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| 1 | Review of magnesium-based biomaterials and their applications显示文摘In biomedical applications,the conventionally used metallic materials,including stainless steel,Co-based alloys and Ti alloys,often times exhibit unsatisfactory results such as stress shielding and metal ion releases.Secondary surgical operation(s)usually become inevitable to prevent long term exposure of body with the toxic implant contents.The metallic biomaterials are being revolutionized with the development of biodegradable materials including several metals,alloys,and metallic glasses.As such,the nature of metallic biomaterials are transformed from the bioinert to bioactive and multi-biofunctional(anti-bacterial,anti-proliferation,anti-cancer,etc.).Magnesium-based biomaterials are candidates to be used as new generation biodegradable metals.Magnesium(Mg)can dissolve in body fluid that means the implanted Mg can degrade during healing process,and if the degradation is controlled it would leave no debris after the completion of healing.Hence,the need for secondary surgical operation(s)for the implant removal could be eliminated.Besides its biocompatibility,the inherent mechanical properties of Mg are very similar to those of human bone.Researchers have been working on synthesis and characterization of Mg-based biomaterials with a variety of composition in order to control the degradation rate of Mg since uncontrolled degradation could result in loss of mechanical integrity,metal contamination in the body and intolerable hydrogen evolution by tissue.It was observed that the applied methods of synthesis and the choice of components affect the characteristics and performance of the Mg-based biomaterials.Researchers have synthesized many Mg-based materials through several synthesis routes and investigated their mechanical properties,biocompatibility and degradation behavior through in vitro,in vivo and in silico studies.This paper is a comprehensive review that compiles,analyses and critically discusses the recent literature on the important aspects of Mg-based biomaterials. | Nurettin Sezer Zafer Evis Said Murat Kayhan Aydin Tahmasebifar Muammer Koça | 2018 | Journal of Magnesium and Alloys2018，6，1： | 38 |
| 2 | Chronic complications of spinal cord injury显示文摘Spinal cord injury(SCI) is a serious medical condition that causes functional, psychological and socioeconomic disorder. Therefore, patients with SCI experience significant impairments in various aspects of their life. The goals of rehabilitation and other treatment approaches in SCI are to improve functional level, decrease secondary morbidity and enhance health-relatedquality of life. Acute and long-term secondary medical complications are common in patients with SCI. However, chronic complications especially further negatively impact on patients' functional independence and quality of life. Therefore, prevention, early diagnosis and treatment of chronic secondary complications in patients with SCI is critical for limiting these complications, improving survival, community participation and health-related quality of life. The management of secondary chronic complications of SCI is also important for SCI specialists, families and caregivers as well as patients. In this paper, we review data about common secondary longterm complications after SCI, including respiratory complications, cardiovascular complications, urinary and bowel complications, spasticity, pain syndromes, pressure ulcers, osteoporosis and bone fractures. The purpose of this review is to provide an overview of risk factors, signs, symptoms, prevention and treatment approaches for secondary long-term complications in patients with SCI. | Nebahat Sezer Selami Akkus Fatma Gülcin Ugurlu | 2015 | World Journal of Orthopedics2015，6，1： | 34 |
| 3 | Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy显示文摘AIM:To measure changes of total oxidant status(TOS)and total antioxidant capacity(TAC) of aqueous humor(AH) in diabetic retinopathy(DR) patients,and to determine if there were any differences in TOS and TAC of AH in diabetic patients without retinopathy compared with non-diabetic patients.·METHODS:One hundred and three eyes of 103patients who were enrolled for cataract surgery were included in this study.Patients were grouped according to presence of diabetes and stage of DR.Prior to cataract surgery,0.1mL to 0.2mL of AH was aspirated and analyzed for TAC and TOS level using a colorimetric method.·RESULTS:TOS levels were highest among proliferative diabetic retinopathy(PDR) patients and lowest in patients with only cataracts.Results were statistically significant between all groups(P <0.05).Whereas result between diabetic without retinopathy patients and non-proliferative diabetic retinopathy(NPDR) patients was not statistically significant(P =0.757).TAC levels were highest in patients with only cataract and lowest among PDR patients and results were statistically significant between all groups(P <0.05).·CONCLUSION:Aqueous humor TAC levels are low in diabetic patients and reduced further in DR patients,TOS levels are increased in diabetic patients and this is exacerbated in DR patients. | Emrullah Beyazyildiz Ali Bülent ankaya Esra Ergan Mustafa Alparslan Anayol Yasemin zdamar Sevilay Sezer Mehmet Hakan Tirhis Pelin Yilmazbas Faruk ztürk | 2013 | International Journal of Ophthalmology(English edition)2013，6，4： | 4 |
| 4 | Can platelet count/spleen diameter ratio be used for cirrhotic children to predict esophageal varices?显示文摘AIM To determine the laboratory and radiologic parameters, including the platelet count(PC)-to-spleen diameter(SD) ratio as a non-invasive marker that may predict the presence of esophageal varices(EV) in children with cirrhosis.METHODS Eighty-nine patients with cirrhosis, but without a history of variceal bleeding were prospectively included. The children were grouped into 6-12 and 12-18 years of age groups. These groups were also divided into 2 subgroups(presence and absence of EV). All of the patients underwent a complete biochemical and radiologic evaluation. The PC(n/mm^3)-to-SD(mm) ratio was calculated for each patient. RESULTS Sixty-nine of 98(70.4%) patients had EV. The presence of ascites in all age groups was significantly associatedwith the presence of EV. There were no differences in serum albumin levels, PC, SD and the PC-to-SD ratio between the presence and absence of EV groups in both age groups(P > 0.05). CONCLUSION Laboratory and radiologic parameters, including the PC-to-SD ratio as a non-invasive marker(except for the presence of ascites), was inappropriate for detecting EV in children with cirrhosis. | Oya Balci Sezer Deniz Celik Nihal Tutar Figen Ozcay | 2016 | World Journal of Hepatology2016，8，33： | 4 |
| 5 | LSTM RNN:detecting exploit kits using redirection chain sequences显示文摘While consumers use the web to perform routine activities,they are under the constant threat of attack from malicious websites.Even when visiting‘trusted’sites,there is always a risk that site is compromised,and,hosting a malicious script.In this scenario,the injected script would typically force the victim’s browser to undergo a series of redirects before reaching an attacker-controlled domain,which,delivers the actual malware.Although these malicious redirection chains aim to frustrate detection and analysis efforts,they could be used to help identify web-based attacks.Building upon previous work,this paper presents the first known application of a Long Short-Term Memory(LSTM)network to detect Exploit Kit(EK)traffic,utilising the structure of HTTP redirects.Samples are processed as sequences,where each timestep represents a redirect and contains a unique combination of 48 features.The experiment is conducted using a ground-truth dataset of 1279 EK and 5910 benign redirection chains.Hyper-parameters are tuned via K-fold cross-validation(5f-CV),with the optimal configuration achieving an F1 score of 0.9878 against the unseen test set.Furthermore,we compare the results of isolated feature categories to assess their importance. | Jonah Burgess Philip O’Kane Sakir Sezer Domhnall Carlin | 2021 | Cybersecurity2021，4，1： | 4 |
| 6 | Neoadjuvant hyperfractionated accelerated radiotherapy plus concomitant 5-fluorouracil infusion in locally advanced rectal cancer: A phase Ⅱ study显示文摘AIM To evaluate the efficacy and tolerability of neoadjuvant hyperfractionated accelerated radiotherapy(HART)and concurrent chemotherapy in patients with locally advanced infraperitoneal rectal cancer. METHODS A total of 30 patients with histopathologically confirmed T2-3/N0+ infraperitoneal adenocarcinoma of rectum cancer patients received preoperative 42 Gy/1.5 Gy/18 days/bid radiotherapy and continuous infusion of 5-fluorouracil(325 mg/m^2). All patients were operated 4-8 wk after neoadjuvant concomitant therapy. RESULTS In the early phase of treatment, 6 patients had grade Ⅲ-Ⅳ gastrointestinal toxicity, 2 patients had grade Ⅲ-Ⅳ hematologic toxicity, and 1 patient had grade Ⅴ toxicity due to postoperative sepsis during chemotherapy. Only 1 patient had radiotherapy-related late side effects, i.e., grade Ⅳ tenesmus. Complete pathological response was achieved in 6 patients(21%), while near-complete pathological response was obtained in 9(31%). After a median follow-up period of 60 mo, the local tumor control rate was 96.6%. In 13 patients, distant metastasis occurred. Disease-free survival rates at 2 and 5 years were 63.3% and 53%, and corresponding overall survival rates were 70% and 53.1%, respectively.CONCLUSION Although it has excellent local control and complete pathological response rates, neoadjuvant HART concurrent chemotherapy appears to not be a feasible treatment regimen in locally advanced rectal cancer, having high perioperative complication and intolerable side effects. Effects of reduced 5-fluorouracil dose or omission of chemotherapy with the aim of reducing toxicity may be examined in further studies. | Zeynep Gural Sezer Saglam Serap Yucel Esra Kaytan-Saglam Oktar Asoglu Cetin Ordu Hediye Acun Rasul Sharifov Semen Onder Ahmet Kizir Ethem N Oral | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 3 |
| 7 | Attributes of cancer patients admitted to the emergency department in one year显示文摘BACKGROUND: Cancer patients frequently visit the emergency department(ED) with various symptoms of cancer. The purpose of this study was to determine the clinical characteristics and 1-year survival rate of cancer patients in the ED of a university hospital.METHODS: We conducted a retrospective review of 408 cancer patients who visited the ED between January 2011 and December 2011. Patient information on demographics, chief complaints, fi ndings, and survival was gathered from the hospital registry and corresponding health administration.RESULTS: The study included 240(58.8%) males and 168(41.2%) females with a median age of 57.9 years(range 19–87). Regarding cancer staging, 266 patients(65.3%) had metastatic disease and 142(34.7%) had local and loco-regional disease. The hospitalization rate was 59.6%. The most common symptoms were shortness of breath(23.2%), pain(17.8%), fever(14.2%), and nausea/vomiting(14.4%). The most common cancer sites were the lung(32.5%), gastrointestinal system(25.4%), and breast(9.3%). The initial evaluation determined progressive disease(42.4%), chemotherapy effects(20.7%), infections(17.2%), radiotherapy effects(4.7%), extravasation(1.8%), anemia(1.4%), and unknown(11.3%). During follow up, 191(46.8%) patients died after admission to the ED. The 1-year overall survival of all patients was 7.3 months.CONCLUSIONS: Symptom management in cancer patients is a complex multifaceted concern for the emergency physician. Because of the increasing prevalence of cancer patients, emergency physicians should develop consensus algorithms in collaboration with the relevant disciplines to manage the commonly encountered problems. | Muallaoglu Sadik Karagün Ozlem Mertsoylu Huseyin Besen AliAyberk Sezer Ahmet Ozyilkan Ozgur | 2014 | World Journal of Emergency Medicine2014，5，2： | 3 |
| 8 | The diagnostic value of non-invasive tests for the evaluation of liver fibrosis in chronic hepatitis B patients显示文摘 | Serpil Erdogan Halef Okan Dogan Sevilay Sezer Sema Uysal Esra Ozhamam Serra Kayacetin Yuksel Koca | 2013 | Scandinavian Journal of Clinical & Laboratory Investigation2013，，4： | 2 |
| 9 | Association of haematological indices with the degree of microvascular injury in patients with acute anterior wall myocardial infarction treated with primary percutaneous coronary intervention显示文摘 | Sezer M Okcular I Goren T | 2007 | Heart2007，3，3： | 1 |
| 10 | Relevance of nutritional route and intercellular adhesion molecule - 1 in patients with acute renal failure and its prognostic implications 显示文摘 | Sezer MT Demir M Gungor G | 2008 | J Ren Nutr2008，18，3： | 1 |
| 11 | Peri- toneal transport status influence on atherosclerosis inflammation in CAPD patients显示文摘 | Sezer S Tutal E Arat Z Akay A Celik H | 2005 | J Ren Nutr2005，15，： | 1 |
| 12 | Compressive strength and sulfate resistance of limestone and/or silica fume mortars显示文摘 | Sezer G I | 2012 | Construction and Building Materials2012，26，1： | 1 |
| 13 | Ultrasonographic prenatal diagnosis of isolated acephaly 显示文摘 | Unsal A Sezer S D Meteoale L | 2007 | Diagn Interv Radial2007，13，4： | 1 |
| 14 | Concise synthesis ?electrochemistry and spectroelectrochemistry of phthalo-cyanines having triazolefunctionality显示文摘 | Karaca H Sezer S §eniz Ozalp-Yaman | 2014 | Polyhedron2014，72，5： | 1 |
| 15 | Serum cytokine levels and periodontal parameters in Ankylosing Spondylitis显示文摘 | Sezer U Erciyas K Pehlivan Y | 2012 | J Periodontal Res2012，47，3： | 1 |
| 16 | Clinical results of the liquidbased cervical cytology tool,Liqui-PREP,in comparison with conventional smears for detection of squamous cell abnormalities显示文摘 | Canda MT Demir N Sezer O | 2009 | Asian Pac J Cancer Prev2009，10，3： | 1 |
| 17 | Mucormycoses显示文摘 | Euckr J Sezer O Graf B | 2001 | Mycoses2001，44，78： | 1 |
| 18 | Factors related to fatigue and subgroups of fatigue in patients with end-stage renal disease 显示文摘 | Km'akan S Sezer S Ozdemir FN | 2001 | Clin Nephrol2001，76，5： | 1 |
| 19 | Effects of Meth anol Addition to Gasoline on the Performance and Fu el Cost of a Spark Ignition Engine显示文摘 | ATILLA BILGIN ISMET SEZER | 2008 | Energy & Fu els2008，22，： | 1 |
| 20 | FUAT-a fuzzy clustering analysis tool显示文摘 | Bozkir A.S Sezer E.A | | 0，，03： | 1 |
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