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| 1 | Jianpijiedu Fang improves survival of hepatocarcinoma mice by affecting phosphatase and tensin homolog, phosphoinositide 3-kinase, and focal adhesion kinase显示文摘OBJECTIVE: To investigate the effect of Jianpijiedu Fang (JPJDF) on phosphatase and tensin homolog (PTEN), phosphoinositide 3-kinase (PI3K), and focal adhesion kinase (FAK), and on the survival of hepatocellular carcinoma (HCC) nude mice. METHODS: Forty male nude mice were randomly divided into 4 groups. Human HCC tissue was implanted in the livers of three groups. After 24 h, the three groups were treated respectively with JPJDF (37.5 g/kg), saline (20 mL/kg) and Tegafur (FT-207, 160 mg/kg) once a day for 10 weeks. The control group without implanting the tissue was concurrently treated with saline (20 mL/kg). The survival data and body weight of all mice were recorded, and expression levels of PTEN, PI3K and FAK in normal tissue and cancer tissue of the livers were eval-uated with immunohistochemical method. RESULTS: The cumulative survival rate of the mice in the JPJDF group was higher than those of the other groups. The rate of weight loss was the lowest in JPJDF group. The survivability and weight loss rate in FT-207 group were the poorest in all groups. The expression intensity of PTEN was higher in normal tissues than in cancer tissues, and lower in the normal tissues of HCC models than in that of mice without HCC. The PTEN expression intensity in normal tissue and cancer tissue from mice treated with FT-207 were lower than that from the mice treated with JPJDF or saline.The expression intensity of PI3K was higher in cancer tissue than in normal tissue. The PI3K expression intensity was the lowest in normal tissue and cancer tissue from mice treated with JPJDF, and the intensity from mice treated with FT-207 was the highest. In mice treated with JPJDF, the expression intensity of FAK was higher in the normal tissue and lower in the cancer tissue than those of the other treatment groups. CONCLUSION: The mechanism accounting for the prolonged survival of HCC-bearing mice treated with JPJDF might be related to the reduction in weight loss and the benign regulation of PTEN, PI3K, and FAK. | Baoguo Sun Jun Meng Ting Xiang Zexiong Chen Yulong Li Lisha Lu Shijun Zhang Xiaolin Chen | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 12 |
| 2 | Single-Atom Catalysts for Electrochemical Hydrogen Evolution Reaction: Recent Advances and Future Perspectives显示文摘Hydrogen,a renewable and outstanding energy carrier with zero carbon dioxide emission,is regarded as the best alternative to fossil fuels.The most preferred route to large-scale production of hydrogen is by water electrolysis from the intermittent sources(e.g.,wind,solar,hydro,and tidal energy).However,the efficiency of water electrolysis is very much dependent on the activity of electrocatalysts.Thus,designing high-effective,stable,and cheap materials for hydrogen evolution reaction(HER)could have a substantial impact on renewable energy technologies.Recently,single-atom catalysts(SACs)have emerged as a new frontier in catalysis science,because SACs have maximum atom-utilization efficiency and excellent catalytic reaction activity.Various synthesis methods and analytical techniques have been adopted to prepare and characterize these SACs.In this review,we discuss recent progress on SACs synthesis,characterization methods,and their catalytic applications.Particularly,we highlight their unique electrochemical characteristics toward HER.Finally,the current key challenges in SACs for HER are pointed out and some potential directions are proposed as well. | Zonghua Pu Ibrahim Saana Amiinu Ruilin Cheng Pengyan Wang Chengtian Zhang Shichun Mu Weiyue Zhao Fengmei Su Gaixia Zhang Shijun Liao Shuhui Sun | 2020 | Nano-Micro Letters2020，12，2： | 10 |
| 3 | Subcutaneous and intramuscular fat transcriptomes show large differences in network organization and associations with adipose traits in pigs显示文摘Subcutaneous fat(SCF)and intramuscular fat(IMF)deposition is relevant to health in humans,as well as meat production and quality in pigs.In this study,we generated RNA sequence data for 122 SCF,120 IMF,and 87 longissimus dorsi muscle(LDM)samples using 155 F6 pigs from a specially designed heterogeneous population generated by intercrossing four highly selected European commercial breeds and four indigenous Chinese pig breeds.The phenotypes including waist back fat thickness and intramuscular fat content were also measured in the 155 F6 pigs.We found that the genes in SCF and IMF differed largely in both expression levels and network connectivity,and highlighted network modules that exhibited strongest gain of connectivity in SCF and IMF,containing genes that were associated with the immune process and DNA double-strand repair,respectively.We identified 215 SCF genes related to kinase inhibitor activity,mitochondrial fission,and angiogenesis,and 90 IMF genes related to lipolysis and fat cell differentiation,displayed a tissue-specific association with back fat thickness and IMF content,respectively.We found that cis-expression QTL for trait-associated genes in the two adipose tissues tended to have tissuedependent predictability for the two adipose traits.Alternative splicing of genes was also found to be associated with SCF or IMF deposition,but the association was much less extensive than that based on expression levels.This study provides a better understanding of SCF and IMF gene transcription and network organization and identified critical genes and network modules that displayed tissue-specific associations with subcutaneous and intramuscular fat deposition.These features are helpful for designing breeding programs to genetically improve the two adipose traits in a balanced way. | Yifeng Zhang Yingchun Sun Zhongzi Wu Xinwei Xiong Junjie Zhang Junwu Ma Shijun Xiao Lusheng Huang Bin Yang | 2021 | Science China(Life Sciences)2021，64，10： | 5 |
| 4 | Contribution of Baroreflex Afferent Pathway to NPY-Mediated Regulation of Blood Pressure in Rats显示文摘Neuropeptide Y (NPY), a metabolism-related cardiovascular factor, plays a crucial role in blood pressure(BP) regulation via peripheral and central pathways. The expression of NPY receptors (Y1R/Y2R) specific to baroreflex afferents impacts on the sexually dimorphic neural control of circulation. This study was designed to investigate the expression profiles of NPY receptors in the nodose ganglion (NG) and nucleus tractus solitary (NTS) under hypertensive conditions. To this end, rats with hypertension induced by NG-nitro-L-arginine methylester (L-NAME) or high fructose drinking (HFD), and spontaneously hypertensive rats (SHRs) were used to explore the effects/mechanisms of NPY on BP using functional, molecular, and electrophysiological approaches. The data showed that BP was elevated along with baroreceptor sensitivity dysfunction in model rats;Y1R was up-or down-regulated in the NG or NTS of male and female HFD/L-NAME groups,while Y2R was only down-regulated in the HFD groups as well as in the NG of the male L-NAME group. In SHRs,Y1R and Y2R were both down-regulated in the NTS, and not in the NG. In addition to NPY-mediated energy homeostasis, leptin-melanocortin activation may be essential for metabolic disturbance-related hypertension. We found that leptin and a-melanocyte stimulating hormone (aMSH) receptors were aberrantly down-regulated in HFD rats. In addition, a-MSH concentrations were reduced and NPY concentrations were elevated in the serum and NTS at 60 and 90 min after acute leptin infusion. Electrophysiological recordings showed that the decay time-constant and area under the curve of excitatory post-synaptic currents were decreased by Y1R activation in A-types, whereas, both were increased by Y2R activation in Ah-or C-types. These results demonstrate that sex-and afferent-specific NPY receptor expression in the baroreflex afferent pathway is likely to be a novel target for the clinical management of metabolism-related and essential hypertension. | Yang Liu Shu-Yang Zhao Yan Feng Jie Sun Xiao-Long Lu Qiu-Xin Yan Ying Li Zhuo Liu Lu-Qi Wang Xun Sun Shijun Li Guo-Fen Qiao Bai-Yan Li | 2020 | Neuroscience Bulletin2020，36，4： | 5 |
| 5 | Deer Body Adaptive Threshold Segmentation Algorithm Based on Color Space显示文摘In large-scale deer farming image analysis,K-means or maximum between-class variance(Otsu)algorithms can be used to distinguish the deer from the background.However,in an actual breeding environment,the barbed wire or chain-link fencing has a certain isolating effect on the deer which greatly interferes with the identification of the individual deer.Also,when the target and background grey values are similar,the multiple background targets cannot be completely separated.To better identify the posture and behaviour of deer in a deer shed,we used digital image processing to separate the deer from the background.To address the problems mentioned above,this paper proposes an adaptive threshold segmentation algorithm based on color space.First,the original image is pre-processed and optimized.On this basis,the data are enhanced and contrasted.Next,color space is used to extract the several backgrounds through various color channels,then the adaptive space segmentation of the extracted part of the color space is performed.Based on the segmentation effect of the traditional Otsu algorithm,we designed a comparative experiment that divided the four postures of turning,getting up,lying,and standing,and successfully separated multiple target deer from the background.Experimental results show that compared with K-means,Otsu and hue saturation value(HSV)+K-means,this method is better in performance and accuracy for adaptive segmentation of deer in artificial breeding scenes and can be used to separate artificially cultivated deer from their backgrounds.Both the subjective and objective aspects achieved good segmentation results.This article lays a foundation for the effective identification of abnormal behaviour in sika deer. | Yuheng Sun Ye Mu Qin Feng Tianli Hu He Gong Shijun Li Jing Zhou | 2020 | Computers, Materials & Continua2020，，8： | 5 |
| 6 | Estimation of thermophysical properties of solid propellants based on particle packing model显示文摘A method for the estimation of thermophysical properties of two-and multi-phase solid propellants is proposed in this paper.The theoretical solutions for thermal conductivity and specific heat of a homogeneous solid propellant cell in the transient thermal conductivity process are deduced on the condition that one boundary of the cell is heated while others are adiabatic.A homogenization theory and the finite element method are employed to compute the mean temperature and heat flux of a representative volume element(RVE).According to the mean results and the theoretical solutions,the effective thermal conductivity and specific heat of solid propellant can be estimated.A packing algorithm,considering the solid particles(ammonium perchlorate(AP)or aluminum)as spheres or discs,is used to match the size distribution and volume fraction of solid propellants,and some mesoscopic models of two-phase and three-phase solid propellants are established.According to the estimation theory proposed in this paper,the effective thermal conductivity and specific heat of solid propellants are predicted.The effect of AP or Al volume fraction is also discussed in this paper. | ZHANG JianWei ZHI ShiJun SUN Bing | 2013 | Science China(Technological Sciences)2013，56，12： | 4 |
| 7 | Effect of polypeptide 2B1 on condition of dampness pattern in rats in terms of Traditional Chinese Medicine显示文摘OBJECTIVE: This study investigated how polypeptide 2B1 is involved in regulating and governing dampness in rat models with dampness pattern defined in terms ofTraditional Chinese Medicine.METHODS: We randomly divided 48 SPF10-week-old male Sprague-Dawley(SD) rats into a normal group, normal + Aristolochic acid I(AA-I) for5 min group, normal + AA-I for 60 min group,dampness pattern group(DS-Group), dampness pattern + AA-I for 5 min group, and dampness pattern + AA-I for 60 min group. Groups were then treated accordingly. We took out the lung, stomach, liver, spleen, kidney, large intestine, and small intestine tissues to detect gene and protein expression of organic anion transporter polypeptide 2B1(OATP2B1).RESULTS: Gene expression of OATP2B1 in spleen,kidney, and small intestine of rats with dampness pattern was lower than that in normal rats(P<0.05).The gene expressions of OATP2B1 in liver, stomach,large intestine, and small intestine were lower than that in control rats at different time points after being stimulated by AA-I(P<0.05).CONCLUSION: There is coordination among multiple viscera in handling the condition of dampness,and the mechanism underlying the action may rely on regulating the expression of OATP2B1. | Zhangbin Yang Ting Xiang Shijun Zhang Hongrui Zhan Zexiong Chen Baoguo Sun Xiaoling Chen Jingli Shi Bin Ren | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 3 |
| 8 | Mechanism of lithium insertion into NiSi_2 anode material for lithium ion batteries显示文摘As a promising high capacity anode material for lithium ion batteries, the lithium insertion performance and possible insertion mechanism of binary alloy of NiSi2 were discussed. The initial lithium insertion of crystal NiSi2 can reach up to 600 mAh·g-1, but large irreversible capacity occurrs simultaneously for serious structure transformation and the irreversible phase forms. XRD and XPS were employed to detect the crystal structure and composition changes produced by lithium insertion. The lithium insertion-extraction behavior of NiSi2 electrode is similar to that of silicon after the first discharge. The structure stability seems related to the non-stoichimometric Ni-Si compound formed by lithium insertion into NiSi2. | WEN Zhongsheng JI Shijun SUN Juncai TIAN Feng TIAN Rujin XIE Jingying | 2006 | Rare Metals2006，25，z1： | 2 |
| 9 | Correlation between pathogenesis of dampness syndrome and Interleukin-2,Interleukin-8 in rats显示文摘OBJECTIVE: To explore the pathogenesis of dampness syndrome by detecting the changes of interleukin-2 (IL-2) and interleukin-8 (IL-8) levels. METHODS: Female Sprague Dawley rats were divided randomly into five groups according to the random number table: a normal group (GroupⅠ), an external dampness group (GroupⅡ), an internal dampness group (Group Ⅲ), and an external and internal dampness group (GroupⅣ). Twenty days after the model made, IL-2 and IL-8 levels were detected by radioimmunoassay method. RESULTS: The IL-2 and IL-8 levels among groups were significant (F=3.102, P<0.05; F=2.657, P<0.05, respectively). The level of IL-2 in Group Ⅱ and Group Ⅲ were higher than that in GroupⅠ(P<0.05, P<0.01, respectively), especially higher in the Group Ⅲ compared with GroupⅡ (P<0.05). The lev- el of IL-8 in Group Ⅲ were higher than those inGroupⅠ, GroupⅡ and GroupⅣ (P<0.05, P<0.01, P< 0.05, respectively). In the GroupⅢ, the 24-hour wa ter and body weight were higher than that in the GroupⅣ (all P<0.05), and spontaneous movemen frequency was higher than those in GroupⅡ and GroupⅣ (P<0.05). CONCLUSION: Immune activation and inflammato ry reaction might be easily caused by externa danpness other than internal dampness. | Xiaolin Chen Youwu Lin Shijun Zhang Zexiong Chen Carlini Fan Hardi Ting Xiang Baoguo Sun | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 2 |
| 10 | Effects of Root Zone Temperature on Growth and Photosynthetic Parameters of Grafted Cucumber显示文摘Taking Cucurbita maxima and Cucurbita moschata as root stocks,and‘Jinyou No 3'cucumber as scion,the effects of different root zone temperature conditions optimal temperature( CK)( 18-20 ℃),suboptimal temperature( 13-15 ℃) and low temperature( 8-10 ℃) on the growth and photosynthesis indexes were studied. The results showed that,compared with optimal temperature( CK),suboptimal temperature and low temperature produced a significant inhibition of growth on cucumbers. The plant height,stem diameter,leaf area,number of leaves and dry weight of aboveground part were all reduced,dry weight of underground part and root shoot ratio all increased,while the inhibition was more significant at low temperature. Low and suboptimal temperature conditions also reduced SPAD value,net photosynthetic rate,transpiration rate,intercellular CO_2 concentration and stomatal conductance of the grafted cucumber. And there were differences between different grafted seedlings,and seedlings with‘black seeds' as stock performed better than those with‘white seeds' as stock at low temperature. | shijun sun shimao cui yang song chongyi fu lihong ye yu gao | 2018 | Agricultural Biotechnology2018，7，2： | 2 |
| 11 | PERFORMANCE OF ULTRA-LOW FREQUENCY PASSIVE VERTICAL VIBRATION ISOLATION SYSTEM WITH REVERSE PENDULUM显示文摘A novel long period passive vertical vibration isolator constructed by mounting reverse pendu-lums on two pairs of torsion springs is presented.By theoretical analysis and nmnerical calculation,it isshown that the isolator can achieve much longer resonant period due to gravitational positive feedback and issmaller in size than the current torsion spring isolators with the same geometric parameters. | Zhao Pengfei Huang Yuying Tang Mengxi Sun Shijun | 2002 | Acta Mechanica Solida Sinica2002，15，1： | 2 |
| 12 | Potential Off-Grid User Prediction System Based on Spark显示文摘With the increasingly fierce competition among communication operators,it is more and more important to make an accurate prediction of potential off grid users.To solve the above problem,it is inevitable to consider the effectiveness of learning algo rithms,the efficiency of data processing,and other factors.Therefore,in this paper,we,from the practical application point of view,propose a potential customer off grid predic tion system based on Spark,including data pre processing,feature selection,model build ing,and effective display.Furthermore,in the research of off grid system,we use the Spark parallel framework to improve the gcForest algorithm which is a novel decision tree ensemble approach.The new parallel gcForest algorithm can be used to solve practical problems,such as the off grid prediction problem.Experiments on two real world datasets demonstrate that the proposed prediction system can handle large scale data for the off grid user prediction problem and the proposed parallel gcForest can achieve satisfying per formance. | LI Xuebing SUN Ying ZHUANG Fuzhen HE Jia ZHANG Zhao ZHU Shijun HE Qing | 2019 | ZTE Communications2019，17，2： | 2 |
| 13 | A Novel Hybrid Tag Identification Protocol for Large-Scale RFID Systems显示文摘Radio frequency identification technology is one of the main technologies of Internet of Things(IoT).Through the transmission and reflection of wireless radio frequency signals,non-contact identification is realized,and multiple objects identification can be realized.However,when multiple tags communicate with a singleton reader simultaneously,collision will occur between the signals,which hinders the successful transmissions.To effectively avoid the tag collision problem and improve the reading performance of RFID systems,two advanced tag identification algorithms namely Adaptive M-ary tree slotted Aloha(AMTS)based on the characteristics of Aloha-based and Query tree-based algorithms are proposed.In AMTS,the reader firstly uses the framed slotted Aloha protocol to map the tag set to different time slots,and then identify the collided tags using binary search method based on collision factor or mapping table.Both performance analysis and extensive experimental results indicate that our proposed algorithms significantly outperforms most existing anti-collision approaches in tag dense RFID systems. | Ye Mu Ruiwen Ni Yuheng Sun Tong Zhang Ji Li Tianli Hu He Gong Shijun Li Thobela Louis Tyasi | 2021 | Computers, Materials & Continua2021，，8： | 1 |
| 14 | Molecular and Clinical Characterization of a Novel SCN5A Mutation Associated With Atrioventricular Block and Dilated Cardiomyopathy显示文摘 | Junbo Ge Aijun Sun Vesa Paajanen Shijun Wang Chunxi Su Zhiyin Yang Ying Li Shaochun Wang Jianguo Jia Keqiang Wang Yunzeng Zou Lizhi Gao Kun Wang Zheng Fan | 2008 | Circulation: Arrhythmia and Electrophysiology2008，，2： | 1 |
| 15 | 显示文摘 | Li Song Ji Shijun Sun Juncai | 2004 | J Functional Materials2004，35，3： | 1 |
| 16 | Bacillus phytases: present scenario and future perspectives显示文摘 | FU Shijun SUN Jianyi QIAN Lichun | 2008 | Appl Biochem Biotechnol2008，151，1： | 1 |
| 17 | Danhong inhibitsoxidized low-density lipoprotein-induced immune maturation of dentritic cells via a peroxisome proliferator activated receptorγmediated pathway显示文摘 | Liu Hongying Wang Shijun Sun Aijun | 2012 | J Pharmacol Sci2012，119，1： | 1 |
| 18 | Molecular and Clinical Characterization of a Novel SCN5A Mutation Associated With Atrioventricular Block and Dilated Cardiomyopathy显示文摘 | Junbo Ge Aijun Sun Vesa Paajanen Shijun Wang Chunxi Su Zhiyin Yang Ying Li Shaochun Wang Jianguo Jia Keqiang Wang Yunzeng Zou Lizhi Gao Kun Wang Zheng Fan | 2008 | Circulation: Arrhythmia and Electrophysiology2008，，2： | 1 |
| 19 | Prediction of thermodynamic properties of actinide and lanthanide compounds显示文摘Several relationship models for thermodynamic functions of actinide and lanthanide compounds are built. The descriptors such as the difference of atomic radii between metal atoms and nonmetal atoms and the molecular mass are used in quantitative structure-activity/property relationships. The relative errors for entropy and heat capacity are less than 20% in the majority of gaseous compounds. Similar results are obtained from solid compounds. | LU Chunhai NI Shijun SUN Ying CHEN Wenkai ZHANG Chengjiang | 2008 | Nuclear Science and Techniques2008，19，3： | 1 |
| 20 | Are EORTC risk tables suitable for Chinese patients with non-muscle-invasive bladder cancer?显示文摘 | Weihong Ding Zhongqing Chen Yuancheng Gou Chuanyu Sun Ke Xu Jun Tan Shijun Tong Guowei Xia Qiang Ding | 2014 | Cancer Epidemiology2014，，： | 1 |
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