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| 1 | Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection显示文摘T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However,whether Tim-3 is involved in hepatitis B virus(HBV) infection remains unknown. Here,we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes,especially on CD8+ T cells,was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs,significantly increased IFN-γ production from hepatic CD8+ T cells in HBV model mice was observed. Very interestingly,we found Tim-3 expression on CD8+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover,Tim-3 knockdown influenced anti-HBs production in vivo. Collectively,our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. | Ying Ju Nan Hou Xiaoning Zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining Zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma | 2009 | Cellular & Molecular Immunology2009，6，1： | 19 |
| 2 | XLORE2: Large-scale Cross-lingual Knowledge Graph Construction and Application显示文摘Knowledge bases(KBs)are often greatly incomplete,necessitating a demand for KB completion.Although XLORE is an English-Chinese bilingual knowledge graph,there are only 423,974 cross-lingual links between English instances and Chinese instances.We present XLORE2,an extension of the XLORE that is built automatically from Wikipedia,Baidu Baike and Hudong Baike.We add more facts by making cross-lingual knowledge linking,cross-lingual property matching and fine-grained type inference.We also design an entity linking system to demonstrate the effectiveness and broad coverage of XLORE2. | Hailong Jin Chengjiang Li Jing Zhang Lei Hou Juanzi Li | 2019 | Data Intelligence2019，1，1： | 5 |
| 3 | New Evidence for Genesis of the Zoige Carbonate-Siliceous-Pelitic Rock Type Uranium Deposit in Southern Qinling:Discovery and Significance of the 64 Ma Intrusions显示文摘在 Zoige 区域的 carbonaceous-siliceous-argillitic 岩石类型铀存款位于西藏的高原的东北边缘,并且由于它的规模,高等级和丰富的联系矿石获得了许多地质学家和矿石存款专家的许多注意。因为恼人的岩石,在矿化作用之间的关系和 magmatic 活动的不够的可靠标明日期仍然是未知的。为了学习这个关键科学问题和 Zoige 铀矿石的形成矿石的过程,回答, magmatic 岩石标明日期的 LA-ICP-MS 锆石 U-Pb 被获得:为 granite-prophyry 的 64.08 ±0.59 妈和为粗玄岩的 ∼200 妈。从 Zoige 铀矿石地标明日期沥青铀矿的结果的 U-Pb 主要被专注于 ∼90 妈和 ∼60 妈。根据 LA-ICP-MS U-Pb 锆石标明日期,为粗玄岩的年龄,斑岩花岗石和 granodiorite 是 200 妈, 64.08 妈近似并且 226.5-200.88 妈分别地。这显示矿化作用与中介酸的岩浆的活动有靠近的关系。花岗石斑岩的年龄与标明日期以前的研究完成的结果的那些沥青铀矿 U-Pb 一致,它在以后的 Yanshanian 期间反映 magmatic 和形成矿石的事件。从以前的研究基于数据, Zoige 铀矿石领域里的矿石身体能被划分成二个范畴:有 polymetal 矿化作用的单个铀类型和铀打字。,在迟了的白垩纪(大约 90 妈) 形成的前者后者,仔细与花岗石斑岩有关,在早 Paleogene (大约 60 妈) 形成了。并且除了矿石形成元素的铀,后者经常与 polymetallic 元素被联系例如铝,镍,锌,等等。 | SONG Hao ZHANG Chengjiang NI Shijun XU Zhengqi HUANG Changhua | 2014 | Acta Geologica Sinica(English Edition)2014，88，6： | 4 |
| 4 | Severe acute respiratory syndrome coronavirus 2(SARSCoV-2)membrane(M)protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has quickly spread worldwide and has affected more than 10 million individuals.A typical feature of COVID-19 is the suppression of type I and III interferon(IFN)-mediated antiviral immunity.However,the molecular mechanism by which SARS-CoV-2 evades antiviral immunity remains elusive.Here,we reported that the SARS-CoV-2 membrane(M)protein inhibits the production of type I and III IFNs induced by the cytosolic dsRNA-sensing pathway mediated by RIG-I/MDA-5–MAVS signaling.In addition,the SARS-CoV-2 M protein suppresses type I and III IFN induction stimulated by SeV infection or poly(I:C)transfection.Mechanistically,the SARS-CoV-2 M protein interacts with RIG-I,MAVS,and TBK1,thus preventing the formation of the multiprotein complex containing RIG-I,MAVS,TRAF3,and TBK1 and subsequently impeding the phosphorylation,nuclear translocation,and activation of IRF3.Consequently,ectopic expression of the SARS-CoV-2 M protein facilitates the replication of vesicular stomatitis virus.Taken together,these results indicate that the SARS-CoV-2 M protein antagonizes type I and III IFN production by targeting RIG-I/MDA-5 signaling,which subsequently attenuates antiviral immunity and enhances viral replication.This study provides insight into the interpretation of SARS-CoV-2-induced antiviral immune suppression and illuminates the pathogenic mechanism of COVID-19. | Yi Zheng Meng-Wei Zhuang Lulu Han Jing Zhang Mei-Ling Nan Peng Zhan Dongwei Kang Xinyong Liu Chengjiang Gao Pei-Hui Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 5 | Comprehensive and high-resolution emission inventory of atmospheric pollutants for the northernmost cities agglomeration of Harbin-Changchun,China:Implications for local atmospheric environment management显示文摘Using a bottom-up estimation method,a comprehensive,high-resolution emission inventory of gaseous and particulate atmospheric pollutants for multiple anthropogenic sectors with typical local sources has been developed for the Harbin-Changchun city agglomeration(HCA).The annual emissions for CO,NO_(x),SO_(2),NH_(3),VOC S,PM_(2.5),PM 10,BC and OC during 2017 in the HCA were estimated to be 5.82 Tg,0.70 Tg,0.34 Tg,0.75 Tg,0.81 Tg,0.67 Tg,1.59 Tg,0.12 Tg and 0.26 Tg,respectively.For PM 10 and SO_(2),the emissions from industry processes were the dominant contributors representing 54.7%and 49.5%,respectively,of the total emissions,while 95.3%and 44.5%of the total NH_(3)and NO x emissions,respectively,were from or associated with agricultural activities and transportation.Spatiotemporal distributions showed that most emissions(except NH_(3))occurred in November to March and were concentrated in the central cities of Changchun and Harbin and the surrounding cities.Open burning of straw made an important contribution to PM_(2.5)in the central regions of the northeastern plain during autumn and spring,while domestic coal combustion for heating purposes was significant with respect to SO_(2)and PM_(2.5)emissions during autumn and winter.Furthermore,based on Principal Component Analysis and Multivariable Linear Regression model,air temperature,relative humidity,electricity and energy consumption,and the urban and rural population were optimized to be representative indicators for rapidly assessing the magnitude of regional atmospheric pollutants in the HCA.Such indicators and equations were demonstrated to be useful for local atmospheric environment management. | Mengduo Zhang Weiwei Chen Xiangjin Shen Hongmei Zhao Chengkang Gao Xuelei Zhang Wei Liu Chengjiang Yang Yang Qin Shichun Zhang Jing Fu Daniel Tong Aijun Xiu | 2021 | Journal of Environmental Sciences2021，33，6： | 3 |
| 6 | Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes显示文摘HBV is considered as a“stealth”virus that does not invoke interferon(IFN)responses;however,the mechanisms by which HBV bypasses innate immune recognition are poorly understood.In this study,we identified adenosine deaminases acting on RNA 1(ADAR1),which is a key factor in HBV evasion from IFN responses in hepatocytes.Mechanically,ADAR1 interacted with HBV RNAs and deaminated adenosine(A)to generate inosine(I),which disrupted host immune recognition and thus promoted HBV replication.Loss of ADAR1 or its deficient deaminase activity promoted IFN responses and inhibited HBV replication in hepatocytes,and blocking the IFN signaling pathways released the inhibition of HBV replication caused by ADAR1 deficiency.Notably,the HBV X protein(HBx)transcriptionally promoted ADAR1 expression to increase the threshold required to trigger intrinsic immune activation,which in turn enhanced HBV escape from immune recognition,leading to persistent infection.Supplementation with 8-azaadenosine,an ADAR1 inhibitor,efficiently enhanced liver immune activation to promote HBV clearance in vivo and in vitro.Taken together,our results delineate a molecular mechanism by which HBx promotes ADAR1-derived HBV immune escape and suggest a targeted therapeutic intervention for HBV infection. | Liyuan Wang Yang Sun Xiaojia Song Zehua Wang Yankun Zhang Ying Zhao Xueqi Peng Xiaodong Zhang Chunyang Li Chengjiang Gao Nailin Li Lifen Gao Xiaohong Liang Zhuanchang Wu Chunhong Ma | 2021 | Cellular & Molecular Immunology2021，18，8： | 2 |
| 7 | Metallogenic Regularity of Hydrothermal Uranium Deposits in the Migmatite of the Kangdian Axis显示文摘1 Introduction The Kangdian axis is an important polymetallic metallogenic belt in Southwest China,and it is also an area with a lot of hydrothermal uranium mineralization(Wang Hongjun,et al.,2009.The | XU Zhengqi OUYANG Xindong CHEN Xuanrong ZHANG Chengjiang YAO Jian | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 2 |
| 8 | OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING显示文摘Stimulator of interferon genes(STING)is an adaptor protein that is critical for effective innate antiviral and antitumor immunity.The activity of STING is heavily regulated by protein ubiquitination,which is fine-tuned by both E3 ubiquitin ligases and deubiquitinases.Here,we report that the deubiquitinase OTUD5 interacts with STING,cleaves its K48-linked polyubiquitin chains,and promotes its stability.Consistently,knockout of OTUD5 resulted in faster turnover of STING and subsequently impaired type I IFN signaling following cytosolic DNA stimulation.More importantly,Lyz2-Cre Otud5^(fl/Y) mice and CD11-Cre Otud5^(fl/Y) mice showed more susceptibility to herpes simplex virus type 1(HSV-1)infection and faster development of melanomas than their corresponding control littermates,indicating that OTUD5 is indispensable for STING-mediated antiviral and antitumor immunity.Our data suggest that OTUD5 is a novel checkpoint in the cGAS-STING cytosolic DNA sensing pathway. | Yunyun Guo Fei Jiang Lingli Kong Haifeng Wu Honghai Zhang Xiaorong Chen Jian Zhao Baoshan Cai Yanqi Li Chunhong Ma Fan Yi Lei Zhang Bingyu Liu Yi Zheng Lingqiang Zhang Chengjiang Gao | 2021 | Cellular & Molecular Immunology2021，18，8： | 2 |
| 9 | MINERALOGICAL FEATURES OF ULTRAMAFIC HYPOXENOLITHS IN ALKALI-RICH PORPHYRY显示文摘Ultramafic hypoxenoliths found in the alkali-rich porphyry in the Liuhe Village, Heqing, Yunnan,China, are of great significance in understanding the origin and evolution of the porphyry. This paper discusses the mineralogical features of the hypoxenoliths. It shows that the xenoliths are characterized by the upper mantle rocks modified to certain extent by the enriched mantle fluid metasomatism in the mantle environment, with the enriched mantle property of Iow-degree partial melting. This constitutes the important mineralogical evidence for the petrogenesis and mineralization of alkali-rich porphyry. | LIU Xianfan , YANG Zhengxi, LIU Jiaduo, ZHANG Chengjiang, WU Dechao and LI Youguo(Institute of Earth Science, Chengdu University of Technology, Erxianqiao Dongsan Road 1#,Chengdu, SC610059, China) | 2003 | Geotectonica et Metallogenia2003，27，1： | 2 |
| 10 | A critical review on the bio-removal of hazardous heavy metals from contaminated soils: Issues, progress, eco-environmental concerns and opportunities显示文摘 | Gang Wu Hubiao Kang Xiaoyang Zhang Hongbo Shao Liye Chu Chengjiang Ruan | 2009 | Journal of Hazardous Materials2009，，1： | 2 |
| 11 | Environmental geology problems caused by mining activities in Panzhihua iron mine显示文摘 | Zhengqi XU Xianguo TUO Chengjiang ZHANG Keliang MU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 2 |
| 12 | SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules显示文摘As a highly pathogenic human coronavirus,SARS-CoV-2 has to counteract an intricate network of antiviral host responses to establish infection and spread.The nucleic acid-induced stress response is an essential component of antiviral defense and is closely related to antiviral innate immunity.However,whether SARS-CoV-2 regulates the stress response pathway to achieve immune evasion remains elusive.In this study,SARS-CoV-2 NSP5 and N protein were found to attenuate antiviral stress granule(avSG)formation.Moreover,NSP5 and N suppressed IFN expression induced by infection of Sendai virus or transfection of a synthetic mimic of dsRNA,poly(I:C),inhibiting TBK1 and IRF3 phosphorylation,and restraining the nuclear translocalization of IRF3.Furthermore,HEK293T cells with ectopic expression of NSP5 or N protein were less resistant to vesicular stomatitis virus infection.Mechanistically,NSP5 suppressed avSG formation and disrupted RIG-I–MAVS complex to attenuate the RIG-I–mediated antiviral immunity.In contrast to the multiple targets of NSP5,the N protein specifically targeted cofactors upstream of RIG-I.The N protein interacted with G3BP1 to prevent avSG formation and to keep the cofactors G3BP1 and PACT from activating RIG-I.Additionally,the N protein also affected the recognition of dsRNA by RIG-I.This study revealed the intimate correlation between SARS-CoV-2,the stress response,and innate antiviral immunity,shedding light on the pathogenic mechanism of COVID-19. | Yi Zheng Jian Deng Lulu Han Meng-Wei Zhuang Yanwen Xu Jing Zhang Mei-Ling Nan Yang Xiao Peng Zhan Xinyong Liu Chengjiang Gao Pei-Hui Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 1 |
| 13 | Prediction of thermodynamic properties of actinide and lanthanide compounds显示文摘Several relationship models for thermodynamic functions of actinide and lanthanide compounds are built. The descriptors such as the difference of atomic radii between metal atoms and nonmetal atoms and the molecular mass are used in quantitative structure-activity/property relationships. The relative errors for entropy and heat capacity are less than 20% in the majority of gaseous compounds. Similar results are obtained from solid compounds. | LU Chunhai NI Shijun SUN Ying CHEN Wenkai ZHANG Chengjiang | 2008 | Nuclear Science and Techniques2008，19，3： | 1 |
| 14 | Genetic mechanisms of the Jinchuan ultramafic intrusion and associated superlarge sulfide deposit, Northwest China显示文摘 | Xie Guanghong Wang Yunliang Fan Caiyun Zhang Chengjiang Zheng Rong | 1998 | Sci China (D)1998，，： | 1 |
| 15 | USP3 deubiquitinates and stabilizes the adapter protein ASC to regulate inflammasome activation显示文摘Inflammasomes are essential components of the innate immune system and its defense against infections,whereas the dysregulation of inflammasome activation has a detrimental effect on human health.The activation of inflammasomes is subjected to tight regulation to maintain immune homeostasis,yet the underlying mechanism remains elusive.Here,we identify USP3 as a direct deubiquitinating enzyme(DUB)for ASC,the central adapter mediating the assembly and activation of most inflammasomes.USP3 removes the K48-linked ubiquitination on ASC and strengthens its stability by blocking proteasomal degradation.Additionally,USP3 promotes inflammasome activation,and this function was confirmed in mouse models of aluminum(Alum)-induced peritonitis,F.novicida infection and flagellin-induced pneumonia in vivo.Our work unveils that USP3 functions as a key regulator of ASC ubiquitination and maintains the physiological role of ASC in mediating inflammasome activation,and we propose a new mechanism by which the ubiquitination of ASC regulates inflammasome activation. | Wanxin Zhuang Lei Zhang Yi Zheng Bingyu Liu Chunhong Ma Wei Zhao Suxia Liu Feng Liu Chengjiang Gao | 2022 | Cellular & Molecular Immunology2022，19，10： | 1 |
| 16 | Geological and geochemical evolution of forming of kalium-rich brine in Sichuan Basin显示文摘1 Introduction Sichuan Basin is basically a salt brine reservoir,large closed and semi-closed artesian sedimentary basin with an area of 200,000 Km2 in southeast China.During the forming and evolution of the basin,it has been affected | XU Zhengqi YIN Guan ZHANG Chengjiang CHEN Xuanrong | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 1 |
| 17 | Roles of TIPE2 in hepatitis B virus-induced hepatic inflammation in humans and mice显示文摘 | Wenjin Xi Yejia Hu Yugang Liu Jiao Zhang Lei Wang Yunwei Lou Zhonghua Qu Jian Cui Guizhong Zhang Xiaohong Liang Chunhong Ma Chengjiang Gao Youhai Chen Suxia Liu | 2011 | Molecular Immunology2011，，9： | 1 |
| 18 | Study on flow control volume in numerical simulation ofwateijet propulsor显示文摘 | LIU Chengjiang WANG Yongsheng ZHANG Zhihong | 2008 | Chinese Journal of Hydrodynamics2008，23，5： | 1 |
| 19 | Review of online coupling of sample preparation tech- niques with liquid chromatography显示文摘 | Pan Jialiang Zhang Chengjiang Zhang Zhuomin | 2014 | Analytica Chimica Acta2014，815，： | 1 |
| 20 | PI4P STimulatING innate immune activation:beyond the Golgi显示文摘The cGAS–STING pathway is pivotal for sensing cytosolic DNA[2].cGAS,a cytoplasmic DNA sensor,can be stimulated by DNA,and it consumes ATP and GTP to synthesize a second messenger,2'3'-cGAMP,which binds to STING,resulting in STING conformational change,oligomerization,and activation;ultimately,this process leads to the production of cytokines such as type I interferon to mediate antiviral and antitumor immune responses(Fig.1).Phosphoinositides,derived from phosphatidylinositol(PI),are phospholipids in membranes and are also crucial signaling molecules[3].The D-3,D-4,or D-5 positions in the inositol head group can be phosphorylated;therefore,a total of seven different PIP molecules exist in eukaryotes.Phosphatidylinositol 4-phosphate(PI4P)is distributed in various membrane components,with the highest amount in the trans-Golgi network(TGN)[4].The PI4P level in cells is regulated by its PI4K synthetases(PI4KA,PI4KB,PI4K2A,and PI4K2B)and the lipid phosphatase SAC1.In addition to being a precursor for PIP2 and PIP3,PI4P is a crucial signaling molecule involved in vesicular transport,lipid transport,and organelle morphology maintenance. | Yi Zheng Xuejing Zhang Chengjiang Gao | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
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