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| 1 | Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats显示文摘Daidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery occlusion were intraperitoneally administered daidzein. Biochemical and immunohistochemical tests showed that superoxide dismutase and nuclear respiratory factor 1 expression levels in the brain tissue decreased after ischemia and they increased obviously after daidzein administration; malondialdehyde level and apoptosis-related cysteine peptidase caspase-3 and caspase-9 immunoreactivity in the brain tissue increased after ischemia and they decreased obviously after daidzein administration. Hematoxylin-eosin staining and luxol fast blue staining results showed that intraperitoneal administration of daidzein markedly alleviated neuronal damage in the ischemic brain tissue. These findings suggest that daidzein exhibits neuroprotective effects on ischemic brain tissue by decreasing oxygen free radical production, which validates the aforementioned hypothesis. | Adem Bozkurt Aras Mustafa Guven Tar?k Akman Adile Ozkan Halil Murat Sen Ugur Duz Y?ld?ray Kalkan Coskun Silan Murat Cosar | 2015 | Neural Regeneration Research2015，10，1： | 4 |
| 2 | Blastocystis in ulcerative colitis patients:Genetic diversity and analysis of laboratory findings显示文摘Objective:To determine Blastocystis frequency and subtypes(ST) in ulcerative colitis(UC) patients and analyse some laboratory findings between Blastocystis positive and negative cases.Methods:Faecal samples from 150 UC patients in Adnan Menderes University,Training and Research Hospital were examined by direct microscopy and cultivated in Jones medium.Blastocystis positive cultures were subjected to DNA isolation and subtypes were identified by sequencing of barcode region.A retrospective analysis was conducted on C reactive protein(CRP),leukocyte counts(WBC),neutrophil counts,and sedimentation rates.Results:The overall positive rate of Blastocystis was 8%(12 patients) and the most abundant subtype was ST3(eight isolates,66.7%),followed by ST1,ST2 and ST7.Laboratory findings between Blastocystis infected and non-infected UC patients were not significantly different.Blastocystisfrequency was 3.8% among the patients in active stage,while it was 11.8% among the patients in remission stage.Conclusions:The present study confirms previous findings that have indicated the predominance of Blastocystis ST3 in humans and contributes additional evidence that suggests the low colonization of Blastocystis infection in ulcerative colitis patients during active stage. | Adil Coskun Erdogan Malatyali Hatice Ertabaklar Mustafa B Yasar Ali O Karaoglu Sema Ertug | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，9： | 3 |
| 3 | Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties显示文摘There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondiadehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and-9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These findings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis. | Aras Adem Bozkurt Guven Mustafa Akman Tar?k Ozkan Adile Sen Halil Murat K?l?coglu Mesut Kalkan Y?ld?ray Silan Coskun Cosar Murat | 2014 | Neural Regeneration Research2014，9，21： | 2 |
| 4 | Polycystic Ovary Syndrome and Prolactinoma Association显示文摘 | Irfan Yavasoglu Mert Kueuk Adil Coskun | 2009 | Inter Med2009，48，8： | 1 |
| 5 | Polycystie ovary syn- drome and prolactinoma association 显示文摘 | Irfan Yavasoglu Melt Kucuk Adil Coskun | 2009 | Intern Med2009，48，8： | 1 |
| 6 | Polycystic ovary syndrome and prolactinoma associa- tion显示文摘 | Irfan Yavasoglu Mert Kucuk Adil Coskun | 2009 | Intern Med2009，48，8： | 1 |
| 7 | 西替利嗪引起的肝中毒:病例系列报道和文献复习显示文摘Drug-induced liver damage is a frequently encountered clinical table caused by many drugs.Cetirizine is a widely preferred and prescribed antihistaminic agent for allergic disorders due to its non-sedative properties.In view of the literature,we present four cases of hepatotoxicity due to cetirizine use.We conclude that in patients with high levels of liver enzymes of unknown origin,cetirizine as well as other hepatotoxic drugs should be reconsidered. | Adil Coskun Irfan Yavasoglu M.Hadi Yasa Nil Culhaci Vahit Yukselen | 2018 | Gastroenterology Report2018，6，3： | 0 |
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