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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Treatment of interstitial cystitis with a quercetin supplement显示文摘 | Katske F Shoskes DA Sender M | 2001 | Tech Urol2001，7，1： | 1 |
| 3 | Transcutaneous bilirubin measurement: a multicenter evaluation of a new device显示文摘 | Rubaltelli FF Gourley GR Loskamp N Modi N Roth-Kleiner M Sender A | 2001 | Pediatrics2001，107，6： | 1 |
| 4 | Failure mode and effects analysis: a novel approach to avoiding dangerous medication errors and accidents显示文摘 | Cohen M R Senders J Davis N M | 1994 | Hosp Pharm1994，29，4： | 1 |
| 5 | Initial validation of a numeric zero to ten scale to measure children's state anxiety 显示文摘 | Crandall M Lammers C Senders C | 2007 | Anesth Analg2007，105，5： | 1 |
| 6 | Validation of a screening questonnaire for the detection of epilepsy seizures in epidemiological studies显示文摘 | Placencia M Sender JWAS Shorvon SD | 1992 | Brain1992，115，： | 1 |
| 7 | Initial validation of anu- meric zero to ten scale to measure children' s state anxiety 显示文摘 | Crandall M Lammers C Senders C | 2007 | AnesthAnal2007，105，5： | 1 |
| 8 | The nonlinear equations of motion of pipe conveying fluid 显示文摘 | Sender C Li G X Paidoussis P M | 1994 | Journal of Sound and Vibration1994，169，5： | 1 |
| 9 | Solution of complete jump relations at discontinuities in a two-and-half-dimensional reconnection model显示文摘 | Sender M Vrsnak B Martinis M | 2003 | Physical Review E2003，68，04： | 1 |
| 10 | CPT-Based method for the installation of suction caissons in sand显示文摘 | SENDERS M RANDOLPH M F | 2009 | Journal of Geotechnical and Geoenviromental Engineering2009，1，14： | 1 |
| 11 | Middle Albian Gymnosperms from the Rio Martin Valley (Teruel, Spain)显示文摘 | Sender L M Diez J B Pons D | 2008 | CRPalevol2008，7，： | 1 |
| 12 | Initial validation of a numeric zero to ten scale to measure Children' s state Anxiety 显示文摘 | Crandall M Lammers C Senders CW | 2007 | Anesth Analg2007，105，5： | 1 |
| 13 | Treatment of interstitial cystitis with a quercetin supplement显示文摘 | Katske F Shoskes DA Sender M | 2001 | Tech Urol2001，7，： | 1 |
| 14 | Initial validation of a numeric zero to ten scale to measure children’s state anxiety显示文摘 | Crandall M Lammers C Sender C | 2007 | Anesth Analg2007，24，19： | 1 |
| 15 | Initial validation of a numeric zero to ten scale to measure children's state anxiety显示文摘 | Crandall M Lammers C Senders C | 2007 | Anesth Analg2007，105，5： | 1 |
| 16 | Initial validation of a numeric zero to ten scale to measure children's state anxiety显示文摘 | Crandall M Lammersc C Senders C | 2007 | Anesth Analg2007，23，8： | 1 |
| 17 | Infrared and computational studies of the adsorption of methanol and ethanol on single-walled carbon nanotubes显示文摘 | Ellison M D Morris S T Sender M R | 2007 | Journal of Physical Chemistry C2007，111，18： | 1 |
| 18 | CPT-based method for theinstallation of suction caissons in sand显示文摘 | Senders M Randolph M F | 2009 | Journal ofGeotechnical and Geoenvironmental Engineering2009，135，1： | 1 |
| 19 | The influence of earlycycling training on balance in stroke patients at the subacutestage:results of a preliminary trial显示文摘 | Katz-Leurer M Sender I Keren O | 2006 | Clin Rehabil2006，20，5： | 1 |
| 20 | CPT- based method for the installation of suction caissons in sand 显示文摘 | SENDERS M RANDOLPH M F | 2009 | Journal of Geotechnical and Geoenvironmental Engineering2009，135，1： | 1 |
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