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| 1 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 2 | Optimization Study on Graphene-Coated Microfiber Bragg Grating Structures for Ammonia Gas Sensing显示文摘在 graphene 的表面地和迅速凋落的改进的刺激出现了对在高敏感的生物化学的察觉到包围媒介和潜在的应用的折射索引敏感。在这份报纸,我们为察觉到的氨气体与不同直径调查 graphene 涂的 microfiber 布拉格栅栏(GMFBG ) 。当 microfibers 直径是大约 10 m 时,有 6 pm/ppm 的最大的敏感试验性地被完成。而且由调整 GMFBG 的直径, GMFBG 的察觉到的表演能被优化。试验性的结果与 12 m 将显示出的 8 m 的直径显示了那 GMFBG 高敏感,相对低变细,和大动态范围的特征。 | Anqi ZHANG Yu WU Baicheng YAO Yuan GONG | 2015 | Photonic Sensors2015，5，1： | 10 |
| 3 | Chinese multidisciplinary guideline for management of hypertensiveintracerebral hemorrhage显示文摘ypertensive intracerebral hemorrhage(HICH)refers tothe sudden onset of hemorrhage within cerebral paren-chyma or ventricles of patients with a history ofhypertension.Secondary intracerebral hemorrhage(ICH)with an underlying causative pathology,such astrauma,structural blood vessel abnormalities,coagulationor hematological disorder(s),systemic diseases,or neo-plasms,should be excluded to make the diagnosis ofHICH.HICH is characterized by high incidence,disabili-ty,mortality,and recurrence rates.In 2015,experts fromthe Chinese Medical Association branch of Neurosurgery,Chinese Medical Doctor Association branch of theEmergency Physician and Stroke Screening,and Preven-tion and Treatment Committee of the National HealthCommission of the People’s Republic of China gathered toformulate and draft the Chinese Multidisciplinary ExpertsConsensus on the Management of Spontaneous Intrace-rebral Hemorrhage.[1]This consensus has played animportant role in guiding and standardizing the manage-ment of spontaneous ICH in China. | Zhiyuan Yu Chuanyuan Tao Anqi Xiao Cong Wu Min Fu Wei Dong Ming Liu Xuezhong Yu Chao You | 2022 | Chinese Medical Journal2022，135，19： | 6 |
| 4 | Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration显示文摘Macrophages play an important role in material-related immune responses and bone formation,but the functionality of macrophage-derived extracellular vesicles(EVs)in material-mediated bone regeneration is still unclear.Here,we evaluated intracellular communication through small extracellular vesicles(sEVs)and its effects on endogenous bone regeneration mediated by biomimetic intrafibrillarly mineralized collagen(IMC).After implantation in the bone defect area,IMC generated more neobone and recruited more mesenchymal stem cells(MSCs)than did extrafibrillarly mineralized collagen(EMC).More CD63+CD90+and CD63+CD163+cells were detected in the defect area in the IMC group than in the EMC group.To determine the functional roles of sEVs,extracellular vesicles from macrophages cultured on different mineralized collagen were isolated,and they showed no morphological differences.However,macrophage-derived sEVs in the IMC group showed an enhanced Young’s modulus and exerted beneficial effects on the osteogenic differentiation of bone marrow MSCs by increasing the expression of the osteoblastic differentiation markers BMP2,BGLAP,COL1,and OSX and calcium nodule formation.Mechanistically,sEVs from IMC-treated macrophages facilitated MSC osteogenesis through the BMP2/Smad5 pathway,and blocking sEV secretion with GW4869 significantly impaired MSC proliferative,immunomodulative and osteogenic potential.Taken together,these findings show that macrophage-derived sEVs may serve as an emerging functional tool in biomaterial-mediated endogenous bone regeneration. | Anqi Liu Shanshan Jin Cuicui Fu Shengji Cui Ting Zhang Lisha Zhu Yu Wang Steve G.F.Shen Nan Jiang Yan Liu | 2020 | International Journal of Oral Science2020，12，4： | 5 |
| 5 | An Improved DV-Hop Localization Algorithm Based on Selected Anchors显示文摘Wireless Sensor Network(WSN)based applications has been extraordinarily helpful in monitoring interested area.Only information of surrounding environment with meaningful geometric information is useful.How to design the localization algorithm that can effectively extract unknown node position has been a challenge in WSN.Among all localization technologies,the Distance Vector-Hop(DV-Hop)algorithm has been most popular because it simply utilizes the hop counts as connectivity measurements.This paper proposes an improved DV-Hop based algorithm,a centroid DV-hop localization with selected anchors and inverse distance weighting schemes(SIC-DV-Hop).We adopt an inverse distance weighting method for average distance amelioration to improve accuracy.Also in this paper,we propose an inclusive checking rule to select proper anchors to avoid the inconsistency existing in centroid localization schemes.Finally,an improved multilateration centroid method is presented for the localization.Simulations are conducted on two different network topologies and experiments results show that compared with existing DV-Hop based algorithms,our algorithm can significantly improve the performance meanwhile cost less network resource. | Jing Wang Anqi Hou Yuanfei Tu Hong Yu | 2020 | Computers, Materials & Continua2020，，10： | 2 |
| 6 | In-situ hydrothermal synthesized γ-Al_2O_3/O-g-C_3N_4 heterojunctions with enhanced visible-light photocatalytic activity in water splitting for hydrogen显示文摘In this work,γ-Al_2O_3 and hydrogen peroxide treated g-C_3N_4(O-g-C_3N_4) were combined through a novel in-situ hydrothermal method to form heterojunction structured photocatalysts.These photocatalysts were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FT-IR),X-ray photoelectron spectroscopy(XPS),UV–vis diffuse reflectance spectroscopy and photoluminescence spectroscopy(PL).FT-IR results indicate that oxygen functional groups can be grafted on the surface of O-g-C_3N_4 by hydrogen peroxide treatment.The visible light photocatalytic hydrogen evolution rate was investigated in 10 vol% TEOA aqueous solution.The optimal Al_2O_3 mass content is set to be 20 wt% and the corresponding hydrogen evolution rate is 1288 μmol/h/g which is approximately 6,3 folds that of pristine g-C_3N_4 and O-g-C_3N_4 respectively and 1.6 folds that of mechanical mixed composite with the same Al_2O_3 mass content.The photocurrent density–time curves were carried out under visible light illumination for four on–off cycles.The electrochemical impedance spectroscopy(EIS) measurements verified the enhanced separation efficiency of electron–hole pairs.This work raised a new method to form the heterojunction structured photocatalysts and achieved a remarkable improvement of the photocatalytic activity in water splitting for hydrogen under visible light irradiation. | Yu Wang Yaping Zeng Boqiao Li Anqi Li Ping Yang Liu Yang Gang Wang Jinwei Chen Ruilin Wang | 2016 | Journal of Energy Chemistry2016，25，4： | 1 |
| 7 | Characteristics of subsurface mesoscale eddies in the northwestern tropical Pacifi c Ocean from an eddy-resolving model显示文摘Subsurface eddies(SSEs)are common features of the ocean interior.They are particularly abundant in oceanic basins and the vicinity of major intermediate water outfl ows.They are responsible for subsurface transport of mass,heat,and salt.Analysis of high-resolution general circulation model data has revealed the existence of subsurface anticyclonic eddies(SSAEs)and subsurface cyclonic eddies(SSCEs)in the northwestern tropical Pacifi c Ocean.SSEs are abundant east of the Philippines(0°–22°N,120°E–140°E)and in latitude bands between 9°N–17°N east of 140°E.The composite structure of SSEs was investigated.SSEs had a core at about 400-m water depth and their maximum meridional velocity exceeded 10 cm/s.They exhibited two cores with diff erent salinity polarities in the surface and subsurface.Additionally,spatial distributions of heat transport induced by SSEs in the northwestern tropical Pacifi c were presented for the fi rst time.A net equatorward heat fl ux toward a temperature up-gradient was observed.The analysis of eddy-mean fl ow interactions revealed that the circulation is baroclinically and barotropically unstable at diff erent depths and to diff ering degrees.The energy conversions suggest that both barotropic and baroclinic instabilities are responsible for SSE generation east of the Philippines,whereas baroclinic instability caused by a horizontal density gradient and vertical eddy heat fl ux are important between 9°N and 17°N east of 140°E.Meridional movement of the north equatorial current and the north equatorial undercurrent can contribute to SSE generation in our study region. | XU Anqi YU Fei NAN Feng REN Qiang | 2020 | Journal of Oceanology and Limnology2020，38，5： | 1 |
| 8 | DNA demethylases remodel DNA methylation in rice gametes and zygote and are required for reproduction显示文摘Fertilization constitutes a critical step in the plant life cycle during which the gamete genomes undergo chromatin dynamics in preparation for embryogenesis. In mammals, parental chromatin is extensively reprogrammed through the global erasure of DNA methylation. However, in flowering plants it remains unclear whether and how DNA methylation is remodeled in gametes and after fertilization in the zygote. In this study, we characterize DNA methylation patterns and investigate the function of DNA glycosylases in rice eggs, sperm, and unicellular zygotes and during embryogenesis. We found that DNA methylation is locally reconfigured after fertilization and is intensified during embryogenesis. Genetic, epigenomic, and transcriptomic analysis revealed that three rice DNA glycosylases, DNG702, DNG701, and DNG704, demethylate DNA at distinct genomic regions in the gametes and the zygote, and are required for zygotic gene expression and development. Collectively, these results indicate that active DNA demethylation takes place in the gametes and the zygote to locally remodel DNA methylation, which is critical for egg and zygote gene expression and reproduction in rice. | Shaoli Zhou Xue Li Qian Liu Yu Zhao Wei Jiang Anqi Wu Dao-Xiu Zhou | 2021 | Molecular Plant2021，14，9： | 1 |
| 9 | Vasorelaxant effects of purified green tea epicatechin derivatives in rat mesenteric artery显示文摘 | HUANG Yu ZHANG Anqi LAU Chiwai | 1998 | Life Sci1998，63，： | 1 |
| 10 | Retrieving chlorophyll content and equivalent water thickness of Moso bamboo(Phyllostachys pubescens) forests under Pantana phyllostachysae Chao-induced stress from Sentinel-2A/B images in a multiple LUTs-based PROSAIL framework显示文摘Biochemical components of Moso bamboo(Phyllostachys pubescens)are critical to physiological and ecological processes and play an important role in the material and energy cycles of the ecosystem.The coupled PROSPECT with SAIL(PROSAIL)radiative transfer model is widely used for vegetation biochemical component content inversion.However,the presence of leaf-eating pests,such as Pantana phyllostachysae Chao(PPC),weakens the performance of the model for estimating biochemical components of Moso bamboo and thus must be considered.Therefore,this study considered pest-induced stress signals associated with Sentinel-2A/B images and field data and established multiple sets of biochemical canopy reflectance look-up tables(LUTs)based on the PROSAIL framework by setting different parameter ranges according to infestation levels.Quantitative inversions of leaf area index(LAI),leaf chlorophyll content(LCC),and leaf equivalent water thickness(LEWT)were derived.The scale conversions from LCC to canopy chlorophyll content(CCC)and LEWT to canopy equivalent water thickness(CEWT)were calculated.The results showed that LAI,CCC,and CEWT were inversely related with PPC-induced stress.When applying multiple LUTs,the p-values were<0.01;the R2 values for LAI,CCC,and CEWT were 0.71,0.68,and 0.65 with root mean square error(RMSE)(normalized RMSE,NRMSE)values of 0.38(0.16),17.56μg cm-2(0.20),and 0.02 cm(0.51),respectively.Compared to the values obtained for the traditional PROSAIL model,for October,R2 values increased by 0.05 and 0.10 and NRMSE decreased by 0.09 and 0.02 for CCC and CEWT,respectively and RMSE decreased by 0.35μg cm-2 for CCC.The feasibility of the inverse strategy for integrating pest-induced stress factors into the PROSAIL model,while establishing multiple LUTs under different pest-induced damage levels,was successfully demonstrated and can potentially enhance future vegetation parameter inversion and monitoring of bamboo forest health and ecosystems. | Zhanghua Xu Anqi He Yiwei Zhang Zhenbang Hao Yifan Li Songyang Xiang Bin Li Lingyan Chen Hui Yu Wanling Shen Xuying Huang Xiaoyu Guo Zenglu Li | 2023 | Forest Ecosystems2023，10，2： | 0 |
| 11 | MtRGF3 peptide activates defense responses and represses the expressions of nodulation signaling genes in Medicago truncatula显示文摘Root meristem growth factors(RGFs)were first discovered in Arabidopsis thaliana and regulate root development,including primary root growth,lateral root formation and root gravitropism,etc.[1‒3].RGF belongs to a 13-amino-acid peptide family,which usually contains conserved aspartate(D1),tyrosine(Y2),proline(P9 and P10),histidine(H12)and asparagine(N13)residues.Among these residues,the second tyrosine residue(Y2)is modified by a sulfate group,and the tenth proline residue(P10)is hydroxylated[1‒3].The active peptide is processed from a precursor that consists of a signal peptide,a variant region and a conserved C-terminal domain.The peptide is recognized by the leucine rich repeat(LRR)receptor kinases(RGFR)and then regulates the activities of the AP transcription factors TLPs in A.[4‒6].Nine genes of AtRGF or AtGLV were identified in A.thaliana,and 15 corresponding genes were reported in the model legume Medicago truncatula[7]. | Qiong Li Dandan Shan Wenjia Zheng Yawen Wang Zhiyin Lin Huibo Jin Anqi Ding Junhui Yan Liangliang Yu Li Luo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 12 | Structural basis of Sphingosine-1-phosphate transport via human SPNS2显示文摘Dear Editor,Sphingosine 1-phosphate(S1P)plays crucial roles in various physiological processes,including immune response,vascular development,and neural system homeostasis1 through activating S1P receptors(S1PRs).Notably,a desirable concentration gradient of S1P which is achieved by S1P transporters,including spinster homolog 2 protein(SPNS2)and MFSD2B that transport S1P from the intracellular side to the extracellular side of cells,2,3 is essential for proper S1P signaling.SPNS2 and MFSD2B belong to the major facilitator superfamily(MFS),and specifically. | Yaning Duan Nancy C.P.Leong Jing Zhao Yu Zhang Dat T.Nguyen Hoa T.T.Ha Na Wang Ruixue Xia Zhenmei Xu Zhengxiong Ma Yu Qian Han Yin Xinyan Zhu Anqi Zhang Changyou Guo Yu Xia Long N.Nguyen Yuanzheng He | 2024 | Cell Research2024，34，2： | 0 |
| 13 | A Novel Design of Antenna Array with Two K-Band Circularly Polarized Antenna显示文摘As an important part of phased array system,the research on phased array antenna is very necessary.The phased array antenna achieves the scanning beam adaptively by regulating the phase difference between each array element.In this paper,a dual K-band circularly polarized antenna with high broadband,broadband beam,wide axial ratio bandwidth and high radiation efficiency is designed.We combine with the advantages of slot antenna and aperture antenna,use multimode waveguide cavity structure to design an aperture antenna,which is fed to waveguide circular polarizer by slot coupling in order to realize circular polarization radiation.Meanwhile,it has the characteristics of broadband,broadband beam,wide axial ratio bandwidth and high radiation efficiency.A slit antenna is designed by using a multimode waveguide cavity structure and a slit coupling feed to a waveguide circular polarizer is used to achieve circularly polarized radiation.The designed antenna consists of two K-band circularly polarized antenna units,and the spacing between the two units is 9.5 mm,which is fed by aK-band T/R module(Transmitter/Receiver module).In order to study the performance of the pattern in the case of the research group,the 2-unit structure is established.The simulation results of frequency–axial ratio bandwidth are given,and the simulation result of the antenna array is shown.The practical results of antenna design and test are also given. | Xiao Liu Anqi Li Zhongjun Yu Ting Lv Meng Li Zhen Zhang | 2023 | Computers, Materials & Continua2023，，3： | 0 |
| 14 | Anti-vascular endothelial growth factor drugs combined with laser photocoagulation maintain retinal ganglion cell integrity in patients with diabetic macular edema: study protocol for a prospective, non-randomized, controlled clinical trial显示文摘The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting vision.The major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser photocoagulation.However,although the macular thickness can be normalized with each of these two therapies used alone,the vision does not improve in many patients.This might result from the incomplete recovery of retinal ganglion cell injury.Therefore,a prospective,non-randomized,controlled clinical trial was designed to investigate the effect of anti-vascular endothelial growth factor drugs combined with laser photocoagulation on the integrity of retinal ganglion cells in patients with diabetic macular edema and its relationship with vision recovery.In this trial,150 patients with diabetic macular edema will be equally divided into three groups according to therapeutic methods,followed by treatment with anti-vascular endothelial growth factor drugs,laser photocoagulation therapy,and their combination.All patients will be followed up for 12 months.The primary outcome measure is retinal ganglion cell-inner plexiform layer thickness at 12 months after treatment.The secondary outcome measures include retinal ganglion cell-inner plexiform layer thickness before and 1,3,6,and 9 months after treatment,retinal nerve fiber layer thickness,best-corrected visual acuity,macular area thickness,and choroidal thickness before and 1,3,6,9,and 12 months after treatment.Safety measure is the incidence of adverse events at 1,3,6,9,and 12 months after treatment.The study protocol hopes to validate the better efficacy and safety of the combined treatment in patients with diabetic macula compared with the other two monotherapies alone during the 12-month follow-up period.The trial is designed to focus on clarifying the time-effect relationship between imaging measures related to the integrity of retinal ganglion cells and best-corrected visual acuity.The trial protocol was approved by the Medical Ethics Committee of the Affiliated Hospital of Beihua University with approval No.(2023)(26)on April 25,2023,and was registered with the Chinese Clinical Trial Registry(registration number:ChiCTR2300072478,June 14,2023,protocol version:2.0). | Xiangjun Li Chunyan Li Hai Huang Dan Bai Jingyi Wang Anqi Chen Yu Gong Ying Leng | 2024 | Neural Regeneration Research2024，19，4： | 0 |
| 15 | Whole-exome sequencing reveals genetic underpinnings of salivary adenoid cystic carcinoma in the Chinese population显示文摘Salivary gland carcinomas(SGCs)are rare malignancies that remain poorly understood owing to their low incidence(Matsuba et al.,1986b;Liu et al.,2012).As per GLOBOCAN 2018.52.800 new cancers arising from salivary glands were estimated to be diag-nosed across the world that year.Because of their high propensity to invade local and perineural structures. | Shuhang Wang Yue Yu Yuan Fang Huiyao Huang Dawei Wu Hong Fang Ying Bai Chao Sun Anqi Yu Qi Fan Zicheng Yu Chao Zhang Changxi Wang Zaixian Tai Yi Huang Ning Li | 2020 | Journal of Genetics and Genomics2020，47，7： | 0 |
| 16 | Dual-engineered cartilage-targeting extracellular vesicles derived from mesenchymal stem cells enhance osteoarthritis treatment via miR-223/NLRP3/pyroptosis axis:Toward a precision therapy显示文摘Osteoarthritis(OA)is the most common disabling joint disease with no effective disease modifying drugs.Extracellular vesicles released by several types of mesenchymal stem cells could promote cartilage repair and ameliorate OA pathology in animal models,representing a novel therapeutic strategy.In this study,we demonstrated that extracellular vesicles derived from human umbilical cord mesenchymal stem cells(hUC-EVs)could maintain chondrocyte homeostasis and alleviate OA,and further revealed a novel molecular mechanism of this therapeutic effect.miR-223,which could directly bind with the 3′UTR of NLRP3 mRNA,was found to be a key miRNA for hUC-EVs to exert beneficial effects on inflammation inhibiting and cartilage protecting.For enhancing the effect on mitigating osteoarthritis,exogenous miR-223 was loaded into hUC-EVs by electroporation,and a collagen II-targeting peptide(WYRGRL)was modified onto the surface of hUC-EVs by genetic engineering to achieve a more targeted and efficient RNA delivery to the cartilage.The dual-engineered EVs showed a maximal effect on inhibiting the NLRP3 inflammasome activation and chondrocyte pyroptosis,and offered excellent results for the treatment of OA.This study provides a novel theoretical basis and a promising therapeutic strategy for the application of engineered extracellular vesicles in OA treatment. | Weixuan Liu Anqi Liu Xujun Li Ziyang Sun Zhenghua Sun Yaru Liu Gang Wang Dan Huang Hao Xiong Shiyang Yu Xintao Zhang Cunyi Fan | 2023 | Bioactive Materials2023，，12： | 0 |
| 17 | Enhancing Li-ion conduction and mechanical properties via addition of fluorine-containing metal–organic frameworks in allsolid-state cross-linked hyperbranched polymer electrolytes显示文摘Poly(ethylene oxide)(PEO)-based solid polymer electrolytes(SPEs)are commonly used in lithium metal batteries(LMBs)for their good Li-salt solvating ability and easy processability.However,the relatively low Li-ion conduction ability hinders their further development.In this work,a novel hyperbranched-polyether-type composite solid polymer electrolyte(CSPE)is prepared via a quick cross-linking reaction between aldehyde-terminated polyethylene glycol(PEG)and hyperbranched poly(ethylene imine)(HPEI)in the presence of lithium salt and fluorine-containing Zr-based metal–organic framework(MOF)UiO-66-(F)_(4).The hydrogen bonds between the fluorine atoms and amino groups in the electrolyte help to the better dispersion of UiO-66-(F)_(4) in the polymer matrix,which is beneficial to solving the problem of aggregation of nanofillers.Besides,the CSPEs with the functional MOF fillers show improvements in both electrochemical and mechanical properties.Notably,the Li-ion transference number(t)is considerably enhanced from 0.23 to 0.54.All-solid-state LMBs based on the CSPE also present good cycling performances.A high specific discharge capacity of 141.4 mAh·g^(−1) is remained after 200 cycles at 0.2 C.This study not only provides an effective synthesis method of the cross-linked hyperbranched polymer electrolyte,but also puts forward a new strategy for uniform dispersion of inorganic fillers in CSPEs. | Wen Wen Qinghui Zeng Pingping Chen Xin Wen Zhenfeng Li Yu Liu Jiazhu Guan Anqi Chen Wei Liu Liaoyun Zhang | 2022 | Nano Research2022，15，10： | 0 |
| 18 | Target Detection Algorithm in Foggy Scenes Based on Dual Subnets显示文摘Under the influence of air humidity,dust,aerosols,etc.,in real scenes,haze presents an uneven state.In this way,the image quality and contrast will decrease.In this case,It is difficult to detect the target in the image by the universal detection network.Thus,a dual subnet based on multi-task collaborative training(DSMCT)is proposed in this paper.Firstly,in the training phase,the Gated Context Aggregation Network(GCANet)is used as the supervisory network of YOLOX to promote the extraction of clean information in foggy scenes.In the test phase,only the YOLOX branch needs to be activated to ensure the detection speed of the model.Secondly,the deformable convolution module is used to improve GCANet to enhance the model’s ability to capture details of non-homogeneous fog.Finally,the Coordinate Attention mechanism is introduced into the Vision Transformer and the backbone network of YOLOX is redesigned.In this way,the feature extraction ability of the network for deep-level information can be enhanced.The experimental results on artificial fog data set FOG_VOC and real fog data set RTTS show that the map value of DSMCT reached 86.56%and 62.39%,respectively,which was 2.27%and 4.41%higher than the current most advanced detection model.The DSMCT network has high practicality and effectiveness for target detection in real foggy scenes. | Yuecheng Yu Liming Cai Anqi Ning Jinlong Shi Xudong Chen Shixin Huang | 2024 | Computers, Materials & Continua2024，78，2： | 0 |
| 19 | Identification of oleic acid as an endogenous ligand of GPR3显示文摘Although GPR3 plays pivotal roles in both the nervous system and metabolic processes,such as cold-induced thermogenesis,its endogenous ligand remains elusive.Here,by combining structural approach(including cryo-electron microscopy),mass spectrometry analysis,and functional studies,we identify oleic acid(OA)as an endogenous ligand of GPR3.Our study reveals a hydrophobic tunnel within GPR3 that connects the extracellular side of the receptor to the middle of plasma membrane,enabling fatty acids to readily engage the receptor.Functional studies demonstrate that OA triggers downstream Gs signaling,whereas lysophospholipids fail to activate the receptor.Moreover,our research reveals that cold stimulation induces the secretion of OA in mice,subsequently activating Gs/cAMP/PKA signaling in brown adipose tissue.Notably,brown adipose tissues from Gpr3 knockout mice do not respond to OA during cold stimulation,reinforcing the significance of GPR3 in this process.Finally,we propose a“born to be activated and cold to enhance”model for GPR3 activation.Our study provides a starting framework for the understanding of GPR3 signaling in cold-stimulated thermogenesis. | Yangjie Xiong Zhenmei Xu Xinzhi Li Yuqin Wang Jing Zhao Na Wang Yaning Duan Ruixue Xia Zhengbin Han Yu Qian Jiale Liang Anqi Zhang Changyou Guo Asuka Inoue Yu Xia Zheng Chen Yuanzheng He | 2024 | Cell Research2024，34，3： | 0 |
| 20 | Research Progress on Biological Activity of Sciadopitysin显示文摘Sciadopitysin(SP)belongs to flavonoids.Recent studies showed that sciadopitysin has anti-tumor,anti-oxidation,treatment of osteoporosis,diabetic osteopathy,Alzheimer's disease and other effects.This study will review the biological activity and related action mechanism of the sciadopitysin in recent years,in order to provide theoretical basis and reference for the future research and drug development of the sciadopitysin. | Wenbo ZUO Yannan LI Hui XUE Tong ZHANG Yu ZHANG Anqi WANG Yue TENG Yinghua LUO Chenghao JIN | 2021 | Medicinal Plant2021，12，6： | 0 |
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