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| 1 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 2 | Total hip arthroplasty for femoral neck fracture : comparing in - hospital mortality, complications, and disposi- tion to an elective patient population显示文摘 | Sassoon A D?tpuzzo M Sems S | 2013 | J Arthroplast2013，28，9： | 1 |
| 3 | Frequency dependence of sonophoresis显示文摘 | Tezel A Sem A Tuchscherer J | 2001 | Pharm Res2001，18，12： | 1 |
| 4 | P revalen ce of asymmetry of mamillary body and fornix size on MR in aging显示文摘 | Ozturk A You sem DM M ahm ood A | 2008 | A JNR Am JN euroradiol2008，29，2： | 1 |
| 5 | Imaging features of CNS tu- berculosis显示文摘 | Sem lali S EI Kharras A Mahi M | 2008 | J Radiaol2008，89，： | 1 |
| 6 | Spray characterization: Numerical prediction of Sauter mean diameter and droplet size distribution 显示文摘 | Sem i a o V Andrade P Carvalho M G | 1996 | Elsevier Science Ltd1996，75，15： | 1 |
| 7 | Detailed measurements in a pulverized coal flame with natural gas rebuming显示文摘 | Was sem A N Robert E J Jacob A P | 1999 | Fuel1999，78，6： | 1 |
| 8 | Expression of the CXCR3ligand I-TAC by hepatocytes in chronic hepatitis C and its correlation with hepatic inflam m ation显示文摘 | H elbig KJ Ruszkiewicz A Sem endric L | 2004 | H epatology2004，39，5： | 1 |
| 9 | Moderate-term, low-dose cortieosteroids for rheumatoid arthritis 显示文摘 | Criswell L A Saag K G Sems K M | 2000 | Cochrane database Syst Rev2000，，00： | 1 |
| 10 | Dietary zinc improves and calcium depresses growth and zinc uptake in rats fed rice bran显示文摘 | Sem'ramis M A Domenea H R Torin J A | 2001 | Nutrition Research2001，21，： | 1 |
| 11 | Mutational spectmm of DMD mutations in dystrophinopathypatients: application of modem diagnostic techniques to a large cohort 显示文摘 | Flanigan KM Dunn DM Vonniederhau Sem A | 2009 | Hum Mutat2009，30，12： | 1 |
| 12 | Total hip arthroplasty for femoral neck fracture:comparing in-hospital mortality,complications,and disposition to an elective patient population显示文摘 | Sassoon A D'Apuzzo M Sems S | | J Arthroplasty0，28，9： | 1 |
| 13 | I3C NMR spectroscopy of a novel amine species in the DEAB-CO,-H,O system: VLE model显示文摘 | Shi H Sem T Naami A Liang Z Ide R Tontiwachwulhikul P | 2012 | Industrial & Engineering Chemistry Research2012，51，25： | 1 |
| 14 | Practical transfer function estimation and its application to wide frequency range representation of transformers显示文摘 | Soysal A O Sem lyen A | 1993 | IEEE Trans on Power Delivery1993，8，3： | 1 |
| 15 | Support Surfaces for Pressure Ulcer Prevention显示文摘 | Mclnnes E Jammali-Blasi A Bell-Syer SEM | 2011 | Conchrane Database Syst Rev2011，13，4： | 1 |
| 16 | The prevalence and in cidence ofpres sure ulcers in hospitalized pat ient sin the Neth erlands:A prospect ire incept ion coh or t study 显示文摘 | Schoon hoven L Bou sem a MT Bus ken s E | 2007 | Int J Nu rsStud2007，44，6： | 1 |
| 17 | Paraquat intoxication显示文摘 | Sem A Domingos F Prata MM | 2003 | Acta Med Port2003，16，1： | 1 |
| 18 | Total hip arthro-plasty for femoral neck fracture: Comparing in - hospitalmortality?complications, and disposition to an elective pa-tient population显示文摘 | SassoonA’D'Apuzzo M Sems S^et a/ | 2013 | J Arthroplasty2013，28，9： | 1 |
| 19 | Conjunctival myxoma:a clinicopathologic report显示文摘 | Kilic A K(o)sem M Demirok A | | 0，，： | 1 |
| 20 | Dietary zinc improves and calcium depresses growth and zinc uptake in rats fed rice bran显示文摘 | Semíramis M A Domenea H R Torin J A | 2001 | Nutrition Research2001，21，： | 1 |
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