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| 1 | Urban Three-dimensional Expansion and Its Driving Forces——A Case Study of Shanghai,China显示文摘Urban expansion is a phenomenon of urban space increase,and an important measuring index of the process of urbanization.Taking Shanghai as an example,the changes of urban average height and built-up area were studied to represent city's vertical and horizontal increases respectively,and statistical methods were used to analyze the driving forces of urban expansion.The research drew following conclusions:1) The urban expansion process of Shanghai from 1985 to 2006 had a clear periodic feature,and could be divided into three stages:vertical expansion in dominance,coordinated vertical and horizontal expansion,and horizontal expansion in dominance.2) The average height and quantity of buildings in core city were significantly bigger than those in suburbs,but the changing speed of the latter was faster.And 3) urbanization process was the major driving force for the city's horizontal expansion,while industrial structure improvement was the key driving factor for the vertical expansion.Those two driving forces were simultaneously affected by city's political factors. | SHI Longyu SHAO Guofan CUI Shenghui LI Xuanqi LIN Tao YIN Kai ZHAO Jingzhu | 2009 | Chinese Geographical Science2009，19，4： | 20 |
| 2 | Dynamic analysis of urban spatial expansion and its determinants in Xiamen Island显示文摘大多数世界城市在沿海的区域被集中。作为沿海的系统的一个特殊地理部件,岛城市的空间扩大是在城市开发和物理环境之间的相互作用的结果。这篇论文拿厦门岛,在东南的中国定位了,,分析岛的一个例子由在城市的发展政策,城市的全面计划,人口生长和工业开发上联合文学的分析的城市的空间扩大和它的决定因素,与用历史的地图和遥感相片的地理信息分析。第一,我们在最后 100 年期间考察了厦门城市发展的历史,它能被划分成四个时期:从 1908 ~ 1949 的胚胎的现代城市和早开发;从 1950 ~ 1979 的行政边界扩大和基础结构开发;从 1980 ~ 2003 的特殊经济地区建设和快速的都市化;并且海湾城市建设自从 2003。海岸线的动态变化,岛形状,布满建筑物区域,交通,行政部门,和主要陆地使用打发生了在期间的变换近似,过去的 100 年被分析并且岛的特征城市的空间扩大被结束:从一个中央点的早扩大,从海岸线内陆沿着海岸线,和扩大的节由扩大列在后面。第二,我们讨论了岛的潜在的决定因素包括行政部门调整,城市的主人计划修订,工业发展,地形学的因素,沿海的区域开垦,交通扩大,和人口的城市的空间扩大生长。最后,岛上的每个潜在的决定因素的效果城市的空间扩大被结束。岛城市的空间扩大是不独立却交往的自然、社会经济的因素的合成的结果。布满建筑物区域扩大是岛土地的主要司机盖子和陆地使用变化。由这份报纸,我们希望提供在远处在中国,和世界贡献岛和沿海的持续都市化的合理理解的一本科学参考书。 | LI Xinhu LIN Tao ZHANG Guoqin XlAO Lishan ZHAO Qianjun CUI Shenghui | 2011 | Journal of Geographical Sciences2011，21，3： | 10 |
| 3 | A New Carbon and Oxygen Balance Model Based on Ecological Service of Urban Vegetation显示文摘The application of human induced oxygen consumption and carbon emission theory in urban region was summed up and on this base a new model of urban carbon and oxygen balance (UCOB) was constructed by calculating the carbon and oxygen fluxes. The purpose was to highlight the role of vegetation in urban ecosystems and evaluate the effects of various human activities on urban annual oxygen consumption and carbon emission. Hopefully,the model would be helpful in theory to keep the regional balance of carbon and oxygen,and provide guidance and support for urban vegetation planning in the future. To test the UCOB model,the Jimei District of Xiamen City,Fujian Province,China,a very typical urban region,was selected as a case study. The results turn out that Jimei′s vegetation service in oxygen emission and carbon sequestration could not meet the demand of the urban population,and more than 31.49 times of vegetation area should be added to meet the whole oxygen consumption in Jimei while 9.60 times of vegetation area are needed to meet the carbon sequestration targets. The results show that the new UCOB model is of a great potential to be applied to quantitative planning of urban vegetation and regional eco-compensation mechanisms. | YIN Kai ZHAO Qianjun LI Xuanqi CUI Shenghui HUA Lizhong LIN Tao | 2010 | Chinese Geographical Science2010，20，2： | 6 |
| 4 | L-type calcium current in right ventricular outflow tract myocytes of rabbit heart显示文摘The mechanism of idiopathic ventricular tachycardia originating from the right ventricular outflow tract (RVOT) is not clear. Many clinical reports have suggested a mechanism of triggered activity. However, there are few studies investigating this because of the technical difficulties associated with examining this theory. The L-type calcium current (ICa-L), an important inward current of the action potential (AP), plays an important role in arrhythmogenesis. The aim of this study was to explore differences in the APs of right ventricular (RV) and RVOT cardiomyocytes, and differences in electrophysiological characteristics of the ICa-L in these myocytes. Rabbit RVOT and RV myocytes were isolated and their AP and ICa-L were investigated using the patch-clamp technique. RVOT cardiomyocytes had a wider range of AP duration (APD) than RV cardiomyocytes, with some markedly prolonged APDs and markedly shortened APDs. The markedly shortened APDs in RVOT myocytes were abolished by treatment with 4-AP, an inhibitor of the transient outward potassium current, but the markedly prolonged APDs remained, with some myocytes with a long AP plateau not repolarizing to resting potential. In addition, early afterdepolarization (EAD) and second plateau responses were seen in RVOT myocytes but not in RV myocytes. RVOT myocytes had a higher current density for ICa-L than RV myocytes (RVOT (13.16±0.87) pA pF-1, RV (8.59±1.97) pA pF-1; P<0.05). The ICa-L and the prolonged APD were reduced, and the EAD and second plateau response disappeared, after treatment with nifedipine (10 μmol L-1), which blocks the ICa-L. In conclusion, there was a wider range of APDs in RVOT myocytes than in RV myocytes, which is one of the basic factors involved in arrhythmogenesis. The higher current density for ICa-L is one of the factors causing prolongation of the APD in RVOT myocytes. The combination of EAD with prolonged APD may be one of the mechanisms of RVOT-VT generation. | LIANG ShengHui LIN ChenHui LI Yuan LIU TaiFeng WANG Yan | 2012 | Science China(Life Sciences)2012，55，1： | 3 |
| 5 | Improvement in quality of life in depressed patients following verum acupuncture or electroacupuncture plus paroxetine:A randomized controlled study of 157 cases显示文摘Depressed patients with scores of 17 or more on the 17 items of the Hamilton Depression Rating Scale were treated with the antidepressant drug paroxetine. They also underwent verum acupuncture or electroacupuncture at Baihui (GV20) and Yintang (GV29). The World Health Organization Quality of Life Scale Brief Version showed a significant increase in the total scores of patients who underwent verum acupuncture and electroacupuncture for 6 weeks compared with those who were given paroxetine only; significantly increased physical domain and social relationship scores in verum acupuncture patients compared with paroxetine only; and significantly elevated psychological domain scores with electroacupuncture compared with paroxetine only. These results indicate that both verum acupuncture and electroacupuncture can improve quality of life in depressed patients undergoing paroxetine treatment. | Shenghui Ma Shanshan Qu Yong Huang Junqi Chen Renyong Lin Chongqi Wang Ganlong Li Canghuan Zhao Shenchang Guo Zhangjin Zhang | 2012 | Neural Regeneration Research2012，7，27： | 3 |
| 6 | Animal exercise studies in cardiovascular research:Current knowledge and optimal design--A position paper of the Committee on Cardiac Rehabilitation,Chinese Medical Doctors’Association显示文摘Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against cardiovascular diseases However,the underlying mechanisms of the beneficial effects of exercise have yet to be elucidated.Animal exercise studies are widely used to investigate the key mechanisms of exercise-induced cardiovascular protection.However,standardized procedures and well-established evaluation indicators for animal exercise models are needed to guide researchers in carrying out effective,high-quality animal studies using exercise to prevent and treat cardiovascular diseases.In our review,we present the commonly used animal exercise models in cardiovascular research and propose a set of standard procedures for exercise training,emphasizing the appropriate measurements and analysis in these chronic exercise models.We also provide recommendations for optimal design of animal exercise studies in cardiovascular research,including the choice of exercise models,control of exercise protocols,exercise at different stages of disease,and other considerations,such as age,sex,and genetic background.We hope that this position paper will promote basic research on exercise-induced cardiovascular protection and pave the way for successful translation of exercise studies from bench to bedside in the prevention and treatment of cardiovascular diseases. | Yihua Bei Lei Wang Rongjing Ding Lin Che Zhiqing Fan Wei Gao Qi Liang Shenghui Lin Suixin Liu Xiao Lu Yuqin Shen Guifu Wu Jian Yang Guolin Zhang Wei Zhao Lan Guo Junjie Xiao | 2021 | Journal of Sport and Health Science2021，10，6： | 2 |
| 7 | Morphology of the anterior mesorectum:a new predictor for local recurrence in patients with rectal cancer显示文摘Background:Pre-operative assessment with high-resolution magnetic resonance imaging(MRI)is useful for assessing the risk of local recurrence(LR)and survival in rectal cancer.However,few studies have explored the clinical importance of the morphology of the anterior mesorectum,especially in patients with anterior cancer.Hence,the study aimed to investigate the impact of the morphology of the anterior mesorectum on LR in patients with primary rectal cancer.Methods:A retrospective study was performed on 176 patients who underwent neoadjuvant treatment and curative-intent surgery.Patients were divided into two groups according to the morphology of the anterior mesorectum on sagittal MRI:(1)linear type:the anterior mesorectum was thin and linear;and(2)triangular type:the anterior mesorectum was thick and had a unique triangular shape.Clinicopathological and LR data were compared between patients with linear type anterior mesorectal morphology and patients with triangular type anterior mesorectal morphology.Results:Morphometric analysis showed that 90(51.1%)patients had linear type anterior mesorectal morphology,while 86(48.9%)had triangular type anterior mesorectal morphology.Compared to triangular type anterior mesorectal morphology,linear type anterior mesorectal morphology was more common in females and was associated with a higher risk of circumferential resection margin involvement measured by MRI(35.6%[32/90]vs.16.3%[14/86],P=0.004)and a higher 5-year LR rate(12.2%vs.3.5%,P=0.030).In addition,the combination of linear type anterior mesorectal morphology and anterior tumors was confirmed as an independent risk factor for LR(odds ratio=4.283,P=0.014).Conclusions:The classification established in this study was a simple way to describe morphological characteristics of the anterior mesorectum.The combination of linear type anterior mesorectal morphology and anterior tumors was an independent risk factor for LR and may act as a tool to assist with LR risk stratification and treatment selection. | Xiaojie Wang Zhifang Zheng Min Chen Jing Lin Xingrong Lu Ying Huang Shenghui Huang Pan Chi | 2022 | Chinese Medical Journal2022，135，20： | 2 |
| 8 | Crystallization phase transition in the precursors of CIGS films by Ar-ion plasma etching process 显示文摘 | Lin Wei-Ting Chen Shenghui Chan Shih-Hao | 2014 | Vacuum2014，99，： | 1 |
| 9 | Electrochromic properties of nano-structured nickel oxide thin film prepared by spray pyrolysis method 显示文摘 | Lin Shenghui Chen Furong Kai Jijung | 2008 | Applied Surface Science2008，254，1： | 1 |
| 10 | Ore-forming age and tectonic setting of the Linjiasandaogou gold deposit in the Liaodong Peninsula,northeast China:constraints from geochronology and geochemistry显示文摘The Linjiasandaogou gold deposit is located in the Qingchengzi Orefield,North China Craton,China,and has not attracted many studies.We present geochronological,whole-rock geochemical,and Sr–Nd–Hf isotopic data to constrain the age and tectonic setting of the mineralization.U–Pb dating of zircon from pre-and post-ore dikes indicates the Linjiasandaogou Au deposit formed at ca.227–226 Ma.The granite porphyry(ca.227 Ma)and quartz diorite porphyry(ca.228 Ma),which are slightly older than the mineralization,have(;Sr/;Sr)i-=0.7127–0.7162,εNd(t)=–13.7 to–17.0,andεHf(t)=–14.6 to–16.9,and display enrichment in light rare earth elements and large ion lithophile elements and depletion in high field strength elements.Two lamprophyres(226 and225 Ma),which are slightly younger than the mineralization,have higher(;Sr/;Sr)i(0.7165–0.7216),negativeεNd(t)(–11.2 to–14.3)andεHf(t)(–15.6 to–18.6)values,and are enriched in light rare earth elements but depleted in high field strength elements(Nb and Ta).The geochemical characteristics of the granitoid and lamprophyres indicate a lower crustal and enriched mantle source,respectively.We infer that the Linjiasandaogou Au deposit formed in a postcollisional tectonic setting,following the collision between the North China,Yangtze craton,and Central Asian Orogeny in Triassic. | Xiaofeng Yao Tingjie Yan Zhicheng Lü Chenggui Lin Kuifeng Mi Shenghui Li Yang Li Wange Du | 2022 | Acta Geochimica2022，41，2： | 1 |
| 11 | Carbon footprints of food production in China显示文摘 | Lin Jianyi Hu Yuanchao Cui Shenghui Kang Jiefeng Xu Lilai | 2015 | Joumal of Cleaner Produc- tion2015，90，： | 1 |
| 12 | Using a network framework to quantitatively select ecological indicators显示文摘 | Lin Tao Lin Jianyi Cui Shenghui | 2009 | Ecological Indicators2009，9，6： | 1 |
| 13 | Low-tem- perature synthesis of graphene on Cu using plasna- asisted thermal chemical vapor deposition显示文摘 | Shihao Chan Shenghui Chen Welting Lin | 2013 | Nanoscale research let- ters2013，8，： | 1 |
| 14 | Managing urban nutrient biogeochemistry for sustainable urbanization显示文摘 | Tao Lin Valerie Gibson Shenghui Cui Chang-Ping Yu Shaohua Chen Zhilong Ye Yong-Guan Zhu | 2014 | Environmental Pollution2014，，： | 1 |
| 15 | Cr^(3+)/Y^(3+)co-doped persistent luminescence nanoparticles with biological window activation for in vivo repeatable imaging显示文摘The near-infrared(NIR)persistent luminescence materials(PLMs)can remain long-lasting luminescence after removal of the excitation light,which permits bioimaging with high sensitivity owing to the absence of background fluorescence interference from in situ excitation.Recently,the NIR PLMs have aroused intensive research interest in bioimaging.However,the optimal excitation wavelength of current NIR PLMs is located in the ultraviolet region with shallow tissue penetration,making it difficult to activate effectively in vivo,and seriously hindering their further application in bioimaging.Herein,we report a novel kind of Cr^(3+)ions and Y^(3+)ions co-doped NIR PLM,Zn_(1.3)Ga_(1.4)Sn_(0.3)O_(4):Cr^(3+),Y^(3+)(ZGSCY),which emits NIR persistent luminescence at 696 nm.Compared with Zn_(1.3)Ga_(1.4)Sn_(0.3)O_(4):Cr^(3+)(ZGSC)excited by the light with a wavelength in the biological window(>650 nm),after being co-doped with Y^(3+)ions,the NIR persistent luminescence performance of ZGSCY is significantly improved because of the increase of trap concentration in the matrix.In addition,we synthesized ZGSCY nanoparticles(NPs)by the combustion method,which exhibit excellent optical properties after being excited by the light with a wavelength in the biological window.After surface modification with PEG,the ZGSCY NPs present low cytotoxicity.Notably,due to the co-doping of Y^(3+)ions,the signal-to-noise ratio(SNR)of ZGSCY NPs in vivo imaging is about 1.8 times higher than that of the ZGSC NPs.Furthermore,the rechargeable in vivo imaging and passive tumor-targeted imaging are successfully achieved by activating with a lightemitting diode(LED,659 nm)after intravenous injection of ZGSCY.Thus,this kind of NIR PLM with high excitation efficiency performance in the biological window is expected to promote its biomedical application in deep tissues. | Huimin Jiang Lin Liu Kexin Yu Xianggui Yin Shenghui Zheng Liang Song Junpeng Shi Yun Zhang | 2022 | Journal of Rare Earths2022，40，9： | 1 |
| 16 | A novel Gd-based phosphor NaGdGeO_(4):Bi^(3+),Li^(+)with super-long ultraviolet-A persistent luminescence显示文摘In very recent years,ultraviolet(UV)persistent luminescent materials(PLMs)have attracted widespread attention due to their potential biological applications.However,owing to the lack of suitable emitters and hosts,the design and development of excellent UV PLMs remain challenging.Here,we report a new Gd-based PLM NaGdGeO_(4):Bi^(3+)with super-long UVA persistent luminescence(PersL).By further codoping Li^(+)ions to increase the concentration of traps,the UVA PersL intensity of NaGdGeO_(4):Bi^(3+)is increased by 5.5 times.The optimal NaGdGeO_(4):Bi^(3+),Li^(+)exhibits excellent UVA PersL and can persist for more than 200 h.Moreover,the phosphor NaGdGeO_(4):Bi^(3+),Li^(+)also exhibits photostimulated property with a red LED or NIR laser excitation after the long-term decay,and can be activated by X-ray.This promising Gd-based UVA PLM is expected to have potential applications in biomedicine through triggering photocatalysts or photosensitizers by its UVA PersL to achieve photodynamic therapy and its potential ability of magnetic resonance(MR)imaging due to Gd^(3+)ions as MR imaging probe contained in the host NaGdGeO_(4). | Lin Liu Kexin Yu Liyan Ming Yangyang Sheng Shenghui Zheng Liang Song Junpeng Shi Yun Zhang | 2022 | Journal of Rare Earths2022，40，9： | 1 |
| 17 | Introgression of chromosome 6PL terminal segment from Agropyron cristatum to increase both grain number and grain weight in wheat显示文摘Agropyron cristatum(2n=4x=28,PPPP),which harbours many high-yield and disease-resistance genes,is a promising donor for wheat improvement.Narrow genetic diversity and the trade-off between grain weight and grain number have become bottlenecks for increasing grain yield in wheat.In this study,a novel translocation line,WAT650l,was derived from the chromosome 6P addition line 4844–12,which can simultaneously increase both grain number per spike(GNS)and thousand-grain weight(TGW).Cytological analysis and molecular marker analysis revealed that WAT650l was a 5BL.5BS-6PL(bin 12–17)translocation line.Assessment of agronomic traits and analysis of the BC4F2 and BC5F2 populations suggested that the 6PL terminal chromosome segment in WAT650l resulted in increased grain number per spike(average increased by 14.07 grains),thousand-grain weight(average increased by 4.31 g),flag leaf length,plant height,spikelet number per spike and kernel number per spikelet during the two growing seasons of 2020–2021 and 2021–2022.Additionally,the increased GNS locus and high-TGW locus of WAT650l were mapped to the bins 16–17 and 12–13,respectively,on chromosome 6PL by genetic population analysis of three translocation lines.In summary,we provide a valuable germplasm resource for broadening the genetic base of wheat and overcoming the negative relationship between GNS and TGW in wheat breeding. | Yida Lin Shenghui Zhou Xuezhong Liang Bing Han Junli Yang Baojin Guo Jinpeng Zhang Haiming Han Weihua Liu Xinming Yang Xiuquan Li Lihui Li | 2023 | The Crop Journal2023，11，3： | 1 |
| 18 | PIM2 regulates stemness through phosphorylation of 4E-BP1显示文摘Embryonic stem cells(ESCs) can undergo unlimited self-renewal and maintain pluripotency to differentiate into any cell type of the three germ layers. Extensive studies have shown ESC identity is regulated by transcription factors, epigenetic regulators and multiple signal transduction pathways. However, the kinase regulation of pluripotency is not well understood. Here we show that the serine/threonine kinase PIM2, which is highly expressed in ESCs but not in somatic cells, functions as a crucial stemness regulator in ESCs. Knockout of Pim2 inhibits the self-renewal and differentiation capability of ESCs. Mechanistic studies identified that PIM2 can directly phosphorylate 4E-BP1, leading to release of e IF4E which facilitates the translation of pluripotent genes in ESCs. Our study highlights a novel kinase cascade pathway for ESC identity maintenance. | Hongyan Sun Jiani Cao Lin Zhao Shaohua Zhu Shenghui Chen Yaqiong Li Bin Zhao Tongbiao Zhao | 2017 | Science Bulletin2017，62，10： | 0 |
| 19 | Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis显示文摘Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM. | Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui Qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao Dongmei Zhang Wencai Ye Minfeng Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 20 | Roadmap toward the metaverse: An AI perspective显示文摘Truth must be told,but not much—a hybrid society of real and virtual is coming.Metaverse,1 rise recently,is attracting significant attention from academia to industry.A metaverse is a network of three-dimensional(3D)virtual worlds focused on social connection.Bearing the outbreak of the coronavirus 2019 pandemic,people are physically isolated,which triggered the growth of the metaverse.Different from existing work,this commentary targets the roadmap of the metaverse from an artificial intelligence(AI)perspective.First,we blueprint a roadmap for this digital cyberspace transformation,including immersion creation,hardware support,text interpretation,audio processing,connection construction,economy operation,and security protection.Second,at each phase of the roadmap,we address the status as well as the advanced technologies to provide indepth views accordingly.The whole pipeline is illustrated from an AI2 perspective,as shown in Figure 1,and we believe that AI is playing an increasingly important role in core techniques toward this technological singularity。 | Shenghui Cheng Yue Zhang Xiaofei Li Lin Yang Xin Yuan Stan Z.Li | 2022 | The Innovation2022，3，5： | 0 |
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