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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 3 | Clinical significance of'anti-HBc alone'in human immunodeficiency virus-positive patients显示文摘AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection('anti-HBc alone')among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,'anti-HBc alone'and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on'anti-HBc alone'patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55'anti-HBc alone'(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the'anti-HBc alone'pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No'anti-HBc alone' patient tested positive for HBV DNA. CONCLUSION:'Anti-HBc alone'prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury. | M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 4 | Dose dependent alteraton in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate 显示文摘 | Lehmann K P Phillips S Sar M | 2004 | Toxicol Sci2004，81，： | 1 |
| 5 | Comparative Evaluation of Efficacy of Use of Tamsulosin and/or Tolterodine for Medical Treatment of Distal Ureteral Stones显示文摘 | Sak?p Erturhan Ahmet Erbagc? Faruk Yagc? Mehmet Celik Mehmet Solakhan Kemal Sar?ca | 2007 | Urology2007，，4： | 1 |
| 6 | Metal adsorption and desorption by lyophilized pseudomonas aeruginosa 显示文摘 | SAR P KAZY S K ASTHANA R K | 1999 | International Biodeterioration & Biodegradation1999，44，： | 1 |
| 7 | Dental anxiety among adults in Turkey显示文摘 | Firat D Tunc E P Sar V | 2006 | J Contemp Dent Pract2006，7，3： | 1 |
| 8 | Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis显示文摘 | Liu Kejun Lehmann Kim P Sar Madhanbananda | 2005 | Biology of Reproduction2005，71，1： | 1 |
| 9 | Extracellular polysaccharides of a copper-sensitive and a copper-resistant Pseudomonas aeruginosa strain:synthesis,chemical nature and copper binding显示文摘 | Kazy S K Sar P Singh S P Sen A K D'Souza S F | | 0，，06： | 1 |
| 10 | Metal adsorption and desorption by lyophilized Pseudomonas aeruginosa 显示文摘 | Sar P Kazy S K Asthara R K | 1999 | Int Biodeter & Biodegr1999，44，： | 1 |
| 11 | Vaccines against peste des petits ruminants virus 显示文摘 | Sen A Sar avanan P | 2010 | Exp Rev Vacci2010，9，7： | 1 |
| 12 | BAALC is an important predictor of refractoriness to chemotherapy and poor survival in intermediate-risk acute myeloid leukemia (AML)显示文摘 | Carlos Santamaría María C. Chillón Ramón García-Sanz Cristina Pérez María D. Caballero María V. Mateos Fernando Ramos Alfonso García Coca José M. Alonso Pilar Giraldo Teresa Bernal José A. Queizán Juan N. Rodríguez Noemí Puig Ana Balanzategui María E. Sar | 2010 | Annals of Hematology2010，，5： | 1 |
| 13 | The effect of antiox- idants on post-thawed Angora goat (Capra hircus ancryrensis) sperm parameters, lipid peroxidation and antioxidant activities 显示文摘 | Bucaka M N Sar 1 ozkan S Tuncer P B | 2010 | Small Ruminant Research2010，89，1： | 1 |
| 14 | Influence of the extraction–purification conditions on final properties of alginates obtained from brown algae ( Macrocystis pyrifera )显示文摘 | César G. Gomez María V. Pérez Lambrecht Jorge E. Lozano Marguerite Rinaudo Marcelo A. Villar | 2009 | International Journal of Biological Macromolecules2009，，4： | 1 |
| 15 | Dose-dependent aherations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate 显示文摘 | LEHMANN K P PHILLIPS S SAR M | 2004 | Toxicol Sci2004，81，1： | 1 |
| 16 | Chloroplast isolation from Laminaria digitata (Phaeophyceae): a reproducible methodology yielding photosynthetically active chloroplasts显示文摘 | DRAGANA S MARCOAURELIO A CF SAR P | 1994 | Planta1994，195，： | 1 |
| 17 | Metal adsorption and desorption by lyophilized Pseudomonas aeruginosa显示文摘 | Sar P Kazy S K Asthana R K | 1999 | International Biodeterioration ~ Biodegradation1999，44，： | 1 |
| 18 | Highly efficient mRNA-based gene transfer in feederfree cultured H9 human embryonic stem cells显示文摘 | Ponsaerts P van der Sar S Van Tendeloo V F etal | 2004 | Cloning Stem Cells2004，6，3： | 1 |
| 19 | SEROPREVALENCE OF HUMAN TOXOCARIASIS IN ANDEAN COMMUNITIES FROM THE NORTHEAST OF LIMA, PERU显示文摘 | Espinoza Yrma A Huapaya Pedro E Roldán William H Jiménez Susana Abanto Enma P Rojas Carlos A Cavero Yuri A Gutiérrez César A | 2010 | Revista do Instituto de Medicina Tropical de S茫o Paulo2010，，1： | 1 |
| 20 | Colorectal cancer in inflammatory bowel disease: Results of the 3rd ECCO pathogenesis scientific workshop (I)显示文摘 | Shaji Sebastian Vincent Hernández P?r Myrelid Revital Kariv Epameinondas Tsianos Murat Toruner Marc Marti-Gallostra Antonino Spinelli Andrea E. van der Meulen-de Jong Elif Sar?tas Yuksel Christoph Gasche Sandro Ardizzone Silvio Danese | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
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