面。通过累积条件的比较分析上面并且更低的结构的层,丰富差别的机制清楚地被解释。更低的结构的层的水库和封口条件比上面的层的那些好,它是更多的水库在前者被发现了的原因。在搬运人系统类型,陷井类型和收费时期在之间的差别上面并且更低的结构的层在水库类型和分布导致差别。一个累积模型为 Tazhong paleouplift 被建立。为上面的结构的层,,结构的水库和 stratigraphic 重叠水库为更低的结构的层在 paleouplift 的上面的部分被形成,捱过的外壳水库在顶被形成,礁石公寓水库在侧面的边缘上被形成,石灰岩地区常见的地形和里面水库在 paleouplift 的更低的部分被形成。 | JIANG Zhenxue YANG Haijun LI Zhuo PANG Xiongqi HAN Jianfa LI Dongxu HUANG Yuyan | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 7 |
| 15 | Delivery of Tapasin-modified CTL epitope peptide via cytoplasmic transduction peptide induces CTLs by JAK/STAT signaling pathway in vivo显示文摘特定的细胞毒素的 T 淋巴细胞(CTL ) 玩的肝炎 B 病毒(HBV ) 在病毒的控制和清理的一个重要角色。最近的研究阐明了那 Tapasin, endoplasmic 蜂窝胃女伴,是看起来在装载肽的过程必要的一个著名分子。Janus kinase/signal 变换器和小径玩的抄写(JAK/STAT ) 的使活跃之物在有免疫力的反应的一个重要角色规定和 cytokines 分泌物。我们以前证实了熔化蛋白质 CTP-HBcAg 18-27-Tapasin 能便于骨头髓的成熟导出的树枝状的房间并且在 vitro 提高特定的 CTL 回答,它可能与 JAK/STAT 发信号的激活被联系小径。为了进一步探索 JAK/STAT 发信号小径是否参予了特定的有免疫力的回答,由我们压制了的 CTP-HBcAg 18-27-Tapasin, 调停了有在 vivo 的药理学禁止者(AG490 ) 的 JAK/STAT 小径。我们的研究证明 IFN-+-CD8+ T 房间的数字在被 AG490 堵住以后与另外的组相比显著地被减少。IFN-+-CD4+ T 房间和 IL-2-CD4 + T 房间的百分比也被减少。而且, Jak2, Tyk2, STAT1,和 STAT4 的更低的表示层次在 AG490 被检测组。另外,象 Th1 一样 cytokines 的分泌物层次被减少,更弱的特定的 T 房间回答在 AG490 组被观察。而且,在这条小径在 HBV 转基因的老鼠被禁止以后,在浆液的 HBV DNA 和 HBsAg 的层次和在肝纸巾的 HBsAg 和 HBcAg 的表示层次被提高。这些结果证明表明小径的 JAK/STAT 参予 CTP-HBcAg 18-27-Tapasin 导致的 Th1 面向的有免疫力的反应,这可能为 HBV 免疫疗法提供一个理论基础。 | Shanshan Wu Xiaohua Chen Yuyan Tang Yi Zhang Dan Li Jie Chen Jieling Wang Zhenghao Tang Guoqing Zang Yongsheng Yu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 6 |
| 16 | Hydrothermal treatment of MSWI fly ash for simultaneous dioxins decomposition and heavy metal stabilization显示文摘Researches on the hydrothermal treatment of municipal solid waste incineration(MSWI)fly ash were conducted to eliminate dioxins and stabilize heavy metals.In order to enhance decomposing polychlorinated dibenzodioxins(PCDDs)and polychlorinated dibenzo-furans(PCDFs)during hydrothermal process,a strong reductant carbohydrazide(CHZ)is introduced.A hydrothermal reactor was set up by mixing raw MSWI fly ash or the pre-treated fly ash with water and then heated to a pre-set temperature;CHZ was spiked into solution according to specially defined dosage.Experimental results showed that under the temperatures of 518 K and 533 K,the decomposition rates of PCDDs/PCDFs were over 80%and 90%,respectively,by total concentration.However,their toxic equivalent(TEQ)decreased only slightly or even increased due to the rising in concentration of congeners 2,3,7,8-TCDD/TCDF,which might be resulted from the highly chlorinated congeners losing their chlorine atoms and being degraded during the hydrothermal process.Better results of TEQ reduction were also obtained under the higher tested temperature of 533 K and reactor with addition of 0.1%wt CHZ was corresponded to the best results.Good stabilization of heavy metals was also obtained in the same hydrothermal process especially when ferrous sulphate was added as auxiliary agent. | Jinlong XIE Yuyan HU Dezhen CHEN Bin ZHOU | 2010 | Frontiers of Environmental Science & Engineering2010，4，1： | 6 |
| 17 | Flavonols Induced by 5-Aminolevulinic Acid Are Involved in Regulation of Stomatal Opening in Apple Leaves显示文摘Flavonols, the main flavonoids in plant leaves, have newly been proposed as a H2O2 scavenger in guard cells. However, whether 5-aminolevulinic acid(5-ALA) is involved in regulating stomatal movement of apple(Malus × domestica Borkh. ‘Fuji') leaves through flavonol accumulation remains unclear. In this study, using diphenylboric acid 2-amino ethyl ester(DPBA, a flavonol fluorescent dye) and a laser scanning confocal microscope,we observed that 5-ALA pretreatment significantly improved flavonol accumulation in guard cells of apple leaves, especially around the nucleus.Then we demonstrated that 5-ALA pretreatment inhibited ABA-induced stomatal closure via decreasing reaction oxygen species(ROS) accumulation in guard cells. Pretreatment with quercetin or kaempferol, two main kinds of flavonols in plants, also inhibited ABA-induced stomatal closure by decreasing ROS content in the guard cells. Furthermore, exogenous flavonols could suppress H2O2-induced stomatal closure in apple leaves.Taken together, we conclude that ALA-induced flavonol accumulation in guard cells is involved in the inhibitory effect of ALA on ABA-induced ROS accumulation and stomatal closure in apple leaves. | LIU Longbo XIONG Lijun AN Yuyan ZHENG Jie WANG Liangju | 2016 | Horticultural Plant Journal2016，2，6： | 6 |
| 18 | Features analysis on Traditional Chinese Medicine syndromes in patients with diabetic peripheral neuropathy显示文摘OBJECTIVE:To study the features of the distribution and differentiation ofTraditional Chinese Medicine(TCM)syndromes in patients with diabetic peripheral neuropathy(DPN).METHODS:We collected clinical data on illness course,age,fasting blood glucose,saccharogenic hemoglobin,TCM syndromes,tongue,and pulse of238 DPN patients.Differentiated main syndromes(Yin deficiency and exuberant heat,invasion of spleen by damp-heat,deficiency of both Qi and Yins,and deficiency of both Yin and Yang)and accompanying syndromes(blood stasis and phlegm-dampness)of diabetes were also recorded.The features of DPN syndromes were then analyzed.RESULTS:Among the four main syndromes of diabetes,deficiency of both Yin and Yang was the most common in the 238 DPN patients,of which89%-96%had blood stasis.CONCLUSION:The method of differentiating syndromes of diabetes can be applied to DPN patients.Deficiency of both Yin and Yang,often accompanied by blood stasis,is commonly seen. | Mingdi Li Hao Su Yuyan Xiang Jingyi Zhang Jingjie Zhao Lan Lin | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 19 | Fighting the enemy: How rice survives the blast pathogen's attack显示文摘Global food security is threatened by rice blast disease caused by the filamentous fungus Magnaporthe oryzae.An understanding of rice resistance mechanisms is fundamental to developing strategies for disease control.In this review,we summarize recent advances in pathogen-associated molecular pattern-triggered immunity,effector-triggered immunity,defense regulator-mediated immunity,and effects of nutrient elements on rice blast resistance.We outline strategies used for breeding rice cultivars with improved disease resistance.We also present the major research challenges for rice blast disease resistance and propose approaches for future investigation. | Junjie Yin Lijuan Zou Xiaobo Zhu Yuyan Cao Min He Xuewei Chen | 2021 | The Crop Journal2021，9，3： | 6 |
| 20 | Co-pyrolysis characteristics of typical components of waste plastics in a falling film pyrolysis reactor显示文摘Waste plastics mainly come from MSW and usually exist in the form of mixed plastics. During the co-pyrolysis process of mixed plastics, various plastic components have different physicochemical properties and reaction mechanisms. Considering the high viscosity and low thermal conductivity of molten plastics, a falling film pyrolysis reactor was selected to explore the rapid co-pyrolysis process of typical plastic components(PP, PE and PS).The oil and gas yields and the compositions of pyrolysis products of the three components under different ratios at pyrolysis temperatures were analyzed to explore the co-pyrolysis characteristics of PP, PE, and PS. The study is of great significance to the recycling of waste plastics. | Zechen Jin Lijie Yin Dezhen Chen Yuanjie Jia Jun Yuan Yuyan Hu | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 5 |
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