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| 1 | Neuroprotection of aucubin in primary diabetic encephalopathy显示文摘Hippocampal neuronal apoptosis accompanied by impairment of cognitive function occurs in primary diabetic encephalopathy. In this study, we investigated the neuroprotective mechanism of the iridoid glycoside, aucubin, using rats (n=8). Diabetes mellitus was induced in the rats by intraperitoneal (i.p.) injection of streptozotocin (60 mg/kg body weight). After 65 d, half of the DM rats were administered aucubin (5 mg/kg; i.p.) for 15 d, yielding treatment DM+A. A third group of rats received no strepto- zotocin or aucibin, and served as controls (CON). Encephalopathy was assessed using Y-maze be- havioral testing. Rats were euthanized on Day 87, and hippocampi were excised for visual (light and transmission electron microscopic) and immunochemical (Western blot; immunohistochemical) as- sessments of the CA1 subfield for apoptosis and expression of regulatory proteins Bcl-2 and Bax. Treatment responses to all the parameters examined (body weight, plasma glucose, Y-maze error rates, pyramidal cell ultrastructure, proportions of apoptotic cells, levels of expression of Bcl-2 and Bax, and survivability of neuronal cells) were identical: there were highly significant differences between DM and CON groups (P<0.001), but the effects were significantly moderated (P<0.01) in DM+A compared with DM. These findings confirm the association of apoptosis with the encephalopathic effects of diabetes mellitus, and suggest a major role of the expression levels of Bcl-2 and Bax in the regulation of apop- totic cell death. All of the results suggest that aucubin could effectively inhibit apoptosis by modulating the expressions of Bcl-2 and Bax genes. | XUE HongYu1, JIN LiJi1,2, JIN Lei1, ZHANG Peng1, LI DanQing4, XIA YanQiu1, LU YaNan1 & XU YongPing1,3 1 Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China 2 State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China 3 Dalian SEM Bioengineer and Biotech Ltd., Dalian 116024, China 4 The Second Affiliated Hospital, Dalian Medical University, Dalian 116024, China | 2008 | Science China(Life Sciences)2008，51，6： | 22 |
| 2 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 3 | The Myofibroblast显示文摘 | Boris Hinz Sem H. Phan Victor J. Thannickal Andrea Galli Marie-Luce Bochaton-Piallat Giulio Gabbiani | 2007 | The American Journal of Pathology2007，，6： | 2 |
| 4 | 中柬贫困儿童先心病社区筛查成本效益分析显示文摘目的对中国与柬埔寨贫困儿童先天性心脏病(先心病)社区筛查进行成本效益分析,为社区及援外先心病筛查提供参考。方法收集2017年10—12月在柬埔寨马德望省和云南省3个县社区贫困儿童先心病筛查相关费用支出和服务儿童人数、疑似及确诊例数等资料,进行中柬贫困儿童先心病筛查成本效益对比分析。结果中国、柬埔寨分别筛查135 231和13 147名儿童,分别确诊先心病儿童130例和26例。国内平均筛查1人、发现1例疑似患儿及确诊1例患儿的支出分别是3.07元、76.36元和1 175.25元;柬埔寨筛查费用较高,上述项目的支出分别是21.20元、913.91元和10 720.87元。如果后期治疗成功,则中、柬分别挽回例均预期损失寿命年81.30人年、81.40人年,例均预期寿命55.03和45.79岁,例均预期国内生产总值658 248.48元、99 013.62元。结论中柬先心病儿童筛查项目卫生经济成本效益明显。 | 肖罗茜 朱旭斌 吴霞 卢江 施艺 朵林 Chandara Sem Lyvann Son 潘湘斌 | 2020 | 应用预防医学2020，26，3： | 2 |
| 5 | Total Hip Arthroplasty For Femoral Neck Fracture显示文摘 | Adam Sassoon Michele D’Apuzzo Stephen Sems Joseph Cass Tad Mabry | 2013 | The Journal of Arthroplasty2013，，： | 1 |
| 6 | Incidence of deep venous thrombosis after temporary joint spanning external fixation for complex lower extremity injuries显示文摘 | Sems SA Levy BA Dajani K Munster | 2009 | J Trauma2009，66，： | 1 |
| 7 | Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis显示文摘 | Naozumi H Sem HP Kazuyoshi I | 2010 | AmJ Respir Cell Mol Biol2010，43，2： | 1 |
| 8 | New Insights into the Pathogenesis and Treatment of Idiopathic Pulmonary Fibrosis: A Potential Role for Stem Cells in the Lung Parenchyma and Implications for Therapy显示文摘 | Mehrnaz Gharaee-Kermani Margaret R. Gyetko Biao Hu Sem H. Phan | 2007 | Pharmaceutical Research2007，，5： | 1 |
| 9 | A benign parathyroid cyst presenting with hoarse voice显示文摘 | SEM P FLOWER N PAPESCH M | 2000 | Aryngol Otol2000，114，2： | 1 |
| 10 | Field emission property of highly ordered monodispersed carbon nanotuber arrays显示文摘 | Sem Mi Yoon | 2004 | Applied Physics Letters2004，4，： | 1 |
| 11 | Iodine seed prostate brachytherapy:Analternative first-line choice for early prostate cancer显示文摘 | Langley SEM Laing RW | 2004 | ProstateCancer Prostatic Dis2004，，： | 1 |
| 12 | The myofibroblast in pulmonary fibrosis显示文摘 | Sem HP | 2002 | Chest2002，122，： | 1 |
| 13 | Radionuclide therapy practice and facilities in Europe显示文摘 | Clarke SEM Fischer M | 1999 | Eur J Nucl Med1999，26，2： | 1 |
| 14 | Total hip arthroplasty for femoral neck fracture : comparing in - hospital mortality, complications, and disposi- tion to an elective patient population显示文摘 | Sassoon A D?tpuzzo M Sems S | 2013 | J Arthroplast2013，28，9： | 1 |
| 15 | Frequency dependence of sonophoresis显示文摘 | Tezel A Sem A Tuchscherer J | 2001 | Pharm Res2001，18，12： | 1 |
| 16 | Mesenteric arterial thrombosis diagnosed on CT显示文摘 | Ridley N Green SEM | 2001 | Am J Roentgenol2001，176，2： | 1 |
| 17 | Results of polyaxial locked-plate fixation of periarticular fractures of the knee显示文摘 | Haidukewych G Sems SA Huebner D | 2007 | J Bone Joint Surg Am2007，89，3： | 1 |
| 18 | P revalen ce of asymmetry of mamillary body and fornix size on MR in aging显示文摘 | Ozturk A You sem DM M ahm ood A | 2008 | A JNR Am JN euroradiol2008，29，2： | 1 |
| 19 | 显示文摘 | Tesfaye S Chaturvedi N Eaton SEM | 2005 | N Engl J Med2005，352，： | 1 |
| 20 | Crystal structure and isomerism of a tumor targeting radiopharmaceutical:ReO(dmsa)2] -(H2dmsa =meso-2,3-dimercaptosuccinic acid)显示文摘 | Singh J Powell AK Clarke SEM | | 0，，： | 1 |
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