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| 1 | Impacts of climate variability and extremes on global net primary production in the first decade of the 21st century显示文摘许多研究估计了全球陆上的网的大小主要生产(NPP ) ,而是它的变化,空间地并且时间地,仍然保持不明确。由使用一个改进基于过程的陆上的生态系统模型( DLEM ,动态陆地生态系统模型),我们提供多重环境因素导致的全球陆上的 NPP 的估计并且在整个 第21 世纪的第一十年在生物群系和全球层次并且沿着纬度检验陆上的 NPP 的反应到气候可变性。模型模拟在 20002009 期间估计 54.6 Pg C 年 1 的平均全球陆上的 NPP,从 2002 ~ 56.4 Pg C 的干燥的年里的 52.8 Pg C 年 1 变化 2008 的湿年里的年 1 。在湿年里,与十的平均数相比的陆上的 NPP 的大增加在 Amazonia,非洲和澳大利亚是流行的。在干燥的年里,然而,我们与十的平均数相比在全球陆上的 NPP 发现了 3.2% 减小,首先由于在热带区域的有限潮湿供应。在全球水平,降水在陆上的 NPP 解释了约 63% 变化,当剩余的在温度和另外的环境因素被归因于变化时。降水是在低纬度的区域在陆上的 NPP 决定内部年度的变化的主要因素。在中间纬度、高纬度的区域,然而,温度可变性大部分控制了陆上的 NPP 的大小。我们的结果暗示温暖并且增加气候极端事件的那投射气候将改变大小和全球陆上的 NPP 的空间与时间的模式。 | PAN Shufen TIAN Hanqin DANGAL Shree R.S. OUYANG Zhiyun LU Chaoqun YANG Jia TAO Bo REN Wei BANGER Kamaljit YANG Qichun ZHANG Bowen | 2015 | Journal of Geographical Sciences2015，25，9： | 15 |
| 2 | JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila显示文摘In multicellular organisms, biological activities are regulated by cell signaling. The various signal transduction path- ways regulate cell fate, proliferation, migration, and polarity. Miscoordination of the communicative signals will lead to disasters like cancer and other fatal diseases. The JAK/STAT signal transduction pathway is one of the pathways, which was first identified in vertebrates and is highly conserved throughout evolution. Studying the JAK/STAT signal transduc- tion pathway in Drosophila provides an excellent opportunity to understand the molecular mechanism of the cell regu- lation during development and tumor formation. In this review, we discuss the general overview of JAK/STAT signaling in Drosophila with respect to its functions in the eye development and stem cell fate determination. | Shree Ram SINGH Steven X. HOU | 2005 | Cell Research2005，15，1： | 9 |
| 3 | Novel degradation products of argatroban: Isolation, synthesis and extensive characterization using NMR and LC-PDA-MS/Q-TOF显示文摘Forced degradation study of argatroban under conditions of hydrolysis(neutral, acidic and alkaline), oxidation,photolysis and thermal stress, as suggested in the ICH Q1 A(R2), was accomplished. The drug showed significant degradation under hydrolysis(acidic, alkaline) and oxidation(peroxide stress) conditions. The drug remained stable under thermal and photolytic stress conditions. In total, seven novel degradation products(DP-1 to DP-7) were found under diverse conditions, which were not reported earlier. The chemical structures of these degradation products were characterized by ~1H NMR,^(13)C NMR, 2 D NMR, Q-TOF-MSnand IR spectral analysis and the proposed degradation products structures were further confirmed by the individual synthesis. | Vinodh Guvvala Venkatesan Chidambaram Subramanian Jaya Shree Anireddy Mahesh Konda | 2018 | Journal of Pharmaceutical Analysis2018，8，2： | 4 |
| 4 | Evidence based review of type 2 diabetes prevention and management in low and middle income countries显示文摘AIM:To identify the newest approaches to type 2diabetes(T2DM)prevention and control in the developingworld context.METHODS:We conducted a systematic review of published studies of diabetes prevention and control programs in low and middle-income countries,as defined by the World Bank.We searched Pub Med using Medical Subject Headings terms.Studies needed to satisfy four criteria:(1)Must be experimental;(2)Must include patients with T2DM or focusing on prevention of T2DM;(3)Must have a lifestyle intervention component;(4)Must be written in English;and(5)Must have measurable outcomes related to diabetes.RESULTS:A total of 66 studies from 20 developing countries were gathered with publication dates through September 2014.India contributed the largest number of trials(11/66).Of the total 66 studies reviewed,all but 3 studies reported evidence of favorable outcomes in the prevention and control of type 2 diabetes.The overwhelming majority of studies reported on diabetes management(56/66),and among these more than half were structured lifestyle education programs.The evidence suggests that lifestyle education led by allied health professionals(nurses,pharmacists)were as effective as those led by physicians or a team of clinicians.The remaining diabetes management interventions focused on diet or exercise,but the evidence to recommend one approach over another was weak.CONCLUSION:Large experimental diabetes prevention/control studies of dietary and exercise interventions are lacking particularly those that consider quality rather than quantity of carbohydrates and alternative exercise. | Aimee Afable Nidhi Shree Karingula | 2016 | World Journal of Diabetes2016，7，10： | 3 |
| 5 | DICER-like Proteins and Their Role in Plant-herbivore Interactions in Nicotiana attenuata显示文摘DICER-like (DCL) proteins produce small RNAs that silence genes involved in development and defenses against viruses and pathogens. Which DCLs participate in plant-herbivore interactions remains unstudied. We identified and stably silenced four distinct DCL genes by RNAi in Nicotiana attenuata (Torrey ex. Watson), a model for the study of plant-herbivore interactions. Silencing DCL1 expression was lethal. Manduca sexta larvae performed significantly better on ir-dcl3 and ir-dcl4 plants, but not on ir-dcl2 plants compared to wild type plants. Phytohormones, defense metabolites and microarray analyses revealed that when DCL3 and DCL4 were silenced separately, herbivore resistance traits were regulated in distinctly different ways. Crossing of the lines revealed complex interactions in the patterns of regulation. Single ir-dcl4 and double ir-dcl2 ir-dcl3 plants were impaired in JA accumulation, while JA- Ile was increased in ir-dcl3 plants. Ir-dcl3 and ir-dcl4 plants were impaired in nicotine accumulation; silencing DCL2 in combination with either DCL3 or DCL4 restored nicotine levels to those of WT. Trypsin proteinase inhibitor activity and transcripts were only silenced in ir-dcl3 plants. We conclude that DCL2/3/4 interact in a complex manner to regulate anti-herbivore defenses and that these interactions significantly complicate the already challenging task of understanding smRNA function in the regulation of biotic interactions. | Tohir Ahmadovich Bozorov Shree Prakash Pandey Son Truong Dinh Sang-Gyu Kim Maria Heinrich Klaus Gase Ian T. Baldwin | 2012 | Journal of Integrative Plant Biology2012，54，3： | 3 |
| 6 | Adaptive immunity at the crossroads of autophagy and metabolism显示文摘The function of lymphocytes is dependent on their plasticity,particularly their adaptation to energy availability and environmental stress,and their protein synthesis machinery.Lymphocytes are constantly under metabolic stress,and macroautophagy/autophagy is the primary metabolic pathway that helps cells overcome stressors.The intrinsic role of autophagy in regulating the metabolism of adaptive immune cells has recently gained increasing attention.In this review,we summarize and discuss the versatile roles of autophagy in regulating cellular metabolism and the implications of autophagy for immune cell function and fate,especially for T and B lymphocytes. | Shree Padma Metur Daniel J.Klionsky | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
| 7 | Gastric cancer stem cells: A novel therapeutic target显示文摘 | Shree Ram Singh | 2013 | Cancer Letters2013，，： | 2 |
| 8 | Patient-derived orthotopic xenograft models for cancer of unknown primary precisely distinguish chemotherapy,and tumor-targeting S.typhimurium A1-R is superior to first-line chemotherapy显示文摘Cancer of unknown primary(CUP)is a recalcitrant disease with poor prognosis because it lacks standard first-line therapy.CUP consists of diverse malignancy groups,making personalized precision therapy essential.The present study aimed to identify an effective therapy for a CUP patient using a patient-derived orthotopic xenograft(PDOX)model.This paper reports the usefulness of the PDOX model to precisely identify effective and ineffective chemotherapy and to compare the efficacy of S.typhimurium A1-R with first-line chemotherapy using the CUP PDOX model.The present study is the first to use a CUP PDOX model,which was able to precisely distinguish the chemotherapeutic course.We found that a carboplatinum(CAR)-based regimen was effective for this CUP patient.We also demonstrated that S.typhimurium A1-R was more effective against the CUP tumor than first-line chemotherapy.Our results indicate that S.typhimurium A1-R has clinical potential for CUP,a resistant disease that requires effective therapy. | Kentaro Miyake Tasuku Kiyuna Masuyo Miyake Kei Kawaguchi Sang Nam Yoon Zhiying Zhang Kentaro Igarashi Sahar Razmjooei Sintawat Wangsiricharoen Takashi Murakami Yunfeng Li Scott D.Nelson Tara A.Russell Arun S.Singh Yukihiko Hiroshima Masashi Momiyama Ryusei Matsuyama Takashi Chishima Shree Ram Singh Itaru Endo Fritz C.Eilber Robert M.Hoffman | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 2 |
| 9 | Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care显示文摘 | Katharine Bushby Richard Finkel David J Birnkrant Laura E Case Paula R Clemens Linda Cripe Ajay Kaul Kathi Kinnett Craig McDonald Shree Pandya James Poysky Frederic Shapiro Jean Tomezsko Carolyn Constantin | 2010 | Lancet Neurology2010，，2： | 1 |
| 10 | Development of dimethylsiloxane based tetraglycidyl epoxy nanocomposites for high performance, aerospace and advanced engineering applications显示文摘 | Shree MK Pradeep JSE Ananda KS and Umapathy MJ | 2012 | Frog Org Coat2012，74，： | 1 |
| 11 | Programma- ble imaging: towards a flexible camera显示文摘 | Shree K Nayar Vlad Branzoi Terry E Boult | 2006 | International Journal of Computer Vision2006，78，1： | 1 |
| 12 | Vision in Bad Weather 显示文摘 | Shree K Nayar Srinivasa G Narasimhan | 1999 | Proceedings of the Seventh IEEE International Conference on Computer Vision1999，2，： | 1 |
| 13 | Catadioptric stereo using planar mirrors显示文摘 | JOSHUA G SHREE K N | 2001 | International Journal of Computer Vision2001，44，65： | 1 |
| 14 | Visual learning recognition of 3D objects from appearance显示文摘 | Murase H Shree K Nayar | 1995 | International Journal of Computer Vision1995，14，1： | 1 |
| 15 | Chromatic Framework for Vision in Bad Weather显示文摘 | Srinivasa G arasimhan Shree K Nayar | 2000 | IEEE Conference on Computer Vision and Pattern Recognition2000，1，： | 1 |
| 16 | Calpain-regulated p35/ cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2 显示文摘 | Smith P D Mount M P Shree R | 2006 | J Neurosei2006，26，2： | 1 |
| 17 | An efficient routing protocol for wireless networks显示文摘 | Shree Murthy J. J. Garcia-Luna-Aceves | 1996 | Mobile Networks and Applications1996，，2： | 1 |
| 18 | Development of dimethylsiloxane based tetraglycidyl epoxy nanocomposites for high performance, aerospace and advanced engineering applications 显示文摘 | Shree Meenakshi K Pradeep Jaya Sudhan E Ananda Kumar S Umapathy M J | 2012 | Progress in Organic Coatings2012，74，1： | 1 |
| 19 | lmmunogenicity and efficacy of recombinant RSV- F vaccine in a mouse model 显示文摘 | Shree R Singh | 2007 | Vaccine2007，14，： | 1 |
| 20 | Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2显示文摘 | Smith PD Mount MP Shree R | | 0，，02： | 1 |
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