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| 1 | 在 esophagogastroduodenoscopy 使用 lidocaine 的实用性与 propofol 表现在镇静下面显示文摘 AIM:To determine whether topical lidocaine benefits esophagogastroduoduenoscopy(EGD) by decreasing propofol dose necessary for sedation or procedurerelated complications.METHODS:The study was designed as a prospective,single centre,double blind,randomised clinical trial and was conducted in 2012 between January and May(NCT01489891).Consecutive patients undergoing EGD were randomly assigned to receive supplemental topical lidocaine(L;50 mg in an excipient solution which was applied as a spray to the oropharynx) or placebo(P;taste excipients solution without active substance,similarly delivered) prior to the standard propofol sedation procedure.The propofol was administered as a bolus intravenous(iv) dose,with patients in the L and P groups receiving initial doses based on the patient’s American Society of Anaesthesiologists(ASA) classification(ASAⅠ-Ⅱ:0.50-0.60 mg/kg;ASA Ⅲ-Ⅳ:0.25-0.35 mg/kg),followed by 10-20 mg iv dose every 30-60 s at the anaesthetist’s discretion.Vital signs,anthropometric measurements,amount of propofol administered,sedation level reached,examination time,and the subjective assessments of the endoscopist’s and anaesthetist’s satisfaction(based upon a four point Likert scale) were recorded.All statistical tests were performed by the Stata statistical software suite(Release 11,2009;StataCorp,LP,College Station,TX,United States).RESULTS:No significant differences were found between the groups treated with lidocaine or placebo in terms of total propofol dose(310.7 ± 139.2 mg/kg per minute vs 280.1 ± 87.7 mg/kg per minute,P = 0.15) or intraprocedural propofol dose(135.3 ± 151.7 mg/kg per minute vs 122.7 ± 96.5 mg/kg per minute,P = 0.58).Only when the L and P groups were analysed with the particular subgroups of female,< 65-year-old,and lower anaesthetic risk level(ASA Ⅰ-Ⅱ) was a statistically significant difference found(L:336.5 ± 141.2 mg/kg per minute vs P:284.6 ± 91.2 mg/kg per minute,P = 0.03) for greater total propofol requirements).The total incidence of complications was also similar between the two groups,with the L group showing a complication rate of 32.2%(95%CI:21.6-45.0) and the P group showing a complication rate of 26.7%(95%CI:17.0-39.0).In addition,the use of lidocaine had no effect on the anaesthetist’s or endoscopist’s satisfaction with the procedure.Thus,the endoscopist’s satisfaction Likert assessments were equally distributed among the L and P groups:unsatisfactory,[L:6.8%(95%CI:2.2-15.5) vs P:0%(95%CI:0-4.8);neutral,L:10.1%(95%CI:4.2-19.9) vs P:15%(95%CI:7.6-25.7)];satisfactory,[L:25.4%(95%CI:10-29.6) vs P:18.3%(95%CI:15.5-37.6);and very satisfactory,L:57.6%(95%CI:54-77.7) vs P:66.6%(95%CI:44.8-69.7)].Likewise,the anaesthetist’s satisfaction Likert assessments regarding the ease of maintaining a patient at an optimum sedation level without agitation or modification of the projected sedation protocol were not affected by the application of lidocaine,as evidenced by the lack of significant differences between the scores for the placebo group:unsatisfactory,L:5.8%(95%CI:1.3-13.2) vs P:0%(95%CI:0-4.8);neutral,L:16.9%(95%CI:8.9-28.4) vs P:16.7%(95%CI:8.8-27.7);satisfactory,L:15.2%(95%CI:7.7-26.1) vs P:20.3%(95%CI:11.3-31.6);and very satisfactory,L:62.7%(95%CI:49.9-74.3) vs P:63.3%(95%CI:50.6-74.7).CONCLUSION:Topical pharyngeal anaesthesia is safe in EGD but does not reduce the necessary dose of propofol or improve the anaesthetist’s or endoscopist’s satisfaction with the procedure. | Felipe de la Morena Cecilio Santander Carlos Esteban Beatriz de Cuenca Juan Antonio García Javier Sánchez Ricardo Moreno | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 3 |
| 2 | Clinical characteristics and type of antithrombotic treatment in a Spanish cohort of elderly patients with atrial fibrillation according to dependency, frailty and cognitive impairment显示文摘根据相关性,脆弱和认知缺陷与 atrial 纤维性颤动(AF ) 考虑老病人的临床的侧面和管理的 BackgroundAvailable 数据是少见的。学习的目的是根据相关性分析 biodemographic 数据,临床的侧面和 antithrombotic 治疗,吗在patients.MethodsCross部分的老 AF 和学习在 75 年与 3 个月在 Spain.ResultsA 在内部药部门出席了的口头的抗凝剂对待的连续 AF 病人执行了的多中心的脆弱和认知缺陷 837 总计病人( 83.0 ???????????????????吗???????????????????￡?? | Jose Maria Mostaza Manuel Jesús Romero Jiménez Fernando José Ruiz Laiglesia José Antonio Díaz Peromingo Manuel Beltrán Robles Ernesto Guevara Sierra Ana Santander Bilbao Carmen Suárez | 2018 | Journal of Geriatric Cardiology2018，15，4： | 2 |
| 3 | Removal of boron from geothermal water by a novel boron selective resin 显示文摘 | SANTANDER P RIVAS B L URBANO B F | 2013 | Desalination2013，310，： | 1 |
| 4 | Tuberculous meningitis in children : Clinical features and outcome in 40 cases 显示文摘 | Paganini HF Gonzalez F Santander C | 2000 | Scand J Infect Dis2000，32，1： | 1 |
| 5 | Oral cancer susceptibility associated with the CYP1A1 and GSTM1 genotypesin Chilean individuals显示文摘 | Karina Cordero Iris Espinoza Dante Caceres Angela Roco Carla Miranda Valentina Squicciarini Paula Santander Kuen Lee Iván Saavedra Luis Qui?ones | 2010 | Oncology Letters2010，，3： | 1 |
| 6 | Safety and efficacy of colistin in Acinetobacter and Pseudomonas infections: a prospective cohort study显示文摘 | Rosa Reina Elisa Estenssoro Gabriela Sáenz Héctor S. Canales Romina Gonzalvo Gabriela Vidal Gustavo Martins Andrea Das Neves Oscar Santander Carlos Ramos | 2005 | Intensive Care Medicine2005，，8： | 1 |
| 7 | Performance optimization of a passive silicon-based micro-direct methanol full Cell 显示文摘 | Tortes N Santander J Esquivel J P | 2008 | Sensors and Actuators B: Chemical2008，132，2： | 1 |
| 8 | Multi-Range Silicon Micromachined Flow Sensor显示文摘 | Sabate N Santander J Fonseca L | 2004 | Sensors and actuators A2004，110，13： | 1 |
| 9 | Muhi-Rangesilicon Micro-Ma- chined Flow Sensor显示文摘 | N Sabate J Santander L Fonseca et 2 | 2004 | Sensor and Actuators A2004，110，： | 1 |
| 10 | Influence of laterotrusive clusal scheme on bilateral masseter EMG activity during clenching and grinding显示文摘 | Campillo MJ Miralles R Santander H | 2008 | Cranio2008，26，4： | 1 |
| 11 | Modified-three-product column(3PC)flotation of copper-gold particles in a rougher feed and tailings显示文摘 | Valderrama L Santander M Paiva M | 2011 | Minerals Processing2011，24，7： | 1 |
| 12 | Myocardial reperfusion injury显示文摘 | Ferez Santander SM Marquez MF Pena Duque MA | 2004 | Rev Esp Cardiol2004，57，1： | 1 |
| 13 | Tuberculous meningitis in children: clinical features and outcome in 40 cases 显示文摘 | Paganini H Gonzalez F Santander C | 2000 | Scand J Infect Dis2000，32，： | 1 |
| 14 | Usefulness of manometry to select patients with anal fissure forcontrolled anal dilatation显示文摘 | SANTANDER C GISBERT JP MORENO-OTERO R | 2010 | Rev Esp Enferm Dig2010，102，12： | 1 |
| 15 | Simulating microwave-heated open systems: Tuning competitive sorption in zeofites显示文摘 | Santander J E Gomez S Malinger K A | 2009 | Journal of Physical Chemistry B2009，113，13： | 1 |
| 16 | Two important examples of nonlinear oscillators显示文摘 | Carinena J F Ranada M F Santander M | 2004 | Proceedings of 10th International Conference inModern Group Analysis Larnaca Cyprus2004，2004，： | 1 |
| 17 | Myocardial reperfusion injury显示文摘 | FEREZ SANTANDER SM MARQUEZ MF PENA DUQUE MA | 2004 | Rev Esp Cardiol2004，57，11： | 1 |
| 18 | A MEMS-based thermal infrared emitter for an integrated NDIR spectrometer显示文摘 | C. Calaza M. Salleras N. Sabaté J. Santander C. Cané L. Fonseca | 2012 | Microsystem Technologies2012，，7： | 1 |
| 19 | Low-grade oncocytic adrenal carcinoma 显示文摘 | Lazaro Santander R Andres Gozalbo C Vizcaino C V | 2001 | Arch Esp Urol2001，54，10： | 1 |
| 20 | In vitro osteoinduction of human mesenchymal stem cells in biomimetic surface modified titanium alloy implants 显示文摘 | Santander S | 2012 | Dent Mater J2012，31，5： | 1 |
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