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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Long term predicion of infratentorial transient ischemic attacks and minor stroke 显示文摘 | Honig CR Lammers C Buttner T | 1992 | Stroke1992，23，2： | 1 |
| 3 | Finite element analysis of the behavior of shape memory alloys and their applications显示文摘 | Brinson L C Lammering R | 1993 | International Journal of Solids and Structures1993，30，23： | 1 |
| 4 | Ireland's footprint: A time series for 1983-2001 显示文摘 | Lammers A Moles R Walsh C | 2008 | Land Use Policy2008，25，： | 1 |
| 5 | Dual Principles in Frame Theory显示文摘 | CASAZZA P G KUTYNIOK G LAMMER M C | 2004 | J Fourier Anal Appl2004，10，： | 1 |
| 6 | Contrastenhanced three-dimensional transcranial color-coded sonography of intracranial stenosis显示文摘 | Klotzsch C Bozzato A Lammers G | 2002 | AJNR2002，30，： | 1 |
| 7 | Lectin binding to small intestinal gobbler cells of newborn, suckling and weaned pigs显示文摘 | Jaeger L A Lammer C H Turek J J | 1989 | Am J Vet Res1989，50，： | 1 |
| 8 | Contrast-enhanced three-dimensional transcranial color-coded sonography of intracranial stenoses显示文摘 | Klotzsch C Bozzato A Lammers G | 2002 | Am J Neuroradiol2002，23，2： | 1 |
| 9 | Ireland' s footprint: a time series for 1983-2001 显示文摘 | LAMMERS A MOLES R WALSH C | 2008 | Land Use Policy2008，25，1： | 1 |
| 10 | Methylated APC and GSTP1 genes in serum DNA correlate with the presence of circulating blood tumor cells and are associated with a more aggressive and advanced breast cancer disease显示文摘 | Matuschek C B(o)lke E Lammering G | 2010 | Eur J Med Res2010，15，： | 1 |
| 11 | Reproductive functions in young fathers and grandfathers显示文摘 | NIESCHLAG E LAMMERS U FREISCHEM C W | 1982 | Clin Endocrinol Metab1982，55，： | 1 |
| 12 | Initial validation of a numeric zero to ten scale to measure children's state anxiety 显示文摘 | Crandall M Lammers C Senders C | 2007 | Anesth Analg2007，105，5： | 1 |
| 13 | Stress and the brain显示文摘 | Heuser I Lammers C L | 2003 | Neurobiol Aging2003，24，1： | 1 |
| 14 | Ireland's footprint: a time series for 1983-2001显示文摘 | LAMMERS A MOLES R WALSH C | 2008 | Land Use Policy2008，25，1： | 1 |
| 15 | Optimal placement of piezoelectric actuators in adaptive truss structures显示文摘 | LAMMERING R JIA J ROGERS C A | 1994 | Journal of Sound and Vibration1994，171，1： | 1 |
| 16 | Vulnerability of rabbit atrium to reentry by hypoxia:role of inhomogeneity in conduction and wavelength显示文摘 | Lammers WJ Kirchhof C Bonke F | 1992 | Circulation1992，262，： | 1 |
| 17 | Maternal-perinatal mor-bidity and mortality associated with adolescent pregnancy in LatinAmerica:Cross-sectional study显示文摘 | Conde-Agudelo A Belizan JM Lammers C | 2004 | Am J Obstet Gynecol2004，192，2： | 1 |
| 18 | Initial validation of anu- meric zero to ten scale to measure children' s state anxiety 显示文摘 | Crandall M Lammers C Senders C | 2007 | AnesthAnal2007，105，5： | 1 |
| 19 | Development and validation of a scoring system to predict outcomes of patients with primary biliary cirrhosis receivingursodeoxycholic acid therapy显示文摘 | Lammers WJ Hirschfield GM Corpechot C | | Gastroeaterolgoy 201S 149 (7) :1804-18120，4，： | 1 |
| 20 | Three-dimensional transcranial color-code sonography of cerebral aneurysms显示文摘 | KLOTZSCH C BOZZATO A LAMMERS G | 1999 | Stroke1999，30，： | 1 |
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