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| 1 | Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism显示文摘BACKGROUND It is well known that an alcohol consumption habit together with inactive heterozygous aldehyde dehydrogenase-2(ALDH2)is an important risk factor for the development of esophageal squamous cell carcinoma(ESCC).It remains controversial whether human papillomavirus(HPV)infection contributes to the occurrence/development of ESCC.There has been no study in which the relationship between ESCC and HPV in addition to alcohol dehydrogenase-1B(ADH1B)and ALDH2 genotypes was evaluated.AIM To evaluate relationships between HPV infection and development of esophageal cancer,particularly early esophageal cancer,based on ADH1B/ALDH2 polymorphisms.METHODS We conducted an exploratory retrospective study using new specimens,and we enrolled 145 patients who underwent endoscopic resection for superficial ESCC and had been observed for more than two years by both physical examination and endoscopic examination in Hokkaido University Hospital.Saliva was collected to analyze genetic polymorphisms of ADH1B/ALDH2.We performed in situ hybridization for resected specimens to detect HPV by using an HPV type 16/18 probe.RESULTS HPV was detected in 15(10.3%)of the 145 patients with ESCC.HPV-positive rates in inactive ALDH2*1/*2 and ALDH2*1/*1+*2/*2 were 10.8%and 9.8%,respectively(P=1.00).HPV-positive rates in slow-metabolizing ADH1B*1/*1 and ADH1B*1/*2+*2/*2 were 12.0%and 10.0%,respectively(P=0.72).HPV-positive rates in the heavy or moderate alcohol consumption group and the light or rare consumption group were 11.1%and 8.7%,respectively(P=0.68).HPV-positive rates in the heavy smoking group and the light or no smoking group were 11.8%and 8.3%,respectively(P=0.59).The 3-year incidence rates of secondary ESCC or head and neck cancer after initial treatment in the HPV-positive and HPVnegative groups were 14.4%and 21.4%(P=0.22),respectively.CONCLUSION In the present situation,HPV status is considered to be less important than other risk factors,such as alcohol consumption,smoking habit,ADH1B/ALDH2 polymorphisms,and HPV status would therefore have no effect on ESCC risk management. | Masaki Inoue Yuichi Shimizu Marin Ishikawa Satoshi Abiko Yoshihiko Shimoda Ikko Tanaka Sayoko Kinowaki Masayoshi Ono Keiko Yamamoto Shoko Ono Naoya Sakamoto | 2020 | World Journal of Gastroenterology2020，26，39： | 2 |
| 2 | Basic fibroblast growth factor‐treated adipose tissue‐derived mesenchymal stem cell infusion to ameliorate liver cirrhosis via paracrine hepatocyte growth factor显示文摘 | Wei‐Ping Tang Tomohiko Akahoshi Jing‐Shu Piao Sayoko Narahara Masaharu Murata Takahito Kawano Nobuhito Hamano Tetsuo Ikeda Makoto Hashizume | 2015 | J Gastroenterol Hepatol2015，，6： | 1 |
| 3 | A new synthesis of some non-steroidal anti-inflammatory agents via cyanophosphates显示文摘 | SHINYA H SHUJI N SAYOKO Y | 1984 | Synth Commun1984，14，14： | 1 |
| 4 | LOX-1: the multifunctional receptor underlying cardiovascular dysfunction显示文摘 | SAYOKO O AKEMI K YUKO S ct al | 2009 | Circ J2009，73，11： | 1 |
| 5 | Progress in organic coatings显示文摘 | RONG L SAYOKO H TAKAHISA I etal | 2004 | (51):238-2432004，，51： | 1 |
| 6 | MHC class?IIB gene sequences and expression in quails (Coturnix japonica) selected for high and low antibody responses显示文摘 | Sayoko Shimizu Takashi Shiina Kazuyoshi Hosomichi Shinji Takahashi Takumi Koyama Takashi Onodera Jerzy K. Kulski Hidetoshi Inoko | 2004 | Immunogenetics2004，，4： | 1 |
| 7 | Lox-1:the multifunctional receptor underlying cardiovascular dysfunction显示文摘 | Sayoko Ogura Akemi Kakino Yuko Sato | 2009 | Circ J2009，73，11： | 1 |
| 8 | Development of a fast drying lacquer based on raw lacquer sap 显示文摘 | RONG L SAYOKO H | 2004 | Progress in Organic Coatings2004，，51： | 1 |
| 9 | Supported Pd and Au nanoparticles on Ti-MCM-41 prepared by a photo-assisted deposition method as efficient catalysts for direct synthesis of H2O2 from H2 and O2 显示文摘 | KOHSUKE M TAKASHI A SAYOKO S | 2009 | Catalysis Letters2009，131，： | 1 |
| 10 | LOX Index, a Novel Predictive Biochemical Marker for Coronary Heart Disease and Stroke显示文摘 | Inoue Nobutaka Okamura Tomonori Kokubo Yoshihiro Fujita Yoshiko Sato Yuko Nakanishi Mamoru Yanagida Kazuki Kakino Akemi Iwamoto Shin Watanabe Makoto Ogura Sayoko Otsui Kazunori Matsuda Haruo Uchida Kagehiro Yoshimoto Ryo Sawamura Tatsuya | 2010 | Clinical Chemistry2010，，4： | 1 |
| 11 | Evaluation of the minimally invasive parathyroidectomy in patients with primary hyperparathyroidism:a retrospective cohort study显示文摘 | Sayoko T Takeki S Norihiro H | 2016 | Annals of Medicine and Surgery2016，7，1： | 1 |
| 12 | Survery of airborne polyfluorinated telomers in Keihan Area 显示文摘 | Sayoko Oono S Matsubara E Harada H K | 2008 | Japan Bull Environ Contain Toxicol2008，80，： | 1 |
| 13 | Case of Mycobacterium tuberculosis meningitis:Gram staining as a usaaeful initial diagnostic clue for tuberculous meningitis显示文摘 | Sayoko Kawakami Yukihisa Miyazawa | 2012 | Journal of Infection and Chemotherapy2012，18，6： | 1 |
| 14 | Ocular ball bullet injury:detection of gonioscopically unrecognisable cyclodialysis by ultrasound biomicroscopy显示文摘 | Shinichiro Endo Gentei Mitsukawa Sayoko Fujisawa | 1999 | Br J Ophthalmol1999，83，8： | 1 |
| 15 | LOX-1 in atherosclerosis: biological functions and pharmacological modifiers显示文摘 | Suowen Xu Sayoko Ogura Jiawei Chen Peter J. Little Joel Moss Peiqing Liu | 2013 | Cellular and Molecular Life Sciences2013，，16： | 1 |
| 16 | Metabolic conversion of castasterone and brassinolide into their glucosides in higher plants显示文摘 | Kazuo Soeno Shozo Fujioka Sayoko Hiranuma | 2006 | Plant Growth Regulation2006，25，： | 1 |
| 17 | Development of a fast drying lacquer based on raw lacquer sap 显示文摘 | Rong Lu Sayoko Harigaya Takahisa Ishimura Kisuke Nagase | 2004 | Progress in Organic Coatings2004，8，： | 1 |
| 18 | New route for the preparation of Pd and Pd/Au nanoparticles using photoexcited Ti-containing zeolite as an efficient support material and investigation of their catalytic properties显示文摘 | Mori Kohsuke Miura Yuke Shironita Sayoko | 2009 | Langmuir2009，25，11： | 1 |
| 19 | Development of a fast drying lacquer based on raw lacquer sap 显示文摘 | RONG L SAYOKO H TAKAHISA I | 2004 | Progress in Organic Coatings2004，51，4： | 1 |
| 20 | Clinical impact of gastrointestinal endoscopy on the early detection of pharyngeal squamous cell carcinoma: A retrospective cohort study显示文摘BACKGROUND In recent years,with the growing availability of image-enhanced gastrointestinal endoscopy,gastroenterologists have contributed to the early detection of pharyngeal squamous cell carcinomas(SCC).AIM To clarify the clinical characteristics of pharyngeal SCCs detected by gastrointestinal endoscopy.METHODS This is a retrospective cohort study conducted in a single-center,a university hospital in Japan.We retrospectively assessed the clinical records of 522 consecutive patients with oropharyngeal or hypopharyngeal SCC who were examined in our hospital between 2011 and 2018.The lesions were classified into two groups:Group GE(detected by gastrointestinal endoscopy)and Group non-GE(detected by means other than gastrointestinal endoscopy).The clinical characteristics were compared between the two groups.Continuous data were compared using the Mann–Whitney U test.Pearson’sχ2 test or Fisher's exact test was used to analyze the categorical data and compare proportions.The Kaplan–Meier method was used to estimate the cumulative patient survival rates.RESULTS In our study group,the median age was 65 years and 474 patients(90.8%)were male.One hundred and ninety-six cases(37.5%)involved the oropharynx and 326 cases(62.5%)involved the hypopharynx.Three hundred and ninety-five cases(75.7%)had some symptoms at the time of diagnosis.One hundred and forty-five(27.8%)cases had concurrent ESCC or a history of ESCC.One hundred and sixtyfour(31.4%)cases were detected by gastrointestinal endoscopy and classified as Group GE.The proportions of asymptomatic cases,cTis-1 cases and cases with no lymph node metastasis were significantly higher in Group GE than Group non-GE(61.6%vs 7.3%,P<0.001,32.9%vs 12.0%,P<0.001 and 69.5%vs 19.0%,P<0.001).Endoscopic laryngo-pharyngeal surgery or endoscopic submucosal dissection were performed in only 0.6%of the lesions in Group non-GE but in 21.3%of the lesions in Group GE(P<0.001).Overall survival was significantly longer in Group GE than in Group non-GE(P=0.018).The 2-year and 4-year survival rates were 82.5%and 70.7%in Group GE,and 71.5%and 59.0%in Group non-GE,respectively.CONCLUSION Gastrointestinal endoscopy plays an important role in the early detection and improving the prognosis of pharyngeal SCCs. | Hideaki Miyamoto Hideaki Naoe Jun Morinaga Kensuke Sakisaka Sayoko Tayama Kenshi Matsuno Ryosuke Gushima Masakuni Tateyama Takashi Shono Masanori Imuta Satoru Miyamaru Daizo Murakami Yorihisa Orita Yasuhito Tanaka | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，10： | 0 |
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