|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 2 | Single-operator cholangioscopy for biliary complications in liver transplant recipients显示文摘AIM To evaluate cholangioscopy in addition to endoscopic retrograde cholangiopancreatography(ERCP) for management of biliary complications after liver transplantation(LT).METHODS Twenty-six LT recipients with duct-to-duct biliary reconstruction who underwent ERCP for suspected biliary complications between April and December2016 at the university hospital of Muenster were consecutively enrolled in this observational study. After evaluating bile ducts using fluoroscopy, cholangioscopy using a modern digital single-operator cholangioscopy s y s t e m(S py G la s s D S ?) wa s pe r fo r me d dur ing the same procedure with patients under conscious sedation. All patients received peri-interventional antibiotic prophylaxis and bile was collected during the intervention for microbial analysis and for antibiotic susceptibility testing.RESULTS Thirty-three biliary complications were found in a total of 22 patients, whereas four patients showed normal bile ducts. Anastomotic strictures were evident in 14(53.8%) patients, non-anastomotic strictures in seven(26.9%), biliary cast in three(11.5%), and stones in six(23.1%). A benefit of cholangioscopy was seen in 12(46.2%) patients. In four of them, cholangioscopy was crucial for selective guidewire placement prior to planned intervention. In six patients, biliary cast and/or stones failed to be diagnosed by ERCP and were only detectable through cholangioscopy. In one case, a bile duct ulcer due to fungal infection was diagnosed by cholangioscopy. In another case, signs of bile duct inflammation caused by acute cholangitis were evident. One patient developed post-interventional cholangitis. No further procedure-related complications occurred. Thirty-seven isolates were found in bile. Sixteen of these were gram-positive(43.2%), 12(32.4%) were gram-negative bacteria, and Candida species accounted for 24.3% of all isolated microorganisms. Interestingly, only 48.6% of specimens were sensitive to prophylactic antibiotics.CONCLUSION Single-operator cholangioscopy can provide important diagnostic information, helping endoscopists to plan and perform interventional procedures in LT-related biliary complications. | Anna Hüsing-Kabar Hauke Sebastian Heinzow Hartmut Hans-Jürgen Schmidt Carina Stenger Hans Ulrich Gerth Michele Pohlen Gerold Tholking Christian Wilms Iyad Kabar | 2017 | World Journal of Gastroenterology2017，23，22： | 4 |
| 3 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 4 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 5 | National Forest Inventories capture the multifunctionality of managed forests in Germany显示文摘Background:Forests perform various important ecosystem functions that contribute to ecosystem services.In many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem services.However,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem services.Based on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem services.We use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory data.Results:Looking at the potential supply of ecosystem services,we found trade-offs(e.g.between both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(e.g.for temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in Germany.No single forest type provided all ecosystem services equally.Some ecosystem services showed comparable levels across forest types(e.g.decomposition or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(e.g.phosphorous availability or cover of edible plants)or tree species composition(e.g.potential nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental conditions.However,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree species.Conclusions:Our results show that forest multifunctionality is limited to subsets of ecosystem services.The importance of tree species composition highlights that a lack of multifunctionality at the stand level can be compensated by managing forests at the landscape level,when stands of complementary forest types are combined.These results imply that multi-purpose forestry should be based on a variety of forest types requiring coordinated planning across larger spatial scales. | Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser | 2021 | Forest Ecosystems2021，8，1： | 2 |
| 6 | Comparative genetic characterization of porcine circovirus type 2 samples from German wild boar populations显示文摘 | Sebastian K Hermann W Barbara H | 2005 | Vet Microbiol2005，109，： | 1 |
| 7 | Treat- ment of non-small cell lung cancer patients with the tri- functional monoclonal antibody catumaxomab (anti-Ep- CAM x anti-CD3):a phase I study显示文摘 | Sebastian M Passlick B Friccius-Quecke H | 2007 | Cancer Immunol Immunother2007，56，10： | 1 |
| 8 | Molecular and phenotypic characterization of Als1 and Als2 mutations conferring tolerance to acetolactate synthase herbicides in soybean显示文摘 | Kay L Walter Stephen D Strachan Nancy M Ferry Henrik H Albert Linda A Castle Scott A Sebastian | 2014 | Pest. Manag. Sci2014，，12： | 1 |
| 9 | Low loss dielectric materials for LTCC applications:a review显示文摘 | SEBASTIAN M T JANTUNEN H | | 0，，02： | 1 |
| 10 | Association of late-life changes in blood pressure and cognitive status显示文摘BackgroundDisagreement 在血压和认知缺陷在在变化之间的协会上存在。我们试图检验在收缩、心脏舒张的血压( SBP 和 DBP )的4年的变化是否从一件基于人口的德国样品(年老的 60-87 年)的 854 个参加者在老人的一件代表性的样品和纵的数据的 women.MethodsAnalysis 与认知地位被联系与标准认知屏蔽和血被执行迫使大小。在 SBP 和 DBP 的变化的效果(10 mmHg 和 5 mmHg 分别地作为回归效果联合起来测量) 用非参量、线性的回归 modeling.ResultsNo 在认知地位上被评估清楚的协会在 SBP 或在 DBP 和认知分数在变化之间被看见。小效果为性别和高血压了解在层化以后被发现。明确地,在 SBP 的更大的减少在知道他们的高血压的那些人与更高认知的分数被联系(在 SBP 的 10 mmHg 减少, β=− 0.26, 95% CI:− 0.51 到 − 0.02 ) 并且有控制高血压的人(在 SBP 的 10 mmHg 减少, β=− 0.44, 95% CI:− 0.92 到 − 0.03 ) 。DBP 的另外更大的增加与控制高血压在人与更高认知的分数被联系(DBP 的 5 mmHg 增加, β= 0.67, 95% CI:0.19-1.15 ) 。为知道他们的高血压的女人,在 DBP 的更大的减少与更高认知的分数被联系(在 DBP 的 5 mmHg 减少, β=− 0.26;95%CI:− 0.51 到 − 0.01 ) 在血压的 .ConclusionsChanges 仅仅微弱地与认知地位被联系。明确地,在 SBP 的减少在知道他们医学上被控制的高血压和特别那些的男人与更高认知的分数被联系。 | Maria E Lacruz Daniel Tiller Alexander Kluttig Karin H Greiser Sebastian Nuding Karl Werdan Johannes Haerting | 2016 | Journal of Geriatric Cardiology2016，13，1： | 1 |
| 11 | Algorithms for Non-negative Matrix Factorization显示文摘 | Lee D D Sebastian S H | 2001 | Advances in Neural Information Processing Systems2001，2001，13： | 1 |
| 12 | The manifold ways of pereeption显示文摘 | Seung H Sebastian D Lee D | 2000 | Science2000，29，5500： | 1 |
| 13 | Properties and processing of magnesium wrought products for automotive applications显示文摘 | Stalmann A Sebastian W Friedrich H | 2001 | Advanced Engineering Materials2001，3，12： | 1 |
| 14 | Monte Carlo simulations of the diffuse backscattering Mueller matrix for highly scattering media显示文摘 | Sebastian B Andreas H H | 2000 | Appl Opt2000，39，： | 1 |
| 15 | Is radical bowel cancer resection under local anaesthesia and sedation feasible?显示文摘 | Sebastian J Sran H Marzouk D | 2015 | Indian J Surg2015，77，4： | 1 |
| 16 | Effect of operating condition and input variation on the partition of metals in a municipal solid waste incinerator显示文摘 | Leo S Morf Paul H Brunner Sebastian Spaun | 2000 | Waste Manage Res2000，18，1： | 1 |
| 17 | Effect of operating conditions and input variations on the partitioning of metals in a municipal solid waste incinerator 显示文摘 | Morf Leo S Brunner Paul H Spaun Sebastian | 2000 | Waste Management and Research2000，18，1： | 1 |
| 18 | Algorithms for on-line order batching in an order picking warehouse显示文摘 | Sebastian H | 2012 | Computers&Operations Research2012，39，： | 1 |
| 19 | C a n cer testisantigens and N Y - B R - 1 expression in p r i m a r breast cancer:prognostic and therapeutic implications 显示文摘 | Dimitrios B Axel Z H Sebastian M | | B M CCancer0，13，： | 1 |
| 20 | Monte Carlo simulations of the diffuse backscattering Mueller matrix for highly scattering media 显示文摘 | Sebastian Barrel Andreas H Hielscher | 2000 | Applied Optics2000，39，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员