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| 1 | Femtojoule electro-optic modulation using a silicon– organic hybrid device显示文摘Energy-efficient electro-optic modulators are at the heart of short-reach optical interconnects,and silicon photonics is considered the leading technology for realizing such devices.However,the performance of all-silicon devices is limited by intrinsic material properties.In particular,the absence of linear electro-optic effects in silicon renders the integration of energy-efficient photonic–electronic interfaces challenging.Silicon–organic hybrid(SOH)integration can overcome these limitations by combining nanophotonic silicon waveguides with organic cladding materials,thereby offering the prospect of designing optical properties by molecular engineering.In this paper,we demonstrate an SOH Mach–Zehnder modulator with unprecedented efficiency:the 1-mm-long device consumes only 0.7 fJ bit^(-1) to generate a 12.5 Gbit s^(-1) data stream with a bit-error ratio below the threshold for hard-decision forward-error correction.This power consumption represents the lowest value demonstrated for a non-resonant Mach–Zehnder modulator in any material system.It is enabled by a novel class of organic electro-optic materials that are designed for high chromophore density and enhanced molecular orientation.The device features an electro-optic coefficient of r33<180 pm V^(-1) and can be operated at data rates of up to 40 Gbit s^(-1). | Sebastian Koeber Robert Palmer Matthias Lauermann Wolfgang Heni Delwin L Elder Dietmar Korn Markus Woessner Luca Alloatti Swen Koenig Philipp C Schindler Hui Yu Wim Bogaerts Larry R Dalton Wolfgang Freude Juerg Leuthold Christian Koos | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 2 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 3 | Postoperative blood salvage and reinfusion in spinal surgery:blood quality,effectiveness and impact on patient blood parameters显示文摘 | Sebastian C Romero R Olalla E | 2000 | Eu Spine J2000，9，6： | 1 |
| 4 | An integrated AFLP and RFLP Brassica oleracea linkage map from two morphologically distinct doubled-haploid mapping population 显示文摘 | Sebastian R L Howell E C King G : | 2000 | Theoretical and Applied Genetics2000，100，1： | 1 |
| 5 | Postoperative blood salvage and refusion in spinal surgery:bood quality,effectiveness and impact on patient blood parameters显示文摘 | Sebastian C Romero R Ferrer C | 2000 | Eur Spine J2000，9，6： | 1 |
| 6 | SIRT3 in calorie restriction:can you hear me now显示文摘 | Sebastian C Mostoslavsky R | | 0，，05： | 1 |
| 7 | Human Protein Reference Database- -2009 update显示文摘 | Keshava Prasad TS Goel R Kandasamy K Keerthikumar S Kumar S Mathivanan S Telikicherla D Raju R Shafreen B Venugopal A Balakrishnan L Mafimuthu A Banerjee S So- manathan DS Sebastian A Rani S Ray S Harrys Kishore C J Kanth S Ahmed M Kashyap MK Mohmood R Ramachandra YL Krishna V Rahiman BA Mohan S Ranganathan P Ram- abadran S Chaerkady R Pandey A | 2009 | Nucleic Acids Res2009，37，： | 1 |
| 8 | Transport-enhanced α-olefin readsorption pathways in Ru-catalyzed hydrocarbon synthesis显示文摘 | Enrique I Sebastian C R Rostam J M | 1991 | Journal of Catalysis1991，129，1： | 1 |
| 9 | Decline in research publications from the United Kingdom in anaesthesia journals from 1997 to 2006 显示文摘 | Feneck RO Natarajan N Sebastian R Naughton C | 2008 | Anasthesia2008，63，3： | 1 |
| 10 | Normotensive salt sensitivity:effects of race and dietary potassium显示文摘 | Morris R C Jr Sebastian A Forman A | 1999 | Hypertension1999，33，1： | 1 |
| 11 | Decline in research publications from the United Kingdom in anaesthesia journals from 1997 to2006 显示文摘 | Feneck RO Natarajan N Sebastian R Naughton C | 2008 | Anaesthesia2008，63，3： | 1 |
| 12 | Pathophysiology of diabetic gastroparesis显示文摘 | McCallum RW Sebastian C Romero R | 1998 | Gastroentriology1998，114，3： | 1 |
| 13 | An integrated AFLP and RFLP Brassica oleracea linkage map from two morpholo- gically distinct doubled-haploid mapping population显示文摘 | Sebastian R L Howell E C King G J | 2000 | Theor Aopl Genet2000，100，1： | 1 |
| 14 | A Topological Route Choice Model for Metro显示文摘 | SEBASTIAN R MUNOZ J C GRANGE L D | 2011 | Transportation Research Part A:Policy and Practice2011，45，2： | 1 |
| 15 | Untangling the fiber yarn:butyrate feeds warburg to suppress colorectal cancer显示文摘 | Sebastian C Mostoslavsky R | 2014 | Cancer Discov2014，4，12： | 1 |
| 16 | CIS and CIGS based photovoltaic structures developed from electrodeposited precursors显示文摘 | C alixto M E Bhattacharya R N | 1999 | Solar Energy Mate rials and Solar Cells1999，59，： | 1 |
| 17 | Continuous morphine infusions for cancer pain in resource-scarce environments: comparison of the subcutaneous and intrave- nous routes of administration显示文摘 | Koshy RC Kuriakose R Sebastian P Koshy C | 2005 | Pain Palliat Care Pharmacother2005，，： | 1 |
| 18 | A Topological Route Choice Model for Metro 显示文摘 | Sebastian R Munoz J C Grange L D | 2011 | Transportation Research Part A: Policy and Practice2011，45，2： | 1 |
| 19 | Phylogenetic analysis of toxic Alexandrium(Dinophyceae) isolates from South Africa: implications for the global phylogeography of the Alexandrium tamarense species complex显示文摘 | SEBASTIAN C R ETHERIDGE S M COOK P A | 2005 | Phyeologia2005，44，1： | 1 |
| 20 | Normotensive salt sensitivity:effects of race and dietary potassium显示文摘 | Morris R C Jr Sebastian A Forman A | 1999 | Hypertension1999，33，： | 1 |
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