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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 3 | Onset and duration of action of rocuronium-from tracheal intubation,through intense block to complete recovery 显示文摘 | SCHULTZ P IBSEN M φSTERGAARD D | 2001 | Acta Anaes- thesiol Scand2001，45，： | 1 |
| 4 | Neural mecha-nisms of observational learning显示文摘 | Burke C J Tobler P N Baddeley M Schultz W | 2010 | Proc Natl Acad Sci USA2010，107，14： | 1 |
| 5 | The effect of biofilms on turbulentboundary layers显示文摘 | Schultz M P Swain G W | 1999 | Journal of Fluids engineering1999，121，1： | 1 |
| 6 | Seismicguided estimation of log properties Part 1: A datadriven interpretation methodology显示文摘 | Schultz P S Ronen S Hattori M | 1994 | The Leading Edge1994，13，5： | 1 |
| 7 | The influence of biofilms on skin friction drag显示文摘 | Schultz M P Swain G W | 2000 | Biofouling2000，15，13： | 1 |
| 8 | Recombinant chicken interferon:a potent antiviral agent that lacks intrinsic macrophage activating factor activity显示文摘 | Schultz U Kaspers B Rinderle C Sekellick M J Marcus P I Staeheli P | 1995 | European Journal of Immunology1995，25，3： | 1 |
| 9 | Improving snow fall forecasting by diagnosing snow density 显示文摘 | Roebber P J Bruening S L Schultz D M | 2003 | Weather and Forecasting2003，18，4： | 1 |
| 10 | Characterization of two divergent lineages of macaque rhadinoviruses related to Kaposi's sarcoma-associated herpesvirus 显示文摘 | Schultz E R Rankin G W Blanc M P | 2000 | Virol2000，74，： | 1 |
| 11 | Onset and duration of action of rocuronium--from tracheal intubation, through intense block to complete recovery 显示文摘 | Schultz P Ibsen M Ostergaard D | 2001 | Acta Anaesthesiol Scand2001，45，5： | 1 |
| 12 | Fluorochemical mass flowsin a municipal wastewater treatment facility显示文摘 | Schultz M M Higgins C P Huset C A | 2006 | Environmental Scienceand Technology2006，40，23： | 1 |
| 13 | RBBP4 regulates histone deacetylation and bipolar spindle assembly during oocyte maturation in the mouse显示文摘 | Balboula A Z Stein P Schultz R M | 2015 | Biol Reprod2015，92，4： | 1 |
| 14 | Effects of coating roughness and biofouling on ship resistance and powering显示文摘 | Schultz M P | | 0，，5： | 1 |
| 15 | Devolatilization characteristics of large particles of tyre rubber under combustioncondifions 显示文摘 | Larsen M B Schultz L Glarbor P | 2005 | Fuel2005，85，1011： | 1 |
| 16 | Improving the accuracy and precision of disease assessments : selection of methods and use of computer-aided training programs 显示文摘 | Nutter F W Schultz P M | 1995 | Canadian Journal of Plant Pathology1995，17，2： | 1 |
| 17 | The use and misuse of condi-tional symmetric instability显示文摘 | Schultz D M Schumacher P N | | 0，，12： | 1 |
| 18 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 19 | The incidence of low ve- nous oxygen saturation on admission to the intensive care unit: a multi-center observational study in Netherlands显示文摘 | Van Beest P Hofstra J Schultz M | 2008 | Crit Care2008，12，1： | 1 |
| 20 | Toward the improvement of aircraft-icing forecasts for the continental United States显示文摘 | SCHULTZ P POLITOVICH M K | 1992 | Weather and Forecasting1992，7，： | 1 |
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