|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Unique cytologic features of thyroiditis caused by immune checkpoint inhibitor therapy for malignant melanoma显示文摘Blockade of immune checkpoint molecules to reverse cancer-induced immune suppression can improve anti-tumor immune responses in cancer patients.Monoclonal antibodies targeting two such molecules,Programmed cell death protein 1(PD-1)and cytotoxic T-lymphocyte associated protein 4(CTLA-4)have shown clinical benefit in the treatment of advanced malignancies,including metastatic melanoma.Adverse effects of these immune checkpoint inhibitors include immune-related adverse events(irAE),of which one of the most common is autoimmune thyroiditis.Though thyroiditis is increasingly recognized,there are no reports of the pathological findings that occur in immunotherapy-induced thyroiditis.We present a case of immunotherapy-induced thyroiditis demonstrating its unique cytopathologic features.A 51-year-old woman with metastatic melanoma was found to have a suppressed TSH and elevated free thyroxine concentration 14 days after starting treatment with nivolumab(PD-1 antagonist)plus ipilimumab(CTLA-4 antagonist)therapy.A thyroid biopsy was performed based on ultrasound findings and cytopathology revealed unique features including abundant clusters of necrotic cells,lymphocytes and CD163-positive histiocytes.This case reports cytopathologic features found in immune checkpoint inhibitor related thyroiditis.These appear to be unique findings and may help inform future research regarding the pathophysiology and mechanisms of this condition. | Trevor E.Angell Le Min Tad J.Wieczorek F.Stephen Hodi | 2018 | Genes & Diseases2018，5，1： | 13 |
| 2 | The crystal structure of the non-liganded 14-3-3σ protein: insights into determinants of isoform specific ligand binding and dimerization显示文摘Seven different, but highly conserved 14-3-3 proteins are involved in diverse signaling pathways in human cells. It isunclear how the 14-3-3σ isoform, a transcriptional target of p53, exerts its inhibitory effect on the cell cycle in thepresence of other 14-3-3 isoforms, which are constitutively expressed at high levels. In order to identify structuraldifferences between the 14-3-3 isoforms, we solved the crystal structure of the human 14-3-3σ protein at a resolutionof 2.8 ? and compared it to the known structures of 14-3-3ζ and 14-3-3τ. The global architecture of the 14-3-3σ foldis similar to the previously determined structures of 14-3-3ζ and 14-3-3τ: two 14-3-3σ molecules form a cup-shapeddimer. Significant differences between these 14-3-3 isoforms were detected adjacent to the amphipathic groove, whichmediates the binding to phosphorylated consensus motifs in 14-3-3-ligands. Another specificity determining region islocalized between amino-acids 203 to 215. These differences presumably select for the interaction with specific ligands,which may explain the different biological functions of the respective 14-3-3 isoforms. Furthermore, the two 14-3-3σmolecules forming a dimer differ by the spatial position of the ninth helix, which is shifted to the inside of the ligandinteraction surface, thus indicating adaptability of this part of the molecule. In addition, 5 non-conserved residues arelocated at the interface between two 14-3-3σ proteins forming a dimer and represent candidate determinants of homo-and hetero-dimerization specificity. The structural differences among the 14-3-3 isoforms described here presumablycontribute to isoform-specific interactions and functions. | Anne BENZINGER Grzegorz M. POPOWICZ Joma K. JOY Sudipta MAJUMDAR Tad A. HOLAK Heiko HERMEKING | 2005 | Cell Research2005，15，4： | 6 |
| 3 | Long-term,multidomain analyses to identify the breed and allelic effects in MSTN-edited pigs to overcome lameness and sustainably improve nutritional meat production显示文摘Beef and mutton production has been aided by breeding to integrate allelic diversity for myostatin(MSTN),but a lack of diversity in the MSTN germplasm has limited similar advances in pig farming.Moreover,insurmountable challenges with congenital lameness and a dearth of data about the impacts of feed conversion,reproduction,and meat quality in MSTN-edited pigs have also currently blocked progress.Here,in a largest-to-date evaluation of multiple MSTN-edited pig populations,we demonstrated a practical alternative edit-site-based solution that overcomes the major production obstacle of hindlimb weakness.We also provide long-term and multidomain datasets for multiple breeds that illustrate how MSTN-editing can sustainably increase the yields of breed-specific lean meat and the levels of desirable lipids without deleteriously affecting feed-conversion rates or litter size.Apart from establishing a new benchmark for the data scale and quality of genome-edited animal production,our study specifically illustrates how gene-editing site selection profoundly impacts the phenotypic outcomes in diverse genetic back-grounds. | Ziyao Fan Zhiguo Liu Kui Xu Tianwen Wu Jinxue Ruan Xinmin Zheng Shideng Bao Yulian Mu Tad Sonstegard Kui Li | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 4 | Indications and contraindications for shock wave lithotripsy and how to improve outcomes显示文摘For over 35 years shock wave lithotripsy has proven to be an effective,safe and truly minimally invasive option for the treatment of nephrolithiasis.Various technical factors as well as patient selection can impact the success of the procedure.We used published work focusing on outcomes of shock wave lithotripsy,risk of complications,and strategies for improving stone fragmentation to create this review.Multiple patient and technical factors have been found to impact success of treatment.Skin to stone distance,stone density and composition,size and location of the stone within the urinary system all influence stone free rates.A slower rate with a gradual increasing voltage,precise targeting,proper coupling will improve stone fragmentation and decrease risk of complications.The selection of appropriate patients through a shared decision making process and attention to the technical factors that improve stone free rates is key to providing an effective treatment and patient satisfaction. | Luke F.Reynolds Tad Kroczak Kenneth T.Pace | 2018 | Asian Journal of Urology2018，5，4： | 4 |
| 5 | Nonlinear model predictive control of an industrial four-stage evaporator system via simulation显示文摘 | G.P Rangaiah P Saha M.O Tadé | 2002 | Chemical Engineering Journal2002，，3： | 2 |
| 6 | The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells显示文摘与正规象 ubiquitin 一样蛋白质不同, Hub1 不形成共有原子价与底层结合,但是 proteinsnon-covalently 绑。在 Saccharomyces cerevisiae, Hub1 与 spliceosomes 联系并且调停,没有影响通常拼接的 pre-mRNA SRC1 的其他的拼接。人的 Hub1 高度类似于它的酵母相当或相同的事物,而是它的细胞的 functionremains 大部分未经勘探。这里,我们证明人的 Hub1 作为在酵母绑在 spliceosomal 蛋白质 Snu66;然而, unlikeits S。cerevisiae 相当或相同的事物,人的 Hub1 为生存能力是必要的。在 Hub1 导致的人的 vivo 弄空延长了各种各样的细胞的缺点,包括拼接的点缀畸形,部分原子 retentionof mRNAs,有丝分裂的大祸,并且因而由 apoptosis 的房间死亡。然而, Hub1 弄空的早后果仅仅是严重 splicingdefects 为特定拼接地点导致 exon 跳过和 intron 保留。因此,象 ubiquitin 一样 proteinHub1 不是为拼接,而是其他的拼接的 spliceosome performanceand facilitator 的一个调节的人通常需要的一个正规 spliceosomal 因素。 | Tim Ammon Shravan Kumar Mishra Kaja Kowalska Grzegorz M. Popowicz Tad A. Holak Stefan Jentsch | 2014 | Journal of Molecular Cell Biology2014，8，4： | 2 |
| 7 | PZT MIM Capacitor With OxygenDoped Ru-Electrodes for Embedded FeRAM Devices显示文摘 | Naoya Inoue Naoya Furutake Akio Toda Munehiro Tads Yoshihiro Hayashi | 2005 | IEEE Transactions on Electron Device2005，52，： | 1 |
| 8 | GA optimization of Petri net-modeled concurrent service systems显示文摘 | Tad Gonsalves Kiyoshi Itoh | 2011 | Applied Soft Computing2011，11，： | 1 |
| 9 | Total Hip Arthroplasty For Femoral Neck Fracture显示文摘 | Adam Sassoon Michele D’Apuzzo Stephen Sems Joseph Cass Tad Mabry | 2013 | The Journal of Arthroplasty2013，，： | 1 |
| 10 | Augmentation of vessel squeezing at coronary-myocardial bridge by nitroglycerin:study by quantitative coronary angiography and intravascular ultrasound显示文摘 | Hongo Y Tads H Ito K | 1999 | Am Heart J1999，138，2： | 1 |
| 11 | How well do people play a quantum prisoner' s dilemma? 显示文摘 | Kay-Yut C Tad H | 2007 | International Journal of Quantum Infor- mation2007，5，5： | 1 |
| 12 | FDG Uptake, Tunmor Characteristics and Response to Therapy: a Review显示文摘 | Smith TAD | 1998 | Nucl Med Commun1998，19，： | 1 |
| 13 | Comparative map alignment of BTA27 and HSA4 and 8to identify conserved segments of genome containing fat deposition QTL 显示文摘 | Wes M Garrett Melissa S Ashwell | 2000 | Mamm Genome2000，11，： | 1 |
| 14 | Controlled synthesis of BN nanotubes,nanobamboos,and nanocables 显示文摘 | MA Ren Zhi BANDO Yo Shio SATA Tad Ao | 2002 | Adv Mater2002，14，5： | 1 |
| 15 | The transient thermal response of a glass-fiber insulation slab with hygroscopic effects显示文摘 | TAD Y X BESANT R W REZKALLAH K S | 1992 | Int J Heat and Mass Transfer1992，35，5： | 1 |
| 16 | Deoxyglucose uptake by a head and neck squamous carcinoma: influence of changes in proliferative fraction显示文摘 | Smith TAD Titley J | 2000 | Int J Radiat Oncol Biol Phys2000，47，1： | 1 |
| 17 | Improvement of plasma bio-markers after switching stroke patients from other angiotensinII type I receptor blockers to olmesartan显示文摘 | TAD A Y YAGI K UNO M | 2015 | Journal of Strokeand Cerebrovascular Diseases :the Official Journal of NationalStroke Association ?2015，24，7： | 1 |
| 18 | Electrochemical reduction of malefic acid at the copper-copper chelate electrode显示文摘 | Tad I Ryuto H Hirai T | 1980 | Denki Kagaku Oyobi Kogyo ButsuriKagaku1980，48，9： | 1 |
| 19 | Novel applications of red mud as coagulant,adsorbent and catalyst for environmentally benign processes显示文摘 | Wang X B Ang H M TadéM O | 2008 | Chemosphere2008，72，11： | 1 |
| 20 | Discovering drug-drug interactions: a text-mining and reasoning approach based on properties of drug metabolism显示文摘 | Tad L Anwar S Liang S | 2010 | Bioinformatics2010，26，18： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员