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| 1 | Multimodality imaging in apical hypertrophic cardiomyopathy显示文摘Apical hypertrophic cardiomyopathy(AHCM) is a relatively rare morphologic variant of HCM in which the hypertrophy of myocardium is localized to the left ventricular apex. Symptoms of AHCM might vary from none to others mimic coronary artery disease including acute coronary syndrome, thus resulting in inappropriate hospitalization. Transthoracic echocardiography is the firstline imaging technique for the diagnosis of hypertrophic cardiomyopathies. However, when the hypertrophy of the myocardium is localized in the ventricular apex might results in missed diagnosis. Aim of this paper is to review the different imaging techniques used for the diagnosis of AHCM and their role in the detection and comprehension of this uncommon disease. | Rosario Parisi Francesca Mirabella Gioel Gabrio Secco Rossella Fattori | 2014 | World Journal of Cardiology2014，6，9： | 11 |
| 2 | Clinical characteristics and prognostic impact of atrial fibrillation in patients with chronic heart failure显示文摘AIM To assess the prevalence, clinical characteristics and independent prognostic impact of atrial fibrillation(AF) in chronic heart failure(CHF) patients, and the potential protective effect of disease-modifying medications, particularly beta-blockers(BB). METHODS We retrospectively reviewed the charts of patients referred to our center since January 2004, and collected all clinical information available at their first visit. We assessed mortality to the end of June 2015. We compared patients with and without AF, and assessed the association between AF and all-cause mortality by multivariate Cox regression and Kaplan-Meyer analysis, particularly accounting for ongoing treatment with BB.RESULTS A total of 903 patients were evaluated(mean age 68 ± 12 years, 73% male). Prevalence of AF was 19%, ranging from 10% to 28% in patients ≤ 60 and ≥ 77 years, respectively. Besides the older age, patients with AF had more symptoms(New York Heart Association II-III 60% vs 44%), lower prevalence of dyslipidemia(23% vs 37%), coronary artery disease(28% vs 52%) and left bundle branch block(9% vs 16%). On the contrary, they more frequently presented with an idiopathic etiology(50% vs 24%), a history of valve surgery(13% vs 4%) and received overall more devices implantation(31% vs 21%). The use of disease-modifying medications(i.e., BB and ACE inhibitors/angiotensin receptor blockers) was lower in patients with AF(72% vs 80% and 71% vs 79%, respectively), who on the contrary were more frequently treated with symptomatic and antiarrhythmic drugs including diuretics(87% vs 69%) and digoxin(51% vs 11%). At a mean follow-up of about 5 years, all-cause mortality was significantly higher in patients with AF as compared to those in sinus rhythm(SR)(45% vs 34%, P value < 0.05 for all previous comparisons). However, in a multivariate analysis including the main significant predictors of allcause mortality, the univariate relationship between AF and death(HR = 1.49, 95%CI: 1.15-1.92) became not statistically significant(HR = 0.98, 95%CI: 0.73-1.32). Nonetheless, patients with AF not receiving BB treatment were found to have the worst prognosis, followed by patients with SR not receiving BB therapy and patients with AF receiving BB therapy, who both had similarly worse survival when compared to patients with SR receiving BB therapy.CONCLUSION AF was highly prevalent and associated with older age, worse clinical presentation and underutilization of disease-modifying medications such as BB in a population of elderly patients with CHF. AF had no independent impact on mortality, but the underutilization of BB in this group of patients was associated to a worse long-term prognosis. | Lorenzo Gigli Pietro Ameri Gianmarco Secco Gabriele De Blasi Roberta Miceli Alessandra Lorenzoni Francesco Torre Francesco Chiarella Claudio Brunelli Marco Canepa | 2016 | World Journal of Cardiology2016，8，11： | 4 |
| 3 | Mean platelet volume and the extent of coronary artery disease: Results from a large prospective study显示文摘 | Giuseppe De Luca Matteo Santagostino Gioel Gabrio Secco Ettore Cassetti Livio Giuliani Elena Franchi Lorenzo Coppo Sergio Iorio Luca Venegoni Elisa Rondano Gabriele Dell’Era Claudia Rizzo Patrizia Pergolini Francesco Monaco Giorgio Bellomo Paolo Marino | 2009 | Atherosclerosis2009，，1： | 2 |
| 4 | Factors influencing incidence and extension of metachronous liver metastases of colorectal adenocarcinoma: a multivariatean alysis显示文摘 | Secco GB Fardelli R Gianquinto D | 1997 | Hepatogastroenterology1997，44，： | 1 |
| 5 | Carotid artery stenting: an update 显示文摘 | Cremonesi A Castriota F Secco GG | 2015 | Eur Heart J2015，36，1： | 1 |
| 6 | Functional characterization of the rice SPX‐MFS family reveals a key role of OsSPX‐MFS1 in controlling phosphate homeostasis in leaves显示文摘 | Chuang Wang Wei Huang Yinghui Ying Shuai Li David Secco Steve Tyerman James Whelan Huixia Shou | 2012 | New Phytologist2012，，1： | 1 |
| 7 | Mean platelet volume and the extent of coronary artery disease:results from a large prospective study显示文摘 | De Luca G Santagostino M Secco G G | | 0，，01： | 1 |
| 8 | Haemoglobin levels do not correlate with the extent of coronary artery disease: results from a large cohort study显示文摘 | De Luca G Secco GG Cassetti E | 2014 | Coron Artery Dis2014，25，6： | 1 |
| 9 | Apparent digestibility of different ingredients in diets for bullfrog Rana catesbeiana Tadpoles 显示文摘 | SECCO E M DE STEFANI M V VIDOTTI R M | 2005 | Journal of the World Aquaculture Society2005，36，1： | 1 |
| 10 | Multipotent stem ceils from umbilical cord: cord is richer than blood! 显示文摘 | Secco M Zucconi E Vieira N M | 2008 | Stem Cells2008，26，1： | 1 |
| 11 | DNA binding by a new metallointercalator that contains a proflavine group bearing a hanging chelating unit显示文摘 | Bazzicalupi C Bencini A Bianchi A Biver T Boggioni A Bonacchi A Danesi A Giorgi C Gratteri P Ingrán A.M Secco F Sissi C Valtancoli B Venturini M | | 0，，1： | 1 |
| 12 | Plasma fibrinogen levels and restenosis after primary percutaneous coronary intervention 显示文摘 | Lupi A Secco GG Rognoni A | 2012 | J Thromb Thrombolysis2012，33，4： | 1 |
| 13 | 显示文摘 | Secco R A Liu H | 2002 | Journal of Physics and Chemistry of Solids2002，63，： | 1 |
| 14 | Systemic delivery of hu- man mesenchymal stromal ceils combined with IGF-1 enhances muscle functional recovery in LAMA2 dy/2j dystrophic mice 显示文摘 | Secco M Bueno C Jr Vieira NM | 2013 | Stem Cell Rev2013，9，1： | 1 |
| 15 | Efficacy and cost of risk-adapted follow-up in patients after colorectal cancer surgery: a prospective, randomized and controlled trial 显示文摘 | Secco G B Fardelli R Gianquinto D | 2002 | Eur J Surg Oncol2002，28，4： | 1 |
| 16 | Plasma fibrinogen levels and restenosis after primary percutaneous coronary intervention 显示文摘 | Lupi A Secco GG Rognoni A | 2012 | J Thromb Thrombolysis2012，33，4： | 1 |
| 17 | Mean platelet volume and the extent of coronary artery disease: Results from a large prospective study 显示文摘 | De Luca G Santagostino M Secco GG | 2009 | Atheroselerosis2009，206，： | 1 |
| 18 | Uric acid does not affect the prevalence and extent of coronary artery disease Results from a prospective study显示文摘 | De Luca G Secco GG Santagostino M | | 0，，05： | 1 |
| 19 | Preoperative aspects and dimensions used for an anatomical (PADUA) classification of renal tumours in patients who are candidates for nephron-sparing surgery显示文摘 | FICARRA V NOVARA G SECCO S | 2009 | Eur Urol2009，56，5： | 1 |
| 20 | Preoperative aspects and dimensions used for an anatomical (PADUA) classification of renal tumours in patients who are candidates for nephron-sparing surgery显示文摘 | FICARRA V NOVARA G SECCO S | 2009 | Eur Urol2009，56，5： | 1 |
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