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| 1 | Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber显示文摘Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system1–4.Advances in wavefrontshaping methods and computational power have recently allowed for a novel approach to high-resolution imaging,utilizing deterministic light propagation through optically complex media and,of particular importance for this work,multimode optical fibers(MMFs)5–7.We report a compact and highly optimized approach for minimally invasive in vivo brain imaging applications.The volume of tissue lesion was reduced by more than 100-fold,while preserving diffraction-limited imaging performance utilizing wavefront control of light propagation through a single 50-μm-core MMF.Here,we demonstrated high-resolution fluorescence imaging of subcellular neuronal structures,dendrites and synaptic specializations,in deep-brain regions of living mice,as well as monitored stimulus-driven functional Ca2+responses.These results represent a major breakthrough in the compromise between high-resolution imaging and tissue damage,heralding new possibilities for deep-brain imaging in vivo. | Sebastian A.Vasquez-Lopez Raphaël Turcotte Vadim Koren Martin Plöschner Zahid Padamsey Martin J.Booth TomášČižmár Nigel J.Emptage | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 2 | Ciliated hepatic foregut cyst:an increasingly diagnosed condition显示文摘BACKGROUND:Ciliated foregut cysts of the liver are rare, with only 96 cases diagnosed since the first description in 1857.They are being increasingly diagnosed recently;the majority of the cases have been reported in the last 15 years. Although they bear a close resemblance to the simple cyst of the liver which has essentially a benign course,ciliated hepatic foregut cysts(CHFCs)can progress to malignancy with devastating consequences.It is imperative that this group of conditions be diagnosed and treated adequately. DATA SOURCES:This review includes discussion of the data from all the 96 reported cases from English and non-English literature.Analysis of the incidence rates, embryogenesis,growth,clinical features,risk of malignancy and the prognosis are highlighted systematically.The roles of various diagnostic modalities including ultrasound, CT,MRI,fine needle aspiration cytology(FNAC), immunohistochemistry and surgery are further discussed. RESULTS:The mean age of patients with CHFC was 48± 12 years.The male/female ratio was 1.1∶1.The majority of patients with CHFC(62%)were asymptomatic,and the common mode of presentation was right upper abdominal pain.The cysts occurred in the left lobe in 51 patients, with sole location in segmentⅣin 44,and in the right lobe in 26.The average size of the cysts was 3.6±2.12 cm. The majority of the cysts were unilocular,and only 7 cases were multilocular.Cyst contents were described as viscous or mucinous in 73 patients,whereas bilious fluid was noted in 3.Large cysts having squamous carcinoma were cited in 3 patients,and 2 had extensive squamous metaplasia without malignancy.Others had benign histopathology. CONCLUSIONS:Clinicians have become increasingly aware of CHFC.Imaging alone is not diagnostic per se, but when considered in the context of the global picture does provide important clues to the diagnosis.FNAC is diagnostic by the presence of the ciliated columnar aspirate but lacks sensitivity.Infantile presentation is usually accompanied by biliary communication and mandates a different surgical approach.The demonstration of malignant transformation in 3 cases and its fatal course emphasizes the need for surgical resection in all cases once the diagnosis is made. | Sharad Sharma Amanda G.Dean Ayumi Corn Vivek Kohli Harlan I Wright Anthony Sebastian Nicolas Jabbour | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，6： | 2 |
| 3 | Quaternion-MUSIC for vector-sensor array processing 显示文摘 | SEBASTIAN M NICOLAS L B JEROME I M | 2006 | IEEE Transactions on Signal Processing2006，54，4： | 1 |
| 4 | MUSIC algorithm for vector-sensors array using hiquaternions 显示文摘 | Nicolas Le Bihan Sebastian Miron Mars J I | 2007 | IEEE Trans Signal Processing2007，55，9： | 1 |
| 5 | Microwave dielectric properties of MO - La2O3 - TiO2 ( M = Ca, Sr, Ba) ceramics 显示文摘 | Jawahar I N Santha N 1 Sebastian M T | 2000 | Materials Research2000，17，： | 1 |
| 6 | Assessing relative risks of infection and rejection: a meta analysis using an immune function assay显示文摘 | Kowalski R J Post D R Mannon R B Sebastian A Wright H I Sigle G | 2006 | Transplantation2006，82，： | 1 |
| 7 | High expression levels of nuclear factor kappa B and gelatinases in the tumorigenesis of oral squamous cell careinoma 显示文摘 | Bindhu OS Ramadas K Sebastian I' | 2006 | Head Neck2006，28，10： | 1 |
| 8 | Natural diversity of potato (Solarium tuberos urn) invertases 显示文摘 | Astrid M D Sebastian M Li I | 2010 | Plant Biology2010，10，： | 1 |
| 9 | Visual 3-D SLAM from UAVs 显示文摘 | ARTIEDA J SEBASTIAN J M CAMPOY P CORREA J F MONDRAGON I F MARTINEZ C OLIVARES M | 2009 | Journal of Intelligent and Robotic Systems2009，55，45： | 1 |
| 10 | Transport-enhanced α-olefin readsorption pathways in Ru-catalyzed hydrocarbon synthesis显示文摘 | Enrique I Sebastian C R Rostam J M | 1991 | Journal of Catalysis1991，129，1： | 1 |
| 11 | A5B4O15 (A=Ba,Sr,Mg,Ca,Zn;B=Nb,Ta) microwave dielectric ceramics显示文摘 | JAWAHAR I N MOHANAN P SEBASTIAN M T | | 0，，24： | 1 |
| 12 | AsB4OIs(A=Ba, Sr, Mg, Ca, Zn; B=Nb, Ta) microwave dielectric ceramics 显示文摘 | JAWAHAR I N MOHANAN P SEBASTIAN M T | 2003 | Mater Lett2003，57，： | 1 |
| 13 | Endovascular treatment of hepatic artery thrombosis following liver transplantation显示文摘 | Ashish Singhal Kenneth Stokes Anthony Sebastian Harlan I Wright Vivek Kohli | 2010 | Transplant International2010，，3： | 1 |
| 14 | A5B4O15 (A=Ba、Sr、Mg、Ca、Zn; B=Nb、Ta) microwave dielectric ceramics显示文摘 | Jawahar I N Mohanan P Sebastian M T | 2003 | Mater Lett2003，57，： | 1 |
| 15 | Studies on radiation grafting of methyl methacrylate onto natural rubber for improving modulus of latex film 显示文摘 | George V Britto I J Sebastian M S | 2003 | Radiation Physics and Chemist ry2003，66，5： | 1 |
| 16 | Microwave dielectric properties of Ba5-xSrxTa4O15 and Sr5NbxTa4-xO15 ceramics 显示文摘 | JAWAHAR I N SEBASTIAN M T MOHANAN P | 2004 | Mater Sci Eng B2004，106，： | 1 |
| 17 | Measuring societal effects of trans-disciplinary research projects: Design and application of an evaluation method显示文摘 | Alexander I W Sebastian H Arnim W | 2007 | Evaluation and Program Planning2007，30，4： | 1 |
| 18 | Influence of biochar on drought tolerance of Chenopodium quirtoa willd and on soil-plant rela- tions显示文摘 | Claudia I K Sebastian L Johannes W | 2011 | Plant Soil2011，345，： | 1 |
| 19 | Incorporation of Ti^4+ into layered double hydroxide sheets and the response by X-ray diffraction and absorption study显示文摘 | Mourad I Sebastian H Jean P B | 2004 | Physics and Chemistry of Solids2004，9，12： | 1 |
| 20 | Global observability analysis of sensorless induction motors显示文摘 | Sebastian I R Jaime M Gerardo E P | 2004 | Automatica2004，40，： | 1 |
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