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| 1 | Sleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosa显示文摘AIM To .investigate if sleep deprivation is able to increase the expression of inducible heat shock protein 70 in gastric mucosa and its possible role in mucosal defense.METHODS Rats for sleep disruption were placed inside a computerized rotating drum, gastric mucosa was taken from rats with 1, 3 and 7 d sleep deprivation. RT-PCR,immunohistochemistry and Western blotting were used to determine the expression of heat shock protein 70.Ethanol (500 mL@ L 1, I.g.) was used to induce gastric muceea damage.RESULTS RT-PCR, Western blotting and immunostaining confirmed that the sleep deprivation as a stress resulted in significantly greater expression of inducible heat shock protein 70 in gastric mucosa of rats. After the 500mL@ L-1 ethanol challenge, the ulcer area found in the rats with 7 d sleep deprivation (19.15 ± 4.2) mm2 was significantly lower (P<0.01) than the corresponding control (53.7 ± 8.1) mm2.CONCLUSION Sleep deprivation as a stress, in addition to lowering the gastric mucosal barrier, is able to stimulate the expression of inducible heat shock protein 70 in gastric mucosa of rats, the heat shock protein 70 may play an important role in gastric mucosal protection. | Xi-Zhong Shen Marcel W.L. Koo Chi-Hin Cho Department of Gastroenterology,Zhongshan Hospital,Fudan University,136 Yixueyuan Road,Shanghai 200032,ChinaDepartment of Pharmacology.Faculty of Medicine,University of Hong Kong,5 Sassoon Road,Pokfulam,Hong Kong,ChinaSupported by .Dr.Marcel W.L.Koo,Department of Pharmacology,FacuLty of Medicine,the University of Hong Kong,5 Sassoon Road,Hong Kong,China.Wlkoo@hkusua.hku.hk | 2001 | World Journal of Gastroenterology2001，7，4： | 14 |
| 2 | Healing effects of heparin on acetic acid-induced gastric ulcers in rats显示文摘HealingefectsofheparinonaceticacidinducedgastriculcersinratsYangLi,QiBingMeiandChiHinChoDepartmentofPharmacology,FacultyofMe... | Yang Li, Qi Bing Mei and Chi Hin Cho Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, 5 Sassoon Road, Hong Kong (Li Y, Mei QB and Cho CH) | 1998 | Chinese Medical Journal1998，，1： | 2 |
| 3 | Myogenic regulatory factors:dissecting their role and regulation during vertebrate embryogenesis显示文摘 | Sassoon D A | 1993 | Dev Biol1993，156，： | 2 |
| 4 | Enchondromas of the hand: factors affecting recurrence, healing, motion, and malig- nant transformation 显示文摘 | Sassoon AA1 Fitz-Gibbon PD Harmsen WS | 2012 | J Hand Surg Am2012，37，6： | 1 |
| 5 | Total Hip Arthroplasty For Femoral Neck Fracture显示文摘 | Adam Sassoon Michele D’Apuzzo Stephen Sems Joseph Cass Tad Mabry | 2013 | The Journal of Arthroplasty2013，，： | 1 |
| 6 | Arthroscopic treatment of localized pigmented villonodular synovitis:long-term functional results显示文摘 | Rhee PC Sassoon AA Sayeed SA | 2010 | Am J Orthop (Belle Mead NJ)2010，39，9： | 1 |
| 7 | Mid-trimester triple test levels in early and late onset severe pre-eclampsia显示文摘 | Shenhav S Gemer O Sassoon E | 2002 | Prenat Diagn2002，22，7： | 1 |
| 8 | Airway occlusion pressure and breathing pattern as predictors of weaning outcome显示文摘 | Sassoon CS Mahutte CK | | 0，，4： | 1 |
| 9 | Chylothorax and pseudochylothorax显示文摘 | Sassoon C S Light R W | 1985 | Clin Chest Med1985，6，16： | 1 |
| 10 | Myogenic regulatory factors: Dissecting their role and regulation during vertebrate embryogenesis显示文摘 | Sassoon DA | 1993 | Dev Biol1993，156，1： | 1 |
| 11 | Differential expression patterns of Wnt genes in the murine female reproductive tract during development and the estrous cycle显示文摘 | Miller C Pavlova A Sassoon DA | 1998 | Mech Dev1998，76，12： | 1 |
| 12 | Complications of patellar fracture repair: treatment and results 显示文摘 | Petrie J Sassoon A Langford J | 2013 | J Knee Surg2013，26，5： | 1 |
| 13 | Myogenin, a factor regula- ting myogenesis, has a domain homologous to MyoD显示文摘 | Wright W E Sassoon D A Lin V K | 1989 | Cell1989，56，： | 1 |
| 14 | Fetal exposure to DES results in de-regulation of Wnt7a during uterine morphogenesis显示文摘 | Miller C Degenhardt K Sassoon DA | 1998 | Nat Genet1998，20，3： | 1 |
| 15 | Myogenic regulatory factors:Dissecting their role and regulation during vertebrate embryogenesis显示文摘 | Sassoon DA | 1993 | Dev Biol1993，156，1： | 1 |
| 16 | Airway occlusion pressure and breathing pattern as predictors of weaning outcome 显示文摘 | Sassoon CS Mahutte CK | 1993 | Am Rev Respir Dis1993，148，41： | 1 |
| 17 | Myogenin, a factor regullating myogenesis, has a domain homologous to MyoD显示文摘 | Wright W E Sassoon D A Lin V K | 1989 | Cell1989，56，： | 1 |
| 18 | Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD 显示文摘 | WRIGHT W E SASSOON D A LIN V K | 1989 | Cell1989，56，： | 1 |
| 19 | Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus显示文摘 | Mericskay M Kitajewski J Sassoon D | 2004 | Development2004，131，9： | 1 |
| 20 | The etiology and treatment of spontaneous pneumothorax显示文摘 | | 1995 | Curr Opin Pulm Med1995，1，4： | 1 |
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