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| 1 | Assessment of vascular invasion in gastric cancer: A comparative study显示文摘AIM: To evaluate and compare detection of lymphatic and blood vessel invasion (LVI and BVI) by hematox-ylin-eosin (HE) and immunohistochemistry (IHC) in gastric cancer specimens, and to correlate with lymph node status. METHODS: IHC using D2-40 (a lymphatic endothelial marker) and CD34 (a pan-endothelial marker) was performed to study LVI and BVI in surgical specimens froma consecutive series of 95 primary gastric cancer cases. The results of the IHC study were compared with the detection by HE using McNemar test and kappa index. The morphologic features of the tumors and the presence of LVI and BVI were related to the presence of lymph node metastasis. A χ2 test was performed to obtain associations between LVI and BVI and other prognostic factors for gastric cancer. RESULTS: The detection rate of LVI was considerably higher than that of BVI. The IHC study identified eight false-positive cases and 13 false-negative cases for LVI, and 24 false-positive cases and 10 false-negative cases for BVI. The average Kappa value determined was moderate for LVI (k=0.50) and low for BVI (k=0.20). Both LVI and BVI were statistically associated with the presence of lymph node metastasis (HE: P=0.001, P=0.013, and IHC: P=0.001, P=0.019). The mor-phologic features associated with LVI were location of the tumor in the distal third of the stomach (P=0.039), Borrmann's macroscopic type (P=0.001), organ inva-sion (P=0.03) and the depth of tumor invasion (P=0.001). The presence of BVI was related only to the depth of tumor invasion (P=0.003). CONCLUSION: The immunohistochemical identification of lymphatic and blood vessels is useful for increasing the accuracy of the diagnosis of vessel invasion and for predicting lymph node metastasis. | Letícia Trivellato Gresta Ismael Alves Rodrigues-Júnior Lúcia Porto Fonseca de Castro Geovanni Dantas Cassali Mnica Maria Demas lva-res Cabral | 2013 | World Journal of Gastroenterology2013，19，24： | 8 |
| 2 | T cells in sputum of asthmatic patients are activated independently of disease severity or control 显示文摘 | Lourenco O Mafalda Fonseca A Taborda-Barata L | 2009 | Allergol hnmunopathol2009，37，6： | 1 |
| 3 | Transmission capacity: availability, maximum, transfer and reliability显示文摘 | Leite da S A M de Carvalho C J G da Fonseca M L A | 2002 | IEEE Transactions on Power Systems2002，17，3： | 1 |
| 4 | Trends in DNA biosensors 显示文摘 | Teles F R R Fonseca L R | 2008 | Talanta2008，77，2： | 1 |
| 5 | Long-term probabilistic evaluation of operating reserve requirements with renewable sources显示文摘 | da SILVA A M L SALES W S da FONSECA MANSO L A | 2010 | IEEE Trans on Power Systems2010，25，1： | 1 |
| 6 | A lignan from needles of himalayan Taxus baccata 显示文摘 | Fonseca S F Nielsen T L Rhveda E A | 1978 | Phytochemistry1978，17，： | 1 |
| 7 | Surgical site infection: rates, etiology and resistance patterns to antimicrobials among strains isolated at Rio de Janeiro University Hospital显示文摘 | Santos K R Fonseca L S Bravo Neto G P | 1997 | Infection1997，25，4： | 1 |
| 8 | Combined Interpolation Restoration of Land-sat Images Through FIR Filter Design Techniques显示文摘 | Fonseca L M G Prasad G S D Mascarenhas N D A | 1993 | International Journal of Remote Sensing1993，14，13： | 1 |
| 9 | Sjogren' s syndrome : a comparative study of impression cytology of the conjunctiva and buccal mucosa, and salivary gland biopsy 显示文摘 | Aguilar A J Fonseca L Croxatto JO | 1991 | Cornea1991，10，3： | 1 |
| 10 | Semivariogram textural classification of JERS-1(FUYO-1) SAR data obtained over a flooded area of the Amazonian rainforest显示文摘 | Miranda F P Fonseca L E N Carr J R | 2000 | International Journal of Remote Sensing2000，19，3： | 1 |
| 11 | Storage of 'Prata Ana' bananas in controlled atmosphere显示文摘 | Botrel N Fonseca M J de O Godoy R L O | | 0，，： | 1 |
| 12 | Preparation and electrical characterization of a silicone elastomer composite charged with multi-wall carbon nanotubes functionalized with 7-octenyltrichlorosilane显示文摘 | Vast L Mekhalif Z Fonseca A | 2007 | Composites Science and Technology2007，67，5： | 1 |
| 13 | The effect of glucose and insulin on the activity of methylene tetrahydrofolate reductase and cystathionine-beta-synthase: studies in hepatocytes 显示文摘 | Dicker-Brown A Fonseca V A Fink L M | 2001 | Atherosclerosis2001，158，2： | 1 |
| 14 | FIDEL - a retrovirus -like retrotransposon and its distinct evolu- tlonary histories in the A - and B - genome components of cultivated peanut 显示文摘 | Nielen S Fonseca F C Bertioli S L | 2010 | Chromosome Research2010，18，： | 1 |
| 15 | Fabrication and characterization of nanostructured conducting polymer films containing magnetic nanopar- ticles显示文摘 | PATERNO L G FONSECA F J ALCANTARA G B | 2009 | Thin Solid Films2009，517，： | 1 |
| 16 | Microglial stress induc-ible protein 1 promotes proliferation and migration in human glioblas-toma cells显示文摘 | Fonseca AC Romao L Amaral RF | | 0，，01： | 1 |
| 17 | Relationship between leptin and body mass and metabolic syndrome in an adult population显示文摘 | MARTINS MDO C LIMA FALEIRO L FONSECA A | 2012 | Rev Port Cardiol2012，31，11： | 1 |
| 18 | Self-consistent calculation of the electronic structure and electron-elec tron interaction in self-assembled InAs-GaAs quantum dot structures 显示文摘 | Fonseca C R L | 1997 | Physical Review B1997，57，7： | 1 |
| 19 | Effects of live weight,maturity and genotype of sheep fed a hay-based diet,on intake,digestion and live weight gain显示文摘 | Lourenco A L G Dias-da-Silva A A Fonseca AJ M | 2000 | Livest Prod Sci2000，63，： | 1 |
| 20 | Transes- terification of soybean oil over sulfonic acid functionalised polymeric membranes 显示文摘 | Guerreiro L Castanheiro J E Fonseca I M | 2006 | Catalysis Today2006，118，12： | 1 |
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