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| 1 | 基质细胞衍生因子在不同的急性髓系白血病细胞系的迁移、黏附和细胞凋亡中的生物学作用显示文摘本研究探讨基质细胞衍生因子(stromal cell derived factor 1,SDF-1)在急性髓系白血病(AML)细胞的迁移、黏附和细胞凋亡中的生物学作用及有关的信号转导。采用流式细胞术检测AML的细胞系KG1a、ML1、U937细胞表面标记物的表达;以免疫荧光技术检测SDF-1对肿瘤细胞膜表面分子的影响;通过微孔细胞转移实验检测SDF-1对AML细胞的趋化作用及磷脂酰肌醇3激酶(PI3K)在趋化过程中的作用;用蛋白免疫印记技术检测PI3K信号途径有关的细胞凋亡分子BCL-XL在SDF-1活化此途径后的变化。结果表明:3种AML细胞系不同程度表达CD34(KG1a=95.6%、ML1=4.6%、U937=4.8%)、CD45(KG1a=98.3%、U937=97.5%、ML1=17.8%)、CXCR4(ML1=85.4%、U937=43.6%、KG1a=3.8%)、ICAM(KG1a=75.8%、U937=41.8%、ML1=46.3%)。SDF-1能促进CXCR4高表达的ML1和U937细胞在基质细胞的黏附并能够诱导此类细胞的迁移,上述作用被G蛋白抑制剂pertussis toxin(PTX)、PI3K抑制剂渥曼青霉素(wortmannin)明显抑制;而对CXCR4低表达的KG1a细胞则无上述作用。SDF通过此途径还促进肿瘤细胞存活;此作用同样可被PI3K抑制剂明显抑制,加用wortman-nin后促肿瘤细胞调亡显著增加。蛋白免疫印记检测phospho-AKT、BCL-XL显示,在SDF组明显增强,加用PTX、wortmannin组则减弱。结论:SDF-1能触发CXCR4高表达的ML1和U937细胞的极化形态的建立及诱导黏附分子的重新分布,从而通过PI3K信号途径促进此类AML细胞的迁移,减少肿瘤细胞的调亡,而对CXCR4低表达的KG1a细胞则无上述作用。上述作用可以被PI3K信号途径阻断剂和G蛋白抑制剂所阻断。 | 常春康 李晓 吴凌云 徐黎 宋陆茜 贺琪 应韶旭 Joachim Deeg | 2008 | 中国实验血液学杂志2008，16，3： | 9 |
| 2 | Sonografische Diagnostik von Hirnfehlbildungen im S?uglingsalter.显示文摘 | K.-H. Deeg I. Gassner | 2010 | Ultraschall in Med2010，，05： | 2 |
| 3 | Inflammatory Markers and Loss of Muscle Mass (Sarcopenia) and Strength显示文摘 | Laura A. Schaap Saskia M.F. Pluijm Dorly J.H. Deeg Marjolein Visser | 2006 | The American Journal of Medicine2006，，6： | 2 |
| 4 | Allogeneic Hematopoietic Cell Transplantation for Chronic Myelomonocytic Leukemia: Relapse-Free Survival Is Determined by Karyotype and Comorbidities显示文摘 | Hesham Eissa Ted A. Gooley Mohamed L. Sorror Franchesca Nguyen Bart L. Scott Kristine Doney Keith R. Loeb Paul J. Martin John M. Pagel Jerry P. Radich Brenda M. Sandmaier E. Houston Warren Rainer Storb Frederick R. Appelbaum H. Joachim Deeg | 2011 | Biology of Blood and Marrow Transplantation2011，，： | 2 |
| 5 | Five-group cytogenetic risk classification,monosomal karyotype,and outcome after hematopoietic cell transplantation for MDS or acute leukemia evolving from MDS显示文摘 | Deeg HJ Scott BL Fang M | | 0，，07： | 1 |
| 6 | Personality predictor recurrence of late-life depression 显示文摘 | Steunenberg B Beekman AT Deeg DJ | 2006 | Affect Disorder2006，19，： | 1 |
| 7 | Frequency of Allogeneic Hematopoietic Cell Transplantation Among Patients With High- or Intermediate-Risk Acute Myeloid Leukemia in First Complete Remission显示文摘 | Raya Mawad Ted A. Gooley Vicky Sandhu Jack Lionberger Bart Scott Brenda M. Sandmaier Paul O’Donnell Pamela S. Becker Stephen Petersdorf Kathleen Shannon Dorcy Paul Hendrie Mohamed L. Sorror Roland B. Walter H. Joachim Deeg Frederick R. Appelbaum Elihu H. | 2013 | Journal of Clinical Oncology2013，，31： | 1 |
| 8 | How I treat refractory acute GVHD显示文摘 | Deeg HJ | 2007 | Blood2007，，10： | 1 |
| 9 | Depression and Generalized Anxiety Disorder: Co-Occurrence and Longitudinal Patterns in Elderly Patients显示文摘 | Robert A. Schoevers D. J.H. Deeg W. van Tilburg A. T.F. Beekman | 2005 | American Journal of Geriatric Psychiatry2005，，1： | 1 |
| 10 | Changes in depression and physical decline in older adults:a longitudinal perspective显示文摘 | Penninx BW Deeg D J van Eijk JT | | 0，，1： | 1 |
| 11 | The longitudinal effect of depression on functional limitations and disability in older adults:an eight wave prospective community-based study显示文摘 | Geerlings SW Beekman AT Deeg DJ | 2001 | Psychol Med2001，31，8： | 1 |
| 12 | The course of cognitive decline in older persons:results from the longitudinal aging study Amsterdam显示文摘 | Comijs HC Dik MG Deeg DJ | 2004 | Dement Geriatr Cogn Disord2004，17，： | 1 |
| 13 | Depression in older age is a risk factor for first ischemic cardiac events显示文摘 | Bremmer MA Hoogendijk WJ Deeg DJ | 2006 | Am J Geriatr Psychiatry2006，14，6： | 1 |
| 14 | Chelerythrin activates caspase-8,downregulates FLIP long and short,and overcomes resistance to tumour necrosis factor-related apoptosis-inducing ligand in KG1a cells显示文摘 | Platzbecker U Ward JL Deeg HJ | 2003 | Br J Haematol2003，122，3： | 1 |
| 15 | 显示文摘 | Deeg HJ Beckham C Loken MR | 2000 | Leuk Lymphoma2000，37，： | 1 |
| 16 | Decline in older per- sons' ability to recognize speech in noise: the influence of de- mographic, health- related, environmental, and cognitive factors显示文摘 | Pronk M Deeg D Festen JM | 2013 | Ear Hear2013，34，： | 1 |
| 17 | Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease显示文摘 | Ellen G.H.M. van den Heuvel Natasja M. van Schoor Paul Lips Elke J.P. Magdeleyns Dorly J.H. Deeg Cees Vermeer Martin den Heijer | 2013 | Maturitas2013，，： | 1 |
| 18 | Soluble TNF receptor fusion protein(etanereept) for the treatment of myelodysplastic syndrome: a pilot study显示文摘 | Deeg H J Gotlib J Beckham C | 2002 | Leukemia2002，16，： | 1 |
| 19 | Myelodysplastic syndromes显示文摘 | Scott BL Deeg HJ | 2010 | Annu Rev Med2010，61，： | 1 |
| 20 | Thelongitudinal effect of depression on functional limitations and disability in older adults:an eight-wave prospective community-based study显示文摘 | Geerlings SW Beekman AT Deeg DJ | 2001 | Psychol Med2001，31，8： | 1 |
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