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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 4 | Developing a global interconnected power system model显示文摘Decarbonizing the power sector is a necessary step towards a low-carbon future. Interconnecting power systems on different continents could be a method to contribute to such a future, by utilizing highly efficient renewable resources around the globe, while simultaneously providing additional benefits of power system integration. In this paper, we describe the process of constructing and simulating a global interconnected power system model with high technical and temporal resolution. Being the first of its kind on the global scale, this paper is designed to showcase the proof of concept as an intermediate step to a high resolution global model, by integrating an existing European power system model with the North-American continent. The work to date has been focused on testing the methodology and building up necessary knowledge to realistically simulate the functionality of a possible future global grid. Some initial results are analysed to support the viability of the model and the concept in general. Furthermore, key factors influencing the development and optimal performance of the global interconnected power system model are identified. | Maarten Brinkerink Paul Deane Seán Collins Brian Ó Gallachóir | 2018 | Global Energy Interconnection2018，1，3： | 2 |
| 5 | Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain显示文摘The role of neurotrophins in neuronal plasticity has recently become a strong focus in neuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses,modify the response to injury,and alter the adaptation response.Intriguingly,the prior studies highlight the role of p75 neurotrophin receptor(p75^(NTR))in various injuries and diseases such as central nervous system injuries,Alzheimer's disease and amyotrophic lateral sclerosis.More comprehensive elucidation of the mechanisms,and therapies targeting these molecular signaling networks may allow for neuronal tissue regeneration following an injury.Due to a diverse role of the p75^(NTR)in biology,the body of evidence comprising its biological role is diffusely spread out over numerous fields.This review condenses the main evidence of p75^(NTR)for clinical applications and presents new findings from published literature how data mining approach combined with bioinformatic analyses can be utilized to gain new hypotheses in a molecular and network level. | Joel F.Ritala Seán BLyne Antti Sajanti Romuald Girard Janne Koskimäki | 2022 | Neural Regeneration Research2022，17，4： | 2 |
| 6 | Functional and neuroanatomic correlations in poststroke depression:the Sunnybrook Stroke Study显示文摘 | Singh A Black SE Herrmann N | 2000 | Stroke2000，31，： | 1 |
| 7 | Steady - state levels of aquaporinl mRNA expression are increased in idiopathic polyhydramnios 显示文摘 | Mann SE Dvorak N Gilbert H | 2006 | Am J Obstet Gynecol2006，194，： | 1 |
| 8 | Pheochromocytom a in pregnancy: when is operative intervention indicated 显示文摘 | Junglee N Harries SE Davies N | 2007 | J Womens Health (Larchmt)2007，16，9： | 1 |
| 9 | Pheochromocytoma inPregnancy: When is Operative Intervention Indicated 显示文摘 | Junglee N Harries SE Davies N | 2007 | JWomens Health (Larchmt)2007，16，9： | 1 |
| 10 | Vascular risk factors and diabetic neuropathy显示文摘 | Tesfaye S Chaturvedi N Eaton SE | 2005 | N Engl J Med2005，352，4： | 1 |
| 11 | Functional and neuroanatomic correlations in poststroke depression显示文摘 | Singh A Black SE Hermann N | 2000 | Stroke2000，31，3： | 1 |
| 12 | Nutritional status of hospitalized acute stroke patients显示文摘 | Gariballa SE Taub N Parker SG | 1998 | British Journal of Nutrition1998，79，6： | 1 |
| 13 | S-allyl cysteine reduces oxidant load in cells involved in the atherogenic process显示文摘 | Ho SE Ide N Lau BH | 2001 | Phytomedicine2001，8，1： | 1 |
| 14 | Effect of atorvastatin on hematologic parameters in patients with hypercholesterolemia显示文摘 | Akin F AyaB Kse N | 2013 | Angiology2013，64，8： | 1 |
| 15 | The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo 显示文摘 | Chiang N Serhan CN Dahl6n SE | 2006 | Pharmacol Rev2006，58，3： | 1 |
| 16 | Implications of premature ovarian failure on bone turnover markers and bone mineral density 显示文摘 | Kurtoglu-Aksoy N Akhan SE Bastu E | 2014 | Clin Exp Obstet Gynecol2014，41，2： | 1 |
| 17 | The role of antibiotic prophylaxis on wound infection after mesh hernia repair under local anesthesia on an ambulatory basis显示文摘 | Angel Celdrán Octavio Frieyro Juan C. Pinta José L. Souto Jaime Esteban José M. Rubio José F. Se?arís | 2004 | Hernia2004，，1： | 1 |
| 18 | IL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium显示文摘 | Nguyen T Robinson N Allison SE | 2013 | Placenta2013，34，9： | 1 |
| 19 | The effect of dexrazoxane on myocan:lial injury in doxorubicin-treated children with acute lymphoblastle leukemia显示文摘 | Lipshultz SE Rifai N Dalton VM | 2004 | N Engl J Med2004，351，2： | 1 |
| 20 | Eating soya improves human memory显示文摘 | File SE Jarrott N Fhck E | 2001 | Psychopharmacology(Bed)2001，157，4： | 1 |
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