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| 1 | α1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation显示文摘尽管为有类型 1 糖尿病的个人的小岛移植被显示了产出优异的血葡萄糖控制,它为长期的控制仍然保持不适当。这是部分,由于小岛损害和压力,那能导致贝它房间损失。过量 IL-1β 的抑制;活动可能最小化小岛损害,因此保存工作。IL-1 受体对手(IL-1Ra ) , IL-1β 的一个内长的禁止者;,保护小岛免受导致 cytokine 的坏死和 apoptosis 的伤害。因此,在 IL-1β 之间的不平衡;并且 IL-1Ra 可能影响到小岛的 allogeneic 和自体免疫的回答的功课。我们的组以前证明传播丝氨酸朊酶禁止者人 alpha-1-antitrypsin (hAAT ) ,以及 immunomodulatory 活动。在现在的学习,我们寻求了决定是否胰腺的小岛 hAAT 的 allograft 保护的活动被 IL-1Ra 调停感应。我们的结果证明 hAAT 在刺激巨噬细胞在 IL-1Ra 表示导致了 2.04 褶层增加并且 hAAT-pre-treated 小岛接枝在 IL-1Ra 抄本层次展出了 4.851 褶层增加,它与中等煽动性的侧面被联系。出人意料地,从 IL-1Ra-knockout 鼠标被孤立并且在 grafting 前与 hAAT 预先对待进野类型的鼠标的小岛在大概从渗入主机房间被导出的 intragraft IL-1Ra 表示产出增加,当主机的 hAAT 处理不在时的虽然。确实, hAAT-pre-treated 小岛产生了能在有教养的巨噬细胞导致 IL-1Ra 生产的 hAAT 免费的调节媒介。最后,我们证明 hAAT 为 p65 支持了不同 phosphorylation 和原子 translocation 模式,为 IL-1Ra 要求的一个关键抄写因素表示。 | Avishag Abecassis Ronen Schuster Galit Shahaf Eyal Ozeri Ross Green David E Ochayon Peleg Rider Eli C Lewis | 2014 | Cellular & Molecular Immunology2014，11，4： | 2 |
| 2 | Learning in networks of cortical neurons显示文摘 | Shahaf G Marom S | 2001 | The Journal of Neuroscience2001，21，22： | 1 |
| 3 | Production of energy from concent rated brines by pressure retarded osmosisⅡ: Experimental results and projected energy costs显示文摘 | Loeb S Hassen F V Shahaf D | 1976 | Membr Sci1976，，1： | 1 |
| 4 | Development,learning and memory in large random networks of cortical neurons:lessons beyond anatomy显示文摘 | Maron S Shahaf G | 2002 | Quarterly Review of Biophysics2002，35，1： | 1 |
| 5 | Learning in networks of cortical neurons显示文摘 | Shahaf G and Marom S | 2001 | The Journal of Neuroscience2001，21，22： | 1 |
| 6 | Development,learning and memory in large random networks of cortical neurons:Lessons beyond anatomy显示文摘 | Marom S Shahaf G | 2002 | Quarterly Reviews of Biophysics2002，35，1： | 1 |
| 7 | 显示文摘 | Loeb S Hassen F V Shahaf D | 1976 | Journal of Membrane Science1976，1，： | 1 |
| 8 | Production of energy from concentrated brines by pressure-retarded osmosis(Ⅱ): Experimental results and projected energy costs 显示文摘 | LOEB S VAN HESSEN F SHAHAF D | 1976 | Journal of Membrane Science1976，1，： | 1 |
| 9 | The intricate involvement of the Insulin-like growth factor receptor signaling in mild traumatic brain injury in mice显示文摘 | Vardit Rubovitch Shahaf Edut Rive Sarfstein Haim Werner Chaim G. Pick | 2010 | Neurobiology of Disease2010，，2： | 1 |
| 10 | Low levels of circulating al- pha - 1 antitrypsin are associated with spontaneous abortions 显示文摘 | Madar T Shahaf G Sheiner E | 2013 | J Matern Fetal Neonatal Med2013，26，18： | 1 |
| 11 | Lower circulation levels and activity of c - 1 antitrypsin in pregnant women with severe pre- eclampsia 显示文摘 | Twina G Sheiner E Shahaf G | 2012 | J Matern Fetal Neonatal Med2012，25，12： | 1 |
| 12 | Geometry and mechanics in the opening of chiral seed pods显示文摘 | Shahaf Armon Eft Efrati Raz Kupferman Eran Sharon | | 0，，： | 1 |
| 13 | Geometry and mechanics in the opening of chiral seed pods Supplementary online material显示文摘 | Shahaf Armon Eft Efrati Eran Sharon Raz Kupferman | | 0，，： | 1 |
| 14 | Development,learning and memory in large random networks of cortical neurons:lessons beyond anatomy显示文摘 | MAROM S SHAHAF G | 2002 | Quarterly Reviews of Biophysics2002，35，1： | 1 |
| 15 | Lower circulation levels and activity of α-1 Antitrypsin in pregnant women with severe preeclampsia显示文摘 | Guy Twina Eyal Sheiner Galit Shahaf Shimrit Yaniv Salem Tamar Madar Joel Baron Arnon Wiznitzer Moshe Mazor Gershon Holcberg Eli C. Lewis | 2012 | Journal of Maternal-Fetal and Neonatal Medicine2012，，： | 1 |
| 16 | α1-Antitrypsin insufficiency is a possible contributor to preterm premature rupture of membranes显示文摘 | Joel Baron Eyal Sheiner Avishag Abecassis Efrat Ashkenazi Galit Shahaf Shimrit Yaniv Salem Tamar Madar Guy Twina Arnon Wiznitzer Gershon Holcberg Eli C. Lewis | 2012 | Journal of Maternal-Fetal and Neonatal Medicine2012，，： | 1 |
| 17 | Low levels of circulating alpha-1 antitrypsin are associated with spontaneous abortions*显示文摘 | Tamar Madar Galit Shahaf&thinsp Eyal Sheiner Jared Brazg Justin Levinson Shimrit Yaniv Salem Guy Twina Joel Baron Moshe Mazor Gershon Holcberg Eli C Lewis | 2013 | The Journal of Maternal-Fetal & Neonatal Medicine2013，，： | 1 |
| 18 | Sustained expression ofcirculating human alpha-1 antitrypsin reduces inflammation, increa-ses CD4 + Foxp3 + Treg cell population and prevents signs of experi-mental autoimmune encephalomyelitis in mice显示文摘 | Subramanian S Shahaf G Ozeri E | 2011 | Metab Brain Dis2011，26，2： | 1 |
| 19 | Production of energy from concentrated brines by pressure-retarded osmosisⅡ:experimental results and projected energy costs显示文摘 | Loeb S Hassen F V Shahaf D | 1976 | Membr Sei1976，，1： | 1 |
| 20 | Sustained ex- pression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4^+ FoxP3^+ Treg cell popu- lation and prevents signs of experimental autoimmune en- cephalomyelitis in mice显示文摘 | Subramanian S Shahaf G Ozeri E | 2011 | Metab Brain Dis2011，26，2： | 1 |
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