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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Design of a Carbon Nanotube/Magnetic Nanoparticle-Based Peroxidase-Like Nanocomplex and Its Application for Highly Efficient Catalytic Oxidation of Phenols显示文摘We report a novel nanotechnology-based approach for the highly efficient catalytic oxidation of phenols and their removal from wastewater.We use a nanocomplex made of multi-walled carbon nanotubes(MWNTs)and magnetic nanoparticles(MNPs).This nanocomplex retains the magnetic properties of individual MNPs and can be effectively separated under an external magnetic fi eld.More importantly,the formation of the nanocomplex enhances the intrinsic peroxidase-like activity of the MNPs that can catalyze the reduction of hydrogen peroxide(H2O2).Significantly,in the presence of H2O2,this nanocomplex catalyzes the oxidation of phenols with high effi ciency,generating insoluble polyaromatic products that can be readily separated from water. | Xiaolei Zuo Cheng Peng Qing Huang Shiping Song Lihua Wang Di Li Chunhai Fan | 2009 | Nano Research2009，2，8： | 8 |
| 3 | Characterization of a disease susceptibility locus for exploring an efficient way to improve rice resistance against bacterial blight显示文摘Bacterial blight caused by Xanthomonas oryzae pv.oryzae(Xoo) is the most harmful bacterial disease of rice worldwide.Previously,we characterized major disease resistance(MR) gene xa25,which confers race-specific resistance to Xoo strain PXO339.The xa25 is a recessive allele of the SWEET13 locus,but SWEET13's interaction with PXO339 and how efficiently using this locus for rice breeding still need to be defined.Here we show that the SWEET 13 allele from rice Zhenshan 97 is a susceptibility gene to PXO339.Using this allele's promoter to regulate xa25 resulted in disease,suggesting that the promoter is a key determinant in SWEET13 caused disease in Zhanshan 97 after PXO339 infection.PXO339 transcriptionally induces SWEET13 to cause disease.Partial suppressing SWEET13 expression leads to a high level of resistance to PXO339.Thus,the transcriptionally suppressed SWEET13 functions as xa25 in resistance to PXO339.Hybrid rice is widely grown in many countries.However,recessive MR genes have not been efficiently used for disease resistance breeding in hybrid rice production for both parents of the hybrid have to carry the same recessive gene.However,the suppressed SWEET 13 functions dominantly,which will have advantage to improve the resistance of hybrid rice to xa25-incomptible Xoo. | Qi Cheng Weihua Mao Wenya Xie Qinsong Liu Jianbo Cao Meng Yuan Qinglu Zhang Xianghua Li Shiping Wang | 2017 | Science China(Life Sciences)2017，60，3： | 4 |
| 4 | Differential transcriptome analysis between Populus and its synthesized allotriploids driven by second-division restitution显示文摘In this report, we compared transcriptomic differences between a synthetic Populus section Tacamahaca triploid driven by second-division restitution and its parents using a high-throughput RNA-seq method. A total of 4,080 genes were differentially expressed between the high-growth vigor allotriploids(SDR-H) and their parents, and 719 genes were non-additively expressed in SDR-H. Differences in gene expression between the allotriploid and male parent were more signi ficant than those between the allotriploid and female parent, which may be caused by maternal effects. We observed3,559 differentially expressed genes(DEGs) between the SDR-H and male parent. Notably, the genes were mainly involved in metabolic process, cell proliferation, DNA methylation, cell division, and meristem and developmental growth. Among the1,056 DEGs between SDR-H and female parent, many genes were associated with metabolic process and carbon utilization.In addition, 1,789 DEGs between high- and low-growth vigor allotriploid were mainly associated with metabolic process,auxin poplar transport, and regulation of meristem growth.Our results indicated that the higher poplar ploidy level can generate extensive transcriptomic diversity compared with its parents. Overall, these results increased our understanding of the driving force for phenotypic variation and adaptation in allopolyploids driven by second-division restitution. | Shiping Cheng Zhen Huang Yun Li Ting Liao Yujing Suo Pingdong Zhang Jun Wang Xiangyang Kang | 2015 | Journal of Integrative Plant Biology2015，57，12： | 3 |
| 5 | Thermodynamic characterization of two novel spin-crossover complexes显示文摘Two novel FeII spin crossover complexes [Fe(L1)3](BF4)25H2O (1) and [Fe(L2)3](BF4)2·2H2O (2) with 4-NHR-1,2,4-triazole (R = isopropyl, L1; cyclohexyl, L2) were synthesized. 1 and 2 remain white at room temperature, whereas they turn purple at liquid temperature. Variable temperature optical detection and magnetic susceptibilities measurement show that the spin-crossover phenomenon for 1 was observed between 120 K and 170 K. The hysteresis loop is about 10 K. The Tc temperature of 2 is 190 K, but no thermal hysteresis loop was found. The molar thermodynamic functions and the microscopic parameters were obtained from the theoretical analysis in terms of the domain model, two level Ising model and regular solution model, respectively. | DING Bin, WANG Hongmei, YI Long, CHENG Peng, LI Licun, ZHAI Yuping, LIAO Daizheng, YAN Shiping & JIANG Zonghui Department of Chemistry, Nankai University, Tianjin 300071, China Correspondence should be addressed to Cheng Peng or Liao Daizheng (e-mail: pcheng@nankai.edu.cn) | 2003 | Chinese Science Bulletin2003，48，22： | 3 |
| 6 | Tracing of dye molecules in living plants through NaGdF_4:Yb^(3+),Er^(3+)fluorescent nanoprobes显示文摘In this paper, we demonstrated trace of dye molecules in living plants. The NaGdF4:Yb^(3+),Er^(3+) nanoparticles probe was used to detect the rhodamine B(RhB) in bean sprout. It is found that the fluorescencedye can be efficiently imbibed during the growing process and the absorbance presented a position dependence effect, which was supported by the upconversion spectra and the fluorescent image characterization. In addition, the concentration of the residual RhB in bean sprout can be efficiently traced by the synthesized probe based on the fluorescent resonant energy transfer. Finally, the relation between the excitation power, concentration and the ratio of yellow to green emission are discussed in detail. These results can be helpful in understanding the RhB dye molecules absorbance process in vegetable growth and provide an efficient way to trace the residual dyes in vivo plant. | Xiaofeng Wu Ya'nan Zhang Shiping Zhan Jin Li Guozheng Nie Shigang Hu Cong Yan Shaobing Wu Shengbin Cheng Junshan Hu Lichun Shi Yunxin Liu | 2019 | Journal of Rare Earths2019，37，3： | 3 |
| 7 | Synthesis and magnetic properties of one-dimensional Mn(Ⅱ)complexes linked by dithiooxalato显示文摘Three dithiooxalato (Dto) bridging one-dimensional Mn(Ⅱ) complexes [Mn(L)Dto](L = Phen (1), Bpy (2) and en (3)) were synthesized. All of the complexes have the similar one-dimensional structure through Dto bridge. The measurement of the variable temperature magnetic susceptibility of complex 1 showed that there are weak antiferromag- netic interactions between the Mn(Ⅱ) ions. | CUI Jianzhong, SHI Wei, CHENG Peng, CHEN Xufang, LIAO Daizheng, YAN Shiping, JIANG Zonghui & WANG GenglinDepartment of Chemistry, Nankai University, Tianjin 300071, China Correspondence should be addressed to Cheng Peng (e-mail: pcheng@ nankai.edu.cn) | 2003 | Chinese Science Bulletin2003，48，9： | 2 |
| 8 | Synthesis, crystal structure of diferrous complex and its reactivity with dioxygen显示文摘 | Shiping Yan Peng Cheng Qinglun Wang Daizheng Liao Zonghui Jiang Genglin Wang | 2000 | Science in China Series B: Chemistry2000，，4： | 1 |
| 9 | Exploring pathogenesis in subjects with subjective Tinnitus having kidney deficiency pattern in terms of Traditional Chinese Medicine based on serum metabolic profiles显示文摘OBJECTIVE: To investigate the metabolic pathogenesis in subjects with subjective tinnitus(ST)having kidney deficiency pattern(KDP)(ST/KDP) in terms of Traditional Chinese Medicine.METHODS: Three groups of subjects, including healthy individuals, subjects with ST/KDP, and subjects who were healthy initially and then developed ST/KDP one year later(healthy → ST/KDP),were recruited for this study. Serum metabolic profiles of all subjects were analyzed using ultra-performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry. The metabolic characteristics of the ST/KDP subjects were determined, and the corresponding biomarkers were predicted. The metabolomics data from the healthy → ST/KDP subjects were collected for further verification.RESULTS: Twelve metabolites in the ST/KDP subjects were different from those of the healthy control subjects. Of these metabolites, according to the prediction, except for octanoic acid, other metabolites might characterize ST/KDP. Ten metabolites at the outcome ST/KDP stage were different from those at the initial(control) stage. Through the comparison of these metabolites with the predicted metabolites, five common metabolites, including upregulated glutamate, serotonin, oroticacid and 8-oxoguanine, as well as downregulated taurine, were found. These common metabolites were significantly associated with canonical pathways including calcium signaling, γ-aminobutyric acid(GABA) receptor signaling, purine and pyrimidine biosynthesis, taurine biosynthesis, and serotonin receptor signaling.CONCLUSION: The metabolic pathogenesis in ST/KDP subjects was characterized by upregulated glutamate, serotonin, orotic acid and 8-oxoguanine, as well as downregulated taurine, additionally, perturbations of calcium signaling, GABA receptor signaling, purine and pyrimidine biosynthesis, taurine biosynthesis, and serotonin receptor signaling. | Tan Yong Shen Shanshan Guan Fulan He Bing Lu Cheng Xiao Cheng Jiang Miao Zhao Ning Li Li Cheng Shiping Zu Xianpeng Zhang Weidong Liu Xinru Lü Aiping | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 1 |
| 10 | Structures of small Pd Pt bimetallic clusters by Monte Carlo simulation 显示文摘 | Daojian Cheng Shiping Huang Wenchuan Wang | 2006 | Chemical Physics2006，330，： | 1 |
| 11 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 12 | Enhanced efficiency and stability of perovskite solar cells by 2D perovskite vapor-assisted interface optimization显示文摘Organic–inorganic perovskites solar cells(PSCs)have attracted great attention due to their rapid progress in power conversion efficiency(PCE).However,there is still an enormous challenge to achieve both high efficiency and stability devices as the decomposition of perovskite materials under humid and light conditions.Herein,we demonstrate that high efficiency and stability of PSCs can be obtained by the reaction of three-dimensional(3D)perovskite with 1,4-butanediamine iodide(BEAI2)vapor.The incorporation of BEAI2 intensively promotes the crystallization of perovskite film with large grain size(~500 nm).Further characterization reveals that the post-treatment perovskite film delivered low interface trap density with long carrier lifetime(>200 ns),long carrier diffusion length(>600 nm)and large carrier mobility(>1.5 cm^2 V-1S-1).Solar cells employing such post-treatment films demonstrated 19.58%PCE without hysteresis.Moreover,the post-treatment devices can retain over 90%original efficiencies stored under ambient atmospheric conditions and exhibit better stability under 85℃and continuous illumination as a two-dimensional(2D)perovskite thin layer is formed on the surface/or at the grain boundaries of 3D perovskite.This study offers an effective way to obtain PSCs with high efficiency and stability. | Minghui Chen Pengwei Li Chao Liang Hao Gu Weishuang Tong Shiping Cheng Weili Li Ganqing Zhao Guosheng Shao | 2020 | Journal of Energy Chemistry2020，29，6： | 1 |
| 13 | Multiband camouflage design with thermal management显示文摘Although the effective“stealth”of space vehicles is important,current camouflage designs are inadequate in meeting all application requirements.Here,a multilayer wavelength-selective emitter is demonstrated.It can realize visible light and dual-band mid-infrared camouflage with thermal control management in two application scenarios,with better effect and stronger radiation cooling capability,which can significantly improve the stealth and survivability of space vehicles in different environments.The selective emitter demonstrated in this paper has the advantages of simple structure,scalability,and ease of large-area fabrication,and has made a major breakthrough in driving multiband stealth technology from simulation research to physical verification and even practical application. | LEHONG HUANG HAOCHUAN LI ZHIGUO LI WENBO ZHANG CAIWEN MA CHUNMIN ZHANG YUXUAN WEI LIANG ZHOU XUN LI ZHIYUAN CHENG XIAOHUI GUO SHIPING GUO | 2023 | Photonics Research2023，11，5： | 0 |
| 14 | Research Progress of miR164 and Target Gene NAC in Regulating Sugarcane Stress Tolerance显示文摘Studies have shown that miR164 is a highly conserved miRNA family between monocot and dicotyledonous plants,and it plays an important role in the growth and development of sugarcane organs and in response to stress.As the main target gene of miR164,NAC transcription factors are mainly regulated at the post-transcriptional level.MiR164:NAC module may play an important role in determining the adaptive response of sugarcane to stress.MiR164 has a regulatory effect on the expression of target gene NAC,and may be closely related to the resistance process of sugarcane to abiotic stress,which provides a reference for using miRNA to carry out sugarcane resistance molecular breeding. | Minghui CHEN Junqing WANG Xuyao ZHAO Shiping CHENG | 2023 | Plant Diseases and Pests2023，14，4： | 0 |
| 15 | Understanding water conservation vs. prof ligation traits in vegetable legumes through a physio-transcriptomic-functional approach显示文摘Abstract Vegetable soybean and cowpea are related warm-season legumes showing contrasting leaf water use behaviors under similar root drought stresses,whose mechanisms are not well understood.Here we conducted an integrative phenomic-transcriptomic study on the two crops grown in a feedback irrigation system that enabled precise control of soil water contents.Continuous transpiration rate monitoring demonstrated that cowpea used water more conservatively under earlier soil drought stages,but tended to maintain higher transpiration under prolonged drought.Interestingly,we observed a soybean-specific transpiration rate increase accompanied by phase shift under moderate soil drought.Time-series transcriptomic analysis suggested a dehydration avoidance mechanism of cowpea at early soil drought stage,in which the VuHAI3 and VuTIP2;3 genes were suggested to be involved.Multifactorial gene clustering analysis revealed different responsiveness of genes to drought,time of day and their interactions between the two crops,which involved species-dependent regulation of the circadian clock genes.Gene network analysis identified two co-expression modules each associated with transpiration rate in cowpea and soybean,including a pair of negatively correlated modules between species.Module hub genes,including the ABA-degrading gene GmCYP707A4 and the trehalose-phosphatase/synthase gene VuTPS9 were identified.Intermodular network analysis revealed putative co-players of the hub genes.Transgenic analyses verified the role of VuTPS9 in regulating transpiration rate under osmotic stresses.These findings propose that species-specific transcriptomic reprograming in leaves of the two crops suffering similar soil drought was not only a result of the different drought resistance level,but a cause of it. | Pingping Fang Ting Sun Arun Kumar Pandey Libo Jiang Xinyang Wu Yannan Hu Shiping Cheng Mingxuan Li Pei Xu | 2023 | Horticulture Research2023，10，3： | 0 |
| 16 | Characteristics of SARS-CoV-2-specific cytotoxic T cells revealed by single-cell immune profiling of longitudinal COVID-19 blood samples显示文摘Dear Editor,The SARS-CoV-2 virus outbreak that started in December 2019 is now a global pandemic with over 42.7 million confirmed cases and 1.15 million deaths as of October 25,2020.It has been predicted that resurgence in contagion may be possible as late as 2024.1 A persistent anti-SARS-CoV-2 adaptive immune surveillance post infection is critical to lower the risk of resurgence and transmission.T cells are the primary effectors of cellular adaptive immunity that not only clear virus-infected cells during infection but also provide long-term protection post infection as memory cells in some pathogen infections.However,little is known regarding the longitudinal T cell response during and after SARSCoV-2 infection.Single-cell T cell receptor(TCR)sequencing allows rapid identification of expanded T cell clones that are potentially the antigen-specific clonotypes.2 To further characterize the anti-SARS-CoV-2 T cells,we sequenced the circulating T cells of five moderate or severe COVID-19 patients at different stages of infection(two patients at 1,7 and 16 weeks and three patients at 1 and 17 weeks post symptom onset)and of two healthy donors(Supplementary Tables S1,S2 and S7). | Qing Xiong Cheng Peng Xiaomin Yan Xueqi Yan Lin Chen Beicheng Sun Shiping Jiao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 17 | Research and Practice on the Construction of Professional Cluster in Application-Oriented Local Undergraduate Universities:Taking Environ-mental Chemical Engineering Professional Cluster in Pingdingshan University as an Example显示文摘Based on the analysis of the importance of professional cluster construction by ecological theory,with the change of social demand for talents,this paper explores the practice of environmental chemical professional cluster construction in Pingdingshan University,including gradually perfecting teaching conditions and reforming teaching mode,breaking through the limitations of resources,integrating the boundaries of colleges and departments,integrating multiple resources,innovating systems and mechanisms,reconstructing professional clusters,decon-structing professional connotations,reorganizing curriculum systems,etc.,in order to better build the ecological chain network of education in application-oriented colleges and universities,realize the deep integration of industry and education,train future-oriented interdisciplinary applied talents of new engineering,and realize the construction of characteristic professional cluster in application-oriented colleges. | Yanjiao LI Jiafei SU Xiaonan HU Hongsheng QIAN Weishuang TONG Shiping CHENG Lihua XIE Zhilu ZHANG | 2024 | Asian Agricultural Research2024，16，2： | 0 |
| 18 | Research and Exploration on Ideological and Political Theories Teaching in the Course of Soil Science Experiment:Taking Pingdingshan University as an Example显示文摘Experimental course is an important link of ideological and political education in colleges and universities under the new situation,and plays an important role in the construction of ideological and political theories teaching in the course.Taking Pingdingshan University as an example,by introducing the real soil cases in Pingdingshan area,the ideological and political elements of the course are integrated into the teaching links of laboratory safety training,self-study before class,experimental teaching implementation,evaluation and improvement.By implementing the concept of'All-round Education'in experimental teaching,we are committed to realizing the comprehensive coverage of value shaping,knowledge inheritance and ability training,and explore and practice the reform of ideological and political theories teaching in the course of Soil Science Experiment. | Xining GENG Yanjiao LI Weishuang TONG Shiping CHENG Pengqiang YAO Fengqin HUANG | 2023 | Asian Agricultural Research2023，15，12： | 0 |
| 19 | cDNA-SCoT Analysis of Differential Expressed Genes in Allium tuberosum Induced by Botrytis cinerea显示文摘[Objectives]To investigate the molecular mechanism of gene differential expression in A.tuberosum under Botrytis cinerea stress.[Methods]The leaf of A.tuberosum was inoculated with B.cinerea to induce resistance,then leaf samples were taken at 2,4,8,12 and 24 h,respectively,after inoculation,and used for cDNA-SCoT analysis to detect the gene differential expressions.[Results]More than 800 bands with length of 100-1800 bp were obtained using 60 SCoT primers.A total of 40 differentially expressed EST sequences were screened out,and 18 non-redundant ESTs with high quality were obtained by cluster analyses of the ESTs sequencing.The results of BlastN showed that the differential genes of A.tuberosum mainly related to disease defense,signal transduction,and protein metabolism.[Conclusions]Further analysis of gene function indicated that brassinosteroid biosynthesis-like proteins,NBS-LRR type disease resistance protein,jasmonic acid induced protein,abscisic stress ripening protein may be involved in the process of the incompatible interaction between the A.tuberosum and B.cinerea. | Minghui CHEN Zhilu ZHANG Yanjiao LI Pengqiang YAO Shiping CHENG Ganqing ZHAO | 2020 | Asian Agricultural Research2020，12，10： | 0 |
| 20 | Characteristics of SARS-CoV-2-specific cytotoxic T cells revealed by single-cell immune profiling of longitudinal COVID-19 blood samples显示文摘Dear Editor,The SARS-CoV-2 virus outbreak that started in December 2019 is now a global pandemic with over 42.7 million confirmed cases and 1.15 million deaths as of October 25,2020.It has been predicted that resurgence in contagion may be possible as late as 2024.1 A persistent anti-SARS-CoV-2 adaptive immune surveillance post infection is critical to lower the risk of resurgence and transmission.T cells are the primary effectors of cellular adaptive immunity that not only clear virus-infected cells during infection but also provide long-term protection post infection as memory cells in some pathogen infections.However,little is known regarding the longitudinal T cell response during and after SARSCoV-2 infection.Single-cell T cell receptor(TCR)sequencing allows rapid identification of expanded T cell clones that are potentially the antigen-specific clonotypes. | Qing Xiong Cheng Peng Xiaomin Yan Xueqi Yan Lin Chen Beicheng Sun Shiping Jiao | 2021 | Signal Transduction and Targeted Therapy2021，6，1： | 0 |
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